Roles of the RAM and ANK domains in signaling by the C.elegans GLP-1 receptor

EMBO Journal

Volumn 15, Issue 24, 1996, Pages 7002-7012

  Roehl, Henry ^a   Bosenberg, Marcus ^a   Blelloch, Robert ^a   Kimble, Judith ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

C.elegans; GLP 1; LAG 1; Signal transduction

Indexed keywords

CELL PROTEIN; CELL RECEPTOR; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; MEMBRANE PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; MISSENSE MUTATION; NEMATODE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA-BINDING PROTEINS; HELMINTH PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, GLUCAGON; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

EID: 0030477188     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01092.x     Document Type: Article

References (46)

1. Artavanis-Tsakonas,S., Matsuno,K. and Fortini,M.E. (1995) Notch signaling. Science, 268, 225-232.
2. Aster,J., Pear,W., Hasserjian,R., Erba,H., Davi,F., Luo,B., Scott,M., Baltimore,D. and Sklar,J. (1994) Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harbor Symp. Quant. Biol., 59, 125-136.
3. Austin,J. and Kimble,J. (1987) glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C.elegans. Cell, 57, 589-599.
4. Ausubel,F.M., Brent,R., Kingston,R.E., Moore,D.D., Seidman,J.G., Smith,J.A. and Struhl,K. (1987) Current Protocols in Molecular Biology. John Wiley & Sons, New York.
5. Bailey,A.M. and Posakony,J.W. (1995) Suppressor of hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity. Genes Dev., 9, 2609-2622.
6. Christensen,S., Kodoyianni,V., Bosenberg,M., Friedman,L. and Kimble,J. (1996) lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development, 122, 1373-1383.
7. Chung,C.N., Hamaguchi,Y., Honjo,T. and Kawaichi,M. (1994) Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jκ. Nucleic Acids Res., 22, 2938-2944.
8. Crittenden,S.L., Troemel,E.R., Evans,T.C. and Kimble,J. (1994) GLP-1 is localized to the mitotic region of the C.elegans germ line. Development, 120, 2901-2911.
9. Diederich,R.J., Matsuno,K., Hing,H. and Artavanis-Tsakonas,S. (1994) Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development, 120, 473-481.
10. Durfee,T., Becherer,K., Chen,P.L., Yeh,S.H., Yang,Y., Kilburn,A.E., Lee,W.H. and Elledge,S.J. (1993) The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev., 7, 555-569.
11. Fields,S. and Song,O. (1989) A novel genetic system to detect protein-protein interactions. Nature, 340, 245-246.
12. Finney,M. and Ruvkun,G. (1990) The unc-86 gene product couples cell lineage and cell identity in C.elegans. Cell, 63, 895-905.
13. Fortini,M.E. and Artavanis-Tsakonas,S. (1994) The Suppressor of Hairless protein participates in Notch receptor signaling. Cell, 79, 273-282.
14. Fortini,M.E., Rebay,I., Caron,L.A. and Artavanis-Tsakonas,S. (1993) An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature, 365, 555-557.
15. Franco del Amo,F., Gendron-Maguire,M., Swiatek,P.J., Jenkins,N.A., Copeland,N.G. and Gridley,T. (1993) Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics, 15, 259-264.
16. Gietz,D., St Jean,A., Woods,R.A. and Schiestl,R.H. (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res., 20, 1425.
17. Greenwald,I.S., Sternberg,P.W. and Horvitz,H.R. (1983) The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell, 34, 435-444.
18. Grossman,S.R., Johannsen,E., Tong,X., Yalamanchili,R. and Kieff,E. (1994) The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the Jκ recombination signal binding protein. Proc. Natl Acad. Sci. USA, 91, 7568-7572.
19. Henderson,S.T., Gao,D., Lambie,E.J. and Kimble,J. (1994) lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C.elegans. Development, 120, 2913-2924.
20. Henkel,T., Ling,P.D., Hayward,S.D. and Peterson,M.G. (1994) Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein JK. Science, 265, 92-95.
21. Hsieh,J.J.D., Henkel,T., Salmon,P., Robey,E., Peterson,M.G. and Hayward,S.D. (1996) Truncated mammalian Notch1 activates CBF1/RBPJκ-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol. Cell. Biol., 16, 952-959.
22. Jarriault,S., Brou,C., Logeat,F., Schroeter,E.H., Kopan,R. and Israël,A. (1995) Signalling downstream of activated mammalian Notch. Nature, 377, 355-358.
23. Johansen,K.M., Fehon,R.G. and Artavanis-Tsakonas,S. (1989) The Notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development. J. Cell Biol., 109, 2427-2440.
24. Kim,J.S. and Raines,R.T. (1993) Ribonuclease S-peptide as a carrier in fusion proteins. Protein Sci., 2, 348-356.
25. Kodoyianni,V., Maine,E.M. and Kimble,J. (1992) Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans. Mol. Biol. Cell, 3, 1199-1213.
26. Kooh,P.J., Fehon,R.G. and Muskavitch,M.A. (1993) Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development, 117, 493-507.
27. Kopan,R., Nye,J.S. and Weintraub,H. (1994) The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development, 120, 2385-2396.
28. Kopan,R., Nye,J.S., Schroeter,E.H. and Weintraub,H. (1996) Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl Acad. Sci. USA, 93, 1683-1688.
29. Lambie,E.J. and Kimble,J. (1991) Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions. Development, 112, 231-240.
30. Lecourtois,M. and Schweisguth,F. (1995) The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling. Genes Dev., 9, 2598-2608.
31. Lieber,J., Kidd,S., Alcamo,E., Corbin,V. and Young,M.W. (1993) Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev., 7, 1949-1965.
32. Mango,S.E., Maine,E.M. and Kimble,J. (1991) Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Nature, 352, 811-815.
33. Matsunami,N., Hamaguchi,Y., Yamamoto,Y., Kuze,K., Kangawa,K., Matsuo,H., Kawaichi,M. and Honjo,T. (1989) A protein binding to the JκK recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Nature, 342, 934-937.
34. Mello,C.C., Kramer,J.M., Stinchcomb,D. and Ambros,V. (1991) Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J., 10, 3959-3970.
35. Nye,J.S. and Kopan,R. (1995) Developmental signaling. Vertebrate ligands for Notch. Curr. Biol., 5, 966-969.
36. Nye,J.S., Kopan,R. and Axel,R. (1994) An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development, 120, 2421-2430.
37. Priess,J.R., Schnabel,H. and Schnabel,R. (1987) The glp-1 locus and cellular interactions in early C.elegans embryos. Cell, 51, 601-611.
38. Rebay,I., Fehon,R.G. and Artavanis-Tsakonas,S. (1993) Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell, 74, 319-329.
39. Roehl,H. and Kimble,J. (1993) Control of cell fate in C.elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Nature, 364, 632-635.
40. Spence,A.M., Coulson,A. and Hodgkin,J. (1990) The product of fem-I, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions. Cell, 60, 981-990.
41. Struhl,G., Fitzgerald,K. and Greenwald,I. (1993) Intrinsic activity of the LIN-12 and Notch intracellular domains in vivo. Cell, 74, 331-345.
42. Tamura,K., Taniguchi,Y., Minoguchi,S., Sakai,T., Tun,T., Furukawa,T. and Honjo,T. (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H). Curr. Biol., 5, 1416-1423.
43. Tax,F.E., Yeargers,J.J. and Thomas,J.H. (1994) Sequence of C.elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature, 368, 150-154.
44. Wharton,K.A., Johansen,K.M., Xu,T. and Artavanis-Tsakonas,S. (1985) Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell, 43, 567-581.
45. Yochem,J. and Greenwald,I. (1989) glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C.elegans, encode similar transmembrane proteins. Cell, 58, 553-563.
46. Yochem,J., Weston,K. and Greenwald,I. (1988) The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Nature, 335, 547-550.