The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions

Genetics

Volumn 143, Issue 2, 1996, Pages 859-875

  Bettler, Donald ^a   Pearson, Stephanie ^a   Yedvobnick, Barry ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN; RNA POLYMERASE;

ANIMAL TISSUE; CENTRAL NERVOUS SYSTEM; DOWN REGULATION; DROSOPHILA; EMBRYO DEVELOPMENT; FORELIMB; GENE EXPRESSION; IMAGINAL DISC; NONHUMAN; OOCYTE DEVELOPMENT; OVARY FOLLICLE CELL; POLYTENE CHROMOSOME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; SENSE ORGAN; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES; DOWN-REGULATION; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT HORMONES; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; SEQUENCE ALIGNMENT;

ANIMALIA;

EID: 0030013445     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (94)

1. ARTAVANIS-TSAKONAS, S., K. MATSUNO and M. E. FORTINI, 1995 Notch signaling. Science 268: 225-232.
2. BAILY, A. M., and J. W. POSAKONY, 1995 Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 9: 2609-2622.
3. BANG, A. G., and J. W. POSAKONY, 1992 The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev. 6: 1752-1769.
4. BANG, A. G., A. BAILY and J. W. POSAKONY, 1995 Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway. Dev. Biol. 172: 479-494.
5. BENDER, L. B., P. J. KOOH and M. A. T MUSKAVITCH, 1993 Complex function and expression of Delta during Drosophila oogenesis. Genetics 133: 967-978.
6. BETTLER, D., A. SCHMID and B. YEDVOBNICK, 1991 Early ventral expression of the neurogenic locus mastermind. Dev. Biol. 144: 436-439.
7. BLACKWELL, T. K., B. BOWERMAN, J. R. PREISS and H. WEINTRAUB, 1994 Formation of a monomeric DNA binding domain by Skn-1 bZip and homeodomain elements. Science 266: 621-628.
8. BOUILIANE, G. L., A. DE LA CONCHA, J. A. CAMPOS-ORTEGA, L. Y. JAN and Y. N. JAN, 1991 The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 10: 2975-2984.
9. BOUROUIS, M., P. MOORE, C. RUEL, Y. GRAU, P. HEITZLER et al., 1990 An early embryonic product of the shaggy gene encodes a serine/ threonine protein kinase related to the CDC 28/CDC 2 subfamily. EMBO J. 9: 2877-2884
10. BOWERMAN, B., B. A. EATON and J. PREISS, 1992 skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68: 1061-1075.
11. BRAND, M., and J. A. CAMPOS-ORTEGA, 1990 Second site modifiers of the split mutation of Notch define genes involved in neurogenesis in Drosophila melanogaster. Wilhelm Roux Arch Dev. Biol. 198: 275-285.
12. BRAND, M., A. P. JARMAN, L. Y. JAN and Y. N. JAN, 1993 asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. Development 119: 1-17.
13. BROU, C., F. LOGEAT, M. LECOURTOIS, J. VANDEKERCKOVE, P. KOURILSKY et al., 1994 Inhibition of the DNA binding activity of Drosophila Suppressor of Hairless and its human homolog KBF2/RBP-Jk, by direct protein-protein interaction with Drosophila Hairless. Genes Dev. 8: 2491-2503.
14. CAGAN, R. L., and D. F. READY, 1989 Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev. 3: 1099-1112.
15. CAMPBELL, G., H. GORING, T. LIN, E. SPANA, S. ANDERSON et al., 1994 RK2, a glial specific homeodomain protein is required for embryonic nerve cord condensation and viability in Drosophila. Development 120: 2957-2966.
16. CAMPOS-ORTEGA, J. A., and V. HARTENSTEIN, 1985 The Embryonic Development of Drosophila melanogaster. Springer Verlag, Berlin.
17. CAVENER, D., 1987 Comparison of the consensus sequence flanking transla tional start sites in Drosophila and vertebrates. Nucleic Acid Res. 15: 1353-1361.
18. CHOU, T. B., and N. PERRIMON, 1992 Use of a vest site-specific recombinase to produce female germline chimeras in Drosophila. Genetics 131: 643-653.
19. CORBIN, V., A. M. MICHELSON, S. M. ABMAYR, V. NEEL, E. ALCOMO et al., 1991 A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67: 311-323.
20. CUBAS, P., J. F. DE CELIS, S. CAMPUZANO and J. MODOLELL, 1991 Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev. 5: 996-1008.
21. CUMMINGS, C. A., and C. CRONMILLER, 1994 The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila. Development 120: 381-394.
22. DE LA CONCHA, A., V. DIETRICH, D. WEIGEL and J. A. CAMPOS-ORTEGA, 1988 Functional interactions of neurogenic genes of Drosophila melanogaster. Genetics 118: 499-508.
23. DELIDAKIS, C., A. PREISS, D. A. HARTLEY and S. ARTAVANIS-TSAKONAS, 1991 Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics 129: 803-823.
24. DIEDERICH, R. J., K. MATSUNO, H. HING and S. ARTAVANIS-TSAKONAS, 1994 Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development 120: 473-48128.
25. DIETRICH, U., and J. A. CAMPOS-ORTEGA, 1984 The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster. J. Neurogenet. 1: 315-322.
26. FEHON, R. G., P. J. KOOH, I. REBAY, C. C. REGAN, T. XU et al., 1990 Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologos genes in Drosophila. Cell 61: 523-534.
27. FEHON, R. G., K. JOHANSEN, I. REBAY and S. ARTAVANIS-TSAKONAS, 1991 Complex cellular and subcellular regulation of Notch expression during embryonic and imaginai development of Drosophila: implications for Notch function. J Cell Biol. 113 (Suppl. 3): 657-669.
28. FORTINI, M. E., and S. ARTAVANIS-TSAKONAS, 1994 The Suppressor of Hairless protein participates in Notch receptor signaling. Cell 79: 273-282.
29. GAIRE, M., B. CHATTON and C. KEDINGER, 1990 Isolation and characterization of two novel, closely related ATF cDNA clones from Hela cells. Nucleic Acids Res. 18: 3467-3473.
30. GINIGER, E., L. Y. JAN and Y. N. JAN, 1993 Specifying the path of the intersegmental nerve of the Drosophila embryo. Development 117: 431-440.
31. GORIELY, A., N. DUMAONT, C. DAMBLY-CHAUDIERE and A. GHYSEN, 1991 The determination of sense organs in Drosophila: effect of the neurogenic mutations in the embryo. Development 113: 1395-1404.
32. GORMAN, M. J., and J. R. GIRTON, 1992 A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster. Genetics 131: 99-112.
33. HAKES, D. J., and J. E. DIXON, 1992 New vectors for high level expression of recombinant proteins in bacteria. Anal. Biochem. 202: 293-298.
34. HARTENSTEIN, V., and J. A. CAMPOS-ORTEGA, 1986 The peripheral nervous system of mutants of early neurogenesis in Drosophila melanogaster. Wilhelm Roux' Arch. Dev. Biol. 195: 210-221
35. HARTENSTEIN, A. Y., A. RUGENDORFF, U. TEPASS and V. HARTENSTEIN, 1992 The function of the neurogenic genes during epithelial development in the Drosophila embryo. Development 116: 1203-1220.
36. HARTLEY, D. A., A. PREISS and S. ARTAVANIS-TSAKONAS, 1988 A deduced gene product from the Drosophila neurogenic locus, Enhancer of split, shows homology to mammalian G-protein beta subunit. Cell 55: 785-795.
37. HEITZLER, P., and P. SIMPSON, 1993 Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. Development 117: 1113-1123.
38. HENKEL, T., P. D. LING, S. D. HAYWARD, and M. G. PETERSON, 1994 Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal binding protein Jk. Science 265: 92-95
39. HINZ, U., B. GIEBEL, and J. A. CAMPOS-ORTEGA, 1994 The basic helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76: 77-87.
40. JAN, Y. N., and L. Y. JAN, 1990 Genes required for specifying cell fates in Drosophila nervous system. TINS 13: 493-498.
41. JARRIAULT, S., C. BROU, F. LOGEAT, E. H. SCHROETER, R. KOPAN and A. ISRAEL, 1995 Signaling downstream of activated mammalian Notch. Nature 377: 355-358.
42. JENNINGS, B., A. PREISS, C. DELIDAKIS and S. BRAY, 1994 The Notch signaling pathway is required for Enhancer of split HLH protein expression during neurogenesis in the Drosophila embryo. Development 120: 3537-3548.
43. JENNINGS, B., J. DE CELIS, C. DELIDAKIS, A. PREISS and S. BRAY, 1995 Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins. Development 121: 3745-3752.
44. JIMENEZ, F., and J. A. CAMPOS-ORTEGA, 1982 Maternal effects of zygotic mutants affecting early neurogenesis in Drosophila. Wilhelm Roux' Arch. Dev. Biol. 191: 191-201.
45. JOHANSEN, K. M., R. G. FEHON and S. ARTAVANIS-TSAKONAS, 1989 The Notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development. J. Cell Biol. 109: 2427-2440.
46. JOHNSON, E., S. WAYNE and R. NAGOSHI, 1995 fs(1)Yb is required for ovary follicle cell differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes. Genetics 140: 207-217.
47. KELEHER, C. A., M. J. REDD, J. SCHULTZ, M. CARLSON and A. D. JOHNSON, 1992 Ssn6-Tup1 is a general represser of transcription in yeast. Cell: 68: 709-719.
48. KIDD, S., M. K. BAYLIES, G. P. GASIC and M. YOUNG, 1989 Structure and distribution of the Notch protein in developing Drosophila. Genes Dev. 3: 1113-1129.
49. KLAMBT, C., E. KNUST, K. TIETZE and J. A. CAMPOS-ORTEGA, 1989 Closely related transcripts encoded by the neurogenic gene complex Enhancer of split of Drosophila melanogaster. EMBO J. 8: 203-210.
50. KNUST, E., H. SCHRONS, F. GRAWE and J. A. CAMPOS-ORTEGA, 1992 Seven genes of the Enhancer of Split complex of Drosophila melanogaster encode helix-loop-helix proteins. Genetics 132: 505-518.
51. KOOH, P., R. G. FEHON and M. A. T. MUSKAVITCH, 1993 Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development 117: 493-507.
52. KOPCZYNSKI, C., A. K. ALTON, K. FECTEL, P. J. KOOH and M. A. T. MUSKAVITCH, 1988 Delta, a Drosophila neurogenic gene is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. Genes Dev. 2: 1723-1735.
53. LABONNE, S. G., I. SUNITHA and A. P. MAHOWALD, 1989 Molecular genetics of pecanex, a maternal effect neurogenic locus of Drosophila melanogaster that potentially encodes a large transmembrane protein. Dev. Biol. 136: 1-16.
54. LECOURTOIS, M., and F. SCHWEISGUTH, 1995 The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling. Genes Dev. 9: 2598-2608.
55. LEHMANN, R., F. JIMENEZ, W. DIETRICH and J. A. CAMPOS-ORTEGA, 1983 On the phenotype and development of mutants of early neurogenesis in D. melanogaster. Wilhelm Roux' Arch. Dev. Biol. 192: 62-74.
56. LIEBER, T., S. KIDD, E. ALCAMO, V. CORBIN and M. W. YOUNG, 1993 Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev. 7: 1949-1965.
57. LYMAN, D., and B. YEDVOBNICK, 1995 Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development. Genetics 141: 1491-1505.
58. MAIER, D., G. STRUMM, K. KUHN and A. PREISS, 1992 Hairless, a Drosophila gene involved in neural development, encodes a novel serine rich protein. Mech. Dev. 38: 143-156.
59. MARKOPOULOU, K., and S. ARTAVANIS-TSAKONAS, 1989 The expression of the neurogenic locus Notch during the postembryonic development of Drosophila melanogaster and its relationship to mitotic activity. J Neurogenet. 6: 11-26.
60. MATSUNO, K., R. J. DIEDERICH, J. M. GO, C. M. BLAUMUELLER and S. ARTAVANIS-TSAKONAS, 1995 Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121: 2633-2644.
61. MATSUZAKI, F., K. KOIZUMI, C. HAMA, T. YOSHIOKA and Y. NABESHIMA, 1992 Cloning of the Drosophila prospero gene and its expression in ganglion mother cells. Biochem. Biophys. Res. Commun. 182: 1326-1332.
62. OELLERS, N., M. DEHIO and E. KNUST, 1994 bHLH proteins encoded by the Enhancer of Split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol. Gen. Genet. 244: 465-473.
63. OHSAKO, S., J. HYER, G. PANGIBAN, I. OLIVER and M. CAUDY, 1994 hairy functions as a DNA binding helix-loop-helix repressor of Drosophila sensory organ formation. Genes Dev. 8: 2743-2755.
64. PALKA, J., M. SCHUBIGER and H. SCHWANINGER, 1990 Neurogenic and antineurogenic effects from modifications at the Notch locus. Development 109: 167-175.
65. PARKS, A. L., and M. A. T. MUSKAVITCH, 1993 Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev. Biol. 157: 484-496.
66. PARKS, A. L., A. L. TURNER and M. A. T. MUSKAVITCH, 1995 Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development. Mech. Dev. 50: 201-216.
67. PARODY, T. R., and M. A. T. MUSKAVITCH, 1993 The pleiotropic function of Delta during postembryonic development of Drosophila melanogaster. Genetics 135: 527-539.
68. PAROUSH, Z., R. L. FINLEY, T. KIDD, S. M. WAINWRIGHT, P. I. INGHAM et al., 1994 Groucho is required for Drosophila neurogenesis, segmentation and sex determination and interacts directly with Hairy-related bHLH proteins. Cell 79: 805-815.
69. POSAKONY, J. W., 1994 Nature vs. nurture: asymmetric cell divisions in Drosophila bristle development. Cell 76: 415-418.
70. PRICE D., Z. CHANG, R. SMITH, S. BOCKHEIM and A. LAUGHON, 1993 The Drosophila neuralized gene encodes a C3C4 zinc protein. EMBO J. 12: 2411-2418.
71. RAO, Y., L. Y. JAN and Y. N. JAN, 1990 Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature 345: 163-167.
72. REBAY, I., R. G. FEHON and S. ARTAVANIS-TSAKONAS, 1993 Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74: 319-329.
73. RUOHOLA, H., K. A. BREMER, D. BAKER, J. R. SWEDLOW, L. Y. JAN et al., 1991 Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila. Cell 66: 433-449.
74. SCHMID, A., T. TINLEY and B. YEDVOBNICK, 1996 Transcription of the neurogenic gene mastermind during Drosophila development. J. Exp. Zool. 274: 207-220.
75. SCHWEISGUTH, F., and J. W. POSAKONY, 1994 Antagonistic activities of Supressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis. Development 120: 1433-1441.
76. SINGSON, A., M. LEVITEN, A. BANG, X. HUA and J. W. POSAKONY, 1994 Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signalling. Genes Dev. 8: 2058-2071.
77. SKEATH, J. B., and S. B. CARROLL, 1991 Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev. 5: 984-995.
78. SKEATH, J. B., G. PANGANIBAN, J. SELEGUE and S. B. CARROLL, 1992 Gene regulation in two dimensions: the proneural achaete and scute genes are controlled by combinations of axis-patterning genes through a common intergenic control region. Genes Dev. 6: 2606-2619.
79. SMITH, D. B., and K. S. JOHNSON, 1988 Single step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67: 31-40.
80. SMOLLER, D., C. FRIEDEL, A. SCHMID, D. BETTLER, L. LAM et al., 1990 The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Genes Dev. 4: 1688-1700.
81. SPANA, E., and C. Q. DOE, 1995 The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121: 3187-3195.
82. STRUHL, G., K. FITZGERALD and I. GREENWALD, 1993 Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74: 331-345.
83. TRUMAN, J. W., and BATE, C. M., 1988 Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster. Dev. Biol. 125: 145-157.
84. VAESSIN, H., E. GRELL, E. WOLFF, E. BIER, L. Y. JAN et al., 1991 prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 67: 941-953.
85. VAN DOREN, M., A. BAILY, J. ESNAYRA, K. EDE and J. POSAKONY. 1994 Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 8: 2729-2742.
86. VASSIN, H., J. VIELMETTER and J. A. CAMPOS-ORTEGA, 1985 Genetic interactions of early neurogenesis of Drosophila melanogaster. J. Neurogenet. 2: 291-308.
87. VASSIN, H., K. A. BREMER, E. KNUST and J. A. CAMPOS-ORTEGA, 1987 The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J. 6: 3431-3440.
88. VINCENT, A. C., and K. STRUHL, 1992 ACR1, a yeast ATF/CREB repressor. Mol. Cell. Biol. 12: 5394-5405.
89. WEEKS, J. R., S. E. HARDIN, J. SHEN, J. M. LEE and A. L. GREENLEAF, 1993 Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. Genes Dev. 7: 2329-2344.
90. XU, T., I. REBAY, R. J. FLEMING, T. N. SCOTTGALE and S. ARTAVANIS-TSAKONAS, 1990 The Notch locus and the genetic circuitry involved in early neurogenesis. Genes Dev. 4: 464-475.
91. XU, T., and S. ARTAVANIS-TSAKONAS, 1990 deltex, a locus interacting with the neurogenic genes Notch, Delta and mastermind in Drosophila melanogaster. Genetics 126: 665-677.
92. XU, T., L. A. CARON, R. G. FEHON and S. ARTAVANIS-TSAKONAS, 1992 The involvement of the Notch locus in Drosophila oogenesis. Development 115: 913-922.
93. YEDVOBNICK, B., D. SMOLLER, P. YOUNG and D. MILLS, 1988 Molecular analysis of the neurogenic locus mastermind of Drosophila melanogaster. Genetics 118: 483-497.
94. ZINK, B., and R. PARO, 1989 In vivo binding pattern of a trans-regulator of the homeotic genes in Drosophila melanogaster. Nature 337: 468-471.