-
1
-
-
0030933977
-
Conservation of the Notch signalling pathway in mammalian neurogenesis
-
De la Pompa JL, Wakeham A, Correia KM, Samper E, Brown S, Aguilera RJ, Nakano T, Honjo T, Mak TW, Rossant J, et al.: Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 1997, 124:1139-1148.
-
(1997)
Development
, vol.124
, pp. 1139-1148
-
-
De La Pompa, J.L.1
Wakeham, A.2
Correia, K.M.3
Samper, E.4
Brown, S.5
Aguilera, R.J.6
Nakano, T.7
Honjo, T.8
Mak, T.W.9
Rossant, J.10
-
2
-
-
0031012155
-
Regulation of neuronal diversity in the Xenopus retina by Delta signalling
-
Dorsky RI, Chang WS, Rapaport DH, Harris WA: Regulation of neuronal diversity in the Xenopus retina by Delta signalling. Nature 1997, 385:67-70. Misexpression of X-Delta-1 mRNA in progenitor cells at different times during development of the Xenopus retina suggests that the timing of Delta expression generates neuronal diversity through lateral inhibition mediated by Notch signaling.
-
(1997)
Nature
, vol.385
, pp. 67-70
-
-
Dorsky, R.I.1
Chang, W.S.2
Rapaport, D.H.3
Harris, W.A.4
-
3
-
-
0031240003
-
Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina
-
Henrique D, Hirsinger E, Adam J, Le Roux I, Pourquié O, Ish-Horowicz D, Lewis J: Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Curr Biol 1997, 7:661-670. Similar Delta misexpression studies as reported in [2•] but in the chick retina using retrovirus infection support a role for Notch signaling in regulating neuronal diversityln addition, the idea that Delta-Notch signaling controls the differentiation of progenitor cells into neurons is presented and this idea is extended as a mechanism by which Notch signaling regulates the differentiation of stem cells in general.
-
(1997)
Curr Biol
, vol.7
, pp. 661-670
-
-
Henrique, D.1
Hirsinger, E.2
Adam, J.3
Le Roux, I.4
Pourquié, O.5
Ish-Horowicz, D.6
Lewis, J.7
-
4
-
-
0030961091
-
Mouse DII3:A novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
-
Dunwoodie SL, Henrique D, Harrison SM, Beddington RS: Mouse DII3:a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 1997, 124:3065-3076.
-
(1997)
Development
, vol.124
, pp. 3065-3076
-
-
Dunwoodie, S.L.1
Henrique, D.2
Harrison, S.M.3
Beddington, R.S.4
-
5
-
-
0031938541
-
Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis
-
Haddon C, Smithers L, Schneider-Maunoury S, Coche T, Henrique D, Lewis J: Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis. Development 1998, 125:359-370. Reports the cloning of four Delta genes from zebrafish and demonstrates a role for Notch signaling in singling out the Mauthner cell on either side of the zebrafish hindbrainLateral inhibition mediated by these genes leads to negative regulation of the Delta genes
-
(1998)
Development
, vol.125
, pp. 359-370
-
-
Haddon, C.1
Smithers, L.2
Schneider-Maunoury, S.3
Coche, T.4
Henrique, D.5
Lewis, J.6
-
6
-
-
0031891341
-
Regulation of neuronal specification in the zebrafish spinal cord by Delta function
-
Appel B, Eisen JS: Regulation of neuronal specification in the zebrafish spinal cord by Delta function. Development 1998, 125:371-380. Demonstrates a role for Delta-Notch signaling in generating neuronal diversity in zebrafish spinal cord. Dominant negative Delta expression produces ectopic differentiation of primary motor neurons with a reduction in the number of secondary motor neurons and interneurons.
-
(1998)
Development
, vol.125
, pp. 371-380
-
-
Appel, B.1
Eisen, J.S.2
-
7
-
-
0029930494
-
Neurogenic genes and vertebrate neurogenesis
-
Lewis J: Neurogenic genes and vertebrate neurogenesis. Curr Opin Neurobiol 1996, 6:3-10.
-
(1996)
Curr Opin Neurobiol
, vol.6
, pp. 3-10
-
-
Lewis, J.1
-
8
-
-
0030807094
-
Notch signaling in vertebrate development and disease
-
Gridley T: Notch signaling in vertebrate development and disease. Mol Cell Neurosci 1997, 9:103-108.
-
(1997)
Mol Cell Neurosci
, vol.9
, pp. 103-108
-
-
Gridley, T.1
-
9
-
-
0027991383
-
The intracellular domain of mouse Notch:a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
-
Kopan R, Nye JS, Weintraub H: The intracellular domain of mouse Notch:a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 1994, 120:2385-2396.
-
(1994)
Development
, vol.120
, pp. 2385-2396
-
-
Kopan, R.1
Nye, J.S.2
Weintraub, H.3
-
10
-
-
0027966977
-
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
-
Nye JS, Kopan R, Axel R: An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 1994, 120:2421-2430.
-
(1994)
Development
, vol.120
, pp. 2421-2430
-
-
Nye, J.S.1
Kopan, R.2
Axel, R.3
-
11
-
-
0028950732
-
Jagged: A mammalian ligand that activates Notch1
-
Lindsell CE, Shawber CJ, Boulter J, Weinmaster G: Jagged: a mammalian ligand that activates Notch1. Cell 1995, 80:909-917.
-
(1995)
Cell
, vol.80
, pp. 909-917
-
-
Lindsell, C.E.1
Shawber, C.J.2
Boulter, J.3
Weinmaster, G.4
-
12
-
-
0030453171
-
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
-
Shawber C, Nofziger D, Hsieh JJ-D, Lindsell C, Bogler O, Hayward D, Weinmaster G: Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 1996, 122:3765-3773.
-
(1996)
Development
, vol.122
, pp. 3765-3773
-
-
Shawber, C.1
Nofziger, D.2
Hsieh, J.J.-D.3
Lindsell, C.4
Bogler, O.5
Hayward, D.6
Weinmaster, G.7
-
13
-
-
0030748716
-
The ins and outs of notch signaling
-
Weinmaster G: The ins and outs of notch signaling. Mol Cell Neurosci 1997, 9:91-102.
-
(1997)
Mol Cell Neurosci
, vol.9
, pp. 91-102
-
-
Weinmaster, G.1
-
14
-
-
0029850324
-
Inhibition of granulocytic differentiation by mNotch1
-
Milner LA, Bigas A, Kopan R, Brashem-Stein C, Bernstein ID, Martin DI: Inhibition of granulocytic differentiation by mNotch1. Ptoc Natl Acad Sci USA 1996, 93:13014-13019.
-
(1996)
Ptoc Natl Acad Sci USA
, vol.93
, pp. 13014-13019
-
-
Milner, L.A.1
Bigas, A.2
Kopan, R.3
Brashem-Stein, C.4
Bernstein, I.D.5
Martin, D.I.6
-
15
-
-
0031930238
-
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
-
Li L, Milner LA, Deng Y, Iwata M, Banta A, Graf L, Marcovina S, Friedman C, Trask BJ, Hood L, Torok-Storb B: The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity 1998, 8:43-55. A soluble extracellular form of human Jagged1 or a Jagged1 peptide can function as an activating ligand for Notch expressed in hematopoietic cells to prevent differentiation
-
(1998)
Immunity
, vol.8
, pp. 43-55
-
-
Li, L.1
Milner, L.A.2
Deng, Y.3
Iwata, M.4
Banta, A.5
Graf, L.6
Marcovina, S.7
Friedman, C.8
Trask, B.J.9
Hood, L.10
Torok-Storb, B.11
-
16
-
-
0031899677
-
Notch1 and Notch2 inhibit myeloid differentiation in respnse to different cytokines
-
Bigas A, Martin DI, Milner LA: Notch1 and Notch2 inhibit myeloid differentiation in respnse to different cytokines. Mol Cell Biol 1998, 18:2324-2333.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2324-2333
-
-
Bigas, A.1
Martin, D.I.2
Milner, L.A.3
-
17
-
-
0030853591
-
Notch in vertebrates
-
Robey E: Notch in vertebrates. Curr Opin Genet Dev 1997, 7:551-557.
-
(1997)
Curr Opin Genet Dev
, vol.7
, pp. 551-557
-
-
Robey, E.1
-
18
-
-
0028348883
-
The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginai discs:control of cell proliferation
-
Speicher SA, Thomas U, Hinz U, Knust E: The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginai discs:control of cell proliferation. Development 1994, 120:535-544.
-
(1994)
Development
, vol.120
, pp. 535-544
-
-
Speicher, S.A.1
Thomas, U.2
Hinz, U.3
Knust, E.4
-
19
-
-
0028936424
-
Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm
-
Tepass U, Hartenstein V: Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm. Development 1995, 121:393-405.
-
(1995)
Development
, vol.121
, pp. 393-405
-
-
Tepass, U.1
Hartenstein, V.2
-
20
-
-
0030062903
-
Proneural and neurogenic genes control specification and morphogenesis of stomatogastric nerve cell precursors in Drosophila
-
Hartenstein V, Tepass U, Gruszynski-deFeo E: Proneural and neurogenic genes control specification and morphogenesis of stomatogastric nerve cell precursors in Drosophila. Dev Biol 1996, 173:213-227.
-
(1996)
Dev Biol
, vol.173
, pp. 213-227
-
-
Hartenstein, V.1
Tepass, U.2
Gruszynski-deFeo, E.3
-
21
-
-
0029857503
-
Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte
-
Larkin MK, Holder K, Yost C, Giniger E, Ruohola-Baker H: Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte. Development 1996, 122:3639-3650.
-
(1996)
Development
, vol.122
, pp. 3639-3650
-
-
Larkin, M.K.1
Holder, K.2
Yost, C.3
Giniger, E.4
Ruohola-Baker, H.5
-
22
-
-
0029064632
-
Expression of Notch1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate
-
Mitsiadis TA, Lardelli M, Lendahl U, Thesleff I: Expression of Notch1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J Cell Biol 1995, 130:407-418.
-
(1995)
J Cell Biol
, vol.130
, pp. 407-418
-
-
Mitsiadis, T.A.1
Lardelli, M.2
Lendahl, U.3
Thesleff, I.4
-
23
-
-
0030956814
-
Mouse Serrate-1 [Jagged-1]: Expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
-
Mitsiadis TA, Henrique D, Thesleff I, Lendahl U: Mouse Serrate-1 [Jagged-1]: Expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4. Development 1997, 124:1473-1483.
-
(1997)
Development
, vol.124
, pp. 1473-1483
-
-
Mitsiadis, T.A.1
Henrique, D.2
Thesleff, I.3
Lendahl, U.4
-
24
-
-
0028071653
-
Structure/function studies of lin-12/Notch proteins
-
Greenwald I: Structure/function studies of lin-12/Notch proteins. Curr Opin Genet Dev 1994, 4:556-562.
-
(1994)
Curr Opin Genet Dev
, vol.4
, pp. 556-562
-
-
Greenwald, I.1
-
25
-
-
0029085935
-
Signalling downstream of activated mammalian Notch
-
Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A: Signalling downstream of activated mammalian Notch. Nature 1995, 377:355-358.
-
(1995)
Nature
, vol.377
, pp. 355-358
-
-
Jarriault, S.1
Brou, C.2
Logeat, F.3
Schroeter, E.H.4
Kopan, R.5
Israel, A.6
-
26
-
-
0029583607
-
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su[H]
-
Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T: Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su[H]. Curr Biol 1995, 5:1416-1423.
-
(1995)
Curr Biol
, vol.5
, pp. 1416-1423
-
-
Tamura, K.1
Taniguchi, Y.2
Minoguchi, S.3
Sakai, T.4
Tun, T.5
Furukawa, T.6
Honjo, T.7
-
27
-
-
0030014642
-
Lag-1. a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su[H]
-
Christensen S, Kodoyianni V, Bosenberg M, Friedman L, Kimble J: lag-1. a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su[H]. Development 1996, 122:1373-1383.
-
(1996)
Development
, vol.122
, pp. 1373-1383
-
-
Christensen, S.1
Kodoyianni, V.2
Bosenberg, M.3
Friedman, L.4
Kimble, J.5
-
28
-
-
0031043087
-
The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis
-
Wettstein DA, Turner DL, Kintner C: The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. Development 1997, 124:693-702. A dominant negative form of X-Su(H) is used to show that induction of ESR requires X-Su(H). Expression of dominant negative X-Su(H) produces a neurogenic phenotype and leads to an upregulation of both X-Delta-1 and XNGNR1 expression. A chimeric X-Su(H)/Notch ankyrin repeat construct supports the idea that the Notch RAM domain functions to bring X-Su(H) and Notch ankyrin repeats together to function in Notch signaling.
-
(1997)
Development
, vol.124
, pp. 693-702
-
-
Wettstein, D.A.1
Turner, D.L.2
Kintner, C.3
-
29
-
-
0030063909
-
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
-
Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD: Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol 1996, 16:952-959.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 952-959
-
-
Hsieh, J.J.1
Henkel, T.2
Salmon, P.3
Robey, E.4
Peterson, M.G.5
Hayward, S.D.6
-
30
-
-
0030003538
-
Signal transduction by activated mNotch:importance of proteolytic processing and its regulation by the extracellular domain
-
Kopan R, Schroeter EH, Weintraub H, Nye JS: Signal transduction by activated mNotch:importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 1996, 93:1683-1688.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1683-1688
-
-
Kopan, R.1
Schroeter, E.H.2
Weintraub, H.3
Nye, J.S.4
-
31
-
-
0031047971
-
Epstein-Barr Virus Immortalization: Notch2 interacts with CBF1 and blocks differentiation
-
Hsieh JJ-D, Nofziger D, Weinmaster G, Hayward SD: Epstein-Barr Virus Immortalization: Notch2 interacts with CBF1 and blocks differentiation. J Virol 1997, 71:1616-1625. Mutagenesis of the Notch2 cytoplasmic domain identify four distinct regions that mediate CBF1 interactions on the basis of the degree of CBF1 transactivation measured in reporter assays. Expression of the cytoplasmic domain of Notch2 that activates CBF1 also induces HES-1 when expressed in C2C12 cells.
-
(1997)
J Virol
, vol.71
, pp. 1616-1625
-
-
Hsieh, J.J.-D.1
Nofziger, D.2
Weinmaster, G.3
Hayward, S.D.4
-
32
-
-
0030782174
-
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
-
Kato H, Taniguchi Y, Kurooka H, Minoguchi S, Sakai T, Nomura-Okazaki S, Tamura K, Honjo T: Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development 1997, 124:4133-4141.
-
(1997)
Development
, vol.124
, pp. 4133-4141
-
-
Kato, H.1
Taniguchi, Y.2
Kurooka, H.3
Minoguchi, S.4
Sakai, T.5
Nomura-Okazaki, S.6
Tamura, K.7
Honjo, T.8
-
33
-
-
0029819667
-
Functional relationships between Notch, Su[H] and the bHLH genes of the E[spl] complex:the E[spl] genes mediate only a subset of Notch activities during imaginai development
-
De Celis JF, de Celis J, Ligoxygakis R Preiss A, Delidakis C, Bray S: Functional relationships between Notch, Su[H] and the bHLH genes of the E[spl] complex:the E[spl] genes mediate only a subset of Notch activities during imaginai development. Development 1996, 122:2719-2728.
-
(1996)
Development
, vol.122
, pp. 2719-2728
-
-
De Celis, J.F.1
De Celis, J.2
Ligoxygakis, R.3
Preiss, A.4
Delidakis, C.5
Bray, S.6
-
34
-
-
0030693878
-
Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
-
Matsuno K, Go MJ, Sun X, Eastman DS, Artavanis-Tsakonas S: Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. Development 1997, 124:4265-4273.
-
(1997)
Development
, vol.124
, pp. 4265-4273
-
-
Matsuno, K.1
Go, M.J.2
Sun, X.3
Eastman, D.S.4
Artavanis-Tsakonas, S.5
-
35
-
-
0030700813
-
Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless
-
Wang S, Younger-Shepherd S, Jan LY, Jan YN: Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless. Development 1997, 124:4435-4446. Data is presented that Su(H) is required for only a subset of the asymmetric divisions regulated by numb and Notch during sensory organ development, providing additional support for the Su(H)-independent Notch signaling pathway.
-
(1997)
Development
, vol.124
, pp. 4435-4446
-
-
Wang, S.1
Younger-Shepherd, S.2
Jan, L.Y.3
Jan, Y.N.4
-
36
-
-
0030611973
-
Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands
-
Ma Q, Sommer L, Cserjesi P, Anderson DJ: Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands. J Neurosci 1997, 17:3644-3652.
-
(1997)
J Neurosci
, vol.17
, pp. 3644-3652
-
-
Ma, Q.1
Sommer, L.2
Cserjesi, P.3
Anderson, D.J.4
-
37
-
-
0028641294
-
Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision
-
Wilkinson HA, Fitzgerald K, Greenwald I: Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 1994, 79:1187-1198.
-
(1994)
Cell
, vol.79
, pp. 1187-1198
-
-
Wilkinson, H.A.1
Fitzgerald, K.2
Greenwald, I.3
-
38
-
-
0030044345
-
Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
-
Heitzler P, Bourouis M, Ruel L, Carteret C, Simpson P: Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 1996, 122:161-171.
-
(1996)
Development
, vol.122
, pp. 161-171
-
-
Heitzler, P.1
Bourouis, M.2
Ruel, L.3
Carteret, C.4
Simpson, P.5
-
39
-
-
0030804540
-
Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
-
Huppert SS, Jacobsen TL, Muskavitch MA: Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development 1997, 124:3283-3291.
-
(1997)
Development
, vol.124
, pp. 3283-3291
-
-
Huppert, S.S.1
Jacobsen, T.L.2
Muskavitch, M.A.3
-
40
-
-
0028027585
-
GLP-1 is localized to the mitotic region of the C. elegans germ line
-
Crittenden SL, Troemel ER, Evans TC, Kimble J: GLP-1 is localized to the mitotic region of the C. elegans germ line. Development 1994, 120:2901-2911.
-
(1994)
Development
, vol.120
, pp. 2901-2911
-
-
Crittenden, S.L.1
Troemel, E.R.2
Evans, T.C.3
Kimble, J.4
-
41
-
-
0028674212
-
Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch
-
Aster J, Pear W, Hasserjian R, Erba H, Davi F, Luo B, Scott M, Baltimore D, Sklar J: Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harb Symp Quant Biol 1994, 59:125-136.
-
(1994)
Cold Spring Harb Symp Quant Biol
, vol.59
, pp. 125-136
-
-
Aster, J.1
Pear, W.2
Hasserjian, R.3
Erba, H.4
Davi, F.5
Luo, B.6
Scott, M.7
Baltimore, D.8
Sklar, J.9
-
42
-
-
0030877659
-
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
-
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S: Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 1997, 90:281-291. Data are presented that the amino-terminal and carboxy-terminal cleavage fragments of Notch are produced in the TGN.
-
Cell 1997
, vol.90
, pp. 281-291
-
-
Blaumueller, C.M.1
Qi, H.2
Zagouras, P.3
Artavanis-Tsakonas, S.4
-
43
-
-
0029788321
-
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
-
Rooke J, Pan D, Xu T, Rubin GM: KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science 1996, 273:1227-1231.
-
(1996)
Science
, vol.273
, pp. 1227-1231
-
-
Rooke, J.1
Pan, D.2
Xu, T.3
Rubin, G.M.4
-
44
-
-
0343196671
-
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
-
Pan D, Rubin GM: Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 1997, 90:271-280. The development of a dominant negative form of Kuz indicates that the metalloproteinase activity intrinsic to Kuz is required for lateral inhibition during neurogenesis in Drosophila and Xenopus. A role for proteolytic processing of Notch in Notch signaling is proposed.
-
(1997)
Cell
, vol.90
, pp. 271-280
-
-
Pan, D.1
Rubin, G.M.2
-
45
-
-
0031470904
-
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling
-
Wen C, Metzstein MM, Greenwald I: SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling. Development 1997, 124:4759-4767. Cell ablation experiments indicate that the metalloproteinase encoded by Sup-17 functions in the Lin-12-expressing cell. The constitutive activity intrinsic to the cytoplasmic domain of Lin-12 does not require Sup-17 in contrast to the lin12(d) mutants that are dependent upon Sup-17 for activity, suggesting the cleavage is required for these mutant proteins to function
-
(1997)
Development
, vol.124
, pp. 4759-4767
-
-
Wen, C.1
Metzstein, M.M.2
Greenwald, I.3
-
46
-
-
0031457037
-
The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginai discs
-
Sotillos S, Roch F, Campuzano S: The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginai discs. Development 1997, 124:4769-4779. Demonstration that Kuz is required upstream of Su(H) and that ligand-dependent hyperactive Notch mutants (Abruptex) require Kuz to signal, suggesting that Kuz is involved in generating a functional receptor capable of binding ligand or its subsequent activation following ligand binding.
-
(1997)
Development
, vol.124
, pp. 4769-4779
-
-
Sotillos, S.1
Roch, F.2
Campuzano, S.3
-
47
-
-
0030048594
-
Furin/PACE/SPC1:A convertase involved in exocytic and endocytic processing of precursor proteins
-
Denault JB, Leduc R: Furin/PACE/SPC1:a convertase involved in exocytic and endocytic processing of precursor proteins. FEBS Lett 1996, 379:113-116.
-
(1996)
FEBS Lett
, vol.379
, pp. 113-116
-
-
Denault, J.B.1
Leduc, R.2
-
48
-
-
0030840415
-
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
-
Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J: Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol 1997, 17:6057-6067. This paper provides evidence for an additional cytoplasmic form of Notch in response to activation by Jagged2. As the additional form is membrane associated, it may arise from cleavage in the extracellular domain of Notch.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6057-6067
-
-
Luo, B.1
Aster, J.C.2
Hasserjian, R.P.3
Kuo, F.4
Sklar, J.5
-
49
-
-
0030941803
-
The SREBP pathway:Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
Brown MS, Goldstein JL: The SREBP pathway:regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331-340.
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
50
-
-
0029960107
-
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
-
Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN: Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev 1996, 10:421-434.
-
(1996)
Genes Dev
, vol.10
, pp. 421-434
-
-
Doherty, D.1
Feger, G.2
Younger-Shepherd, S.3
Jan, L.Y.4
Jan, Y.N.5
-
51
-
-
0027945519
-
Fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
-
Irvine KD, Wieschaus E: fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 1994, 79:595-606.
-
(1994)
Cell
, vol.79
, pp. 595-606
-
-
Irvine, K.D.1
Wieschaus, E.2
-
52
-
-
0030756962
-
Fringe modulates Notch-ligand interactions
-
Panin VM, Papayannopoulos V, Wilson R, Irvine KD: Fringe modulates Notch-ligand interactions. Nature 1997, 387:908-912. The authors provide data to support that Fringe inhibits Serrate signaling through Notch but functions to potentiate Delta mediated Notch signaling in the Drosophila wing margin. In addition, Serrate and Delta, through activation of Notch, positively regulate each other's expression in a feedback loop.
-
(1997)
Nature
, vol.387
, pp. 908-912
-
-
Panin, V.M.1
Papayannopoulos, V.2
Wilson, R.3
Irvine, K.D.4
-
53
-
-
0031282505
-
Limb development:marginal fringe benefits
-
Blair SS: Limb development:marginal fringe benefits. Curr Biol 1997, 7:R686-R690.
-
(1997)
Curr Biol
, vol.7
-
-
Blair, S.S.1
-
54
-
-
0030845799
-
Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginai disc
-
Fleming RJ, Gu Y, Hukriede NA: Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginai disc. Development 1997, 124:2973-2981. This paper shows that Fringe can inhibit both endogenous and ectopic Serrate from signaling through Notch yet Fringe has little effect on Delta signaling. Replacement of the Serrate amino-terminal region with the corresponding region from Delta produces a chimeric Delta/Serrate ligand that is immune to the negative effects of Fringe, demonstrating the requirement for these Serrate sequences in the Fringe effect.
-
(1997)
Development
, vol.124
, pp. 2973-2981
-
-
Fleming, R.J.1
Gu, Y.2
Hukriede, N.A.3
-
55
-
-
0030744231
-
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
-
Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF: A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development 1997, 124:2245-2254.
-
(1997)
Development
, vol.124
, pp. 2245-2254
-
-
Johnston, S.H.1
Rauskolb, C.2
Wilson, R.3
Prabhakaran, B.4
Irvine, K.D.5
Vogt, T.F.6
-
56
-
-
0030981168
-
Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila
-
Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher WW, Leow CC, Whiting E, Ryan D, Zinyk D, Boulianne G et al.: Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet 1997, 16:283-288.
-
(1997)
Nat Genet
, vol.16
, pp. 283-288
-
-
Cohen, B.1
Bashirullah, A.2
Dagnino, L.3
Campbell, C.4
Fisher, W.W.5
Leow, C.C.6
Whiting, E.7
Ryan, D.8
Zinyk, D.9
Boulianne, G.10
-
57
-
-
0030976083
-
Maintenance of somite borders in mice requires the Delta homologue DIM
-
Hrabe de Angelis M, McIntyre JN, Gossler A: Maintenance of somite borders in mice requires the Delta homologue DIM. Nature 1997, 386:717-721.
-
(1997)
Nature
, vol.386
, pp. 717-721
-
-
Hrabe De Angelis, M.1
McIntyre, J.N.2
Gossler, A.3
-
58
-
-
0028989016
-
Notch1 is required for the coordinate segmentation of somites
-
Conlon RA, Reaume AG, Rossant J: Notch1 is required for the coordinate segmentation of somites. Development 1995, 121:1533-1545.
-
(1995)
Development
, vol.121
, pp. 1533-1545
-
-
Conlon, R.A.1
Reaume, A.G.2
Rossant, J.3
-
59
-
-
0031561502
-
Secreted fringe-like signaling molecules may be glycosyltransferases
-
Yuan YP, Schultz J, Mlodzik M, Bork P: Secreted fringe-like signaling molecules may be glycosyltransferases [letter]. Cell 1997, 88:9-11.
-
(1997)
Cell
, vol.88
, pp. 9-11
-
-
Yuan, Y.P.1
Schultz, J.2
Mlodzik, M.3
Bork, P.4
-
60
-
-
0029610006
-
Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo
-
Fitzgerald K, Greenwald I: Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Development 1995, 121:4275-4282.
-
(1995)
Development
, vol.121
, pp. 4275-4282
-
-
Fitzgerald, K.1
Greenwald, I.2
-
61
-
-
0030812755
-
Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans
-
Henderson ST, Gao D, Christensen S, Kimble J: Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans. Mol Biol Cell 1997, 8:1751-1762.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 1751-1762
-
-
Henderson, S.T.1
Gao, D.2
Christensen, S.3
Kimble, J.4
-
62
-
-
0030869670
-
A dominant-negative form of Serrate acts as a general antagonist of Notch activation
-
Hukriede NA, Gu Y, Fleming RJ: A dominant-negative form of Serrate acts as a general antagonist of Notch activation. Development 1997, 124:3427-3437.
-
(1997)
Development
, vol.124
, pp. 3427-3437
-
-
Hukriede, N.A.1
Gu, Y.2
Fleming, R.J.3
-
63
-
-
0030882580
-
Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila
-
Sun X, Artavanis-Tsakonas S: Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development 1997, 124:3439-3448.
-
(1997)
Development
, vol.124
, pp. 3439-3448
-
-
Sun, X.1
Artavanis-Tsakonas, S.2
-
64
-
-
0029813479
-
The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
-
Sun X, Artavanis-Tsakonas S: The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development 1996, 122:2465-2474.
-
(1996)
Development
, vol.122
, pp. 2465-2474
-
-
Sun, X.1
Artavanis-Tsakonas, S.2
-
65
-
-
0032524325
-
Nuclear access and action of Notch in vivo
-
Struhl G, Adachi A: Nuclear access and action of Notch in vivo. Cell 1998, 93:649-660.
-
(1998)
Cell
, vol.93
, pp. 649-660
-
-
Struhl, G.1
Adachi, A.2
-
66
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter EH, Kisslinger JA, Kopan R: Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998, 393:382-386.
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
67
-
-
0032543565
-
Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos
-
Lecourtois M, Schweisguth F: Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos. Curr Biol 1998, 8:771-774.
-
(1998)
Curr Biol
, vol.8
, pp. 771-774
-
-
Lecourtois, M.1
Schweisguth, F.2
|