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Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J: Mechanism of activation of TGF-β receptor. Nature 1994, 370:341-347. An elegant paper describing a model for the molecular mechanism of TGFβ receptor activation. The type II receptor is a constitutively active kinase even in the absence of ligand. Ligand bound to the type II receptor is recognized by the type I receptor, which, upon association with the type II receptor, becomes phosphorylated, predominantly in its GS domain. The phosphorylated and activated type I receptor propagates signals to intracellular downstream elements of the TGF-β receptor complex.
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GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex
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Wieser R, Wrana JL, Massagué J: GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J 1995, 14:2199-2208. A mutational analysis of serine and threonine residues in the juxtamembrane region of the type I receptor reveals that replacement of threonine 204 with an aspartic acid residue generates a type I receptor that signals in the absence of ligand and type II receptor. This finding implies that the type I receptor acts downstream of the type II receptor, and that its activation is essential and sufficient for most TGF-β mediated responses.
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Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex
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Cárcamo J, Zentella A, Massagué J: Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol Cell Biol 1995, 15:1573-1581.
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Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP-12
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Wang T, Donahoe PK, Zervos AS: Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP-12. Science 1994, 265:674-676.
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Interaction of the TGF-β type I receptor with farnesyl transferase-α
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Kawabata M, Imamura T, Miyazono K, Engel ME, Moses HL: Interaction of the TGF-β type I receptor with farnesyl transferase-α. J Biol Chem 1995, 270:29628-29631.
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A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor
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Chen R-H, Mieltinen PJ, Maruoka EM, Choy L, Derynck R: A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor. Nature 1995, 377:548-552.
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Derynck, R.5
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55
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0029072998
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The Drosophila schnurri gene acts in the dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family
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Arora K, Dai H, Kazuko SG, Jamal J, O'Conner MB, Letsou A, Warrior R: The Drosophila schnurri gene acts in the dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell 1995, 81:781-790.
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Letsou, A.6
Warrior, R.7
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56
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Schnurri is required for Drosophila dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1
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Grieder NC, Nellen D, Burke R, Basler K, Affolter M: schnurri is required for Drosophila dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell 1995, 81:791-800.
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Trypanosome invasion of mammalian cells requires activation of the TGFβ signaling pathway
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Ming M, Ewen ME, Pereira MEA: Trypanosome invasion of mammalian cells requires activation of the TGFβ signaling pathway. Cell 1995, 82:287-296. Activation of the TGF-β signaling pathway is shown to be required for entry of Trypanosoma cruzi into host cells. Trypanosoma itself may activate this pathway.
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Ming, M.1
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Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
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Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B et al.: Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 1995, 268:1336-1338. Colon cancer cell lines with high rates of microsatellite instability caused by defective mismatch repair are shown to have inactivating mutations in the gene encoding the TGF-β type II receptor. This study suggests that type II receptor inactivation, which leads to escape from TGF-β mediated growth inhibition, may contribute to tumor progression.
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Science
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Markowitz, S.1
Wang, J.2
Myeroff, L.3
Parsons, R.4
Sun, L.5
Lutterbaugh, J.6
Fan, R.S.7
Zborowska, E.8
Kinzler, K.W.9
Vogelstein, B.10
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