Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

Journal of Biological Chemistry

Volumn 271, Issue 36, 1996, Pages 21920-21926

  Kohn, Aimee D ^a   Takeuchi, Fumito ^a   Roth, Richard A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLECKSTRIN; PROTEIN SERINE THREONINE KINASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD PROTEINS; CELL LINE; CRICETINAE; CRICETULUS; ENZYME ACTIVATION; INSULIN; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES;

ANIMALIA;

EID: 0029810181     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.36.21920     Document Type: Article

References (17)

1. Franke, T. F., Yang, S.-I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995) Cell 81, 727-736
2. Burgering, B. M. Th., and Coffer, P. J. (1995) Nature 376, 599-602
3. Kohn, A. D., Kovacina, K. S., and Roth, R. A. (1995) EMBO J. 14, 4288-4295
4. Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995) Nature 378, 785-789
5. Carpenter, C. L., and Cantley, L. C. (1996) Adv. Cell Regul. 8, 153-158
6. Fry, M. J. (1994) Biochim. Biophys. Acta 1226, 237-268
7. James, S. R., Downes, C. P., Gigg, R., Grove, S. J., Homes, A. B., and Alessi, D. R. (1996) Biochem. J. 316, 709-713
8. Bellacosa, A., Testa, J. R., Staal, S. P., and Tsichlis, P. N. (1991) Science 254, 274-277
9. Ahmed, N. N., Franke, T. F., Bellacosa, A., Datta, K., Gonzales-Portal, M.-E., Taguchi, T., Testa, J. R., and Tsichlis, P. N. (1992) Oncogene 8, 1957-1963
10. Cross, F. R., Garber, E. A., Pellman, D., and Hanafusa, H. (1984) Mol. Cell. Biol. 4, 1834-1842
11. Klippel, A., Escobedo, J. A., Hirano, M., and Williams, L. T. (1994) Mol. Cell. Biol. 14, 2675-2685
12. Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Science 268, 100-102
13. Pear, W. S., Nolan, G. P., Seott, M. L., and Baltimore, D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 8392-8396
14. Chin, J. E., Liu, F., and Roth, R. A. (1994) Mol. Endocrinol. 8, 51-58
15. Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazan, J. F., Howard, M., Copeland, N. G., Jenkins, N. A., and Witte, O. N. (1993) Science 261, 358-361
16. Valius, M., and Kazlauskas, A. (1993) Cell 13, 321-334
17. Shaw, G. (1996) Bioessays 18, 35-46