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Volumn 22, Issue 4, 2004, Pages 604-619

Tumor-activated prodrugs - A new approach to cancer therapy

Author keywords

Activated prodrugs; Cancer therapy; Tumor

Indexed keywords

1,4 BIS[[2 (DIMETHYLAMINO N OXIDE)ETHYL]AMINO] 5,8 DIHYDROXYANTHRAQUINONE; 5 (1 AZIRIDINYL) 3 HYDROXYMETHYL 2 (3 HYDROXY 1 PROPENYL) 1 METHYL 4,7 INDOLEDIONE; ALKYLATING AGENT; AMIDASE; AMIDE; AROMATIC NITRO COMPOUND; CYCLOPHOSPHAMIDE; CYTOSINE DEAMINASE; DOXORUBICIN; DOXORUBICIN DERIVATIVE; DUOCARMYCIN A; FLUCYTOSINE; GANCICLOVIR; GEMTUZUMAB OZOGAMICIN; GLYCOSIDASE; HEPTAPEPTIDE; L 377202; MONOCLONAL ANTIBODY; NUCLEOSIDE DERIVATIVE; OXIDE; PHOSPHATASE; PHOSPHOTRANSFERASE; PRODRUG; QUINONE DERIVATIVE; RACHELMYCIN; SB 408075; TIAZOFURIN; TIRAPAZAMINE; TUMOR ACTIVATED PRODRUG; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 8644280287     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.1081/CNV-200027148     Document Type: Review
Times cited : (132)

References (90)
  • 1
    • 0023798680 scopus 로고    scopus 로고
    • Preclinical studies and clinical correlation of the effect of alkylating dose
    • Frei, E.; Teicher, B.A.; Holden, S.A.; Cathcart, K.N.; Wang, Y.Y. Preclinical studies and clinical correlation of the effect of alkylating dose. Cancer Res. 1998, 48, 6417-6423.
    • (1998) Cancer Res. , vol.48 , pp. 6417-6423
    • Frei, E.1    Teicher, B.A.2    Holden, S.A.3    Cathcart, K.N.4    Wang, Y.Y.5
  • 2
    • 0029884764 scopus 로고    scopus 로고
    • Recent developments in the design of bioreductive drugs
    • Denny, W.A.; Wilson, W.R.; Hay, M.P. Recent developments in the design of bioreductive drugs. Br. J. Cancer 1996, 74 (Supp. 27), 32-38.
    • (1996) Br. J. Cancer , vol.74 , Issue.SUPPL. 27 , pp. 32-38
    • Denny, W.A.1    Wilson, W.R.2    Hay, M.P.3
  • 3
    • 0036494169 scopus 로고    scopus 로고
    • Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures
    • Wilson, W.R.; Pullen, S.M.; Hogg, A.; Helsby, N.A.; Hicks, K.O.; Denny, W.A. Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures. Cancer Res. 2002, 62, 1425-1432.
    • (2002) Cancer Res. , vol.62 , pp. 1425-1432
    • Wilson, W.R.1    Pullen, S.M.2    Hogg, A.3    Helsby, N.A.4    Hicks, K.O.5    Denny, W.A.6
  • 4
    • 0035415493 scopus 로고    scopus 로고
    • Prodrug strategies in cancer therapy
    • Denny, W.A. Prodrug strategies in cancer therapy. Eur. J. Med. Chem. 2001, 36, 577-595.
    • (2001) Eur. J. Med. Chem. , vol.36 , pp. 577-595
    • Denny, W.A.1
  • 5
    • 0027219332 scopus 로고
    • Bioreducible mustards: A paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
    • Denny, W.A.; Wilson, W.R. Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs). Cancer Met. Rev. 1993, 12, 135-151.
    • (1993) Cancer Met. Rev. , vol.12 , pp. 135-151
    • Denny, W.A.1    Wilson, W.R.2
  • 7
    • 0030710552 scopus 로고    scopus 로고
    • Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA crosslinking and sequence selectivity of the bioreductive antitumor agent EO9
    • Bailey, S.M.; Wyatt, M.D.; Friedlos, F.; Hartley, J.A.; Knox, R.J.; Lewis, A.D.; Workman, P. Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA crosslinking and sequence selectivity of the bioreductive antitumor agent EO9. Br. J. Cancer 1997, 76, 1596-1603.
    • (1997) Br. J. Cancer , vol.76 , pp. 1596-1603
    • Bailey, S.M.1    Wyatt, M.D.2    Friedlos, F.3    Hartley, J.A.4    Knox, R.J.5    Lewis, A.D.6    Workman, P.7
  • 8
    • 0029917028 scopus 로고    scopus 로고
    • Reductase enzyme expression across the National Cancer Institute tumor cell line panel: Correlation with sensitivity to mitomycin C and EO9
    • Fitzsimmons, S.A.; Workman, P.; Grever, M.; Paull, K.; Camalier, R.; Lewis, A.D. Reductase enzyme expression across the National Cancer Institute tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. J. Natl. Cancer Inst. 1996, 88, 259-269.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 259-269
    • Fitzsimmons, S.A.1    Workman, P.2    Grever, M.3    Paull, K.4    Camalier, R.5    Lewis, A.D.6
  • 9
    • 0030016605 scopus 로고    scopus 로고
    • A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: A study of the EORTC Early Clinical Studies Group (ECSG)
    • Pavlidis, N.; Hanauske, A.R.; Gamucci, T.; Smyth, J.; Lehnert, M.; Te Velde, A.; Lan, J.; Verweij, J. A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG). Ann. Oncol. 1996, 7, 529-531.
    • (1996) Ann. Oncol. , vol.7 , pp. 529-531
    • Pavlidis, N.1    Hanauske, A.R.2    Gamucci, T.3    Smyth, J.4    Lehnert, M.5    Te Velde, A.6    Lan, J.7    Verweij, J.8
  • 11
    • 0032007820 scopus 로고    scopus 로고
    • Pharmacological and biochemical determinants of the antitumor activity of the indoloquinone EO9
    • Cummings, J.; Spanswick, V.J.; Gardiner, J.; Ritchie, A.; Smyth, J.F. Pharmacological and biochemical determinants of the antitumor activity of the indoloquinone EO9. Biochem. Pharmacol. 1998, 55, 253-260.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 253-260
    • Cummings, J.1    Spanswick, V.J.2    Gardiner, J.3    Ritchie, A.4    Smyth, J.F.5
  • 12
    • 0030217846 scopus 로고    scopus 로고
    • Phase I pharmacokinetics and limited sampling strategies for the bioreductive alkylating drug E09
    • McLeod, H.L.; Graham, M.A.; Aamdal, S.; Setanoians, A.; Groot, Y.; Lund, B. Phase I pharmacokinetics and limited sampling strategies for the bioreductive alkylating drug E09. Eur. J. Cancer 1996, 32A, 1518-1522.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 1518-1522
    • McLeod, H.L.1    Graham, M.A.2    Aamdal, S.3    Setanoians, A.4    Groot, Y.5    Lund, B.6
  • 13
    • 0032169889 scopus 로고    scopus 로고
    • The antitumor activity of the prodrug N-L-leucyldoxorubicin and its parent compound doxorubicin in human tumor xenografts
    • Breistol, K.; Hendriks, H.R.; Berger, D.P.; Langdon, S.P.; Fiebig, H.H.; Fodstad, O. The antitumor activity of the prodrug N-L-leucyldoxorubicin and its parent compound doxorubicin in human tumor xenografts. Eur. J. Cancer 1998, 34, 1602-1606.
    • (1998) Eur. J. Cancer , vol.34 , pp. 1602-1606
    • Breistol, K.1    Hendriks, H.R.2    Berger, D.P.3    Langdon, S.P.4    Fiebig, H.H.5    Fodstad, O.6
  • 15
    • 0035111756 scopus 로고    scopus 로고
    • PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites
    • Wong, B.K.; DeFeo-Jones, D.; Jones, R.E.; Garsky, V.M.; Feng, D.M.; Oliff, A.; Chiba, M.; Ellis, J.D.; Lin, J.H. PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites. Drug Met. Disp. 2001, 29, 313-318.
    • (2001) Drug Met. Disp. , vol.29 , pp. 313-318
    • Wong, B.K.1    DeFeo-Jones, D.2    Jones, R.E.3    Garsky, V.M.4    Feng, D.M.5    Oliff, A.6    Chiba, M.7    Ellis, J.D.8    Lin, J.H.9
  • 17
    • 0033180164 scopus 로고    scopus 로고
    • Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs
    • Dubowchik, G.M.; Walker, M.A. Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs. Pharm. Ther. 1999, 83, 67-123.
    • (1999) Pharm. Ther. , vol.83 , pp. 67-123
    • Dubowchik, G.M.1    Walker, M.A.2
  • 18
    • 1842369073 scopus 로고    scopus 로고
    • Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats
    • Sjogren, H.O.; Isaksson, M.; Willner, D.; Hellstrom, I.; Hellstrom, K.E.; Trail, P.A. Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats. Cancer Res. 1997, 57, 4530-4536.
    • (1997) Cancer Res. , vol.57 , pp. 4530-4536
    • Sjogren, H.O.1    Isaksson, M.2    Willner, D.3    Hellstrom, I.4    Hellstrom, K.E.5    Trail, P.A.6
  • 20
    • 0027194197 scopus 로고
    • Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: A novel and potent family of antitumor antibiotics
    • Hinman, L.M.; Hamann, P.R.; Wallace, R.; Menendez, A.T.; Durr, F.E.; Upeslacis, J. Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics. Cancer Res. 1993, 53, 3336-3342.
    • (1993) Cancer Res. , vol.53 , pp. 3336-3342
    • Hinman, L.M.1    Hamann, P.R.2    Wallace, R.3    Menendez, A.T.4    Durr, F.E.5    Upeslacis, J.6
  • 21
    • 0034326838 scopus 로고    scopus 로고
    • Targeted therapy of experimental renal cell carcinoma with a novel conjugate of monoclonal antibody 138H11 and calicheamicin γII
    • Knoll, K.; Wrasidlo, W.; Scherberich, J.E.; Gaedicke, G.; Fischer, P. Targeted therapy of experimental renal cell carcinoma with a novel conjugate of monoclonal antibody 138H11 and calicheamicin γII. Cancer Res. 2000, 60, 6089-6094.
    • (2000) Cancer Res. , vol.60 , pp. 6089-6094
    • Knoll, K.1    Wrasidlo, W.2    Scherberich, J.E.3    Gaedicke, G.4    Fischer, P.5
  • 22
    • 0030805884 scopus 로고    scopus 로고
    • Calicheamicin derivatives conjugated to monoclonal antibodies: Determination of loading values and distributions by infrared and UV matrix-assisted laser desorption/ionization mass spectrometry and electrospray ionization mass spectrometry
    • Siegel, M.M.; Tabei, K.; Kunz, A.; Hollander, I.J.; Hamann, P.R.; Bell, D.H.; Berkenkamp, S.; Hillenkamp, F. Calicheamicin derivatives conjugated to monoclonal antibodies: determination of loading values and distributions by infrared and UV matrix-assisted laser desorption/ionization mass spectrometry and electrospray ionization mass spectrometry. Anal. Chem. 1997, 69, 2716-2726.
    • (1997) Anal. Chem. , vol.69 , pp. 2716-2726
    • Siegel, M.M.1    Tabei, K.2    Kunz, A.3    Hollander, I.J.4    Hamann, P.R.5    Bell, D.H.6    Berkenkamp, S.7    Hillenkamp, F.8
  • 24
    • 0031047177 scopus 로고    scopus 로고
    • The development of antibody delivery systems to target cancer with highly potent maytansinoids
    • Liu, C.; Chari, R.V.J. The development of antibody delivery systems to target cancer with highly potent maytansinoids. Expert Opin. Investig. Drugs 1997, 6, 169-172.
    • (1997) Expert Opin. Investig. Drugs , vol.6 , pp. 169-172
    • Liu, C.1    Chari, R.V.J.2
  • 26
    • 0029782488 scopus 로고    scopus 로고
    • CC-1065 and the duocarmycins - Understanding their biological function through mechanistic studies
    • Boger, D.L.; Johnson, D.S. CC-1065 and the duocarmycins-understanding their biological function through mechanistic studies. Angew. Chem., Int. Ed. 1996, 35, 1438-1474.
    • (1996) Angew. Chem., Int. Ed. , vol.35 , pp. 1438-1474
    • Boger, D.L.1    Johnson, D.S.2
  • 27
    • 0033865139 scopus 로고    scopus 로고
    • Synthesis of a novel duocarmycin derivative DU-257 and its application to immunoconjugate using poly(ethylene glycol)-dipeptidyl linker capable of tumor specific activation
    • Suzawa, T.; Nagamura, S.; Saito, H.; Ohta, S.; Hanai, N.; Yamasaki, M. Synthesis of a novel duocarmycin derivative DU-257 and its application to immunoconjugate using poly(ethylene glycol)-dipeptidyl linker capable of tumor specific activation. Bioorg. Med. Chem. 2000, 8, 2175-2184.
    • (2000) Bioorg. Med. Chem. , vol.8 , pp. 2175-2184
    • Suzawa, T.1    Nagamura, S.2    Saito, H.3    Ohta, S.4    Hanai, N.5    Yamasaki, M.6
  • 28
    • 0028154911 scopus 로고
    • Targeting enzymes for cancer therapy: Old enzymes in new roles
    • Deonarain, M.P.; Epenetos, A.A. Targeting enzymes for cancer therapy: old enzymes in new roles. Br. J. Cancer 1994, 70, 786-794.
    • (1994) Br. J. Cancer , vol.70 , pp. 786-794
    • Deonarain, M.P.1    Epenetos, A.A.2
  • 30
    • 0028592664 scopus 로고
    • Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects
    • Bagshawe, K.D.; Sharma, S.K.; Springer, C.J.; Rogers, G. Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects. Anal. Oncol. 1994, 5, 879-891.
    • (1994) Anal. Oncol. , vol.5 , pp. 879-891
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.J.3    Rogers, G.4
  • 32
    • 0034131048 scopus 로고    scopus 로고
    • Cellular glutathione as a determinant of the sensitivity of colorectal tumor cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT)
    • Monks, N.R.; Calvete, J.A.; Curtin, N.J.; Blakey, D.C.; East, S.J.; Newell, D.R. Cellular glutathione as a determinant of the sensitivity of colorectal tumor cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT). Br. J. Cancer 2000, 83, 267-269.
    • (2000) Br. J. Cancer , vol.83 , pp. 267-269
    • Monks, N.R.1    Calvete, J.A.2    Curtin, N.J.3    Blakey, D.C.4    East, S.J.5    Newell, D.R.6
  • 33
    • 0029095503 scopus 로고
    • Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anticancer prodrugs
    • Kerr, D.E.; Schreiber, G.J.; Vrudhula, V.M.; Svensson, H.P.; Hellstrom, I.; Hellstrom, K.E.; Senter, P.D. Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anticancer prodrugs. Cancer Res. 1995, 55, 3558-3563.
    • (1995) Cancer Res. , vol.55 , pp. 3558-3563
    • Kerr, D.E.1    Schreiber, G.J.2    Vrudhula, V.M.3    Svensson, H.P.4    Hellstrom, I.5    Hellstrom, K.E.6    Senter, P.D.7
  • 34
    • 0026487592 scopus 로고
    • Preparation and characterization of a β-lactamase-Fab′ conjugate for the site-specific activation of oncolytic agents
    • Meyer, D.L.; Jungheim, L.N.; Mikolajczyk, S.D.; Starling, J.J.; Alhem, C.N. Preparation and characterization of a β-lactamase-Fab′ conjugate for the site-specific activation of oncolytic agents. Bioconjug. Chem. 1992, 3, 42-48.
    • (1992) Bioconjug. Chem. , vol.3 , pp. 42-48
    • Meyer, D.L.1    Jungheim, L.N.2    Mikolajczyk, S.D.3    Starling, J.J.4    Alhem, C.N.5
  • 35
    • 0027220125 scopus 로고
    • Site-specific prodrug activation by antibody-beta-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models
    • Meyer, D.L.; Jungheim, L.N.; Law, K.L.; Mikolajczyk, S.D.; Shepherd, T.A.; Makensen, D.G.; Briggs, S.L.; Starling, J.J. Site-specific prodrug activation by antibody-beta-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models. Cancer Res. 1993, 53, 3956-3963.
    • (1993) Cancer Res. , vol.53 , pp. 3956-3963
    • Meyer, D.L.1    Jungheim, L.N.2    Law, K.L.3    Mikolajczyk, S.D.4    Shepherd, T.A.5    Makensen, D.G.6    Briggs, S.L.7    Starling, J.J.8
  • 36
    • 0029019242 scopus 로고
    • In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody β-lactamase conjugates
    • Svensson, H.P.; Vrudhula, V.M.; Emswiler, J.E.; MacMaster, J.F.; Cosand, W.L.; Senter, P.D.; Wallace, P.M. In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody β-lactamase conjugates. Cancer Res. 1995, 55, 2357-2365.
    • (1995) Cancer Res. , vol.55 , pp. 2357-2365
    • Svensson, H.P.1    Vrudhula, V.M.2    Emswiler, J.E.3    MacMaster, J.F.4    Cosand, W.L.5    Senter, P.D.6    Wallace, P.M.7
  • 37
    • 0026794283 scopus 로고
    • Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy
    • Wang, S.M.; Chern, J.W.; Yeh, M.Y.; Ng, J.C.; Tung, E.; Roffler, S.R. Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy. Cancer Res. 1992, 52, 4484-4491.
    • (1992) Cancer Res. , vol.52 , pp. 4484-4491
    • Wang, S.M.1    Chern, J.W.2    Yeh, M.Y.3    Ng, J.C.4    Tung, E.5    Roffler, S.R.6
  • 38
    • 0035106974 scopus 로고    scopus 로고
    • A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: Distribution and efficacy in experimental human ovarian cancer
    • Houba, P.H.J.; Boven, E.; Van Der Meulen-Muileman, I.H.; Leenders, R.G.G.; Scheeren, J.W.; Pinedo, H.M.; Haisma, H.J. A novel doxorubicin- glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer. Int. J. Cancer 2001, 91, 550-554.
    • (2001) Int. J. Cancer , vol.91 , pp. 550-554
    • Houba, P.H.J.1    Boven, E.2    Van Der Meulen-Muileman, I.H.3    Leenders, R.G.G.4    Scheeren, J.W.5    Pinedo, H.M.6    Haisma, H.J.7
  • 39
    • 0035123128 scopus 로고    scopus 로고
    • Gene directed enzyme/ prodrug therapy of cancer: Historical appraisal and future prospectives
    • Greco, O.; Dachs, G.U. Gene directed enzyme/ prodrug therapy of cancer: historical appraisal and future prospectives. J. Cell. Physiol. 2001, 187, 22-36.
    • (2001) J. Cell. Physiol. , vol.187 , pp. 22-36
    • Greco, O.1    Dachs, G.U.2
  • 40
    • 0033374374 scopus 로고    scopus 로고
    • In situ use of suicide genes for therapy of brain tumours
    • Wildner, O. In situ use of suicide genes for therapy of brain tumours. Ann. Med. 1999, 31, 421-429.
    • (1999) Ann. Med. , vol.31 , pp. 421-429
    • Wildner, O.1
  • 42
    • 0033900009 scopus 로고    scopus 로고
    • Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communication
    • Mesnil, M.; Yamasaki, H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res. 2000, 60, 3989-3999.
    • (2000) Cancer Res. , vol.60 , pp. 3989-3999
    • Mesnil, M.1    Yamasaki, H.2
  • 43
    • 0034694011 scopus 로고    scopus 로고
    • A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    • Rainov, N.G.; Fetell, M.; Cloughesy, T.; et al. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum. Gene Ther. 2000, 11, 2389-2401.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 2389-2401
    • Rainov, N.G.1    Fetell, M.2    Cloughesy, T.3
  • 44
    • 0038685423 scopus 로고    scopus 로고
    • Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy)
    • Denny, W.A. Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy). J. Biomed. Biotech. 2003, 3, 49-70.
    • (2003) J. Biomed. Biotech. , vol.3 , pp. 49-70
    • Denny, W.A.1
  • 45
    • 0033119291 scopus 로고    scopus 로고
    • Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts
    • Kievit, E.; Bershad, E.; Ng, E.; Sethna, P.; Dev, I.; Lawrence, T.S.; Rehemtulla, A. Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. Cancer Res. 1999, 59, 1417-1421.
    • (1999) Cancer Res. , vol.59 , pp. 1417-1421
    • Kievit, E.1    Bershad, E.2    Ng, E.3    Sethna, P.4    Dev, I.5    Lawrence, T.S.6    Rehemtulla, A.7
  • 46
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
    • Huber, B.; Austin, E.; Richards, C.; Davis, S.; Good, S. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc. Natl. Acad. Sci. U. S. A. 1994, 91, 8302-8306.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 8302-8306
    • Huber, B.1    Austin, E.2    Richards, C.3    Davis, S.4    Good, S.5
  • 47
    • 0033022611 scopus 로고    scopus 로고
    • Prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression
    • Pandha, H.S.; Martin, L.; Rigg, A.; Hurst, H.C.; Stamp, G.W.H.; Sikora, K.; Lemoine, N.R. Prodrug activation therapy for breast cancer: a phase I clinical trial of erbB-2-directed suicide gene expression. J. Clin. Oncol. 1999, 17, 2180-2189.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2180-2189
    • Pandha, H.S.1    Martin, L.2    Rigg, A.3    Hurst, H.C.4    Stamp, G.W.H.5    Sikora, K.6    Lemoine, N.R.7
  • 48
    • 0032770163 scopus 로고    scopus 로고
    • Schedule dependency of 5-fluorouracil
    • Leichman, C.G. Schedule dependency of 5-fluorouracil. Oncology 1999, 13, 26-32.
    • (1999) Oncology , vol.13 , pp. 26-32
    • Leichman, C.G.1
  • 49
    • 0032901285 scopus 로고    scopus 로고
    • Cytochrome P450-based cancer gene therapy: Recent advances and future prospects
    • Waxman, D.J.; Chen, L.; Hecht, J.E.; Jounaidi, Y. Cytochrome P450-based cancer gene therapy: recent advances and future prospects. Drug Met. Rev. 1999, 31, 503-522.
    • (1999) Drug Met. Rev. , vol.31 , pp. 503-522
    • Waxman, D.J.1    Chen, L.2    Hecht, J.E.3    Jounaidi, Y.4
  • 50
    • 0028832191 scopus 로고
    • Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm
    • Wei, M.X.; Tamiya, T.; Rhee, R.J.; Breakefield, X.O.; Chiocca, E.A. Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm. Clin. Cancer Res. 1995, 1, 1171-1177.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1171-1177
    • Wei, M.X.1    Tamiya, T.2    Rhee, R.J.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 51
    • 0035672798 scopus 로고    scopus 로고
    • Technology evaluation: MetXia-P450, Oxford BioMedica
    • Hunt, S. Technology evaluation: MetXia-P450, Oxford BioMedica. Curr. Opin. Mol. Ther. 2001, 3, 595-598.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 595-598
    • Hunt, S.1
  • 52
    • 0003374533 scopus 로고    scopus 로고
    • Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intraarterially in patients with advanced-stage pancreatic carcinoma: A phase I/II study
    • Lohr, M.; Bago, Z.T.; Bergmeister, H.; et al. Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intraarterially in patients with advanced-stage pancreatic carcinoma: a phase I/II study. J. Mol. Med. 1999, 77, 393-398.
    • (1999) J. Mol. Med. , vol.77 , pp. 393-398
    • Lohr, M.1    Bago, Z.T.2    Bergmeister, H.3
  • 53
    • 0036244747 scopus 로고    scopus 로고
    • Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: The magic bullets of the 21st century
    • Lohr, M.; Hummel, F.; Faulmann, G.; Ringel, J.; Sailer, R.; Hain, J.; Gunzburg, W.H.; Salmons, B. Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century. Cancer Chemother. Pharmacol. 2002, 49 (Suppl. 1), S21-S24.
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , Issue.SUPPL. 1
    • Lohr, M.1    Hummel, F.2    Faulmann, G.3    Ringel, J.4    Sailer, R.5    Hain, J.6    Gunzburg, W.H.7    Salmons, B.8
  • 54
    • 0026745562 scopus 로고
    • The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954). I. Purification and properties of a nitroreductase enzyme from Escherichia coil. A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
    • Anlezark, G.M.; Melton, R.G.; Sherwood, R.F.; Coles, B.; Friedlos, F.; Knox, R.J. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954). I. Purification and properties of a nitroreductase enzyme from Escherichia coil. A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT). Biochem. Pharmacol. 1992, 44, 2289-2295.
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 2289-2295
    • Anlezark, G.M.1    Melton, R.G.2    Sherwood, R.F.3    Coles, B.4    Friedlos, F.5    Knox, R.J.6
  • 55
    • 0026075733 scopus 로고
    • Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand cross-linking species
    • Knox, R.J.; Friedlos, F.; Marchbank, T.; Roberts, J.J. Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand cross-linking species. Biochem. Pharmacol. 1991, 42, 1691-1697.
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 1691-1697
    • Knox, R.J.1    Friedlos, F.2    Marchbank, T.3    Roberts, J.J.4
  • 59
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumor growth
    • Harris, A.L. Hypoxia-a key regulatory factor in tumor growth. Nat. Rev. Cancer 2002, 2, 38-47.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 60
    • 0031105658 scopus 로고    scopus 로고
    • Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors
    • Baish, J.W.; Netti, P.A.; Jain, R.K. Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors. Microvasc. Res. 1997, 53, 128-141.
    • (1997) Microvasc. Res. , vol.53 , pp. 128-141
    • Baish, J.W.1    Netti, P.A.2    Jain, R.K.3
  • 63
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy - Eighteenth Bruce F. Cain Memorial Award Lecture
    • Brown, J.M. The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award Lecture. Cancer Res. 1999, 59, 5863-5870.
    • (1999) Cancer Res. , vol.59 , pp. 5863-5870
    • Brown, J.M.1
  • 64
    • 0033607196 scopus 로고    scopus 로고
    • Reaction of the hypoxia-selective antitumor agent tirapazamine with a Cl′-radical in single-stranded and double-stranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions
    • Hwang, J.T.; Greenberg, M.M.; Fuchs, T.; Gates, K.S. Reaction of the hypoxia-selective antitumor agent tirapazamine with a Cl′-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions. Biochemistry 1999, 38, 14248-14255.
    • (1999) Biochemistry , vol.38 , pp. 14248-14255
    • Hwang, J.T.1    Greenberg, M.M.2    Fuchs, T.3    Gates, K.S.4
  • 65
    • 0028928551 scopus 로고
    • Does tirapazamine (SR-4233) have any cytotoxic or sensitizing effect on three human tumour cell lines at clinically relevant partial oxygen pressure?
    • Lartigau, E.; Guichard, M. Does tirapazamine (SR-4233) have any cytotoxic or sensitizing effect on three human tumour cell lines at clinically relevant partial oxygen pressure? Int. J. Radiat. Biol. 1995, 67, 211-216.
    • (1995) Int. J. Radiat. Biol. , vol.67 , pp. 211-216
    • Lartigau, E.1    Guichard, M.2
  • 68
    • 0033063810 scopus 로고    scopus 로고
    • Cisplatin antitumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin
    • Kovacs, M.S.; Hocking, D.J.; Evans, J.W.; Slim, B.G.; Wouters, B.G.; Brown, J.M. Cisplatin antitumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin. Br. J. Cancer 1999, 80, 1245-1251.
    • (1999) Br. J. Cancer , vol.80 , pp. 1245-1251
    • Kovacs, M.S.1    Hocking, D.J.2    Evans, J.W.3    Slim, B.G.4    Wouters, B.G.5    Brown, J.M.6
  • 70
    • 0031462199 scopus 로고    scopus 로고
    • Phase II study of the combination of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer
    • Miller, V.A.; Ng, K.K.; Grant, S.C.; Kindler, H.; Pizzo, B.; Heelan, R.T.; von Roemeling, R.; Kris, M.G. Phase II study of the combination of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer. Ann. Oncol. 1997, 8, 1269-1271.
    • (1997) Ann. Oncol. , vol.8 , pp. 1269-1271
    • Miller, V.A.1    Ng, K.K.2    Grant, S.C.3    Kindler, H.4    Pizzo, B.5    Heelan, R.T.6    Von Roemeling, R.7    Kris, M.G.8
  • 71
    • 0034652379 scopus 로고    scopus 로고
    • Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice
    • Lee, A.E.; Wilson, W.R. Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicol. Appl. Pharmacol. 2000, 163, 50-59.
    • (2000) Toxicol. Appl. Pharmacol. , vol.163 , pp. 50-59
    • Lee, A.E.1    Wilson, W.R.2
  • 72
    • 0031742538 scopus 로고    scopus 로고
    • Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug
    • Raleigh, S.M.; Wanogho, E.; Burke, M.D.; McKeown, S.R.; Patterson, L.H. Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. Int. J. Radiat. Oncol. Biol. Phys. 1998, 42, 763-767.
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.42 , pp. 763-767
    • Raleigh, S.M.1    Wanogho, E.2    Burke, M.D.3    McKeown, S.R.4    Patterson, L.H.5
  • 74
    • 0034029002 scopus 로고    scopus 로고
    • Enhancement of chemotherapy and radiotherapy of murine tumors by AQ4N, a bioreductively activated anti-tumor agent
    • Patterson, L.H.; McKeown, S.R.; Ruparelia, K.; Double, J.A.; Bibby, M.C.; Cole, S.; Stratford, I.J. Enhancement of chemotherapy and radiotherapy of murine tumors by AQ4N, a bioreductively activated anti-tumor agent. Br. J. Cancer 2000, 82, 1984-1990.
    • (2000) Br. J. Cancer , vol.82 , pp. 1984-1990
    • Patterson, L.H.1    McKeown, S.R.2    Ruparelia, K.3    Double, J.A.4    Bibby, M.C.5    Cole, S.6    Stratford, I.J.7
  • 76
    • 0036041236 scopus 로고    scopus 로고
    • Bioreductively activated antitumor N-oxides: The case of AO4N, a unique approach to hypoxia-activated cancer chemotherapy
    • Patterson, L.H. Bioreductively activated antitumor N-oxides: the case of AO4N, a unique approach to hypoxia-activated cancer chemotherapy. Drug Met. Rev. 2002, 34, 581-592.
    • (2002) Drug Met. Rev. , vol.34 , pp. 581-592
    • Patterson, L.H.1
  • 77
    • 0030028739 scopus 로고    scopus 로고
    • Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase
    • Belcourt, M.F.; Hodnick, W.F.; Rockwell, S.; Sartorelli, A.C. Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase. Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 456-460.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 456-460
    • Belcourt, M.F.1    Hodnick, W.F.2    Rockwell, S.3    Sartorelli, A.C.4
  • 78
    • 0031875844 scopus 로고    scopus 로고
    • Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase
    • Belcourt, M.F.; Hodnick, W.F.; Rockwell, S.; Sartorelli, A.C. Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase. Adv. Enzyme Regul. 1998, 38, 111-133.
    • (1998) Adv. Enzyme Regul. , vol.38 , pp. 111-133
    • Belcourt, M.F.1    Hodnick, W.F.2    Rockwell, S.3    Sartorelli, A.C.4
  • 79
    • 0031278015 scopus 로고    scopus 로고
    • The mitomycin bioreductive antitumor agents: Cross-linking and alkylation of DNA as the molecular basis of their activity
    • Tomasz, M.; Palom, Y. The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity. Pharmacol. Ther. 1997, 76, 73-87.
    • (1997) Pharmacol. Ther. , vol.76 , pp. 73-87
    • Tomasz, M.1    Palom, Y.2
  • 81
    • 0034218702 scopus 로고    scopus 로고
    • Mechanisms of action of quinone-containing alkylating agents. I. NQOI-directed drug development
    • Beall, H.D.; Winski, S.L. Mechanisms of action of quinone-containing alkylating agents. I. NQOI-directed drug development. Front. Biosci. 2000, 5, D639-D648.
    • (2000) Front. Biosci. , vol.5
    • Beall, H.D.1    Winski, S.L.2
  • 83
    • 0031969730 scopus 로고    scopus 로고
    • Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer
    • Breider, M.A.; Pilcher, G.D.; Graziano, M.J.; Gough, A.W. Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer. Toxicol. Pathol. 1998, 26, 234-239.
    • (1998) Toxicol. Pathol. , vol.26 , pp. 234-239
    • Breider, M.A.1    Pilcher, G.D.2    Graziano, M.J.3    Gough, A.W.4
  • 84
    • 0031706557 scopus 로고    scopus 로고
    • Reduction of nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine by radiation
    • Wilson, W.R.; Tercel, M.; Anderson, R.F.; Denny, W.A. Reduction of nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine by radiation. Anti-Cancer Drug Des. 1998, 13, 663-685.
    • (1998) Anti-Cancer Drug Des. , vol.13 , pp. 663-685
    • Wilson, W.R.1    Tercel, M.2    Anderson, R.F.3    Denny, W.A.4
  • 86
    • 0034725814 scopus 로고    scopus 로고
    • Stereoelectronic effect on one-electron reductive release of 5-fluorouracil from 5-fluoro-1-(2′-oxocycloalkyl)uracils as a new class of radiation-activated antitumor prodrugs
    • Mori, M.; Hatta, H.; Nishimoto, S.J. Stereoelectronic effect on one-electron reductive release of 5-fluorouracil from 5-fluoro-1-(2′- oxocycloalkyl)uracils as a new class of radiation-activated antitumor prodrugs. Org. Chem. 2000, 65, 4641-4647.
    • (2000) Org. Chem. , vol.65 , pp. 4641-4647
    • Mori, M.1    Hatta, H.2    Nishimoto, S.J.3
  • 87
    • 0034024791 scopus 로고    scopus 로고
    • A novel class of antitumor prodrug, 1-(2′-Oxopropyl)-5-fluorouracil (OFU001), that releases 5-fluorouracil upon hypoxic irradiation
    • Shibamoto, Y.; Zhou, L.; Hatta, H.; Mori, M.; Nishimoto, S.-I. A novel class of antitumor prodrug, 1-(2′-Oxopropyl)-5-fluorouracil (OFU001), that releases 5-fluorouracil upon hypoxic irradiation. Jpn. J. Cancer Res. 2000, 91, 433-438.
    • (2000) Jpn. J. Cancer Res. , vol.91 , pp. 433-438
    • Shibamoto, Y.1    Zhou, L.2    Hatta, H.3    Mori, M.4    Nishimoto, S.-I.5
  • 88
    • 0035254229 scopus 로고    scopus 로고
    • In vivo evaluation of a novel antitumor prodrug, 1-(2′-oxopropyl)- 5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation
    • Shibamoto, Y.; Zhou, L.; Hatta, H.; Mori, M.; Nishmoto, S. In vivo evaluation of a novel antitumor prodrug, 1-(2′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2001, 49, 407-413.
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.49 , pp. 407-413
    • Shibamoto, Y.1    Zhou, L.2    Hatta, H.3    Mori, M.4    Nishmoto, S.5
  • 89
    • 0031938856 scopus 로고    scopus 로고
    • Radiation-activated prodrugs as hypoxia-selective cytotoxins: Model studies with nitroarylmethyl quaternary salts
    • Wilson, W.R.; Ferry, D.M.; Tercel, M.; Anderson, R.F.; Denny, W.A. Radiation-activated prodrugs as hypoxia-selective cytotoxins: model studies with nitroarylmethyl quaternary salts. Radiat. Res. 1998, 149, 237-245.
    • (1998) Radiat. Res. , vol.149 , pp. 237-245
    • Wilson, W.R.1    Ferry, D.M.2    Tercel, M.3    Anderson, R.F.4    Denny, W.A.5
  • 90
    • 8644221458 scopus 로고    scopus 로고
    • Anticancer 8-Substituted Quinolines and 2,3-Dihydro-1H-Pyrrolo[3,2-f] Quinoline Complexes of Cobalt and Chromium; PCT Int. Appl. WO 0259122 A1, Auckland Uniservices Limited: NZ, August 1, 2002; 97 pp
    • Denny, W.A.; Wilson, W.R.; Ware, D.C.; Atwell, G.J.; Milbank, J.B.J.; Stevenson, R.J. Anticancer 8-Substituted Quinolines and 2,3-Dihydro-1H- Pyrrolo[3,2-f]Quinoline Complexes of Cobalt and Chromium; PCT Int. Appl. WO 0259122 A1, Auckland Uniservices Limited: NZ, August 1, 2002; 97 pp.
    • Denny, W.A.1    Wilson, W.R.2    Ware, D.C.3    Atwell, G.J.4    Milbank, J.B.J.5    Stevenson, R.J.6


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