메뉴 건너뛰기




Volumn 56, Issue 14, 1996, Pages 3287-3292

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID DERIVATIVE; CARBOXYPEPTIDASE G2; CARCINOEMBRYONIC ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; PRODRUG;

EID: 8944233863     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (62)

References (35)
  • 1
    • 0027355456 scopus 로고
    • Antibody-directed enzyme prodrug therapy (ADEPT)
    • Bagshawe, K. D. Antibody-directed enzyme prodrug therapy (ADEPT) Adv. Pharmacol., 24: 99-121, 1993.
    • (1993) Adv. Pharmacol. , vol.24 , pp. 99-121
    • Bagshawe, K.D.1
  • 2
    • 0028796170 scopus 로고
    • Antibody-directed enzyme prodrug therapy
    • Knox, R. J., and Connors, T. A. Antibody-directed enzyme prodrug therapy. Clin Immunother., 3: 136-153, 1995
    • (1995) Clin Immunother. , vol.3 , pp. 136-153
    • Knox, R.J.1    Connors, T.A.2
  • 3
    • 0028972656 scopus 로고
    • Antibody-directed enzyme prodrug therapy (ADEPT), a targeting strategy in cancer chemotherapy
    • Niculescu-Duvaz, I., and Springer, C. J. Antibody-directed enzyme prodrug therapy (ADEPT), a targeting strategy in cancer chemotherapy Current Medicinal Chemistry, 2: 687-706, 1995.
    • (1995) Current Medicinal Chemistry , vol.2 , pp. 687-706
    • Niculescu-Duvaz, I.1    Springer, C.J.2
  • 5
    • 0020625285 scopus 로고
    • A Cellular heterogeneity in tumours
    • Woodruff, M F. A Cellular heterogeneity in tumours Br. J Cancer, 47: 589-594, 1983.
    • (1983) Br. J Cancer , vol.47 , pp. 589-594
    • Woodruff, M.F.1
  • 6
    • 0024505574 scopus 로고
    • Delivery of novel therapeutic agents to tumors physiological barriers and strategies
    • Jain, R. K. Delivery of novel therapeutic agents to tumors physiological barriers and strategies. J. Natl. Cancer Inst., 81: 570-576, 1989
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 570-576
    • Jain, R.K.1
  • 7
    • 0027655158 scopus 로고
    • Antitumour activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates
    • Vrudhula, V. M., Svensson, H. P., Kennedy, K. A., Senter, P. D., and Wallace, P. M. Antitumour activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates. Bioconjugate Chem , 4: 334-340, 1993.
    • (1993) Bioconjugate Chem , vol.4 , pp. 334-340
    • Vrudhula, V.M.1    Svensson, H.P.2    Kennedy, K.A.3    Senter, P.D.4    Wallace, P.M.5
  • 8
    • 0027220125 scopus 로고
    • Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models
    • Meyer, D L., Jungheim, L N., Law, K. L., Mikolajczyk, S. D., Shepherd, T. A., Mackensen, D. G , Briggs, S. L , and Starling, J. J. Site-specific prodrug activation by antibody-β-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models. Cancer Res., 53: 3956-3963, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 3956-3963
    • Meyer, D.L.1    Jungheim, L.N.2    Law, K.L.3    Mikolajczyk, S.D.4    Shepherd, T.A.5    Mackensen, D.G.6    Briggs, S.L.7    Starling, J.J.8
  • 9
    • 0028348376 scopus 로고
    • Tumor-selective prodrug activation by fusion protein-mediated catalysis
    • Bosslet, K., Czech, J , and Hoffmann, D. Tumor-selective prodrug activation by fusion protein-mediated catalysis. Cancer Res., 54: 2151-2159, 1994
    • (1994) Cancer Res. , vol.54 , pp. 2151-2159
    • Bosslet, K.1    Czech, J.2    Hoffmann, D.3
  • 11
    • 0021871027 scopus 로고
    • Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16: Use of a novel triazine-dye affinity method
    • Sherwood, R. F., Melton, R. G., Alwan, S M., and Hughes, P Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16: use of a novel triazine-dye affinity method Eur. J. Biochem , 148: 447-453, 1985.
    • (1985) Eur. J. Biochem , vol.148 , pp. 447-453
    • Sherwood, R.F.1    Melton, R.G.2    Alwan, S.M.3    Hughes, P.4
  • 16
    • 0028694296 scopus 로고
    • Antibody-directed enzyme prodrug therapy (ADEPT): A three-phase study in ovarian tumour xenografts
    • Sharma, S. K., Boden, J A., Springer, C. J., Burke, P. J., and Bagshawe, K D. Antibody-directed enzyme prodrug therapy (ADEPT): a three-phase study in ovarian tumour xenografts Cell Biophys., 24: 219-228, 1994.
    • (1994) Cell Biophys. , vol.24 , pp. 219-228
    • Sharma, S.K.1    Boden, J.A.2    Springer, C.J.3    Burke, P.J.4    Bagshawe, K.D.5
  • 17
    • 0002726158 scopus 로고
    • Antibody-directed enzyme prodrug therapy a pilot-scale clinical trial
    • Bagshawe, K. D., Sharma, S. K., Springer, C J , and Antoniw, P. Antibody-directed enzyme prodrug therapy a pilot-scale clinical trial Tumor Targeting, 1: 17-29, 1995.
    • (1995) Tumor Targeting , vol.1 , pp. 17-29
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.J.3    Antoniw, P.4
  • 18
    • 0023810403 scopus 로고
    • Clinical applications of carcinoembryonic antigen
    • Sikorska, H., Shuster, J , and Gold, P Clinical applications of carcinoembryonic antigen Cancer Detect Prev., 12: 321-355, 1988
    • (1988) Cancer Detect Prev. , vol.12 , pp. 321-355
    • Sikorska, H.1    Shuster, J.2    Gold, P.3
  • 19
    • 0026335039 scopus 로고
    • Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethyl-benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)
    • Springer, C J., Antoniw, P , Bagshawe, K. D , and Wilman, D E V. Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethyl-benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT). Anti-Cancer Drug Design, 6: 467-479, 1991.
    • (1991) Anti-Cancer Drug Design , vol.6 , pp. 467-479
    • Springer, C.J.1    Antoniw, P.2    Bagshawe, K.D.3    Wilman, D.E.V.4
  • 22
    • 0029621825 scopus 로고
    • Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: A new clinical candidate prodrug (ZD2767) for ADEPT
    • Springer, C. J., Dowell, R , Burke, P. J , Hadley, E , Davies, D. H., Blakey, D. C., Melton, R. G., and Niculescu-Duvaz, I. Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for ADEPT. J. Med. Chem., 38: 5051-5065, 1995.
    • (1995) J. Med. Chem. , vol.38 , pp. 5051-5065
    • Springer, C.J.1    Dowell, R.2    Burke, P.J.3    Hadley, E.4    Davies, D.H.5    Blakey, D.C.6    Melton, R.G.7    Niculescu-Duvaz, I.8
  • 23
    • 0021054335 scopus 로고
    • Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia colt and Pseudomonas putida
    • Minton, N. P., Atkinson, T , and Sherwood, R. F. Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia colt and Pseudomonas putida. J. Bacteriol., 156: 1222-1227, 1983.
    • (1983) J. Bacteriol. , vol.156 , pp. 1222-1227
    • Minton, N.P.1    Atkinson, T.2    Sherwood, R.F.3
  • 28
    • 0025880550 scopus 로고
    • Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies
    • Yuan, F., Baxter, L. T., and Jain, R. K. Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies Cancer Res., 51: 3119-3130, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 3119-3130
    • Yuan, F.1    Baxter, L.T.2    Jain, R.K.3
  • 29
    • 0027219332 scopus 로고
    • Bioreducible mustards, a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
    • Denny, W A , and Wilson, W. R. Bioreducible mustards, a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs). Cancer Metastasis Rev , 12: 135-151, 1993.
    • (1993) Cancer Metastasis Rev , vol.12 , pp. 135-151
    • Denny, W.A.1    Wilson, W.R.2
  • 30
    • 0023798680 scopus 로고
    • Preclinical studies and clinical correlation of the effect of alkylating dose
    • Frei, E., III., Teicher, B A., Holden, S. A., Cathcart, K N. S , and Wang, Y. Preclinical studies and clinical correlation of the effect of alkylating dose Cancer Res., 48 6417-6423, 1988
    • (1988) Cancer Res. , vol.48 , pp. 6417-6423
    • Frei III, E.1    Teicher, B.A.2    Holden, S.A.3    Cathcart, K.N.S.4    Wang, Y.5
  • 31
    • 0025967325 scopus 로고
    • Proliferation activity of human tumours assessment using bromodeoxyuridine and flow cytometry
    • Shimomatsuya, T., Tanigawa, N., and Muraoka, R. Proliferation activity of human tumours assessment using bromodeoxyuridine and flow cytometry. Jpn J. Carcer Res., 82: 357-362, 1991
    • (1991) Jpn J. Carcer Res. , vol.82 , pp. 357-362
    • Shimomatsuya, T.1    Tanigawa, N.2    Muraoka, R.3
  • 33
    • 0025373638 scopus 로고
    • Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model
    • Sharma, S K., Bagshawe, K. D., Burke, P. J., Boden, R. W., and Rogers, G. T. Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model Br. J Cancer, 61: 659-662, 1990.
    • (1990) Br. J Cancer , vol.61 , pp. 659-662
    • Sharma, S.K.1    Bagshawe, K.D.2    Burke, P.J.3    Boden, R.W.4    Rogers, G.T.5
  • 35
    • 0026635616 scopus 로고
    • Factors influencing variability of localisation of antibodies to carcinoembryonic antigen (CEA) in patients with colorectal carcinoma, implications for radioimmunotherapy
    • Boxer, G M., Begent, R. H. J., Kelly, A. M. B., Southall, P J., Blair, S B , Theodorou, N. A., Dawson, P. M., and Ledermann, J. A. Factors influencing variability of localisation of antibodies to carcinoembryonic antigen (CEA) in patients with colorectal carcinoma, implications for radioimmunotherapy. Br. J. Cancer, 65: 825-831, 1992.
    • (1992) Br. J. Cancer , vol.65 , pp. 825-831
    • Boxer, G.M.1    Begent, R.H.J.2    Kelly, A.M.B.3    Southall, P.J.4    Blair, S.B.5    Theodorou, N.A.6    Dawson, P.M.7    Ledermann, J.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.