Stereoelectronic effect on one-electron reductive release of 5-Fluorouracil from 5-fluoro-1-(2'-oxocycloalkyl)uracils as a new class of radiation-activated antitumor prodrugs

Journal of Organic Chemistry

Volumn 65, Issue 15, 2000, Pages 4641-4647

  Mori, Mayuko ^a   Hatta, Hiroshi ^a   Nishimoto, Sei Ichi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO 1 (2' OXOPROPYL)URACIL; ANTINEOPLASTIC AGENT; FLUOROURACIL; FLUOROURACIL DERIVATIVE; PRODRUG; TRANS 5 FLUORO 1 (5' TERT BUTYL 2' OXOCYCLOHEXYL)URACIL; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CANCER RADIOTHERAPY; CRYSTAL STRUCTURE; CYCLIC POTENTIOMETRY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCHEMISTRY; OXIDATION REDUCTION REACTION; TUMOR CELL; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; FLUOROURACIL; FREE RADICALS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXIDATION-REDUCTION; PRODRUGS; SOLUTIONS; X-RAYS;

EID: 0034725814     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo000245u     Document Type: Article

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