Tiazofurin: Molecular and clinical action

Anticancer Research

Volumn 16, Issue 6 A, 1996, Pages 3313-3322

  Weber, George ^a   Prajda, Noemi ^b,d,e   Abonyi, Margit ^b,d,e   Look, Katherine Y ^a   Tricot, Guido ^c  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^e SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Clinical response; GPRT; GTP; Human leukemia; IMP DH; Phospholipase C; PI kinase; PIP kinase; Ribavirin; TAD; Tiazofurin

Indexed keywords

ALLOPURINOL; ANTILEUKEMIC AGENT; BREFELDIN A; DIPYRIDAMOLE; DRUG METABOLITE; GEMCITABINE; GUANINE; GUANOSINE TRIPHOSPHATE; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INOSINE PHOSPHATE; INOSITOL TRISPHOSPHATE; ISOENZYME; MESSENGER RNA; OXIDOREDUCTASE; PACLITAXEL; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHATIDYLINOSITOL KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RETINOIC ACID; RIBAVIRIN; TIAZOFURIN; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; BLAST CELL; CELL MATURATION; CONTROLLED STUDY; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA; LEUKEMIA CELL; MYELOID LEUKEMIA; NONHUMAN; ONCOGENE MYC; ONCOGENE RAS; PRIORITY JOURNAL; RAT; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ALLOPURINOL; ANTIMETABOLITES, ANTINEOPLASTIC; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; GUANOSINE TRIPHOSPHATE; HUMANS; IMP DEHYDROGENASE; LEUKEMIA; NAD; NEOPLASM PROTEINS; RIBAVIRIN; SIGNAL TRANSDUCTION;

EID: 0030499593     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (16)

1. Weber G: Biochemical strategy of cancer cells and the design of chemotherapy, G.H.A.Clowes Memorial Lecture. Cancer Res 43: 3466-3492, 1983.
2. Tricot G, Jayaram HN, Weber G and Hoffman R: Tiazofurin: Biological effects and clinical uses. Intl J Cell Cloning 8: 161-170, 1990.
3. Wright DG, Boosalis MS, Oshry IJ and Waraska K: Tiazofurin effects on IMP dehydrogenase activity and expression in the leukemia cells of patients with CML blast crisis. Anticancer Res 16: 3349-3354, 1996.
4. Natsumeda Y, Ikegami T, Olah E and Weber G: Significance of purine salvage in circumventing the action of antimetabolites. Cancer Res 49: 88-92, 1989.
5. Weber G, Prajda N and Jackson RC: Key enzymes of IMP metabolism: transformation and proliferation-linked alteration in gene expression. Advan Enzyme Regul 14: 3-24, 1976.
6. Weber G: Enzymology of cancer cells, Parts 1 and 2. N Engl J Med 296: 486-493 and 541-551, 1977.
7. Robins RK: Nucleoside and nucleotide inhibitors of inosine monophosphate (IMP) dehydrogenase as potential antitumor inhibitors. Nucleosides and Nucleotides 1: 35-44, 1982.
8. Cooney DA, Jayaram HN, Glazer RI, Kelley JA, Marquez VE, Gebeyehu G, Van Cott AC, Zwelling LA and Johns DG: Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase activity. Advan Enzyme Regul 21: 271-303, 1983.
9. Yamada Y, Natsumeda Y and Weber G: Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase. Biochemistry 27: 2193-2196, 1988.
10. Tricot G and Weber G: Biochemically targeted therapy of refractory leukemia and myeloid blast crisis of chronic granulocytic leukemia with tiazofurin, a selective blocker of inosine 5′-phosphate dehydrogenase activity. Anticancer Res 16: 3341-3348, 1996.
11. Prajda N, Hata Y, Abonyi M, Singhal RL and Weber G: Sequential impact of tiazofurin and ribavirin on enzymic program of the bone marrow. Cancer Res 53: 9519-9523, 1993.
12. Look KY, Sutton GP, Natsumeda Y, Eble JN, Stehman FB, Ehrlich CE, Olah E, Prajda N, Bosze P, Eckhardt S and Weber G: Inhibition by tiazofurin of inosine 5′-monophosphate dehydrogenase (IMPDH) activity in the extracts of ovarian carcinomas. Gynecol Oncol 47: 66-70, 1992.
13. Weber G and Cantero A: Glucose-6-phosphate utilization in hepatoma, regenerating and newborn rat liver, and in the liver of fed and fasted normal rats. Cancer Res 17: 995-1005, 1957.
14. Jackson RC, Weber G and Morris HP: IMP dehydrogenase, an enzyme linked with proliferation and malignancy. Nature 256: 331-333, 1975.
15. Weber G, Jayaram HN, Lapis E, Natsumeda Y, Yamada Y, Yamaji Y, Tricot GJ and Huffman R: Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia. Advan Enzyme Regul 27: 405-433, 1988.
16. Tricot GJ, Jayaram HN, Nichols CR, Pennington K, Lapis E, Weber G and Hoffman R: Hematological and biochemical action of tiazofurin in a case of refractory acute myeloid leukemia. Cancer Res 47: 4988-4991, 1987.