-
1
-
-
0027328452
-
The experimental development of bioreductive drugs and their role in cancer therapy
-
Workman P, Stratford IJ. The experimental development of bioreductive drugs and their role in cancer therapy. Cancer Metastasis Rev 1993;12:73-82.
-
(1993)
Cancer Metastasis Rev
, vol.12
, pp. 73-82
-
-
Workman, P.1
Stratford, I.J.2
-
2
-
-
0026686324
-
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas
-
Walton MI, Bihhy MC, Double JA, Plumb JA, Workman P. DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas. Eur J Cancer 1992;28A:1597-600.
-
(1992)
Eur J Cancer
, vol.28 A
, pp. 1597-1600
-
-
Walton, M.I.1
Bihhy, M.C.2
Double, J.A.3
Plumb, J.A.4
Workman, P.5
-
3
-
-
0026724635
-
The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?
-
Robertson N, Stratford IJ, Houlbrook S, Carmichael J, Adams GE. The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase? Biochem Pharmacol 1992;44:409-12.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 409-412
-
-
Robertson, N.1
Stratford, I.J.2
Houlbrook, S.3
Carmichael, J.4
Adams, G.E.5
-
4
-
-
0028101349
-
Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia
-
Robertson N, Haigh A, Adams GE, Stratford IJ. Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia. Eur J Cancer 1994;30A:1013-9.
-
(1994)
Eur J Cancer
, vol.30 A
, pp. 1013-1019
-
-
Robertson, N.1
Haigh, A.2
Adams, G.E.3
Stratford, I.J.4
-
5
-
-
0028282993
-
Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines
-
Plumb JA, Gerritsen M, Milroy R, Thomson P, Workman P. Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines. Int J Radiat Oncol Biol Phys 1994;29:295-9.
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.29
, pp. 295-299
-
-
Plumb, J.A.1
Gerritsen, M.2
Milroy, R.3
Thomson, P.4
Workman, P.5
-
6
-
-
0026575978
-
In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity
-
Phillips RM, Hulbert PB, Bibby MC, Sleigh NR, Double JA. In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity. Br J Cancer 1992;65:359-64.
-
(1992)
Br J Cancer
, vol.65
, pp. 359-364
-
-
Phillips, R.M.1
Hulbert, P.B.2
Bibby, M.C.3
Sleigh, N.R.4
Double, J.A.5
-
7
-
-
0028293074
-
Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression
-
Smitskamp-Wilms E, Peters GJ, Pinedo HM, van Ark-Otte J, Giaccone G. Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression. Biochem Pharmacol 1994;47:1325-32.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 1325-1332
-
-
Smitskamp-Wilms, E.1
Peters, G.J.2
Pinedo, H.M.3
Van Ark-Otte, J.4
Giaccone, G.5
-
8
-
-
0028645493
-
Enzyme-directed bioreductive drug development revisited: A commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase
-
Workman P. Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. Oncol Res 1994;6:461-75.
-
(1994)
Oncol Res
, vol.6
, pp. 461-475
-
-
Workman, P.1
-
9
-
-
0028657069
-
Clinical studies with EO9. A new indoloquinone bioreductive alkylating cytoloxic agent
-
EORTC Early Clinical Trials Group
-
Verweij J, Aamdal S, Schellens J. Koier I, Lund B. Clinical studies with EO9. a new indoloquinone bioreductive alkylating cytoloxic agent. EORTC Early Clinical Trials Group. Oncol Res 1994;6:519-23.
-
(1994)
Oncol Res
, vol.6
, pp. 519-523
-
-
Verweij, J.1
Aamdal, S.2
Schellens, J.3
Koier, I.4
Lund, B.5
-
10
-
-
0028338822
-
Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09
-
Schellens JH, Planting AS, van Acker BA, Loos WJ, de Boer-Dennert M, van der Burg ME, et al. Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09. J Natl Cancer Inst 1994;86:906-12.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 906-912
-
-
Schellens, J.H.1
Planting, A.S.2
Van Acker, B.A.3
Loos, W.J.4
De Boer-Dennert, M.5
Van Der Burg, M.E.6
-
11
-
-
0027295491
-
DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C
-
Ross D, Siegel D, Beall H, Prakash AS, Mulcahy RT, Gibson NW. DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. Cancer Metastasis Rev 1993;12:83-101.
-
(1993)
Cancer Metastasis Rev
, vol.12
, pp. 83-101
-
-
Ross, D.1
Siegel, D.2
Beall, H.3
Prakash, A.S.4
Mulcahy, R.T.5
Gibson, N.W.6
-
12
-
-
0028610410
-
Bioactivation of quinones by DT-diaphorase. molecular, biochemical, and chemical studies
-
Ross D, Beall H, Traver RD, Siegel D, Phillips RM, Gibson NW. Bioactivation of quinones by DT-diaphorase. molecular, biochemical, and chemical studies. Oncol Res 1994;6:493-500.
-
(1994)
Oncol Res
, vol.6
, pp. 493-500
-
-
Ross, D.1
Beall, H.2
Traver, R.D.3
Siegel, D.4
Phillips, R.M.5
Gibson, N.W.6
-
13
-
-
0024312538
-
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algorithm
-
Paull KD, Shoemaker RH, Hodes L, Monks A, Scudiero DA. Rubinstein L. et al. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst 1989;81:1088-92.
-
(1989)
J Natl Cancer Inst
, vol.81
, pp. 1088-1092
-
-
Paull, K.D.1
Shoemaker, R.H.2
Hodes, L.3
Monks, A.4
Scudiero, D.A.5
Rubinstein, L.6
-
14
-
-
0026752669
-
Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data
-
Paull KD, Lin CM, Malspeis L, Hamel E. Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data. Cancer Res 1992;52:3892-900.
-
(1992)
Cancer Res
, vol.52
, pp. 3892-3900
-
-
Paull, K.D.1
Lin, C.M.2
Malspeis, L.3
Hamel, E.4
-
15
-
-
0026498426
-
Neural computing in cancer drug development: Predicting mechanism of action
-
Weinstein JN, Kohn KW, Grever MR, Viswanadhan VN, Rubinstein LV. Monks AP. et al. Neural computing in cancer drug development: predicting mechanism of action. Science 1992;258:447-51.
-
(1992)
Science
, vol.258
, pp. 447-451
-
-
Weinstein, J.N.1
Kohn, K.W.2
Grever, M.R.3
Viswanadhan, V.N.4
Rubinstein, L.V.5
Monks, A.P.6
-
16
-
-
0028576841
-
Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents
-
van Osdol WW, Myers TG, Paull KD, Kohn KW, Weinstein JN. Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents. J Natl Cancer Inst 1994;86:1853-9.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 1853-1859
-
-
Van Osdol, W.W.1
Myers, T.G.2
Paull, K.D.3
Kohn, K.W.4
Weinstein, J.N.5
-
17
-
-
0028906786
-
Some practical considerations and applications of the National Cancer Institute in vitro drug discovery screen
-
Boyd MR, Paull KD. Some practical considerations and applications of the National Cancer Institute in vitro drug discovery screen. Drug Develop Res 1995;34:91-109.
-
(1995)
Drug Develop Res
, vol.34
, pp. 91-109
-
-
Boyd, M.R.1
Paull, K.D.2
-
18
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
-
Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 1991;83:757-66.
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 757-766
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
Shoemaker, R.4
Paull, K.5
Vistica, D.6
-
19
-
-
0022186670
-
Measurement of protein using bicinchoninic acid
-
published erratum appears in Anal Biochem 1987;163:279
-
Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, et al. Measurement of protein using bicinchoninic acid [published erratum appears in Anal Biochem 1987;163:279]. Anal Biochem 1985; 150:76-85.
-
(1985)
Anal Biochem
, vol.150
, pp. 76-85
-
-
Smith, P.K.1
Krohn, R.I.2
Hermanson, G.T.3
Mallia, A.K.4
Gartner, F.H.5
Provenzano, M.D.6
-
20
-
-
77957000392
-
DT-diaphorase
-
Ernster L, DT-diaphorase. Methods Enzymol 1967;10:309-17.
-
(1967)
Methods Enzymol
, vol.10
, pp. 309-317
-
-
Ernster, L.1
-
22
-
-
0023277545
-
Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
-
Chomcynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
-
(1987)
Anal Biochem
, vol.162
, pp. 156-159
-
-
Chomcynski, P.1
Sacchi, N.2
-
23
-
-
0026560328
-
Quantitation of thymidylate synthase, dihydrofolate reducse, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
-
Horikoshi T, Dunenberg KD, Stadlbauer TH, Volkenandt M, Shea LC, Aigner K. et al. Quantitation of thymidylate synthase, dihydrofolate reducse, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 1992;52:108-16.
-
(1992)
Cancer Res
, vol.52
, pp. 108-116
-
-
Horikoshi, T.1
Dunenberg, K.D.2
Stadlbauer, T.H.3
Volkenandt, M.4
Shea, L.C.5
Aigner, K.6
-
24
-
-
0023724493
-
Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16
-
Jaiswal AK, McBride OW, Adesnik M, Neben DW. Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. J Biol Chem 1988;263:13572-8.
-
(1988)
J Biol Chem
, vol.263
, pp. 13572-13578
-
-
Jaiswal, A.K.1
McBride, O.W.2
Adesnik, M.3
Neben, D.W.4
-
26
-
-
0009462436
-
Variation among human 28S ribosomal RNA genes
-
Gonzalez IL, Gorski JL, Campen TJ, Dorney DJ, Erickson JM, Sylvester JE. et al. Variation among human 28S ribosomal RNA genes. Proc Natl Acad Sci U S A 1985;82:7666-70.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 7666-7670
-
-
Gonzalez, I.L.1
Gorski, J.L.2
Campen, T.J.3
Dorney, D.J.4
Erickson, J.M.5
Sylvester, J.E.6
-
27
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
Skehan P, Storeng R, Scudiero DA, Monks A, McMahon J, Vistica D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990;82:1107-12.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.A.3
Monks, A.4
McMahon, J.5
Vistica, D.6
-
28
-
-
0003088186
-
The future of new drug development
-
Neiderhuber J, editor. Philadelphia: B. C. Decker, Inc.,.
-
Boyd MR. The future of new drug development. In: Neiderhuber J, editor. Current therapy in oncology. Philadelphia: B. C. Decker, Inc.,. 1993:11-22.
-
(1993)
Current Therapy in Oncology
, pp. 11-22
-
-
Boyd, M.R.1
-
29
-
-
0026612119
-
DT-diaphorase and cancer chemotherapy
-
Riley RJ, Workman P. DT-diaphorase and cancer chemotherapy. Biochem Pharmacol 1992;43:1657-69.
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 1657-1669
-
-
Riley, R.J.1
Workman, P.2
-
30
-
-
0027931173
-
Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075. SR 4233) to a DNA-damaging species: A direct role for NADPH:cytochrome P450 oxidoreductase
-
Fitzsimmons SA, Lewis AD, Riley RJ, Workman P. Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075. SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase. Carcinogenesis 1994;15:1503-10.
-
(1994)
Carcinogenesis
, vol.15
, pp. 1503-1510
-
-
Fitzsimmons, S.A.1
Lewis, A.D.2
Riley, R.J.3
Workman, P.4
-
32
-
-
0028063368
-
DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone E09
-
Plumb JA, Gerritsen M, Workman P. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone E09. Br J Cancer 1994;70:1136-43.
-
(1994)
Br J Cancer
, vol.70
, pp. 1136-1143
-
-
Plumb, J.A.1
Gerritsen, M.2
Workman, P.3
-
33
-
-
0028282995
-
The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233)
-
Patterson AV, Robertson N, Houlbrook S, Stephens MA, Adams GE, Harris AL, et al. The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233). Int J Radial Oncol Biol Phys 1994;29:369-72.
-
(1994)
Int J Radial Oncol Biol Phys
, vol.29
, pp. 369-372
-
-
Patterson, A.V.1
Robertson, N.2
Houlbrook, S.3
Stephens, M.A.4
Adams, G.E.5
Harris, A.L.6
-
34
-
-
0025248106
-
Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
-
Schlager JJ, Powis G. Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol. Int J Cancer 1990;45:403-9.
-
(1990)
Int J Cancer
, vol.45
, pp. 403-409
-
-
Schlager, J.J.1
Powis, G.2
-
35
-
-
0028783332
-
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
-
Smitskamp-Wilms E, Giaccone G, Pinedo HM, van der Laan BF, Peters GJ. DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents? Br J Cancer 1995; 72:917-21.
-
(1995)
Br J Cancer
, vol.72
, pp. 917-921
-
-
Smitskamp-Wilms, E.1
Giaccone, G.2
Pinedo, H.M.3
Van Der Laan, B.F.4
Peters, G.J.5
-
36
-
-
0000842721
-
Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer
-
Rosvold EA, McGlynn KA, Lustbader ED, Buetow KH. Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer. Proc Am Assoc Cancer Res 1993;34:144.
-
(1993)
Proc Am Assoc Cancer Res
, vol.34
, pp. 144
-
-
Rosvold, E.A.1
McGlynn, K.A.2
Lustbader, E.D.3
Buetow, K.H.4
-
37
-
-
0025688249
-
Metabolism of mitomycin C by DT-diaphorase: Role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells
-
Siegel D, Gibson NW, Preusch PC, Ross D. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res 1990;50:7483-9.
-
(1990)
Cancer Res
, vol.50
, pp. 7483-7489
-
-
Siegel, D.1
Gibson, N.W.2
Preusch, P.C.3
Ross, D.4
-
38
-
-
0027052362
-
Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol
-
Gustafson DL, Pritsos CA. Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol. Cancer Res 1992;52:6936-9.
-
(1992)
Cancer Res
, vol.52
, pp. 6936-6939
-
-
Gustafson, D.L.1
Pritsos, C.A.2
-
39
-
-
0027427924
-
Kinetics and mechanism of mitomycin C bioactivation by xanthine dehydrogenase under aerobic and hypoxic conditions
-
Gustafson DL, Pritsos CA. Kinetics and mechanism of mitomycin C bioactivation by xanthine dehydrogenase under aerobic and hypoxic conditions. Cancer Res 1993;53:5470-4.
-
(1993)
Cancer Res
, vol.53
, pp. 5470-5474
-
-
Gustafson, D.L.1
Pritsos, C.A.2
-
40
-
-
0025352024
-
Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions
-
Hoban PR, Walton MI, Robson CN, Godden J, Stratford IJ, Workman P, et al. Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions. Cancer Res 1990;50:4692-7.
-
(1990)
Cancer Res
, vol.50
, pp. 4692-4697
-
-
Hoban, P.R.1
Walton, M.I.2
Robson, C.N.3
Godden, J.4
Stratford, I.J.5
Workman, P.6
-
41
-
-
0028097816
-
Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity
-
Plumb JA, Workman P. Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity. Int J Cancer 1994;56:134-9.
-
(1994)
Int J Cancer
, vol.56
, pp. 134-139
-
-
Plumb, J.A.1
Workman, P.2
-
42
-
-
0002563124
-
Enzyme-directed bioreductive drug development
-
Adams GE, Breccia A, Fielden EM, Wardman P, editors. New York: Plenum
-
Workman P, Walton MI. Enzyme-directed bioreductive drug development. In: Adams GE, Breccia A, Fielden EM, Wardman P, editors. Selective activation of drugs by redox processes. New York: Plenum, 1990:173-91.
-
(1990)
Selective Activation of Drugs by Redox Processes
, pp. 173-191
-
-
Workman, P.1
Walton, M.I.2
|