Schedule dependency of 5-fluorouracil

ONCOLOGY

Volumn 13, Issue 7 SUPPL., 1999, Pages 26-32

  Leichman, Cynthia Gail ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINATE CALCIUM;

CELL CYCLE; CLINICAL TRIAL; COLORECTAL CANCER; CONFERENCE PAPER; CYTOTOXICITY; DOSE RESPONSE; DRUG HALF LIFE; DRUG MECHANISM; HUMAN; META ANALYSIS; ORAL DRUG ADMINISTRATION; SURVIVAL RATE; TUMOR SUPPRESSOR GENE;

ADMINISTRATION, ORAL; ANTIMETABOLITES, ANTINEOPLASTIC; CELL CYCLE; CLINICAL TRIALS; COLORECTAL NEOPLASMS; DRUG ADMINISTRATION SCHEDULE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; TREATMENT OUTCOME;

EID: 0032770163     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (27)

1. Ansfield F Klotz J, Nealon T, et al: A phase III study comparing the clinical utility of four regimens of 5-fIuorouracil: A preliminary report. Cancer 39:34-40, 1977.
2. Danenberg PV, Lockshin A: Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthase. Pharmacol Ther 13:69-90, 1981.
3. Calabro-Jones PM, Byfield JE, Ward JF: Time-dose relationships for 5-fluorouracil cytotoxicity against human epithelial cancer cells in vitro. Cancer Res 42:4413-4420, 1982.
4. Byfield JE: The clinical use of 5-fluorouracil and other halopyrimidines as radiosensitizers in man, in: Lokich JJ (ed): Cancer Chemotherapy by Infusion, Chicago, Precept Press, 1987.
5. Hryniuk WM, Bush H: The importance of dose intensity in chemotherapy of breast cancer. J Clin Oncol 2:1281-1288, 1984.
6. Savarese DMF, Hsieh C, Stewart FM: Clinical impact of chemotherapy dose escalation in patients with hematologic malignancies and solid tumors. J Clin Oncol 15:2981-2995, 1997.
7. Leichman CG, Leichman L, Spears CP, et al: Biological modification of protracted infusion 5-fluorouracil with disseminated gastrointestinal cancers. Cancer Chemother Pharmacol 26:57-61, 1990.
8. Tempero M, Berg A, Block M, et al: A phase II trial of protracted therapy with 5-fluorouracil and leucovorin in metastatic colorectal cancer (abstract). Proc Am Soc Clin Oncol 12:594, 1993.
9. Leichman CG, Fleming TR, Muggia FM, et al: Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group study. J Clin Oncol 13:1303-1311, 1995.
10. O'Dwyer PJ, Ryan LM, Valone FH, et al: Phase III trial of biochemical modulation of 5-fluorouracil by IV or oral leucovorin or by interferon in advanced colorectal cancer: An ECOG/CALGB phase III trial (abstract). Proc Am Soc Clin Oncol 15:469, 1996.
11. Meta-Analysis Group in Cancer: Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in ad- vanced colorectal cancer. J Clin Oncol 16:301-308, 1998.
12. Lokich JJ, Moore CL, Anderson NR: Comparison of costs for infusion versus bolus chemotherapy administration: Analysis of five standard chemotherapy regimens in three common tumors - Part one. Model projections for cost based on charges. Cancer 15:294-299, 1996.
13. Buroker TR, O'Connell MJ, Wieand HS, et al: Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 12:14-20, 1994.
14. Poplin EA, Jacobson J, Herskovic A, et al: Evaluation of multimodality treatment of locoregional esophageal carcinoma by Southwest Oncology Group 9060. Cancer 78:1851-1856, 1996.
15. Urba S, Orringer M, Turrisi A, et al: A randomized trial comparing surgery (S) to preoperative concomitant chemoradiation plus surgery in patients (pts) with resectable esophageal cancer (CA): Updated analysis (abstract). Proc Am Soc Clin Oncol 16:983, 1997.
16. Wibault P, Bensmaine MA, de Forni M, et al: Intensive concomitant chemoradiotherapy in locally advanced unresectable squamous cell carcinoma of the head and neck: A phase II study of radiotherapy with cisplatin and 7-week continuous infusional fluorouracil. J Clin Oncol 14:1192-1200, 1996.
17. Olver IN, Hughes PG, Smith JG, et al: Concurrent radiotherapy and continuous ambulatory infusion 5-fluorouracil in advanced head and neck cancer. Eur J Cancer 32:249-254, 1996.
18. Formenti SC, Dunnington G, Lenz H, et al: Original p53 status predicts for pathological response to 5-fiuorouracil and radiation in locally advanced breast cancer (abstract). Proc Am Soc Clin Oncol 16:590, 1996.
19. O'Connell MJ, Martenson JA, Wieand HS, et al: Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331:502-507, 1994.
20. DiCostanzo F, Gasperoni S, Malacarne P, et al: High-dose folinic acid and 5-fluorouracil alone or combined with hydroxyurea in advanced colorectal cancer: A randomized trial of the Italian Oncology Group for Cancer Research. Am J Clin Oncol 21:369-375, 1998.
21. Hartmann JT, Kohne CH, Schmoll HJ, et al: Is continuous 24-hour infusion of 5-fluorou-racil plus high-dose folinic acid effective in patients with progressive or recurrent colorectal cancer? A phase II study. Oncology 55:320-325, 1998.
22. Nobile MT, Barzacch MC, Sanguinetti O, et al: Activity of high dose 24 hour 5-fluorouracil infusion plus L-leucovorin in advanced colorectal cancer. Anticancer Res 18:517-521, 1998.
23. Kohne CH, Schoffski P, Wilke H, et al: Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: Results of a randomized trial in patients with advanced colorectal cancer. J Clin Oncol 16:418-426, 1998.
24. Klaassen U, Wilke H, Weyhofen R, et al: Phase II study with cisplatin and paclitaxel in combination with weekly high-dose 24 h infusional 5-fluorouracil/leucovorin for first-line treatment of metastatic breast cancer. Anticancer Drugs 9:203-207, 1998.
25. Cheng AL, Yeh KH, Lin JT, et al: Cisplatin, etoposide and weekly high-dose 5-fluorouracil and leucovorin infusion (PE-HDFL) - A very effective regimen with good patients' compliance for advanced gastric cancer. Anticancer Res 18:1267-1272, 1998.
26. Klaassen U, Wilke H, Harstrick A, et al: Fluorouracil-based combinations in the treatment of metastatic breast cancer. Oncology 12:31-35, 1998.
27. Bleiberg H, de Gramont A: Oxaliplatin plus 5-fluorouracil: Clinical experience in patients with advanced colorectal cancer. Semin Oncol 25:32-39, 1998.