Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 1, 1996, Pages 456-460

  Belcourt, Michael F ^a   Hodnick, William F ^a   Rockwell, Sara ^a   Sartorelli, Alan C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

bioreductive activation; chemotherapy; mitomycins; transfectants; tumor hypoxia

Indexed keywords

MITOMYCIN C; PORFIROMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA ALKYLATION; DRUG ACTIVATION; DRUG ACTIVITY; NONHUMAN; PRIORITY JOURNAL;

AEROBIOSIS; ANIMALS; ANOXIA; BIOTRANSFORMATION; CHO CELLS; CRICETINAE; GLUTATHIONE TRANSFERASE; HUMANS; MITOMYCIN; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PORFIROMYCIN; RECOMBINANT PROTEINS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030028739     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.1.456     Document Type: Article

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