A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: Distribution and efficacy in experimental human ovarian cancer

British Journal of Cancer

Volumn 84, Issue 4, 2001, Pages 550-557

  Houba, P H J ^a   Boven, E ^a   Van Der Meulen Muileman, I H ^a   Leenders, R G G ^b   Scheeren, J W ^b   Pinedo, H M ^a   Haisma, H J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

glucuronidase; Anthracyclines; Cancer chemotherapy; Glucuronide

Indexed keywords

BETA GLUCURONIDASE; DOX GA3; DOXORUBICIN; GLUCURONIDE; N [4 DOXORUBICIN N CARBONYL(OXYMETHYL)PHENYL] O BETA GLUCURONYLCARBAMATE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NUDE MOUSE; OVARY CANCER; PRIORITY JOURNAL; TISSUE NECROSIS; TUMOR VOLUME;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AREA UNDER CURVE; DOXORUBICIN; FEMALE; GLUCURONIC ACIDS; HUMANS; INJECTIONS, INTRAVENOUS; MICE; MICE, NUDE; NECROSIS; NEOPLASMS, EXPERIMENTAL; OVARIAN NEOPLASMS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0035106974     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1640     Document Type: Article

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