Calicheamicin Derivatives Conjugated to Monoclonal Antibodies: Determination of Loading Values and Distributions by Infrared and UV Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry and Electrospray Ionization Mass Spectrometry

Analytical Chemistry

Volumn 69, Issue 14, 1997, Pages 2716-2726

  Siegel, Marshall M ^a   Tabei, Keiko ^a   Kunz, Arthur ^a   Hollander, Irwin J ^a   Hamann, Philip R ^a   Bell, Duncan H ^a   Berkenkamp, Stefan ^b   Hillenkamp, Franz ^b  

^a WYETH RESEARCH   (United States)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALICHEAMICIN DERIVATIVE; HYDRAZONE DERIVATIVE; MONOCLONAL ANTIBODY;

ABSORPTION SPECTROPHOTOMETRY; ARTICLE; CANCER CHEMOTHERAPY; COVALENT BOND; DRUG DEGRADATION; EXTRACELLULAR MATRIX; HYDROLYSIS; INFRARED RADIATION; MASS SPECTROMETRY; ULTRAVIOLET RADIATION;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; CARBOHYDRATE SEQUENCE; DRUG DELIVERY SYSTEMS; INFRARED RAYS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; ULTRAVIOLET RAYS;

EID: 0030805884     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac970035q     Document Type: Article

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