A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Nature Medicine

Volumn 6, Issue 11, 2000, Pages 1248-1252

  DeFeo Jones, Deborah ^a   Garsky, Victor M ^a   Wong, Bradley K ^a   Feng, Dong Mei ^a   Bolyar, Trina ^a   Haskell, Kathleen ^a   Kiefer, David M ^a   Leander, Karen ^a   McAvoy, Elizabeth ^a   Lumma, Patricia ^a   Wai, Jenny ^a   Senderak, Edith T ^a   Motzel, Sherri L ^a   Keenan, Kevin ^a   Zwieten, Matthew Van ^a   Lin, Jiunn H ^a   Freidinger, Roger ^a   Huff, Joel ^a   Oliff, Allen ^b   Jones, Raymond E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; DOXORUBICIN DERIVATIVE; L 377202; N GLUTARYL(4 HYDROXYPROLYL)ALANYLSERYLCYCLOHEXAGLYCYLGLUTAMINYLSERYLLEUCINE; PEPTIDE DERIVATIVE; PRODRUG; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GRAFT; CANCER INHIBITION; CELL KILLING; CONTROLLED STUDY; DRUG ACTIVATION; DRUG DISTRIBUTION; DRUG EFFICACY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

ANIMALS; DOXORUBICIN; HUMANS; MALE; MICE; MICE, NUDE; OLIGOPEPTIDES; PRODRUGS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; MUS MUSCULUS;

EID: 0033678680     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/81351     Document Type: Article

References (22)

1. Southwest Ontology Group studies in hormone-refractory prostate cancer
2. A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein
3. The chymotrypsin-like activity of human prostate specific antigen, g-seminoprotein
4. Ectopic production of prostate specific antigen by a breast tumor metastatic to the ovary
5. Detection of prostate specific antigen immunoreactivity in breast tumors
6. Immunoreactive prostate specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age
7. Prostate specific antigen expression by various tumors
8. New diagnostic applications and physiological functions of prostate specific antigen
9. Measurement of prostrate-specific antigen in serum as a screening test for prostrae cancer
10. Enzymatic activity of prostate specific antigen and its reactions with extracellular serine proteinase inhibitors
11. Complex formation between psa isoenzymes and protease inhibitors
12. Prostate specific antigen forms complexes with human a2-macroglobulin and binds to the a2-macroglobulin receptor/Idl receptor-related protein
13. Complex formation between protein C inhibitor and prostate specific antigen in vitro and in human semen
14. CWR22: Androgen-dependent xenograft model derived from a primary prostatic carcinoma
15. Enzymatic activation of a doxorubicin-peptide prodrug by prostate specific antigen
16. Daunorubicin, an antitumoral antibiotic in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia
17. Accidents cardiaques observes en cours des traitment par rubidomycine
18. Doxorubicin pharmacokinetics after intravenous and intraperitoneal administration in the nude mouse
19. A multiple comparison procedure for comparing several treatments with a control