Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment

Gene Therapy

Volumn 4, Issue 3, 1997, Pages 244-251

  Ishii Morita, H ^a   Agbaria, R ^b   Mullen, C A ^a   Hirano, H ^b   Koeplin, D A ^c   Ram, Z ^d   Oldfield, E H ^d   Johns, D G ^b   Blaese, R M ^a,e  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Howard Hughes Med Res Inst S   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Bystander effect; Cancer; Ganciclovir; Gene therapy; Suicide gene; Thymidine kinase

Indexed keywords

ANTIVIRUS AGENT; GANCICLOVIR; THYMIDINE KINASE; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CELL KILLING; CONTROLLED STUDY; DRUG ABSORPTION; GENE THERAPY; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; ISOTOPE LABELING; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SUICIDE GENE; VIRUS GENE;

EID: 0030996607     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300379     Document Type: Article

References (33)

1. Moolten FL Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46, 5276-5281.
2. Moolten FL, Wells JM. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst 1990; 82: 297-300.
3. Miller WH, Miller RL. Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase. J Biol Chem 1980; 255: 7204-7207.
4. Mullen CA. The use of suicide vectors for the gene therapy of cancer. Pharmacol Therapeut 1994; 63: 199-207.
5. Frank KB, Chiou J, Cheng Y. Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl) guanine triphosphate. J Biol Chem 1984; 259: 1566-1569.
6. Mar E, Chiou J, Cheng Y, Huang E. Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxy-ethoxymethy)guanine and 9-(1,3-dihydroxy-2-propoxymethyl) guanine. J Virol 1985; 53: 776-780.
7. Culver KW et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-1552.
8. Oldfield EH et al. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 1993; 4: 39-69.
9. Ezzeddine ZD et al. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol 1991; 3: 608-614.
10. Short MP et al. Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neurosci Res 1990; 27: 427-439.
11. Ram Z et al. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 1993; 53: 83-88.
12. Takamiya Y et al. An experimental model of retrovirus gene therapy for malignant brain tumors. J Neurosurg 1993; 79: 104-110.
13. Agbaria R et al. Effects of IMP dehydrogenase inhibitors on the phosphorylation of gancirlovir in MOLT-4 cells before and after herpes simplex virus thymidine kinase gene transduction. Mol Pharmacol 1994; 45: 777-782.
14. Freeman SM et al. The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-5283.
15. Hamel W, Magnelli L, Chiarugi VP, Israel MA. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res 1996; 56: 2697-2702.
16. Freeman SM et al. The role of cytokines in mediating the bystander effect using HSV-tk xenogeneic cells. Cancer Lett 1995; 92: 167-174.
17. Bi WL, Parysek LM, Warnick R, Stambrook PJ. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum Gene Ther 1993; 4: 725-731.
18. Subak-Sharpe JH, Burk RR, Pitts JD. Metabolic cooperation by cell to cell transfer between genetically different mammalian cells. Heredity 1966; 21: 342-343.
19. Subak-Sharpe JH, Burk RR, Pitts JD. Metabolic co-operation between biochemically marked mammalian cells in tissue culture. J Cell Sci 1969; 4: 353-367.
20. Gilula NB, Reeves OR, Steinbach A. Metabolic coupling, ionic coupling and cell contacts. Nature 1972; 235: 262-265.
21. Kuriyama S et al. Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepato-cellular carcinoma. Hepatology 1995; 22: 1838-1846.
22. Vrionis FD et al. A more potent bystander cytocidal effect elicited by tumor cells expressing the herpes simplex virus-thymidine kinase gene than by fibroblast virus-producer cells in vitro. J Neurosurg 1995; 83: 698-704.
23. Wu JK et al. Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 1994; 35: 1094-1102.
24. Fick J et al. The extent of hetcrocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro Proc Natl Acad Sci USA 1995; 92: 11071-11075.
25. Samejima Y, Meruelo D. 'Bystander killing' induces apoptosis and is inhibited by forskolin. Gene Therapy 1995; 2: 50-58.
26. Elshami AA et al. Gap junctions play a role in the bystander effect of the herpes simplex virus thymidine kinase ganciclovir system in vitro. Gene Therapy 1996; 3: 85-92.
27. Mesnil M et al. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc Natl Acad Sci USA 1996; 93: 1831-1835.
28. Shinoura N et al. Protein and messenger RNA expression of connexin 43 in astrocytomas - implications in brain tumor gene therapy. J Neurosurg 1996; 84: 839-845.
29. Restifo NP et al. Defective presentation of endogenous antigens by a murine sarcoma: implications for the failure of an antitumor immune response. J Immunol 1991; 147: 1453-1459.
30. Giard DJ et al In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 1991; 51: 1417-1423.
31. Schwartzentruber DJ, Topalian SL, Mancini M, Rosenberg SA. Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-α and IFN-γ by human tumor-infiltrating lymphocytes after autologous tumor stimulation. J Immunol 1991; 146: 3674-3681.
32. Harstrick A et al. Comparison of the antitumor activity of cisplatin, carboplatin, and iproplatin against established human testicular cancer cell lines in vivo and in vitro. Cancer 1989; 63: 1079-1083.
33. Horgan K, Shaw S. Immunomagnetic purification of T cell subpopulations. In: Coligan JE et al (eds). Current Protocols in Immunology, Vol. I Wiley-Interscience: New York, 1991, pp 7.4.1-7.4.6.