Synthesis of a novel duocarmycin derivative DU-257 and its application to immunoconjugate using poly(ethylene glycol)-dipeptidyl linker capable of tumor specific activation

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 8, 2000, Pages 2175-2184

  Suzawa, Toshiyuki ^a   Nagamura, Satoru ^a   Saito, Hiromitsu ^a   Ohta, So ^a   Hanai, Nobuo ^a   Yamasaki, Motoo ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; DU 257; DUOCARMYCIN DERIVATIVE; MACROGOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KM231; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONJUGATE; CONJUGATION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL;

ANTIBIOTICS, ANTINEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; HELA CELLS; HUMANS; IMMUNOTOXINS; INDOLES; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; PYRROLIDINONES; TUMOR CELLS, CULTURED;

EID: 0033865139     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00157-7     Document Type: Article

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