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Volumn 12, Issue 1, 2019, Pages

Ferroptosis, a new form of cell death: Opportunities and challenges in cancer

Author keywords

Apoptosis; Autophagy; Cancers; Ferroptosis; NcRNAs; P53

Indexed keywords

MICRORNA; MICRORNA 101; MICRORNA 137; MICRORNA 142 5P; MICRORNA 144; MICRORNA 152; MICRORNA 153; MICRORNA 193B; MICRORNA 19B 3P; MICRORNA 200A; MICRORNA 200B; MICRORNA 205; MICRORNA 20A; MICRORNA 210; MICRORNA 224 5P; MICRORNA 26B; MICRORNA 27A; MICRORNA 28; MICRORNA 29 B1; MICRORNA 34A; MICRORNA 3595; MICRORNA 365 1; MICRORNA 375; MICRORNA 455; MICRORNA 485 3P; MICRORNA 9; MICRORNA 93; MICRORNA LET 7D; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNTRANSLATED RNA;

EID: 85063738581     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-019-0720-y     Document Type: Review
Times cited : (1221)

References (113)
  • 1
    • 85018960248 scopus 로고    scopus 로고
    • Ferroptosis: Bug or feature?
    • 1:CAS:528:DC%2BC2sXmvVelurk%3D 28462529 28462529
    • Dixon SJ. Ferroptosis: bug or feature? Immunol Rev. 2017;277:150-7.
    • (2017) Immunol Rev , vol.277 , pp. 150-157
    • Dixon, S.J.1
  • 2
    • 34250372956 scopus 로고    scopus 로고
    • RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels
    • 17568748 3047570 1:CAS:528:DC%2BD2sXms1WjsL0%3D
    • Yagoda N, Von RM, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 2007;447:864-8.
    • (2007) Nature. , vol.447 , pp. 864-868
    • Yagoda, N.1    Von, R.M.2    Zaganjor, E.3    Bauer, A.J.4    Yang, W.S.5    Fridman, D.J.6
  • 3
    • 85000658863 scopus 로고    scopus 로고
    • Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
    • 1:CAS:528:DC%2BC2sXktFSisbs%3D 27860262 27860262
    • Yu H, Guo P, Xie X, Wang Y, Chen G. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. J Cell Mol Med. 2017;21:648-57.
    • (2017) J Cell Mol Med , vol.21 , pp. 648-657
    • Yu, H.1    Guo, P.2    Xie, X.3    Wang, Y.4    Chen, G.5
  • 4
    • 85019715011 scopus 로고    scopus 로고
    • Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy
    • 1:CAS:528:DC%2BC2sXos1ektrk%3D
    • Latunde-Dada GO. Ferroptosis: role of lipid peroxidation, iron and ferritinophagy. Biochim Biophys Acta. 2017;1861(8):1893.
    • (2017) Biochim Biophys Acta , vol.1861 , Issue.8 , pp. 1893
    • Latunde-Dada, G.O.1
  • 5
    • 84962637563 scopus 로고    scopus 로고
    • Mechanisms of ferroptosis
    • 1:CAS:528:DC%2BC28XlsValurw%3D 27048822 4887533
    • Cao JY, Dixon SJ. Mechanisms of ferroptosis. Cell Mol Life Sci. 2016;73:2195-209.
    • (2016) Cell Mol Life Sci , vol.73 , pp. 2195-2209
    • Cao, J.Y.1    Dixon, S.J.2
  • 6
    • 84957429081 scopus 로고    scopus 로고
    • Ferroptosis: Process and function
    • 1:CAS:528:DC%2BC28Xhsl2jtbk%3D 26794443 5072448
    • Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, et al. Ferroptosis: process and function. Cell Death Differ. 2016;23(3):369-79.
    • (2016) Cell Death Differ , vol.23 , Issue.3 , pp. 369-379
    • Xie, Y.1    Hou, W.2    Song, X.3    Yu, Y.4    Huang, J.5    Sun, X.6
  • 7
    • 40849085503 scopus 로고    scopus 로고
    • Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells
    • 1:CAS:528:DC%2BD1cXjs1Klsrs%3D 18355723 2683762
    • Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15:234-45.
    • (2008) Chem Biol , vol.15 , pp. 234-245
    • Yang, W.S.1    Stockwell, B.R.2
  • 8
    • 84861541814 scopus 로고    scopus 로고
    • Ferroptosis: An iron-dependent form of nonapoptotic cell death
    • 1:CAS:528:DC%2BC38XnslSntrw%3D 22632970 3367386
    • Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060-72.
    • (2012) Cell. , vol.149 , pp. 1060-1072
    • Dixon, S.J.1    Lemberg, K.M.2    Lamprecht, M.R.3    Skouta, R.4    Zaitsev, E.M.5    Gleason, C.E.6
  • 9
    • 85034030884 scopus 로고    scopus 로고
    • How do we fit ferroptosis in the family of regulated cell death?
    • 1:CAS:528:DC%2BC2sXhs1Wns7jK 28984871 5686356
    • Fearnhead HO, Vandenabeele P, Vanden TB. How do we fit ferroptosis in the family of regulated cell death? Cell Death Differ. 2017;24:1991-8.
    • (2017) Cell Death Differ , vol.24 , pp. 1991-1998
    • Fearnhead, H.O.1    Vandenabeele, P.2    Vanden, T.B.3
  • 10
    • 0032534748 scopus 로고    scopus 로고
    • Redox regulation of caspase-3(-like) protease activity: Regulatory roles of thioredoxin and cytochrome c
    • 1:CAS:528:DyaK1cXotFWqtrk%3D 9862698
    • Ueda S, Nakamura H, Masutani H, Sasada T, Yonehara S, Takabayashi A, et al. Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c. J Immunol. 1998;161:6689-95.
    • (1998) J Immunol , vol.161 , pp. 6689-6695
    • Ueda, S.1    Nakamura, H.2    Masutani, H.3    Sasada, T.4    Yonehara, S.5    Takabayashi, A.6
  • 11
    • 85042429525 scopus 로고    scopus 로고
    • Non-apoptotic cell death in malignant tumor cells and natural compounds
    • 1:CAS:528:DC%2BC1cXjtFals7k%3D 29410006
    • Ye J, Zhang R, Wu F, Zhai L, Wang K, Xiao M, et al. Non-apoptotic cell death in malignant tumor cells and natural compounds. Cancer Lett. 2018;420:210-27.
    • (2018) Cancer Lett , vol.420 , pp. 210-227
    • Ye, J.1    Zhang, R.2    Wu, F.3    Zhai, L.4    Wang, K.5    Xiao, M.6
  • 12
    • 85027880924 scopus 로고    scopus 로고
    • The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity
    • 1:CAS:528:DC%2BC2sXhtlClsL7N 28813679
    • Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, et al. The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity. Cell Rep. 2017;20:1692-704.
    • (2017) Cell Rep , vol.20 , pp. 1692-1704
    • Xie, Y.1    Zhu, S.2    Song, X.3    Sun, X.4    Fan, Y.5    Liu, J.6
  • 13
    • 84926387317 scopus 로고    scopus 로고
    • Ferroptosis as a p53-mediated activity during tumour suppression
    • 1:CAS:528:DC%2BC2MXltVSisLw%3D 25799988 4455927
    • Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520:57-62.
    • (2015) Nature. , vol.520 , pp. 57-62
    • Jiang, L.1    Kon, N.2    Li, T.3    Wang, S.J.4    Su, T.5    Hibshoosh, H.6
  • 14
    • 85042169410 scopus 로고    scopus 로고
    • Deconstructing networks of p53-mediated tumor suppression in vivo
    • 1:CAS:528:DC%2BC2sXhslGksb%2FP 29099489
    • Kaiser AM, Attardi LD. Deconstructing networks of p53-mediated tumor suppression in vivo. Cell Death Differ. 2018;25:93-103.
    • (2018) Cell Death Differ , vol.25 , pp. 93-103
    • Kaiser, A.M.1    Attardi, L.D.2
  • 15
    • 85041647871 scopus 로고    scopus 로고
    • P53 suppresses metabolic stress-induced ferroptosis in cancer cells
    • 1:CAS:528:DC%2BC1cXhvFahtbY%3D 29346757 5791910
    • Tarangelo A, Magtanong L, Bieging-Rolett KT, Li Y, Ye J, Attardi LD, et al. p53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep. 2018;22(3):569-75.
    • (2018) Cell Rep , vol.22 , Issue.3 , pp. 569-575
    • Tarangelo, A.1    Magtanong, L.2    Bieging-Rolett, K.T.3    Li, Y.4    Ye, J.5    Attardi, L.D.6
  • 16
    • 85044026151 scopus 로고    scopus 로고
    • How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
    • 29149101 5729529 1:CAS:528:DC%2BC2sXhvVahs7jP
    • Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 2017;25:104-13.
    • (2017) Cell Death Differ , vol.25 , pp. 104-113
    • Aubrey, B.J.1    Kelly, G.L.2    Janic, A.3    Herold, M.J.4    Strasser, A.5
  • 18
    • 85017015542 scopus 로고    scopus 로고
    • Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
    • e2307 1:CAS:528:DC%2BC28Xht12jt7%2FP 27441659 4973350
    • Ma S, Henson ES, Chen Y, Gibson SB. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7:e2307.
    • (2016) Cell Death Dis , vol.7
    • Ma, S.1    Henson, E.S.2    Chen, Y.3    Gibson, S.B.4
  • 19
    • 85044925079 scopus 로고    scopus 로고
    • Ferroptosis: A novel anti-tumor action for cisplatin
    • 1:CAS:528:DC%2BC1MXksVOqtLg%3D 28494534
    • Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, et al. Ferroptosis: a novel anti-tumor action for cisplatin. Cancer Res Treat. 2018;50:445-60.
    • (2018) Cancer Res Treat , vol.50 , pp. 445-460
    • Guo, J.1    Xu, B.2    Han, Q.3    Zhou, H.4    Xia, Y.5    Gong, C.6
  • 20
    • 85036582367 scopus 로고    scopus 로고
    • NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
    • 1:CAS:528:DC%2BC2sXhvVynsb7I 29168506 5808442
    • Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 2017;551:639-43.
    • (2017) Nature. , vol.551 , pp. 639-643
    • Alvarez, S.W.1    Sviderskiy, V.O.2    Terzi, E.M.3    Papagiannakopoulos, T.4    Moreira, A.L.5    Adams, S.6
  • 21
    • 85027053896 scopus 로고    scopus 로고
    • Iron, oxidative damage and ferroptosis in rhabdomyosarcoma
    • 5578108 1:CAS:528:DC%2BC1cXitVWgurrE 5578108
    • Fanzani A, Poli M. Iron, oxidative damage and ferroptosis in rhabdomyosarcoma. Int J Mol Sci. 2017;18:1718.
    • (2017) Int J Mol Sci. , vol.18 , pp. 1718
    • Fanzani, A.1    Poli, M.2
  • 22
    • 85052245827 scopus 로고    scopus 로고
    • AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system xc(-) activity
    • 1:CAS:528:DC%2BC1cXhsVSmsLbF 30057310
    • Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, et al. AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system xc(-) activity. Curr Biol. 2018;28:2388-99.e5.
    • (2018) Curr Biol , vol.28 , pp. 2388-2388e5
    • Song, X.1    Zhu, S.2    Chen, P.3    Hou, W.4    Wen, Q.5    Liu, J.6
  • 23
    • 85053322934 scopus 로고    scopus 로고
    • BECN1 is a new driver of ferroptosis
    • 1:CAS:528:DC%2BC1cXhslSnsrfP 30145930
    • Kang R, Zhu S, Zeh HJ, Klionsky DJ, Tang D. BECN1 is a new driver of ferroptosis. Autophagy. 2018;14:2173-5.
    • (2018) Autophagy. , vol.14 , pp. 2173-2175
    • Kang, R.1    Zhu, S.2    Zeh, H.J.3    Klionsky, D.J.4    Tang, D.5
  • 24
    • 85049643031 scopus 로고    scopus 로고
    • A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53
    • 1:CAS:528:DC%2BC1cXht1altbrM 29588351
    • Mao C, Wang X, Liu Y, Wang M, Yan B, Jiang Y, et al. A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53. Cancer Res. 2018;78:3484-96.
    • (2018) Cancer Res , vol.78 , pp. 3484-3496
    • Mao, C.1    Wang, X.2    Liu, Y.3    Wang, M.4    Yan, B.5    Jiang, Y.6
  • 25
    • 85052665188 scopus 로고    scopus 로고
    • MiR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma
    • 1:CAS:528:DC%2BC1cXhsV2ju7nF 30035324
    • Zhang K, Wu L, Zhang P, Luo M, Du J, Gao T, et al. miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma. Mol Carcinog. 2018;57:1566-76.
    • (2018) Mol Carcinog , vol.57 , pp. 1566-1576
    • Zhang, K.1    Wu, L.2    Zhang, P.3    Luo, M.4    Du, J.5    Gao, T.6
  • 26
    • 85040691316 scopus 로고    scopus 로고
    • MiR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
    • 1:CAS:528:DC%2BC1cXkslahur4%3D 29348676 6113319
    • Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, et al. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ. 2018;25:1457-72.
    • (2018) Cell Death Differ , vol.25 , pp. 1457-1472
    • Luo, M.1    Wu, L.2    Zhang, K.3    Wang, H.4    Zhang, T.5    Gutierrez, L.6
  • 27
    • 85020509517 scopus 로고    scopus 로고
    • MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion
    • 1:CAS:528:DC%2BC2sXhtFCku77O 28627030 5504333
    • Wu Y, Sun X, Song B, Qiu X, Zhao J. MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion. Cancer Med. 2017;6:1686-97.
    • (2017) Cancer Med , vol.6 , pp. 1686-1697
    • Wu, Y.1    Sun, X.2    Song, B.3    Qiu, X.4    Zhao, J.5
  • 28
    • 84898721879 scopus 로고    scopus 로고
    • Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11
    • 1:CAS:528:DC%2BC2cXls1ehs78%3D 24516043 3974662
    • Drayton RM, Dudziec E, Peter S, Bertz S, Hartmann A, Bryant HE, et al. Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11. Clin Cancer Res. 2014;20:1990-2000.
    • (2014) Clin Cancer Res , vol.20 , pp. 1990-2000
    • Drayton, R.M.1    Dudziec, E.2    Peter, S.3    Bertz, S.4    Hartmann, A.5    Bryant, H.E.6
  • 29
    • 79955578079 scopus 로고    scopus 로고
    • MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11
    • 1:CAS:528:DC%2BC3MXlvVynt7k%3D 21510944
    • Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, et al. MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. FEBS Lett. 2011;585:1363-7.
    • (2011) FEBS Lett , vol.585 , pp. 1363-1367
    • Liu, X.X.1    Li, X.J.2    Zhang, B.3    Liang, Y.J.4    Zhou, C.X.5    Cao, D.X.6
  • 30
    • 85021628506 scopus 로고    scopus 로고
    • Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11
    • 1:CAS:528:DC%2BC1cXhtlSnt7w%3D 29441937 29441937
    • Yuan J, Liu Z, Song R. Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11. Pharmazie. 2017;72:402-7.
    • (2017) Pharmazie. , vol.72 , pp. 402-407
    • Yuan, J.1    Liu, Z.2    Song, R.3
  • 31
    • 84944089083 scopus 로고    scopus 로고
    • MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression
    • 1:CAS:528:DC%2BC2MXhs1CqtL%2FP 26453926 4684759
    • Kabaria S, Choi DC, Chaudhuri AD, Jain MR, Li H, Junn E. MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression. Free Radic Biol Med. 2015;89:548-56.
    • (2015) Free Radic Biol Med , vol.89 , pp. 548-556
    • Kabaria, S.1    Choi, D.C.2    Chaudhuri, A.D.3    Jain, M.R.4    Li, H.5    Junn, E.6
  • 32
    • 81755171451 scopus 로고    scopus 로고
    • MiR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
    • 1:CAS:528:DC%2BC3MXhsVOqu7jI 21926171 3220489
    • Eades G, Yang M, Yao Y, Zhang Y, Zhou Q. miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. J Biol Chem. 2011;286:40725-33.
    • (2011) J Biol Chem , vol.286 , pp. 40725-40733
    • Eades, G.1    Yang, M.2    Yao, Y.3    Zhang, Y.4    Zhou, Q.5
  • 33
    • 80052570740 scopus 로고    scopus 로고
    • MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
    • 1:CAS:528:DC%2BC3MXhtFGitbrI 21638050 3752913
    • Yang M, Yao Y, Eades G, Zhang Y, Zhou Q. MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism. Breast Cancer Res Treat. 2011;129:983-91.
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 983-991
    • Yang, M.1    Yao, Y.2    Eades, G.3    Zhang, Y.4    Zhou, Q.5
  • 34
    • 84914172382 scopus 로고    scopus 로고
    • Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3
    • 1:CAS:528:DC%2BC2cXhvF2ltbbI 24844779 4245877
    • Kim JH, Lee KS, Lee DK, Kim J, Kwak SN, Ha KS, et al. Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid Redox Signal. 2014;21:2469-82.
    • (2014) Antioxid Redox Signal , vol.21 , pp. 2469-2482
    • Kim, J.H.1    Lee, K.S.2    Lee, D.K.3    Kim, J.4    Kwak, S.N.5    Ha, K.S.6
  • 35
    • 85029113726 scopus 로고    scopus 로고
    • MicroRNA-455 targets cullin 3 to activate Nrf2 signaling and protect human osteoblasts from hydrogen peroxide
    • 28938631 5601727
    • Xu D, Zhu H, Wang C, Zhu X, Liu G, Chen C, et al. microRNA-455 targets cullin 3 to activate Nrf2 signaling and protect human osteoblasts from hydrogen peroxide. Oncotarget. 2017;8:59225-34.
    • (2017) Oncotarget. , vol.8 , pp. 59225-59234
    • Xu, D.1    Zhu, H.2    Wang, C.3    Zhu, X.4    Liu, G.5    Chen, C.6
  • 36
    • 84870859466 scopus 로고    scopus 로고
    • Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells
    • 1:CAS:528:DC%2BC38XhvV2qsbvF 23236440 3517581
    • Narasimhan M, Patel D, Vedpathak D, Rathinam M, Henderson G, Mahimainathan L. Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells. PLoS One. 2012;7:e51111.
    • (2012) PLoS One , vol.7 , pp. e51111
    • Narasimhan, M.1    Patel, D.2    Vedpathak, D.3    Rathinam, M.4    Henderson, G.5    Mahimainathan, L.6
  • 37
    • 78549277802 scopus 로고    scopus 로고
    • MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
    • 1:CAS:528:DC%2BC3cXhsFChsrzO 20709907 2993631
    • Sangokoya C, Telen MJ, Chi JT. microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. Blood. 2010;116:4338-48.
    • (2010) Blood. , vol.116 , pp. 4338-4348
    • Sangokoya, C.1    Telen, M.J.2    Chi, J.T.3
  • 38
    • 84877113289 scopus 로고    scopus 로고
    • MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis
    • 1:CAS:528:DC%2BC3sXntV2is74%3D 23492819 3643421
    • Singh B, Ronghe AM, Chatterjee A, Bhat NK, Bhat HK. MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis. Carcinogenesis. 2013;34:1165-72.
    • (2013) Carcinogenesis. , vol.34 , pp. 1165-1172
    • Singh, B.1    Ronghe, A.M.2    Chatterjee, A.3    Bhat, N.K.4    Bhat, H.K.5
  • 39
    • 85021697080 scopus 로고    scopus 로고
    • Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway
    • 1:CAS:528:DC%2BC2sXhtFSmu7%2FE 28514495 5513863
    • Zhang Y, Tao X, Yin L, Xu L, Xu Y, Qi Y, et al. Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway. Br J Pharmacol. 2017;174:2512-27.
    • (2017) Br J Pharmacol , vol.174 , pp. 2512-2527
    • Zhang, Y.1    Tao, X.2    Yin, L.3    Xu, L.4    Xu, Y.5    Qi, Y.6
  • 40
    • 84867317004 scopus 로고    scopus 로고
    • Identification of novel NRF2-regulated genes by ChIP-Seq: Influence on retinoid X receptor alpha
    • 1:CAS:528:DC%2BC38Xht1Kjs7nK 22581777 3424561
    • Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, et al. Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res. 2012;40:7416-29.
    • (2012) Nucleic Acids Res , vol.40 , pp. 7416-7429
    • Chorley, B.N.1    Campbell, M.R.2    Wang, X.3    Karaca, M.4    Sambandan, D.5    Bangura, F.6
  • 41
    • 84946763263 scopus 로고    scopus 로고
    • MiR-20a regulates expression of the iron exporter ferroportin in lung cancer
    • 1:CAS:528:DC%2BC2MXhvVaqsLbO
    • Babu KR, Muckenthaler MU. miR-20a regulates expression of the iron exporter ferroportin in lung cancer. J Mol Med (Berl). 2016;94:347-59.
    • (2016) J Mol Med (Berl) , vol.94 , pp. 347-359
    • Babu, K.R.1    Muckenthaler, M.U.2
  • 42
    • 84876883321 scopus 로고    scopus 로고
    • Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin
    • 1:CAS:528:DC%2BC3sXnt1aqsLs%3D 23593016 3616902
    • Sangokoya C, Doss JF, Chi JT. Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin. PLoS Genet. 2013;9:e1003408.
    • (2013) PLoS Genet , vol.9 , pp. e1003408
    • Sangokoya, C.1    Doss, J.F.2    Chi, J.T.3
  • 43
    • 84867241288 scopus 로고    scopus 로고
    • Micromanaging iron homeostasis: Hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins
    • 1:CAS:528:DC%2BC38XhsVKlsLjN 22896707 3464520
    • Yoshioka Y, Kosaka N, Ochiya T, Kato T. Micromanaging iron homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins. J Biol Chem. 2012;287:34110-9.
    • (2012) J Biol Chem , vol.287 , pp. 34110-34119
    • Yoshioka, Y.1    Kosaka, N.2    Ochiya, T.3    Kato, T.4
  • 44
    • 84957667663 scopus 로고    scopus 로고
    • MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
    • 26657500 26657500
    • Kindrat I, Tryndyak V, de Conti A, Shpyleva S, Mudalige TK, Kobets T, et al. MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis. Oncotarget. 2016;7:1276-87.
    • (2016) Oncotarget. , vol.7 , pp. 1276-1287
    • Kindrat, I.1    Tryndyak, V.2    De Conti, A.3    Shpyleva, S.4    Mudalige, T.K.5    Kobets, T.6
  • 46
    • 77956054423 scopus 로고    scopus 로고
    • Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA let-7d in erythroid cells
    • 1:CAS:528:DC%2BC3cXhtlShu7rK 20410187 2913071
    • Andolfo I, De Falco L, Asci R, Russo R, Colucci S, Gorrese M, et al. Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA let-7d in erythroid cells. Haematologica. 2010;95:1244-52.
    • (2010) Haematologica. , vol.95 , pp. 1244-1252
    • Andolfo, I.1    De Falco, L.2    Asci, R.3    Russo, R.4    Colucci, S.5    Gorrese, M.6
  • 47
    • 85041561772 scopus 로고    scopus 로고
    • Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis
    • 29393361 5810201
    • Wu X, Zhi F, Lun W, Deng Q, Zhang W. Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis. Int J Mol Med. 2018;41:1992-2002.
    • (2018) Int J Mol Med , vol.41 , pp. 1992-2002
    • Wu, X.1    Zhi, F.2    Lun, W.3    Deng, Q.4    Zhang, W.5
  • 48
    • 84896319508 scopus 로고    scopus 로고
    • Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4
    • 1:CAS:528:DC%2BC2cXjsVWnurk%3D 24576478 24576478
    • Cui M, Xiao ZL, Sun BD, Wang Y, Zheng MY, Ye LH, et al. Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4. Biochem Biophys Res Commun. 2014;445:651-5.
    • (2014) Biochem Biophys Res Commun , vol.445 , pp. 651-655
    • Cui, M.1    Xiao, Z.L.2    Sun, B.D.3    Wang, Y.4    Zheng, M.Y.5    Ye, L.H.6
  • 49
    • 84879042710 scopus 로고    scopus 로고
    • MiR-224 impairs adipocyte early differentiation and regulates fatty acid metabolism
    • 1:CAS:528:DC%2BC3sXhtFaktrjP 23665235 23665235
    • Peng Y, Xiang H, Chen C, Zheng R, Chai J, Peng J, et al. MiR-224 impairs adipocyte early differentiation and regulates fatty acid metabolism. Int J Biochem Cell Biol. 2013;45:1585-93.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 1585-1593
    • Peng, Y.1    Xiang, H.2    Chen, C.3    Zheng, R.4    Chai, J.5    Peng, J.6
  • 50
    • 85053050538 scopus 로고    scopus 로고
    • Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis
    • 1:CAS:528:DC%2BC1cXhslWhurfP
    • Park S, Oh J, Kim M, Jin E-J. Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis. Anim Cells Syst. 2018;22:334-40.
    • (2018) Anim Cells Syst. , vol.22 , pp. 334-340
    • Park, S.1    Oh, J.2    Kim, M.3    Jin, E.-J.4
  • 51
    • 84929492983 scopus 로고    scopus 로고
    • MicroRNA profiling of atrial fibrillation in canines: MiR-206 modulates intrinsic cardiac autonomic nerve remodeling by regulating SOD1
    • 25816284 4376950 1:CAS:528:DC%2BC2MXhsFymsr7N
    • Zhang Y, Zheng S, Geng Y, Xue J, Wang Z, Xie X, et al. MicroRNA profiling of atrial fibrillation in canines: miR-206 modulates intrinsic cardiac autonomic nerve remodeling by regulating SOD1. PLoS One. 2015;10:e0122674.
    • (2015) PLoS One , vol.10 , pp. e0122674
    • Zhang, Y.1    Zheng, S.2    Geng, Y.3    Xue, J.4    Wang, Z.5    Xie, X.6
  • 52
    • 84940749648 scopus 로고    scopus 로고
    • Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer
    • Peng W, Zhu CF, Ma MZ, Gang C, Ming S, Zeng ZL, et al. Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer. Oncotarget. 2015;6:21148-58.
    • (2015) Oncotarget. , vol.6 , pp. 21148-21158
    • Peng, W.1    Zhu, C.F.2    Ma, M.Z.3    Gang, C.4    Ming, S.5    Zeng, Z.L.6
  • 53
    • 84879057626 scopus 로고    scopus 로고
    • MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart
    • 1:CAS:528:DC%2BC3sXht1Shtr%2FL 23722270 23722270
    • Varga ZV, Kupai K, Szucs G, Gaspar R, Paloczi J, Farago N, et al. MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart. J Mol Cell Cardiol. 2013;62:111-21.
    • (2013) J Mol Cell Cardiol , vol.62 , pp. 111-121
    • Varga, Z.V.1    Kupai, K.2    Szucs, G.3    Gaspar, R.4    Paloczi, J.5    Farago, N.6
  • 54
    • 84950312458 scopus 로고    scopus 로고
    • Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy
    • 1:CAS:528:DC%2BC2sXktVOlsrY%3D 26503985 4648202
    • Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J, Shirokova N. Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy. Cardiovasc Res. 2015;108:324-34.
    • (2015) Cardiovasc Res , vol.108 , pp. 324-334
    • Kyrychenko, S.1    Kyrychenko, V.2    Badr, M.A.3    Ikeda, Y.4    Sadoshima, J.5    Shirokova, N.6
  • 55
    • 85016257475 scopus 로고    scopus 로고
    • Switching apoptosis to ferroptosis: Metal-organic network for high-efficiency anticancer therapy
    • 1:CAS:528:DC%2BC28XitFGgtL7J 28027643 28027643
    • Zheng DW, Lei Q, Zhu JY, Fan JX, Li CX, Li C, et al. Switching apoptosis to ferroptosis: metal-organic network for high-efficiency anticancer therapy. Nano Lett. 2017;17:284-91.
    • (2017) Nano Lett , vol.17 , pp. 284-291
    • Zheng, D.W.1    Lei, Q.2    Zhu, J.Y.3    Fan, J.X.4    Li, C.X.5    Li, C.6
  • 56
    • 85049316178 scopus 로고    scopus 로고
    • Ferroptosis-induced endoplasmic reticulum stress: Cross-talk between ferroptosis and apoptosis
    • 1:CAS:528:DC%2BC1cXht1alurfF 29592897 29592897
    • Lee YS, Lee DH, Choudry HA, Bartlett DL, Lee YJ. Ferroptosis-induced endoplasmic reticulum stress: cross-talk between ferroptosis and apoptosis. Mol Cancer Res. 2018;16:1073-6.
    • (2018) Mol Cancer Res , vol.16 , pp. 1073-1076
    • Lee, Y.S.1    Lee, D.H.2    Choudry, H.A.3    Bartlett, D.L.4    Lee, Y.J.5
  • 57
    • 0037085261 scopus 로고    scopus 로고
    • Glutathione dependence of caspase-8 activation at the death-inducing signaling complex
    • 1:CAS:528:DC%2BD38XhsFCjtL0%3D 11734564 11734564
    • Hentze H, Schmitz I, Latta M, Krueger A, Krammer PH, Wendel A. Glutathione dependence of caspase-8 activation at the death-inducing signaling complex. J Biol Chem. 2002;277:5588-95.
    • (2002) J Biol Chem , vol.277 , pp. 5588-5595
    • Hentze, H.1    Schmitz, I.2    Latta, M.3    Krueger, A.4    Krammer, P.H.5    Wendel, A.6
  • 58
    • 85027859916 scopus 로고    scopus 로고
    • Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells
    • 28827805 5565111 1:CAS:528:DC%2BC1cXps1Gltw%3D%3D
    • Ma S, Dielschneider RF, Henson ES, Xiao W, Choquette TR, Blankstein AR, et al. Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells. PLoS One. 2017;12:e0182921.
    • (2017) PLoS One , vol.12 , pp. e0182921
    • Ma, S.1    Dielschneider, R.F.2    Henson, E.S.3    Xiao, W.4    Choquette, T.R.5    Blankstein, A.R.6
  • 59
    • 85052442724 scopus 로고    scopus 로고
    • Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases
    • 1:CAS:528:DC%2BC1cXhsVCgtLrK 30076709 30076709
    • Tang M, Chen Z, Wu D, Chen L. Ferritinophagy/ferroptosis: iron-related newcomers in human diseases. J Cell Physiol. 2018;233:9179-90.
    • (2018) J Cell Physiol. , vol.233 , pp. 9179-9190
    • Tang, M.1    Chen, Z.2    Wu, D.3    Chen, L.4
  • 60
    • 85052133477 scopus 로고    scopus 로고
    • Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells
    • 1:CAS:528:DC%2BC1cXhsFKqtbzP 30081711 30081711
    • Zhang Z, Yao Z, Wang L, Ding H, Shao J, Chen A, et al. Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells. Autophagy. 2018;14:2083-103.
    • (2018) Autophagy. , vol.14 , pp. 2083-2103
    • Zhang, Z.1    Yao, Z.2    Wang, L.3    Ding, H.4    Shao, J.5    Chen, A.6
  • 61
    • 85063755252 scopus 로고    scopus 로고
    • Targeting AMPK, mTOR and β-catenin by combined metformin and aspirin therapy in HCC: An appraisal in Egyptian HCC patients
    • Abdelmonsif DA, Sultan AS, El-Hadidy WF, Abdallah DM. Targeting AMPK, mTOR and β-catenin by combined metformin and aspirin therapy in HCC: an appraisal in Egyptian HCC patients. Mol Diagn Ther. 2017;22(5):1-13.
    • (2017) Mol Diagn Ther , vol.22 , Issue.5 , pp. 1-13
    • Abdelmonsif, D.A.1    Sultan, A.S.2    El-Hadidy, W.F.3    Abdallah, D.M.4
  • 62
    • 85015149861 scopus 로고    scopus 로고
    • Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: From pathophysiology to treatment
    • 28279189 5345270 1:CAS:528:DC%2BC1cXksl2msr4%3D
    • Yoshida GJ. Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment. J Hematol Oncol. 2017;10(1):67.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 67
    • Yoshida, G.J.1
  • 63
    • 85040462389 scopus 로고    scopus 로고
    • The role of ferroptosis in cancer development and treatment response
    • 29375387 5770584 1:CAS:528:DC%2BC1cXitFGrsb%2FK
    • Lu BCX, Ying MD, He QJ, Cao J, Yang B. The role of ferroptosis in cancer development and treatment response. Front Pharmacol. 2018;8:992.
    • (2018) Front Pharmacol , vol.8 , pp. 992
    • Lu, B.C.X.1    Ying, M.D.2    He, Q.J.3    Cao, J.4    Yang, B.5
  • 64
    • 84982123825 scopus 로고    scopus 로고
    • Ferroptosis is an autophagic cell death process
    • 1:CAS:528:DC%2BC28XhtlGmsbrL 27514700 5034113
    • Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26:1021.
    • (2016) Cell Res , vol.26 , pp. 1021
    • Gao, M.1    Monian, P.2    Pan, Q.3    Zhang, W.4    Xiang, J.5    Jiang, X.6
  • 65
    • 85051276927 scopus 로고    scopus 로고
    • Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis
    • 30082680 6079099 1:CAS:528:DC%2BC1cXhsVGhurfI
    • Buccarelli M, Marconi M, Pacioni S, De Pascalis I, D'Alessandris QG, Martini M, et al. Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis. Cell Death Dis. 2018;9:841.
    • (2018) Cell Death Dis , vol.9 , pp. 841
    • Buccarelli, M.1    Marconi, M.2    Pacioni, S.3    De Pascalis, I.4    D'Alessandris, Q.G.5    Martini, M.6
  • 66
    • 85032735852 scopus 로고    scopus 로고
    • SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes
    • 1:CAS:528:DC%2BC1MXhtlCqt7g%3D
    • Saintgermain E, Lian M, Vernier M. SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. Aging. 2017;9(10):2137-62.
    • (2017) Aging. , vol.9 , Issue.10 , pp. 2137-2162
    • Saintgermain, E.1    Lian, M.2    Vernier, M.3
  • 67
    • 84975469729 scopus 로고    scopus 로고
    • Chemical genetics: Unraveling cell death mysteries
    • 1:CAS:528:DC%2BC28XhtVSksbbI 27315536 5610897
    • Cotto-Rios XM, Gavathiotis E. Chemical genetics: unraveling cell death mysteries. Nat Chem Biol. 2016;12:470-1.
    • (2016) Nat Chem Biol , vol.12 , pp. 470-471
    • Cotto-Rios, X.M.1    Gavathiotis, E.2
  • 68
    • 84956873539 scopus 로고    scopus 로고
    • Using small molecules to dissect non-apoptotic programmed cell death: Necroptosis, Ferroptosis, and Pyroptosis
    • 1:CAS:528:DC%2BC2MXhs1Kit7%2FF 26388514 26388514
    • Dong T, Liao D, Liu X, Lei X. Using small molecules to dissect non-apoptotic programmed cell death: necroptosis, Ferroptosis, and Pyroptosis. Chembiochem. 2015;16:2557-61.
    • (2015) Chembiochem , vol.16 , pp. 2557-2561
    • Dong, T.1    Liao, D.2    Liu, X.3    Lei, X.4
  • 69
    • 85016771461 scopus 로고    scopus 로고
    • BID links ferroptosis to mitochondrial cell death pathways
    • 1:CAS:528:DC%2BC2sXlsFams7g%3D 28384611 5382034
    • Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, et al. BID links ferroptosis to mitochondrial cell death pathways. Redox Biol. 2017;12:558-70.
    • (2017) Redox Biol , vol.12 , pp. 558-570
    • Neitemeier, S.1    Jelinek, A.2    Laino, V.3    Hoffmann, L.4    Eisenbach, I.5    Eying, R.6
  • 70
    • 84947035915 scopus 로고    scopus 로고
    • HSPB1 as a novel regulator of ferroptotic cancer cell death
    • 1:CAS:528:DC%2BC2MXjs1Grsbo%3D 25728673 4640181
    • Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, et al. HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene. 2015;34:5617-25.
    • (2015) Oncogene. , vol.34 , pp. 5617-5625
    • Sun, X.1    Ou, Z.2    Xie, M.3    Kang, R.4    Fan, Y.5    Niu, X.6
  • 71
    • 84919432703 scopus 로고    scopus 로고
    • The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells
    • 1:CAS:528:DC%2BC2cXhvFGitb3I 25444922 25444922
    • Louandre C, Marcq I, Bouhlal H, Lachaier E, Godin C, Saidak Z, et al. The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells. Cancer Lett. 2015;356:971-7.
    • (2015) Cancer Lett , vol.356 , pp. 971-977
    • Louandre, C.1    Marcq, I.2    Bouhlal, H.3    Lachaier, E.4    Godin, C.5    Saidak, Z.6
  • 72
    • 85053269521 scopus 로고    scopus 로고
    • Role of ferroptosis in hepatocellular carcinoma
    • 1:CAS:528:DC%2BC1cXhs1Chur3J 30167889 30167889
    • Nie J, Lin B, Zhou M, Wu L, Zheng T. Role of ferroptosis in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2018;144:2329-37.
    • (2018) J Cancer Res Clin Oncol. , vol.144 , pp. 2329-2337
    • Nie, J.1    Lin, B.2    Zhou, M.3    Wu, L.4    Zheng, T.5
  • 73
    • 85033481786 scopus 로고    scopus 로고
    • Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells
    • 1:CAS:528:DC%2BC2sXhslChsLbI 29144989 5686465
    • Hao S, Yu J, He W, Huang Q, Zhao Y, Liang B, et al. Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells. Neoplasia. 2017;19:1022-32.
    • (2017) Neoplasia , vol.19 , pp. 1022-1032
    • Hao, S.1    Yu, J.2    He, W.3    Huang, Q.4    Zhao, Y.5    Liang, B.6
  • 74
    • 84962909319 scopus 로고    scopus 로고
    • Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
    • Masanori H, Hidekazu T, Hasan R, Maroof A, Yozo S, Li Y, et al. Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells. Oncotarget. 2016;7:11756-69.
    • (2016) Oncotarget. , vol.7 , pp. 11756-11769
    • Masanori, H.1    Hidekazu, T.2    Hasan, R.3    Maroof, A.4    Yozo, S.5    Li, Y.6
  • 75
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc and thereby promotes tumor growth
    • 1:CAS:528:DC%2BC3MXjtFKisrY%3D 21397861 21397861
    • Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc and thereby promotes tumor growth. Cancer Cell. 2011;19(3):387-400.
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3    Tamada, M.4    Motohara, T.5    Oshima, H.6
  • 76
    • 85015710412 scopus 로고    scopus 로고
    • Iron addiction: A novel therapeutic target in ovarian cancer
    • 1:CAS:528:DC%2BC2sXkvFagsLw%3D 28319068 5540148
    • Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, et al. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017;36:4089-99.
    • (2017) Oncogene. , vol.36 , pp. 4089-4099
    • Basuli, D.1    Tesfay, L.2    Deng, Z.3    Paul, B.4    Yamamoto, Y.5    Ning, G.6
  • 77
    • 84959194657 scopus 로고    scopus 로고
    • Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate
    • 26878598 1:CAS:528:DC%2BC28XisFWisr8%3D 26878598
    • Greenshields AL, Shepherd TG, Hoskin DW. Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate. Mol Carcinog. 2016;56:75-93.
    • (2016) Mol Carcinog , vol.56 , pp. 75-93
    • Greenshields, A.L.1    Shepherd, T.G.2    Hoskin, D.W.3
  • 79
    • 85042228290 scopus 로고    scopus 로고
    • Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma
    • 1:CAS:528:DC%2BC1cXhtFOnu7jF 29463878 29463878
    • Kinowaki Y, Kurata M, Ishibashi S, Ikeda M, Tatsuzawa A, Yamamoto M, et al. Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma. Lab Investig. 2018;98:609-19.
    • (2018) Lab Investig , vol.98 , pp. 609-619
    • Kinowaki, Y.1    Kurata, M.2    Ishibashi, S.3    Ikeda, M.4    Tatsuzawa, A.5    Yamamoto, M.6
  • 80
    • 85024121807 scopus 로고    scopus 로고
    • The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents
    • 27308510 4905356 1:CAS:528:DC%2BC28XhtlKlu7Y%3D
    • Yu Y, Xie Y, Cao L, Yang L, Yang M, Lotze MT, et al. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. Mol Cell Oncol. 2015;2:e1054549.
    • (2015) Mol Cell Oncol , vol.2 , pp. e1054549
    • Yu, Y.1    Xie, Y.2    Cao, L.3    Yang, L.4    Yang, M.5    Lotze, M.T.6
  • 81
    • 0037932865 scopus 로고    scopus 로고
    • Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
    • 1:CAS:528:DC%2BD3sXislOrtbk%3D 12676586
    • Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 2003;3:285-96.
    • (2003) Cancer Cell , vol.3 , pp. 285-296
    • Dolma, S.1    Lessnick, S.L.2    Hahn, W.C.3    Stockwell, B.R.4
  • 82
    • 84943246936 scopus 로고    scopus 로고
    • Metabolic reprogramming: The emerging concept and associated therapeutic strategies
    • 1:CAS:528:DC%2BC28XhtVGjs7fN
    • Yoshida GJ. Metabolic reprogramming: the emerging concept and associated therapeutic strategies. J Exp Clin Cancer Res. 2015;34(1):1-10.
    • (2015) J Exp Clin Cancer Res , vol.34 , Issue.1 , pp. 1-10
    • Yoshida, G.J.1
  • 83
    • 85037704971 scopus 로고    scopus 로고
    • Administering xCT inhibitors based on circadian clock improves antitumor effects
    • 1:CAS:528:DC%2BC2sXhvFWhsb7K
    • Okazaki F, Matsunaga N, Hamamura K, Suzuki K, Nakao T, Okazaki H, et al. Administering xCT inhibitors based on circadian clock improves antitumor effects. Cancer Res. 2017;77(23):0720.2017.
    • (2017) Cancer Res , vol.77 , Issue.23 , pp. 720-2017
    • Okazaki, F.1    Matsunaga, N.2    Hamamura, K.3    Suzuki, K.4    Nakao, T.5    Okazaki, H.6
  • 84
    • 85050749737 scopus 로고    scopus 로고
    • Emerging roles of Myc in stem cell biology and novel tumor therapies
    • 30053872 6062976 1:CAS:528:DC%2BC1MXivVemtrk%3D
    • Yoshida GJ. Emerging roles of Myc in stem cell biology and novel tumor therapies. J Exp Clin Cancer Res. 2018;37(1):173.
    • (2018) J Exp Clin Cancer Res , vol.37 , Issue.1 , pp. 173
    • Yoshida, G.J.1
  • 85
    • 85018770280 scopus 로고    scopus 로고
    • Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis
    • 1:CAS:528:DC%2BC2sXmslais70%3D 28433662
    • Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S. Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis. Free Radic Biol Med. 2017;108:610-26.
    • (2017) Free Radic Biol Med , vol.108 , pp. 610-626
    • Toyokuni, S.1    Ito, F.2    Yamashita, K.3    Okazaki, Y.4    Akatsuka, S.5
  • 86
    • 85041598801 scopus 로고    scopus 로고
    • Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
    • 1:CAS:528:DC%2BC1cXitFGrtbbK 29393418 29393418
    • Yamaguchi Y, Kasukabe T, Kumakura S. Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis. Int J Oncol. 2018;52(3):1011-22.
    • (2018) Int J Oncol , vol.52 , Issue.3 , pp. 1011-1022
    • Yamaguchi, Y.1    Kasukabe, T.2    Kumakura, S.3
  • 87
    • 84979872952 scopus 로고    scopus 로고
    • Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer
    • 1:CAS:528:DC%2BC28Xht1OktbvK 27477897 27477897
    • Roh JL, Kim EH, Jang HJ, Park JY, Shin D. Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer. Cancer Lett. 2016;381:96-103.
    • (2016) Cancer Lett , vol.381 , pp. 96-103
    • Roh, J.L.1    Kim, E.H.2    Jang, H.J.3    Park, J.Y.4    Shin, D.5
  • 88
    • 85007349764 scopus 로고    scopus 로고
    • Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
    • 1:CAS:528:DC%2BC28XitFGnsb%2FM 28012440 28012440
    • Roh JL, Kim EH, Jang H, Shin D. Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis. Redox Biol. 2017;11:254-62.
    • (2017) Redox Biol , vol.11 , pp. 254-262
    • Roh, J.L.1    Kim, E.H.2    Jang, H.3    Shin, D.4
  • 89
    • 84921647344 scopus 로고    scopus 로고
    • Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function
    • 1:CAS:528:DC%2BC2sXpvFemtw%3D%3D 25585997 25585997
    • Chen L, Li X, Liu L, Yu B, Xue Y, Liu Y. Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function. Oncol Rep. 2015;33:1465-74.
    • (2015) Oncol Rep , vol.33 , pp. 1465-1474
    • Chen, L.1    Li, X.2    Liu, L.3    Yu, B.4    Xue, Y.5    Liu, Y.6
  • 90
    • 84996807781 scopus 로고    scopus 로고
    • Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis
    • 27612422 5342691
    • Sehm T, Rauh M, Wiendieck K, Buchfelder M, Eyupoglu IY, Savaskan NE. Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis. Oncotarget. 2016;7:74630-47.
    • (2016) Oncotarget. , vol.7 , pp. 74630-74647
    • Sehm, T.1    Rauh, M.2    Wiendieck, K.3    Buchfelder, M.4    Eyupoglu, I.Y.5    Savaskan, N.E.6
  • 91
    • 84916241447 scopus 로고    scopus 로고
    • Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors
    • 1:CAS:528:DC%2BC2cXitV2jtb3K 25368241
    • Lachaier E, Louandre C, Godin C, Saidak Z, Baert M, Diouf M, et al. Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors. Anticancer Res. 2014;34:6417-22.
    • (2014) Anticancer Res , vol.34 , pp. 6417-6422
    • Lachaier, E.1    Louandre, C.2    Godin, C.3    Saidak, Z.4    Baert, M.5    Diouf, M.6
  • 92
    • 85026478644 scopus 로고    scopus 로고
    • Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells
    • 1:CAS:528:DC%2BC2sXht1GisbrK 28756230
    • Bai T, Wang S, Zhao Y, Zhu R, Wang W, Sun Y. Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2017;491:919-25.
    • (2017) Biochem Biophys Res Commun , vol.491 , pp. 919-925
    • Bai, T.1    Wang, S.2    Zhao, Y.3    Zhu, R.4    Wang, W.5    Sun, Y.6
  • 93
    • 85041463791 scopus 로고    scopus 로고
    • Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells
    • 29492203 5823558
    • Sauzay C, Louandre C, Bodeau S, Anglade F, Godin C, Saidak Z, et al. Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells. Oncotarget. 2018;9:8400-14.
    • (2018) Oncotarget. , vol.9 , pp. 8400-8414
    • Sauzay, C.1    Louandre, C.2    Bodeau, S.3    Anglade, F.4    Godin, C.5    Saidak, Z.6
  • 94
    • 85040771432 scopus 로고    scopus 로고
    • Emerging strategies of cancer therapy based on ferroptosis
    • 29356212 6377162 1:CAS:528:DC%2BC1cXhtlOls7g%3D
    • Shen Z, Song J, Yung BC, Zhou Z, Wu A, Chen X. Emerging strategies of cancer therapy based on ferroptosis. Adv Mater. 2018;30:e1704007.
    • (2018) Adv Mater , vol.30 , pp. e1704007
    • Shen, Z.1    Song, J.2    Yung, B.C.3    Zhou, Z.4    Wu, A.5    Chen, X.6
  • 95
    • 79957722003 scopus 로고    scopus 로고
    • Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress
    • 1:CAS:528:DC%2BC3MXntVWhur0%3D 21555567 3102385
    • Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, et al. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proc Natl Acad Sci U S A. 2011;108:8773-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 8773-8778
    • Shaw, A.T.1    Winslow, M.M.2    Magendantz, M.3    Ouyang, C.4    Dowdle, J.5    Subramanian, A.6
  • 96
    • 84939933823 scopus 로고    scopus 로고
    • Passive targeting of nanoparticles to cancer: A comprehensive review of the literature
    • 25279172 4179822
    • Bazak R, Houri M, Achy SE, Hussein W, Refaat T. Passive targeting of nanoparticles to cancer: a comprehensive review of the literature. Mol Clin Oncol. 2014;2:904-8.
    • (2014) Mol Clin Oncol , vol.2 , pp. 904-908
    • Bazak, R.1    Houri, M.2    Achy, S.E.3    Hussein, W.4    Refaat, T.5
  • 97
    • 84903768676 scopus 로고    scopus 로고
    • Tackling the cancer stem cells - What challenges do they pose?
    • 1:CAS:528:DC%2BC2cXhtVOisbzI 24981363 4234172
    • Pattabiraman DR, Weinberg RA. Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov. 2014;13:497-512.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 497-512
    • Pattabiraman, D.R.1    Weinberg, R.A.2
  • 98
    • 84896722338 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation
    • 1:CAS:528:DC%2BC2cXitFymtr0%3D 24302555
    • Salt MB, Bandyopadhyay S, Mccormick F. Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation. Cancer Discovery. 2014;4:186-99.
    • (2014) Cancer Discovery , vol.4 , pp. 186-199
    • Salt, M.B.1    Bandyopadhyay, S.2    McCormick, F.3
  • 99
    • 84898738821 scopus 로고    scopus 로고
    • BRAF inhibitor resistance mechanisms in metastatic melanoma: Spectrum and clinical impact
    • 1:CAS:528:DC%2BC2cXls1ehsrc%3D 24463458
    • Rizos H, Menzies AM, Pupo GM, Carlino MS, Fung C, Hyman J, et al. BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Clin Cancer Res. 2014;20:1965.
    • (2014) Clin Cancer Res , vol.20 , pp. 1965
    • Rizos, H.1    Menzies, A.M.2    Pupo, G.M.3    Carlino, M.S.4    Fung, C.5    Hyman, J.6
  • 100
    • 85036533976 scopus 로고    scopus 로고
    • Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
    • 29362479 5864239
    • Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25:486-541.
    • (2018) Cell Death Differ , vol.25 , pp. 486-541
    • Galluzzi, L.1    Vitale, I.2    Aaronson, S.A.3    Abrams, J.M.4    Adam, D.5    Agostinis, P.6
  • 102
    • 85052535422 scopus 로고    scopus 로고
    • Ferroptosis and necroinflammation, a yet poorly explored link
    • 1:CAS:528:DC%2BC1cXhsVGrs7fL 30082768
    • Proneth B, Conrad M. Ferroptosis and necroinflammation, a yet poorly explored link. Cell Death Differ. 2019;26:14-24.
    • (2019) Cell Death Differ. , vol.26 , pp. 14-24
    • Proneth, B.1    Conrad, M.2
  • 103
    • 85031115658 scopus 로고    scopus 로고
    • Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses
    • 1:CAS:528:DC%2BC2sXhs1CitrfL 29027218
    • Garg AD, Agostinis P. Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses. Immunol Rev. 2017;280:126-48.
    • (2017) Immunol Rev , vol.280 , pp. 126-148
    • Garg, A.D.1    Agostinis, P.2
  • 104
    • 84988735000 scopus 로고    scopus 로고
    • Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth
    • 1:CAS:528:DC%2BC28XhsFyms7fN 27668796 5108575
    • Kim SE, Zhang L, Ma K, Riegman M, Chen F, Ingold I, et al. Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth. Nat Nanotechnol. 2016;11:977-85.
    • (2016) Nat Nanotechnol , vol.11 , pp. 977-985
    • Kim, S.E.1    Zhang, L.2    Ma, K.3    Riegman, M.4    Chen, F.5    Ingold, I.6
  • 105
    • 85015149861 scopus 로고    scopus 로고
    • Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: From pathophysiology to treatment
    • 28279189 5345270 1:CAS:528:DC%2BC1cXksl2msr4%3D
    • Yoshida GJ. Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment. J Hematol Oncol. 2017;10:67.
    • (2017) J Hematol Oncol , vol.10 , pp. 67
    • Yoshida, G.J.1
  • 106
    • 85045182964 scopus 로고    scopus 로고
    • Targeting dependency on the GPX4 lipid peroxide repair pathway for cancer therapy
    • 1:CAS:528:DC%2BC1cXlvFOlu7Y%3D 29584411
    • Liu H, Schreiber SL, Stockwell BR. Targeting dependency on the GPX4 lipid peroxide repair pathway for cancer therapy. Biochemistry. 2018;57:2059-60.
    • (2018) Biochemistry. , vol.57 , pp. 2059-2060
    • Liu, H.1    Schreiber, S.L.2    Stockwell, B.R.3
  • 107
    • 85040345199 scopus 로고    scopus 로고
    • Negative regulators of cell death pathways in cancer: Perspective on biomarkers and targeted therapies
    • 1:CAS:528:DC%2BC1cXnt1Kqtg%3D%3D 29322476
    • Razaghi A, Heimann K, Schaeffer PM, Gibson SB. Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies. Apoptosis. 2018;23:93-112.
    • (2018) Apoptosis , vol.23 , pp. 93-112
    • Razaghi, A.1    Heimann, K.2    Schaeffer, P.M.3    Gibson, S.B.4
  • 108
    • 84901323900 scopus 로고    scopus 로고
    • Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis
    • 24844246 4054777
    • Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. eLife. 2014;3:e02523.
    • (2014) ELife. , vol.3 , pp. e02523
    • Dixon, S.J.1    Patel, D.N.2    Welsch, M.3    Skouta, R.4    Lee, E.D.5    Hayano, M.6
  • 109
    • 84957431913 scopus 로고    scopus 로고
    • Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells
    • 26097885 4468338
    • Eling N, Reuter L, Hazin J, Hamacherbrady A, Brady NR. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience. 2015;2:517-32.
    • (2015) Oncoscience. , vol.2 , pp. 517-532
    • Eling, N.1    Reuter, L.2    Hazin, J.3    Hamacherbrady, A.4    Brady, N.R.5
  • 110
    • 85047541890 scopus 로고    scopus 로고
    • Alterations in cellular iron metabolism provide more therapeutic opportunities for cancer
    • 5983609 1:CAS:528:DC%2BC1cXisVOqtrbI
    • Zhou L, Zhao B, Zhang L, Wang S, Dong D, Lv H, et al. Alterations in cellular iron metabolism provide more therapeutic opportunities for cancer. Int J Mol Sci. 2018;19:1545.
    • (2018) Int J Mol Sci. , vol.19 , pp. 1545
    • Zhou, L.1    Zhao, B.2    Zhang, L.3    Wang, S.4    Dong, D.5    Lv, H.6
  • 111
    • 85040769180 scopus 로고    scopus 로고
    • The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells
    • 29343855 5772355 1:CAS:528:DC%2BC1MXls1Cmtrc%3D
    • Sato M, Kusumi R, Hamashima S, Kobayashi S, Sasaki S, Komiyama Y, et al. The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells. Sci Rep. 2018;8:968.
    • (2018) Sci Rep , vol.8 , pp. 968
    • Sato, M.1    Kusumi, R.2    Hamashima, S.3    Kobayashi, S.4    Sasaki, S.5    Komiyama, Y.6
  • 112
    • 85053676186 scopus 로고    scopus 로고
    • Vitamin e hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase
    • 30110365 6093661 1:CAS:528:DC%2BC1cXit1emtrjE
    • Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, Mccusker KP, et al. Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase. PLoS One. 2018;13:e0201369.
    • (2018) PLoS One , vol.13 , pp. e0201369
    • Hinman, A.1    Holst, C.R.2    Latham, J.C.3    Bruegger, J.J.4    Ulas, G.5    McCusker, K.P.6
  • 113
    • 85026433120 scopus 로고    scopus 로고
    • EGLN1/c-Myc induced lymphoid-specific helicase inhibits ferroptosis through lipid metabolic gene expression changes
    • 1:CAS:528:DC%2BC1cXitVWgs7bP 28900510 5595132
    • Jiang Y, Mao C, Yang R, Yan B, Shi Y, Liu X, et al. EGLN1/c-Myc induced lymphoid-specific helicase inhibits ferroptosis through lipid metabolic gene expression changes. Theranostics. 2017;7:3293-305.
    • (2017) Theranostics. , vol.7 , pp. 3293-3305
    • Jiang, Y.1    Mao, C.2    Yang, R.3    Yan, B.4    Shi, Y.5    Liu, X.6


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