BRAF inhibitor resistance mechanisms in metastatic melanoma: Spectrum and clinical impact

Clinical Cancer Research

Volumn 20, Issue 7, 2014, Pages 1965-1977

  Rizos, Helen ^a   Menzies, Alexander M ^c   Pupo, Gulietta M ^a   Carlino, Matteo S ^a,b   Fung, Carina ^a   Hyman, Jessica ^c,e   Haydu, Lauren E ^c,d   Mijatov, Branka ^a   Becker, Therese M ^a   Boyd, Suzanah C ^a   Howle, Julie ^b,c,d   Saw, Robyn ^c,d,e   Thompson, John F ^c,d,e   Kefford, Richard F ^a,b,c   Scolyer, Richard A ^a,c,e   Long, Georgina V ^a,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

^c MELANOMA INSTITUTE AUSTRALIA   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; DABRAFENIB; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; VEMURAFENIB; BRAF PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OXIME; SULFONAMIDE;

ADOLESCENT; ADULT; AGED; ARTICLE; ATK1 GENE; BRAF GENE; BRAIN METASTASIS; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER STAGING; CLINICAL ARTICLE; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DRUG RESPONSE; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MEK1 GENE; MEK2 GENE; METASTATIC MELANOMA; MIDDLE AGED; ONCOGENE; ONCOGENE N RAS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; TUMOR GROWTH; VERY ELDERLY; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; MELANOMA; MUTATION; NEOPLASM METASTASIS; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDAZOLES; INDOLES; MALE; MELANOMA; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; NEOPLASM METASTASIS; OXIMES; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 84898738821     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-3122     Document Type: Article

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