-
1
-
-
84897537717
-
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
-
Birsoy, K. et al. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature 508, 108-112 (2014).
-
(2014)
Nature
, vol.508
, pp. 108-112
-
-
Birsoy, K.1
-
2
-
-
84958138936
-
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer
-
Davidson, S. M. et al. Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer. Cell Metab. 23, 517-528 (2016).
-
(2016)
Cell Metab.
, vol.23
, pp. 517-528
-
-
Davidson, S.M.1
-
3
-
-
84878464291
-
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
-
Kamphorst, J. J. et al. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc. Natl Acad. Sci. USA 110, 8882-8887 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 8882-8887
-
-
Kamphorst, J.J.1
-
4
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
Vaupel, P., Kallinowski, F. & Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res. 49, 6449-6465 (1989).
-
(1989)
Cancer Res.
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
5
-
-
84897000909
-
Mitochondrial iron-sulfur protein biogenesis and human disease
-
Stehling, O., Wilbrecht, C. & Lill, R. Mitochondrial iron-sulfur protein biogenesis and human disease. Biochimie 100, 61-77 (2014).
-
(2014)
Biochimie
, vol.100
, pp. 61-77
-
-
Stehling, O.1
Wilbrecht, C.2
Lill, R.3
-
6
-
-
84899477188
-
Maturation of cytosolic and nuclear iron-sulfur proteins
-
Netz, D. J., Mascarenhas, J., Stehling, O., Pierik, A. J. & Lill, R. Maturation of cytosolic and nuclear iron-sulfur proteins. Trends Cell Biol. 24, 303-312 (2014).
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 303-312
-
-
Netz, D.J.1
Mascarenhas, J.2
Stehling, O.3
Pierik, A.J.4
Lill, R.5
-
7
-
-
33645065589
-
Iron-sulfur clusters and the problem with oxygen
-
Imlay, J. A. Iron-sulfur clusters and the problem with oxygen. Mol. Microbiol. 59, 1073-1082 (2006).
-
(2006)
Mol. Microbiol.
, vol.59
, pp. 1073-1082
-
-
Imlay, J.A.1
-
8
-
-
84941042486
-
CDD: NCBI's conserved domain database
-
Marchler-Bauer, A. et al. CDD: NCBI's conserved domain database. Nucleic Acids Res. 43, D222-D226 (2015).
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. D222-D226
-
-
Marchler-Bauer, A.1
-
9
-
-
84927766436
-
Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability
-
Paul, V. D. & Lill, R. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Biochim. Biophys. Acta 1853, 1528-1539 (2015).
-
(2015)
Biochim. Biophys. Acta
, vol.1853
, pp. 1528-1539
-
-
Paul, V.D.1
Lill, R.2
-
10
-
-
54449085541
-
A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis
-
Marelja, Z., Stöcklein, W., Nimtz, M. & Leimkühler, S. A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis. J. Biol. Chem. 283, 25178-25185 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 25178-25185
-
-
Marelja, Z.1
Stöcklein, W.2
Nimtz, M.3
Leimkühler, S.4
-
11
-
-
0025807618
-
Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
-
Vaupel, P., Schlenger, K., Knoop, C. & Höckel, M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res. 51, 3316-3322 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 3316-3322
-
-
Vaupel, P.1
Schlenger, K.2
Knoop, C.3
Höckel, M.4
-
12
-
-
84885008220
-
Pan-cancer patterns of somatic copy number alteration
-
Zack, T. I. et al. Pan-cancer patterns of somatic copy number alteration. Nat. Genet. 45, 1134-1140 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 1134-1140
-
-
Zack, T.I.1
-
13
-
-
0032899012
-
A 4-base pair deletion in the mitochondrial cytochrome b gene associated with parkinsonism/MELAS overlap syndrome
-
De Coo, I. F. et al. A 4-base pair deletion in the mitochondrial cytochrome b gene associated with parkinsonism/MELAS overlap syndrome. Ann. Neurol. 45, 130-133 (1999).
-
(1999)
Ann. Neurol.
, vol.45
, pp. 130-133
-
-
De Coo, I.F.1
-
14
-
-
0039604509
-
A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen
-
van Loon, A. P., Pesold-Hurt, B. & Schatz, G. A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen. Proc. Natl Acad. Sci. USA 83, 3820-3824 (1986).
-
(1986)
Proc. Natl Acad. Sci. USA
, vol.83
, pp. 3820-3824
-
-
Van Loon, A.P.1
Pesold-Hurt, B.2
Schatz, G.3
-
15
-
-
0022403531
-
Is hydroxyl radical generated by the Fenton reaction in vivo
-
Bilinski, T., Krawiec, Z., Liczmanski, A. & Litwinska, J. Is hydroxyl radical generated by the Fenton reaction in vivo Biochem. Biophys. Res. Commun. 130, 533-539 (1985).
-
(1985)
Biochem. Biophys. Res. Commun.
, vol.130
, pp. 533-539
-
-
Bilinski, T.1
Krawiec, Z.2
Liczmanski, A.3
Litwinska, J.4
-
16
-
-
0027165156
-
The role and properties of the iron-sulfur cluster in Escherichia coli dihydroxy-acid dehydratase
-
Flint, D. H., Emptage, M. H., Finnegan, M. G., Fu, W. & Johnson, M. K. The role and properties of the iron-sulfur cluster in Escherichia coli dihydroxy-acid dehydratase. J. Biol. Chem. 268, 14732-14742 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14732-14742
-
-
Flint, D.H.1
Emptage, M.H.2
Finnegan, M.G.3
Fu, W.4
Johnson, M.K.5
-
17
-
-
0023882711
-
Iron-responsive elements: Regulatory RNA sequences that control mRNA levels and translation
-
Casey, J. L. et al. Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science 240, 924-928 (1988).
-
(1988)
Science
, vol.240
, pp. 924-928
-
-
Casey, J.L.1
-
18
-
-
10844282789
-
Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo
-
Meyron-Holtz, E. G., Ghosh, M. C. & Rouault, T. A. Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science 306, 2087-2090 (2004).
-
(2004)
Science
, vol.306
, pp. 2087-2090
-
-
Meyron-Holtz, E.G.1
Ghosh, M.C.2
Rouault, T.A.3
-
19
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxiainduced transcription
-
Chandel, N. S. et al. Mitochondrial reactive oxygen species trigger hypoxiainduced transcription. Proc. Natl Acad. Sci. USA 95, 11715-11720 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
-
20
-
-
0024430918
-
The role of iron in oxygen radical mediated lipid peroxidation
-
Minotti, G. & Aust, S. D. The role of iron in oxygen radical mediated lipid peroxidation. Chem. Biol. Interact. 71, 1-19 (1989).
-
(1989)
Chem. Biol. Interact.
, vol.71
, pp. 1-19
-
-
Minotti, G.1
Aust, S.D.2
-
21
-
-
84958103915
-
Ferroptosis: Death by lipid peroxidation
-
Yang, W. S. & Stockwell, B. R. Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 26, 165-176 (2016).
-
(2016)
Trends Cell Biol.
, vol.26
, pp. 165-176
-
-
Yang, W.S.1
Stockwell, B.R.2
-
22
-
-
84892685001
-
Regulation of ferroptotic cancer cell death by GPX4
-
Yang, W. S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317-331 (2014).
-
(2014)
Cell
, vol.156
, pp. 317-331
-
-
Yang, W.S.1
-
23
-
-
84861541814
-
Ferroptosis: An iron-dependent form of nonapoptotic cell death
-
Dixon, S. J. et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell 149, 1060-1072 (2012).
-
(2012)
Cell
, vol.149
, pp. 1060-1072
-
-
Dixon, S.J.1
-
24
-
-
84996993100
-
Systemic depletion of l-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
-
Cramer, S. L. et al. Systemic depletion of l-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat. Med. 23, 120-127 (2017).
-
(2017)
Nat. Med.
, vol.23
, pp. 120-127
-
-
Cramer, S.L.1
-
25
-
-
84922783167
-
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
-
Harris, I. S. et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell 27, 211-222 (2015).
-
(2015)
Cancer Cell
, vol.27
, pp. 211-222
-
-
Harris, I.S.1
-
26
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346-350 (2011).
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
-
27
-
-
33845792555
-
CellProfiler: Image analysis software for identifying and quantifying cell phenotypes
-
Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).
-
(2006)
Genome Biol.
, vol.7
, pp. R100
-
-
Carpenter, A.E.1
-
28
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim, R. et al. The landscape of somatic copy-number alteration across human cancers. Nature 463, 899-905 (2010).
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
-
29
-
-
84855369366
-
Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas
-
Okayama, H. et al. Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res. 72, 100-111 (2012).
-
(2012)
Cancer Res.
, vol.72
, pp. 100-111
-
-
Okayama, H.1
-
30
-
-
84859169877
-
The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607 (2012).
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
-
31
-
-
68149157175
-
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
-
DuPage, M., Dooley, A. L. & Jacks, T. Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat. Protocols 4, 1064-1072 (2009).
-
(2009)
Nat. Protocols
, vol.4
, pp. 1064-1072
-
-
DuPage, M.1
Dooley, A.L.2
Jacks, T.3
-
32
-
-
0141960109
-
AMP-activated protein kinase activity is critical for hypoxiainducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells
-
Lee, M. et al. AMP-activated protein kinase activity is critical for hypoxiainducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells. J. Biol. Chem. 278, 39653-39661 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39653-39661
-
-
Lee, M.1
-
33
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis. Nature 399, 271-275 (1999).
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
34
-
-
84947471999
-
Identification and characterization of essential genes in the human genome
-
Wang, T. et al. Identification and characterization of essential genes in the human genome. Science 350, 1096-1101 (2015).
-
(2015)
Science
, vol.350
, pp. 1096-1101
-
-
Wang, T.1
|