Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Nature Nanotechnology

Volumn 11, Issue 11, 2016, Pages 977-985

  Kim, Sung Eun ^a,b   Zhang, Li ^a   Ma, Kai ^c   Riegman, Michelle ^a   Chen, Feng ^a   Ingold, Irina ^d   Conrad, Marcus ^d   Turker, Melik Ziya ^c   Gao, Minghui ^a   Jiang, Xuejun ^a,b   Monette, Sebastien ^e   Pauliah, Mohan ^a   Gonen, Mithat ^a   Zanzonico, Pat ^a   Quinn, Thomas ^f   Wiesner, Ulrich ^c   Bradbury, Michelle S ^a   Overholtzer, Michael ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Cornell University   (United States)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e ROCKEFELLER UNIVERSITY   (United States)

^f University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; DISEASES; MAMMALS; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; PHYSICOCHEMICAL PROPERTIES; POLYETHYLENE GLYCOLS; SILICA; TUMORS;

COATED SILICA NANOPARTICLES; MULTIPLE INJECTIONS; NUTRIENT-DEPRIVED; PHARMACOLOGICAL INHIBITORS; PROGRAMMED CELL DEATHS; TARGETING PEPTIDES; THERAPEUTIC POTENTIALS; TUMOUR XENOGRAFTS;

SILICA NANOPARTICLES;

MACROGOL; PEPTIDE; SILICA NANOPARTICLE; ALPHA INTERMEDIN; AMINO ACID; ANTINEOPLASTIC AGENT; IRON; LIPROXSTATIN-1; NANOPARTICLE; QUINOXALINE DERIVATIVE; SILICON DIOXIDE; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; FERROPTOSIS; HUMAN; HUMAN CELL; KWASHIORKOR; LIPID OXIDATION; LYSOSOME; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TUMOR REGRESSION; TUMOR XENOGRAFT; ANIMAL; CHEMISTRY; DEFICIENCY; DRUG SCREENING; MELANOMA; METABOLISM; SCID MOUSE; TUMOR CELL LINE;

ALPHA-MSH; AMINO ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; HUMANS; IRON; LYSOSOMES; MELANOMA; MICE; MICE, SCID; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; QUINOXALINES; SILICON DIOXIDE; SPIRO COMPOUNDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84988735000     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2016.164     Document Type: Article

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