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Volumn 9, Issue APR, 2018, Pages

The p53 tumor suppressor in the control of metabolism and ferroptosis

Author keywords

Apoptosis; Ferroptosis; Metabolism; P53; Tumor suppressor

Indexed keywords

LIPID PEROXIDE; PROTEIN P53;

EID: 85045273071     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2018.00124     Document Type: Review
Times cited : (143)

References (57)
  • 1
    • 85034831352 scopus 로고    scopus 로고
    • The most popular genes in the human genome
    • Dolgin E. The most popular genes in the human genome. Nature (2017) 551(7681):427-31. doi:10.1038/d41586-017-07291-9
    • (2017) Nature , vol.551 , Issue.7681 , pp. 427-431
    • Dolgin, E.1
  • 2
    • 85037162455 scopus 로고    scopus 로고
    • Deciphering p53 signaling in tumor suppression
    • Mello SS, Attardi LD. Deciphering p53 signaling in tumor suppression. Curr Opin Cell Biol (2017) 51:65-72. doi:10.1016/j.ceb.2017.11.005
    • (2017) Curr Opin Cell Biol , vol.51 , pp. 65-72
    • Mello, S.S.1    Attardi, L.D.2
  • 3
    • 84977558184 scopus 로고    scopus 로고
    • Regulation of cellular metabolism and hypoxia by p53
    • Humpton TJ, Vousden KH. Regulation of cellular metabolism and hypoxia by p53. Cold Spring Harb Perspect Med (2016) 6(7):211-30. doi:10.1101/cshperspect.a026146
    • (2016) Cold Spring Harb Perspect Med , vol.6 , Issue.7 , pp. 211-230
    • Humpton, T.J.1    Vousden, K.H.2
  • 4
    • 84861541814 scopus 로고    scopus 로고
    • Ferroptosis: an iron-dependent form of nonapoptotic cell death
    • Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell (2012) 149(5):1060-72. doi:10.1016/j.cell.2012.03.042
    • (2012) Cell , vol.149 , Issue.5 , pp. 1060-1072
    • Dixon, S.J.1    Lemberg, K.M.2    Lamprecht, M.R.3    Skouta, R.4    Zaitsev, E.M.5    Gleason, C.E.6
  • 5
    • 84926387317 scopus 로고    scopus 로고
    • Ferroptosis as a p53-mediated activity during tumour suppression
    • Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature (2015) 520(7545):57-62. doi:10.1038/nature14344
    • (2015) Nature , vol.520 , Issue.7545 , pp. 57-62
    • Jiang, L.1    Kon, N.2    Li, T.3    Wang, S.J.4    Su, T.5    Hibshoosh, H.6
  • 6
    • 79955795151 scopus 로고    scopus 로고
    • Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
    • Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM, et al. Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 145(4):571-83. doi:10.1016/j.cell.2011.03.035
    • (2011) Cell , vol.145 , Issue.4 , pp. 571-583
    • Brady, C.A.1    Jiang, D.2    Mello, S.S.3    Johnson, T.M.4    Jarvis, L.A.5    Kozak, M.M.6
  • 8
    • 77952212178 scopus 로고    scopus 로고
    • Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    • Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 107(16):7455-60. doi:10.1073/pnas.1001006107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.16 , pp. 7455-7460
    • Hu, W.1    Zhang, C.2    Wu, R.3    Sun, Y.4    Levine, A.5    Feng, Z.6
  • 9
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res (2004) 64(7):2627-33. doi:10.1158/0008-5472.CAN-03-0846
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2627-2633
    • Schwartzenberg-Bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 10
    • 84906237532 scopus 로고    scopus 로고
    • Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD
    • Zhang C, Liu J, Wu R, Liang Y, Lin M, Liu J, et al. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget (2014) 5(14):5535-46. doi:10.18632/oncotarget.2137
    • (2014) Oncotarget , vol.5 , Issue.14 , pp. 5535-5546
    • Zhang, C.1    Liu, J.2    Wu, R.3    Liang, Y.4    Lin, M.5    Liu, J.6
  • 11
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 126(1):107-20. doi:10.1016/j.cell.2006.05.036
    • (2006) Cell , vol.126 , Issue.1 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3    Vidal, M.N.4    Nakano, K.5    Bartrons, R.6
  • 12
    • 79952280229 scopus 로고    scopus 로고
    • p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, et al. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol (2011) 13(3):310-6. doi:10.1038/ncb2172
    • (2011) Nat Cell Biol , vol.13 , Issue.3 , pp. 310-316
    • Jiang, P.1    Du, W.2    Wang, X.3    Mancuso, A.4    Gao, X.5    Wu, M.6
  • 13
    • 85006001577 scopus 로고    scopus 로고
    • The role of the p53 tumor suppressor in metabolism and diabetes
    • Kung CP, Murphy ME. The role of the p53 tumor suppressor in metabolism and diabetes. J Endocrinol (2016) 231(2):R61-75. doi:10.1530/JOE-16-0324
    • (2016) J Endocrinol , vol.231 , Issue.2 , pp. R61-R75
    • Kung, C.P.1    Murphy, M.E.2
  • 15
    • 84890695935 scopus 로고    scopus 로고
    • Tumour-associated mutant p53 drives the Warburg effect
    • Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, et al. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun (2013) 4:2935. doi:10.1038/ncomms3935
    • (2013) Nat Commun , vol.4 , pp. 2935
    • Zhang, C.1    Liu, J.2    Liang, Y.3    Wu, R.4    Zhao, Y.5    Hong, X.6
  • 16
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell (2011) 144(5):646-74. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 17
    • 84977743422 scopus 로고    scopus 로고
    • Metabolic interplay between glycolysis and mitochondrial oxidation: the reverse Warburg effect and its therapeutic implication
    • Lee M, Yoon JH. Metabolic interplay between glycolysis and mitochondrial oxidation: the reverse Warburg effect and its therapeutic implication. World J Biol Chem (2015) 6(3):148-61. doi:10.4331/wjbc.v6.i3.148
    • (2015) World J Biol Chem , vol.6 , Issue.3 , pp. 148-161
    • Lee, M.1    Yoon, J.H.2
  • 18
    • 0037372005 scopus 로고    scopus 로고
    • The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
    • Dumont P, Leu JI, Della Pietra AC III, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet (2003) 33(3):357-65. doi:10.1038/ng1093
    • (2003) Nat Genet , vol.33 , Issue.3 , pp. 357-365
    • Dumont, P.1    Leu, J.I.2    Della Pietra, A.C.3    George, D.L.4    Murphy, M.5
  • 19
    • 84923861307 scopus 로고    scopus 로고
    • Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes
    • Kung CP, Khaku S, Jennis M, Zhou Y, Murphy ME. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Mol Cancer Res (2015) 13(2):250-62. doi:10.1158/1541-7786.MCR-14-0385
    • (2015) Mol Cancer Res , vol.13 , Issue.2 , pp. 250-262
    • Kung, C.P.1    Khaku, S.2    Jennis, M.3    Zhou, Y.4    Murphy, M.E.5
  • 20
    • 79955591120 scopus 로고    scopus 로고
    • Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model
    • Azzam GA, Frank AK, Hollstein M, Murphy ME. Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model. Cell Cycle (2011) 10(9):1352-5. doi:10.4161/cc.10.9.15344
    • (2011) Cell Cycle , vol.10 , Issue.9 , pp. 1352-1355
    • Azzam, G.A.1    Frank, A.K.2    Hollstein, M.3    Murphy, M.E.4
  • 21
    • 80051975909 scopus 로고    scopus 로고
    • Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner
    • Bitti ML, Saccucci P, Capasso F, Piccinini S, Angelini F, Rapini N, et al. Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner. J Pediatr Endocrinol Metab (2011) 24(7-8):437-9. doi:10.1515/jpem.2011.058
    • (2011) J Pediatr Endocrinol Metab , vol.24 , Issue.7-8 , pp. 437-439
    • Bitti, M.L.1    Saccucci, P.2    Capasso, F.3    Piccinini, S.4    Angelini, F.5    Rapini, N.6
  • 22
    • 84879199886 scopus 로고    scopus 로고
    • The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study
    • Bonfigli AR, Sirolla C, Testa R, Cucchi M, Spazzafumo L, Salvioli S, et al. The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. Acta Diabetol (2013) 50(3):429-36. doi:10.1007/s00592-012-0450-x
    • (2013) Acta Diabetol , vol.50 , Issue.3 , pp. 429-436
    • Bonfigli, A.R.1    Sirolla, C.2    Testa, R.3    Cucchi, M.4    Spazzafumo, L.5    Salvioli, S.6
  • 23
    • 84960387270 scopus 로고    scopus 로고
    • The P72R polymorphism of p53 predisposes to obesity and metabolic dysfunction
    • Kung CP, Leu JI, Basu S, Khaku S, Anokye-Danso F, Liu Q, et al. The P72R polymorphism of p53 predisposes to obesity and metabolic dysfunction. Cell Rep (2016) 14(10):2413-25. doi:10.1016/j.celrep.2016.02.037
    • (2016) Cell Rep , vol.14 , Issue.10 , pp. 2413-2425
    • Kung, C.P.1    Leu, J.I.2    Basu, S.3    Khaku, S.4    Anokye-Danso, F.5    Liu, Q.6
  • 24
    • 85020751745 scopus 로고    scopus 로고
    • The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation
    • Kung CP, Liu Q, Murphy ME. The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation. Cancer Biol Ther (2017) 18(7):484-91. doi:10.1080/15384047.2017.1323595
    • (2017) Cancer Biol Ther , vol.18 , Issue.7 , pp. 484-491
    • Kung, C.P.1    Liu, Q.2    Murphy, M.E.3
  • 26
    • 84874947662 scopus 로고    scopus 로고
    • Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model
    • Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ, et al. Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Cell Death Differ (2013) 20(4):659-68. doi:10.1038/cdd.2012.168
    • (2013) Cell Death Differ , vol.20 , Issue.4 , pp. 659-668
    • Sanchez-Macedo, N.1    Feng, J.2    Faubert, B.3    Chang, N.4    Elia, A.5    Rushing, E.J.6
  • 27
    • 80555135898 scopus 로고    scopus 로고
    • ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress
    • Assaily W, Rubinger DA, Wheaton K, Lin Y, Ma W, Xuan W, et al. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell (2011) 44(3):491-501. doi:10.1016/j.molcel.2011.08.038
    • (2011) Mol Cell , vol.44 , Issue.3 , pp. 491-501
    • Assaily, W.1    Rubinger, D.A.2    Wheaton, K.3    Lin, Y.4    Ma, W.5    Xuan, W.6
  • 28
    • 33747853190 scopus 로고    scopus 로고
    • Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
    • Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, et al. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab (2006) 4(3):199-210. doi:10.1016/j.cmet.2006.08.005
    • (2006) Cell Metab , vol.4 , Issue.3 , pp. 199-210
    • Finck, B.N.1    Gropler, M.C.2    Chen, Z.3    Leone, T.C.4    Croce, M.A.5    Harris, T.E.6
  • 29
    • 77649216053 scopus 로고    scopus 로고
    • EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
    • Guo D, Prins RM, Dang J, Kuga D, Iwanami A, Soto H, et al. EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Sci Signal (2009) 2(101):ra82. doi:10.1126/scisignal.2000446
    • (2009) Sci Signal , vol.2 , Issue.101
    • Guo, D.1    Prins, R.M.2    Dang, J.3    Kuga, D.4    Iwanami, A.5    Soto, H.6
  • 30
    • 1542615071 scopus 로고    scopus 로고
    • Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence
    • Ettinger SL, Sobel R, Whitmore TG, Akbari M, Bradley DR, Gleave ME, et al. Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence. Cancer Res (2004) 64(6):2212-21. doi:10.1158/0008-5472.CAN-2148-2
    • (2004) Cancer Res , vol.64 , Issue.6 , pp. 2212-2221
    • Ettinger, S.L.1    Sobel, R.2    Whitmore, T.G.3    Akbari, M.4    Bradley, D.R.5    Gleave, M.E.6
  • 31
    • 85006091069 scopus 로고    scopus 로고
    • p53 as a regulator of lipid metabolism in cancer
    • Parrales A, Iwakuma T. p53 as a regulator of lipid metabolism in cancer. Int J Mol Sci (2016) 17(12):1-17. doi:10.3390/ijms17122074
    • (2016) Int J Mol Sci , vol.17 , Issue.12 , pp. 1-17
    • Parrales, A.1    Iwakuma, T.2
  • 33
    • 84903627732 scopus 로고    scopus 로고
    • Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation
    • Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, et al. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell (2014) 54(6):960-74. doi:10.1016/j.molcel.2014.04.024
    • (2014) Mol Cell , vol.54 , Issue.6 , pp. 960-974
    • Zhou, G.1    Wang, J.2    Zhao, M.3    Xie, T.X.4    Tanaka, N.5    Sano, D.6
  • 34
    • 84862908644 scopus 로고    scopus 로고
    • Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
    • Freed-Pastor WA, Mizuno H, Zhao X, Langerod A, Moon SH, Rodriguez-Barrueco R, et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 148(1-2):244-58. doi:10.1016/j.cell.2011.12.017
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 244-258
    • Freed-Pastor, W.A.1    Mizuno, H.2    Zhao, X.3    Langerod, A.4    Moon, S.H.5    Rodriguez-Barrueco, R.6
  • 36
    • 0036087776 scopus 로고
    • Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
    • Park SH, Gammon SR, Knippers JD, Paulsen SR, Rubink DS, Winder WW. Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol (1985) (2002) 92(6):2475-82. doi:10.1152/japplphysiol.00071.2002
    • (1985) J Appl Physiol , vol.92 , Issue.6 , pp. 2475-2482
    • Park, S.H.1    Gammon, S.R.2    Knippers, J.D.3    Paulsen, S.R.4    Rubink, D.S.5    Winder, W.W.6
  • 37
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 13(4):376-88. doi:10.1016/j.cmet.2011.03.009
    • (2011) Cell Metab , vol.13 , Issue.4 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4    Hou, X.5    Jiang, B.6
  • 38
    • 77957009531 scopus 로고    scopus 로고
    • apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53
    • Ashur-Fabian O, Har-Zahav A, Shaish A, Wiener Amram H, Margalit O, Weizer-Stern O, et al. apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53. Cell Cycle (2010) 9(18):3761-70. doi:10.4161/cc.9.18.12993
    • (2010) Cell Cycle , vol.9 , Issue.18 , pp. 3761-3770
    • Ashur-Fabian, O.1    Har-Zahav, A.2    Shaish, A.3    Wiener Amram, H.4    Margalit, O.5    Weizer-Stern, O.6
  • 40
    • 84867142011 scopus 로고    scopus 로고
    • Regulation of lipid metabolism by p53-fighting two villains with one sword
    • Goldstein I, Rotter V. Regulation of lipid metabolism by p53-fighting two villains with one sword. Trends Endocrinol Metab (2012) 23(11):567-75. doi:10.1016/j.tem.2012.06.007
    • (2012) Trends Endocrinol Metab , vol.23 , Issue.11 , pp. 567-575
    • Goldstein, I.1    Rotter, V.2
  • 43
    • 84960429987 scopus 로고    scopus 로고
    • Emerging roles for lipids in non-apoptotic cell death
    • Magtanong L, Ko PJ, Dixon SJ. Emerging roles for lipids in non-apoptotic cell death. Cell Death Differ (2016) 23(7):1099-109. doi:10.1038/cdd.2016.25
    • (2016) Cell Death Differ , vol.23 , Issue.7 , pp. 1099-1109
    • Magtanong, L.1    Ko, P.J.2    Dixon, S.J.3
  • 44
    • 85030552365 scopus 로고    scopus 로고
    • Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
    • Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell (2017) 171(2):273-85. doi:10.1016/j.cell.2017.09.021
    • (2017) Cell , vol.171 , Issue.2 , pp. 273-285
    • Stockwell, B.R.1    Friedmann Angeli, J.P.2    Bayir, H.3    Bush, A.I.4    Conrad, M.5    Dixon, S.J.6
  • 45
    • 84861973567 scopus 로고    scopus 로고
    • Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
    • Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, et al. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 149(6):1269-83. doi:10.1016/j.cell.2012.04.026
    • (2012) Cell , vol.149 , Issue.6 , pp. 1269-1283
    • Li, T.1    Kon, N.2    Jiang, L.3    Tan, M.4    Ludwig, T.5    Zhao, Y.6
  • 46
    • 85004093132 scopus 로고    scopus 로고
    • Acetylation is crucial for p53-mediated ferroptosis and tumor suppression
    • Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao Y, et al. Acetylation is crucial for p53-mediated ferroptosis and tumor suppression. Cell Rep (2016) 17(2):366-73. doi:10.1016/j.celrep.2016.09.022
    • (2016) Cell Rep , vol.17 , Issue.2 , pp. 366-373
    • Wang, S.J.1    Li, D.2    Ou, Y.3    Jiang, L.4    Chen, Y.5    Zhao, Y.6
  • 47
    • 84937525519 scopus 로고    scopus 로고
    • Glutaminolysis and transferrin regulate ferroptosis
    • Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and transferrin regulate ferroptosis. Mol Cell (2015) 59(2):298-308. doi:10.1016/j.molcel.2015.06.011
    • (2015) Mol Cell , vol.59 , Issue.2 , pp. 298-308
    • Gao, M.1    Monian, P.2    Quadri, N.3    Ramasamy, R.4    Jiang, X.5
  • 48
    • 84963814113 scopus 로고    scopus 로고
    • An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model
    • Jennis M, Kung CP, Basu S, Budina-Kolomets A, Leu JI, Khaku S, et al. An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model. Genes Dev (2016) 30(8):918-30. doi:10.1101/gad.275891.115
    • (2016) Genes Dev , vol.30 , Issue.8 , pp. 918-930
    • Jennis, M.1    Kung, C.P.2    Basu, S.3    Budina-Kolomets, A.4    Leu, J.I.5    Khaku, S.6
  • 49
    • 84994059408 scopus 로고    scopus 로고
    • Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses
    • Ou Y, Wang SJ, Li D, Chu B, Gu W. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci U S A (2016) 113(44):E6806-12. doi:10.1073/pnas.1607152113
    • (2016) Proc Natl Acad Sci U S A , vol.113 , Issue.44 , pp. E6806-E6812
    • Ou, Y.1    Wang, S.J.2    Li, D.3    Chu, B.4    Gu, W.5
  • 50
    • 85041647871 scopus 로고    scopus 로고
    • p53 suppresses metabolic stress-induced ferroptosis in cancer cells
    • Tarangelo A, Magtanong L, Bieging-Rolett KT, Li Y, Ye J, Attardi LD, et al. p53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep (2018) 22(3):569-75. doi:10.1016/j.celrep.2017.12.077
    • (2018) Cell Rep , vol.22 , Issue.3 , pp. 569-575
    • Tarangelo, A.1    Magtanong, L.2    Bieging-Rolett, K.T.3    Li, Y.4    Ye, J.5    Attardi, L.D.6
  • 51
    • 85027880924 scopus 로고    scopus 로고
    • The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity
    • Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, et al. The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity. Cell Rep (2017) 20(7):1692-704. doi:10.1016/j.celrep.2017.07.055
    • (2017) Cell Rep , vol.20 , Issue.7 , pp. 1692-1704
    • Xie, Y.1    Zhu, S.2    Song, X.3    Sun, X.4    Fan, Y.5    Liu, J.6
  • 52
    • 33845433364 scopus 로고    scopus 로고
    • Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
    • Feng L, Hollstein M, Xu Y. Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle (2006) 5(23):2812-9. doi:10.4161/cc.5.23.3526
    • (2006) Cell Cycle , vol.5 , Issue.23 , pp. 2812-2819
    • Feng, L.1    Hollstein, M.2    Xu, Y.3
  • 53
    • 79952275158 scopus 로고    scopus 로고
    • The codon 72 polymorphism of p53 regulates interaction with NF-(kappa)B and transactivation of genes involved in immunity and inflammation
    • Frank AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, et al. The codon 72 polymorphism of p53 regulates interaction with NF-(kappa)B and transactivation of genes involved in immunity and inflammation. Mol Cell Biol (2011) 31(6):1201-13. doi:10.1128/MCB.01136-10
    • (2011) Mol Cell Biol , vol.31 , Issue.6 , pp. 1201-1213
    • Frank, A.K.1    Leu, J.I.2    Zhou, Y.3    Devarajan, K.4    Nedelko, T.5    Klein-Szanto, A.6
  • 54
    • 0035905749 scopus 로고    scopus 로고
    • Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool
    • Luo JL, Yang Q, Tong WM, Hergenhahn M, Wang ZQ, Hollstein M. Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool. Oncogene (2001) 20(3):320-8. doi:10.1038/sj.onc.1204080
    • (2001) Oncogene , vol.20 , Issue.3 , pp. 320-328
    • Luo, J.L.1    Yang, Q.2    Tong, W.M.3    Hergenhahn, M.4    Wang, Z.Q.5    Hollstein, M.6
  • 55
    • 42549126097 scopus 로고    scopus 로고
    • Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72
    • Reinbold M, Luo JL, Nedelko T, Jerchow B, Murphy ME, Whibley C, et al. Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72. Oncogene (2008) 27(19):2788-94. doi:10.1038/sj.onc.1210932
    • (2008) Oncogene , vol.27 , Issue.19 , pp. 2788-2794
    • Reinbold, M.1    Luo, J.L.2    Nedelko, T.3    Jerchow, B.4    Murphy, M.E.5    Whibley, C.6
  • 56
    • 84952639010 scopus 로고    scopus 로고
    • Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
    • Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology (2016) 63(1):173-84. doi:10.1002/hep.28251
    • (2016) Hepatology , vol.63 , Issue.1 , pp. 173-184
    • Sun, X.1    Ou, Z.2    Chen, R.3    Niu, X.4    Chen, D.5    Kang, R.6
  • 57
    • 85016394935 scopus 로고    scopus 로고
    • Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation
    • Liu DS, Duong CP, Haupt S, Montgomery KG, House CM, Azar WJ, et al. Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation. Nat Commun (2017) 8:14844. doi:10.1038/ncomms14844
    • (2017) Nat Commun , vol.8 , pp. 14844
    • Liu, D.S.1    Duong, C.P.2    Haupt, S.3    Montgomery, K.G.4    House, C.M.5    Azar, W.J.6


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