MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

Journal of Molecular and Cellular Cardiology

Volumn 62, Issue , 2013, Pages 111-121

  Varga, Zoltán V ^a,b   Kupai, Krisztina ^a   Szucs, Gergo ^a   Gáspár, Renáta ^a   Pálóczi, János ^a   Faragó, Nóra ^c   Zvara, Ágnes ^c   Puskás, László G ^c   Rázga, Zsolt ^d   Tiszlavicz, László ^d   Bencsik, Péter ^a,e   Görbe, Anikó ^a,e   Csonka, Csaba ^a,e   Ferdinandy, Péter ^a,b,e   Csont, Tamás ^a,e  

^a UNIVERSITY OF SZEGED   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

^e PHARMAHUNGARY GROUP   (Hungary)

Author keywords

Cholesterol; Hyperlipidemia; Metabolic syndrome; Nitrosative stress; Peroxynitrite; Superoxide

Indexed keywords

CHOLESTEROL; DIPHENYLIODONIUM SALT; HYDROETHIDINE; MICRORNA; MICRORNA 25; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; COMPUTER ANALYSIS; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSFECTION; HEART DISEASE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LUCIFERASE REPORTER ASSAY; MALE; MICROARRAY ANALYSIS; NITRATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; PROTEIN OXIDATION ASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE LEVEL; UPREGULATION;

CHOLESTEROL; HYPERLIPIDEMIA; METABOLIC SYNDROME; NITROSATIVE STRESS; PEROXYNITRITE; SUPEROXIDE;

ANIMALS; HEART; HEART DISEASES; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; MALE; MICRORNAS; MICROSCOPY, ELECTRON, TRANSMISSION; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 84879057626     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.05.009     Document Type: Article

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