메뉴 건너뛰기




Volumn 36, Issue 29, 2017, Pages 4089-4099

Iron addiction: A novel therapeutic target in ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD71 ANTIGEN; ERASTIN; FERRITIN; FERROPORTIN; INTERLEUKIN 6; IRON; IRON CHELATING AGENT; IRON REGULATORY PROTEIN 2; MATRIX METALLOPROTEINASE; MESSENGER RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 85015710412     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2017.11     Document Type: Article
Times cited : (331)

References (48)
  • 1
    • 77953454584 scopus 로고    scopus 로고
    • National Cancer Institute. Available from accessed 21 December 2015
    • A snapshot of ovarian cancer. National Cancer Institute. Available from http://www.cancer.gov/research/progress/snapshots/ovarian (accessed 21 December 2015).
    • A Snapshot of Ovarian Cancer
  • 2
    • 69349088990 scopus 로고    scopus 로고
    • Ovarian low-grade and high-grade serous carcinoma: Pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems
    • Vang R, Shih IeM, Kurman RJ. Ovarian low-grade and high-grade serous carcinoma: Pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol 2009; 16: 267-282.
    • (2009) Adv Anat Pathol , vol.16 , pp. 267-282
    • Vang, R.1    IeM, S.2    Kurman, R.J.3
  • 4
    • 52649085237 scopus 로고    scopus 로고
    • Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    • Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 2008; 14: 5198-5208.
    • (2008) Clin Cancer Res , vol.14 , pp. 5198-5208
    • Tothill, R.W.1    Tinker, A.V.2    George, J.3    Brown, R.4    Fox, S.B.5    Lade, S.6
  • 5
    • 77956495728 scopus 로고    scopus 로고
    • Ovarian cancer development and metastasis
    • Lengyel E. Ovarian cancer development and metastasis. Am J Pathol 2010; 177: 1053-1064.
    • (2010) Am J Pathol , vol.177 , pp. 1053-1064
    • Lengyel, E.1
  • 7
    • 79957917044 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival
    • Silva IA, Bai S, McLean K, Yang K, Griffith K, Thomas D et al. Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res 2011; 71: 3991-4001.
    • (2011) Cancer Res , vol.71 , pp. 3991-4001
    • Silva, I.A.1    Bai, S.2    McLean, K.3    Yang, K.4    Griffith, K.5    Thomas, D.6
  • 8
    • 77951784627 scopus 로고    scopus 로고
    • Ovarian cancer pathogenesis: A model in evolution
    • Karst AM, Drapkin R. Ovarian cancer pathogenesis: A model in evolution. J Oncol 2010; 2010: 932371.
    • (2010) J Oncol , vol.2010 , pp. 932371
    • Karst, A.M.1    Drapkin, R.2
  • 9
    • 84942297491 scopus 로고    scopus 로고
    • Ovary and fimbrial stem cells: Biology, niche and cancer origins
    • Ng A, Barker N. Ovary and fimbrial stem cells: Biology, niche and cancer origins. Nat Rev Mol Cell Biol 2015; 16: 625-638.
    • (2015) Nat Rev Mol Cell Biol , vol.16 , pp. 625-638
    • Ng, A.1    Barker, N.2
  • 10
    • 84959129489 scopus 로고    scopus 로고
    • In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells
    • Yamamoto Y, Ning G, Howitt BE, Mehra K, Wu L, Wang X et al. In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells. J Pathol 2016; 238: 519-530.
    • J Pathol 2016 , vol.238 , pp. 519-530
    • Yamamoto, Y.1    Ning, G.2    Howitt, B.E.3    Mehra, K.4    Wu, L.5    Wang, X.6
  • 11
    • 84876854791 scopus 로고    scopus 로고
    • Iron and cancer: More ore to be mined
    • Torti SV, Torti FM. Iron and cancer: More ore to be mined. Nat Rev Cancer 2013; 13: 342-355.
    • (2013) Nat Rev Cancer , vol.13 , pp. 342-355
    • Torti, S.V.1    Torti, F.M.2
  • 12
    • 79952227712 scopus 로고    scopus 로고
    • Ironing out cancer
    • Torti SV, Torti FM. Ironing out cancer. Cancer Res 2011; 71: 1511-1514.
    • (2011) Cancer Res , vol.71 , pp. 1511-1514
    • Torti, S.V.1    Torti, F.M.2
  • 13
    • 0037932865 scopus 로고    scopus 로고
    • Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
    • Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003; 3: 285-296.
    • (2003) Cancer Cell , vol.3 , pp. 285-296
    • Dolma, S.1    Lessnick, S.L.2    Hahn, W.C.3    Stockwell, B.R.4
  • 14
    • 84899575209 scopus 로고    scopus 로고
    • Advances in serous tubal intraepithelial carcinoma: Correlation with high grade serous carcinoma and ovarian carcinogenesis
    • Li HX, Lu ZH, Shen K, Cheng WJ, Malpica A, Zhang J et al. Advances in serous tubal intraepithelial carcinoma: Correlation with high grade serous carcinoma and ovarian carcinogenesis. Int J Clin Exp Pathol 2014; 7: 848-857.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 848-857
    • Li, H.X.1    Zh, L.2    Shen, K.3    Cheng, W.J.4    Malpica, A.5    Zhang, J.6
  • 15
    • 84888213291 scopus 로고    scopus 로고
    • Origin and molecular pathogenesis of ovarian high-grade serous carcinoma
    • Kurman RJ. Origin and molecular pathogenesis of ovarian high-grade serous carcinoma. Ann Oncol 2013; 24(Suppl 10): X16-x21.
    • (2013) Ann Oncol , vol.24 , pp. X16-x21
    • Kurman, R.J.1
  • 16
    • 84896702756 scopus 로고    scopus 로고
    • Revisiting the pathogenesis of ovarian cancer: The central role of the fallopian tube
    • Dietl J. Revisiting the pathogenesis of ovarian cancer: The central role of the fallopian tube. Arch Gynecol Obstet 2014; 289: 241-246.
    • (2014) Arch Gynecol Obstet , vol.289 , pp. 241-246
    • Dietl, J.1
  • 18
    • 84946222402 scopus 로고    scopus 로고
    • The life and times of low-grade serous carcinoma of the ovary
    • Gershenson DM. The life and times of low-grade serous carcinoma of the ovary. Am Soc Clin Oncol Educ Book 2013; e195-e199.
    • (2013) Am Soc Clin Oncol Educ Book , pp. e195-e199
    • Gershenson, D.M.1
  • 19
    • 0037093202 scopus 로고    scopus 로고
    • Regulation of ferritin genes and protein
    • Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood 2002; 99: 3505-3516.
    • (2002) Blood , vol.99 , pp. 3505-3516
    • Torti, F.M.1    Torti, S.V.2
  • 20
    • 58249095085 scopus 로고    scopus 로고
    • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
    • Baba T, Convery PA, Matsumura N, Whitaker RS, Kondoh E, Perry T et al. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene 2009; 28: 209-218.
    • (2009) Oncogene , vol.28 , pp. 209-218
    • Baba, T.1    Convery, P.A.2    Matsumura, N.3    Whitaker, R.S.4    Kondoh, E.5    Perry, T.6
  • 21
    • 70349859809 scopus 로고    scopus 로고
    • Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
    • Kurrey NK, Jalgaonkar SP, Joglekar AV, Ghanate AD, Chaskar PD, Doiphode RY et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009; 27: 2059-2068.
    • (2009) Stem Cells , vol.27 , pp. 2059-2068
    • Kurrey, N.K.1    Jalgaonkar, S.P.2    Joglekar, A.V.3    Ghanate, A.D.4    Chaskar, P.D.5    Doiphode, R.Y.6
  • 22
    • 84911432455 scopus 로고    scopus 로고
    • The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium
    • Ning G, Bijron JG, Yamamoto Y, Wang X, Howitt BE, Herfs M et al. The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium. J Pathol 2014; 234: 478-487.
    • (2014) J Pathol , vol.234 , pp. 478-487
    • Ning, G.1    Bijron, J.G.2    Yamamoto, Y.3    Wang, X.4    Howitt, B.E.5    Herfs, M.6
  • 24
    • 77950965840 scopus 로고    scopus 로고
    • Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
    • Ahmed AA, Etemadmoghadam D, Temple J, Lynch AG, Riad M, Sharma R et al. Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J Pathol 2010; 221: 49-56.
    • (2010) J Pathol , vol.221 , pp. 49-56
    • Ahmed, A.A.1    Etemadmoghadam, D.2    Temple, J.3    Lynch, A.G.4    Riad, M.5    Sharma, R.6
  • 26
    • 84880291315 scopus 로고    scopus 로고
    • Evaluating cell lines as tumour models by comparison of genomic profiles
    • Domcke S, Sinha R, Levine DA, Sander C, Schultz N. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat commun 2013; 4: 2126.
    • (2013) Nat Commun , vol.4 , pp. 2126
    • Domcke, S.1    Sinha, R.2    Levine, D.A.3    Sander, C.4    Schultz, N.5
  • 28
    • 21544442328 scopus 로고    scopus 로고
    • Functional consequences of ferroportin 1 mutations
    • Liu XB, Yang F, Haile DJ. Functional consequences of ferroportin 1 mutations. Blood cells mol dis 2005; 35: 33-46.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 33-46
    • Liu, X.B.1    Yang, F.2    Haile, D.J.3
  • 29
    • 67649440886 scopus 로고    scopus 로고
    • The biology of ovarian cancer: New opportunities for translation
    • Bast Jr RC, Hennessy B, Mills GB. The biology of ovarian cancer: New opportunities for translation. Nat Rev Cancer 2009; 9: 415-428.
    • (2009) Nat Rev Cancer , vol.9 , pp. 415-428
    • Bast, R.C.1    Hennessy, B.2    Mills, G.B.3
  • 32
    • 84890922670 scopus 로고    scopus 로고
    • The role of iron and reactive oxygen species in cell death
    • Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol 2014; 10: 9-17.
    • (2014) Nat Chem Biol , vol.10 , pp. 9-17
    • Dixon, S.J.1    Stockwell, B.R.2
  • 33
    • 79956313481 scopus 로고    scopus 로고
    • Modeling high-grade serous ovarian carcinogenesis from the fallopian tube
    • Karst AM, Levanon K, Drapkin R. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc Natl Acad Sci USA 2011; 108: 7547-7552.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7547-7552
    • Karst, A.M.1    Levanon, K.2    Drapkin, R.3
  • 37
    • 84942888188 scopus 로고    scopus 로고
    • Hepcidin regulation in prostate and its disruption in prostate cancer
    • Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD et al. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res 2015; 75: 2254-2263.
    • (2015) Cancer Res , vol.75 , pp. 2254-2263
    • Tesfay, L.1    Clausen, K.A.2    Kim, J.W.3    Hegde, P.4    Wang, X.5    Miller, L.D.6
  • 38
    • 84867499521 scopus 로고    scopus 로고
    • Interleukin-6/interleukin-6 receptor pathway as a new therapy target in epithelial ovarian cancer
    • Dijkgraaf EM, Welters MJ, Nortier JW, van der Burg SH, Kroep JR. Interleukin-6/interleukin-6 receptor pathway as a new therapy target in epithelial ovarian cancer. Curr Pharm Des 2012; 18: 3816-3827.
    • (2012) Curr Pharm des , vol.18 , pp. 3816-3827
    • Dijkgraaf, E.M.1    Welters, M.J.2    Nortier, J.W.3    Van Der Burg, S.H.4    Kroep, J.R.5
  • 39
    • 85025445067 scopus 로고    scopus 로고
    • IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells
    • Zou M, Zhang X, Xu C. IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells. Cell Oncol (Dordr) 2015.
    • (2015) Cell Oncol (Dordr)
    • Zou, M.1    Zhang, X.2    Xu, C.3
  • 40
    • 84925283220 scopus 로고    scopus 로고
    • Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: Inhibition of constitutive and interleukin 6-induced activation by iron depletion
    • Lui GY, Kovacevic Z, V Menezes S, Kalinowski DS, Merlot AM, Sahni S et al. Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: Inhibition of constitutive and interleukin 6-induced activation by iron depletion. Mol Pharmacol 2015; 87: 543-560.
    • (2015) Mol Pharmacol , vol.87 , pp. 543-560
    • Lui, G.Y.1    Kovacevic, Z.2    Menezes, S.V.3    Kalinowski, D.S.4    Merlot, A.M.5    Sahni, S.6
  • 41
    • 4444283611 scopus 로고    scopus 로고
    • Iron-induced interleukin-6 gene expression: Possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
    • Dai J, Huang C, Wu J, Yang C, Frenkel K, Huang X. Iron-induced interleukin-6 gene expression: Possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. Toxicology 2004; 203: 199-209.
    • (2004) Toxicology , vol.203 , pp. 199-209
    • Dai, J.1    Huang, C.2    Wu, J.3    Yang, C.4    Frenkel, K.5    Huang, X.6
  • 42
    • 84861535833 scopus 로고    scopus 로고
    • Ironing out cell death mechanisms
    • Reed JC, Pellecchia M. Ironing out cell death mechanisms. Cell 2012; 149: 963-965.
    • (2012) Cell , vol.149 , pp. 963-965
    • Reed, J.C.1    Pellecchia, M.2
  • 44
    • 84958103915 scopus 로고    scopus 로고
    • Ferroptosis: Death by lipid peroxidation
    • Yang WS, Stockwell BR. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol 2015; 26: 165-176.
    • (2015) Trends Cell Biol , vol.26 , pp. 165-176
    • Yang, W.S.1    Stockwell, B.R.2
  • 45
    • 84894083580 scopus 로고    scopus 로고
    • Ovarian cancer stem cells: Are they real and why are they important?
    • Shah MM, Landen CN. Ovarian cancer stem cells: Are they real and why are they important? Gynecol Oncol 2014; 132: 483-489.
    • (2014) Gynecol Oncol , vol.132 , pp. 483-489
    • Shah, M.M.1    Landen, C.N.2
  • 46
    • 34248209648 scopus 로고    scopus 로고
    • PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger
    • Deng Z, Wan M, Sui G. PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger. Mol cell biol 2007; 27: 3780-3792.
    • (2007) Mol Cell Biol , vol.27 , pp. 3780-3792
    • Deng, Z.1    Wan, M.2    Sui, G.3
  • 47
    • 84862007363 scopus 로고    scopus 로고
    • Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT
    • Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I et al. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell metab 2012; 15: 905-917.
    • (2012) Cell Metab , vol.15 , pp. 905-917
    • Ross, S.L.1    Tran, L.2    Winters, A.3    Lee, K.J.4    Plewa, C.5    Foltz, I.6
  • 48
    • 84924296891 scopus 로고    scopus 로고
    • Quantifying chromogen intensity in immunohistochemistry via reciprocal intensity
    • Nguyen DH, Zhou T, Shu J, Mao J. Quantifying chromogen intensity in immunohistochemistry via reciprocal intensity. CancerInCytes 2013; 2: 1-3e.
    • (2013) CancerInCytes , vol.2 , pp. 1-3e
    • Nguyen, D.H.1    Zhou, T.2    Shu, J.3    Mao, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.