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Volumn 34, Issue 1, 2015, Pages

Metabolic reprogramming: The emerging concept and associated therapeutic strategies

Author keywords

AMPK mTOR signal; Cancer stem like cells; Cancer associated fibroblasts; Drug repositioning; Glutaminolysis; Intra tumoral heterogeneity; Metabolic symbiosis; Metformin; Minimal residual disease; Reverse Warburg effect

Indexed keywords

GLUTAMINE; ITRACONAZOLE; METFORMIN; SALAZOSULFAPYRIDINE; SIMVASTATIN; TERFENADINE; ANTINEOPLASTIC AGENT;

EID: 84943246936     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-015-0221-y     Document Type: Review
Times cited : (506)

References (88)
  • 1
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: A major contributor to minimal residual disease
    • 1:CAS:528:DC%2BD1MXhtVWhsb%2FP 19693095
    • Meads MB, Gatenby RA, Dalton WS. Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer. 2009;9(9):665-74.
    • (2009) Nat Rev Cancer , vol.9 , Issue.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 2
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • 1:CAS:528:DC%2BC3sXhsVOms7%2FK 24048067
    • Junttila MR, de Sauvage FJ. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature. 2013;501(7467):346-54.
    • (2013) Nature , vol.501 , Issue.7467 , pp. 346-354
    • Junttila, M.R.1    De Sauvage, F.J.2
  • 3
    • 84924048777 scopus 로고    scopus 로고
    • Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing
    • 4346117 25881093
    • Lee JY, Yoon JK, Kim B, Kim S, Kim MA, Lim H, et al. Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing. BMC Cancer. 2015;15:85.
    • (2015) BMC Cancer , vol.15 , pp. 85
    • Lee, J.Y.1    Yoon, J.K.2    Kim, B.3    Kim, S.4    Kim, M.A.5    Lim, H.6
  • 4
    • 84856226651 scopus 로고    scopus 로고
    • Cancer stem cells: An evolving concept
    • 1:CAS:528:DC%2BC38XlsFygtA%3D%3D 22237392
    • Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: an evolving concept. Nat Rev Cancer. 2012;12(2):133-43.
    • (2012) Nat Rev Cancer , vol.12 , Issue.2 , pp. 133-143
    • Nguyen, L.V.1    Vanner, R.2    Dirks, P.3    Eaves, C.J.4
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 1:CAS:528:DC%2BC3MXjsFeqtrk%3D 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 84555189751 scopus 로고    scopus 로고
    • Emerging roles of the FBW7 tumour suppressor in stem cell differentiation
    • 3246256 1:CAS:528:DC%2BC3MXhs1OltbbP
    • Wang Z, Inuzuka H, Fukushima H, Wan L, Gao D, Shaik S, et al. Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Rep. 2012;13(1):36-43.
    • (2012) EMBO Rep , vol.13 , Issue.1 , pp. 36-43
    • Wang, Z.1    Inuzuka, H.2    Fukushima, H.3    Wan, L.4    Gao, D.5    Shaik, S.6
  • 7
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    • 1:CAS:528:DC%2BC3MXjtFKisrY%3D 21397861
    • Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell. 2011;19(3):387-400.
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3    Tamada, M.4    Motohara, T.5    Oshima, H.6
  • 8
    • 84863321158 scopus 로고    scopus 로고
    • Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell
    • 22673910
    • Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, et al. Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nat Commun. 2012;3:883.
    • (2012) Nat Commun , vol.3 , pp. 883
    • Yae, T.1    Tsuchihashi, K.2    Ishimoto, T.3    Motohara, T.4    Yoshikawa, M.5    Yoshida, G.J.6
  • 9
    • 84922388823 scopus 로고    scopus 로고
    • Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
    • 1:CAS:528:DC%2BC2cXitFamsrfE 25470039
    • Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, et al. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature. 2015;517(7533):209-13.
    • (2015) Nature , vol.517 , Issue.7533 , pp. 209-213
    • Kurtova, A.V.1    Xiao, J.2    Mo, Q.3    Pazhanisamy, S.4    Krasnow, R.5    Lerner, S.P.6
  • 10
    • 84911861458 scopus 로고    scopus 로고
    • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
    • 4376130 1:CAS:528:DC%2BC2cXhtlGnt7vO 25119024
    • Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchez N, Marchesini M, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014;514(7524):628-32.
    • (2014) Nature , vol.514 , Issue.7524 , pp. 628-632
    • Viale, A.1    Pettazzoni, P.2    Lyssiotis, C.A.3    Ying, H.4    Sanchez, N.5    Marchesini, M.6
  • 11
    • 84876436850 scopus 로고    scopus 로고
    • Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF
    • 3635826 1:CAS:528:DC%2BC3sXktVOksbk%3D 23477830
    • Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, et al. Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF. Cancer Cell. 2013;23(3):302-15.
    • (2013) Cancer Cell , vol.23 , Issue.3 , pp. 302-315
    • Haq, R.1    Shoag, J.2    Andreu-Perez, P.3    Yokoyama, S.4    Edelman, H.5    Rowe, G.C.6
  • 12
    • 84902131034 scopus 로고    scopus 로고
    • Cancer stem cells: Constantly evolving and functionally heterogeneous therapeutic targets
    • 4112560 1:CAS:528:DC%2BC2cXovFalurs%3D 24713433
    • Yang T, Rycaj K, Liu ZM, Tang DG. Cancer stem cells: constantly evolving and functionally heterogeneous therapeutic targets. Cancer Res. 2014;74(11):2922-7.
    • (2014) Cancer Res , vol.74 , Issue.11 , pp. 2922-2927
    • Yang, T.1    Rycaj, K.2    Liu, Z.M.3    Tang, D.G.4
  • 13
    • 84880911745 scopus 로고    scopus 로고
    • Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: Basic knowledge and therapeutic possibilities for an innovative approach
    • 3734167 23902592
    • Tomao F, Papa A, Rossi L, Strudel M, Vici P, Lo Russo G, et al. Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approach. J Exp Clin Cancer Res. 2013;32:48.
    • (2013) J Exp Clin Cancer Res , vol.32 , pp. 48
    • Tomao, F.1    Papa, A.2    Rossi, L.3    Strudel, M.4    Vici, P.5    Lo Russo, G.6
  • 14
    • 84855838173 scopus 로고    scopus 로고
    • Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia
    • 1:CAS:528:DC%2BC38XhsVKmt74%3D 22039260
    • Buccisano F, Maurillo L, Del Principe MI, Del Poeta G, Sconocchia G, Lo-Coco F, et al. Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia. Blood. 2012;119(2):332-41.
    • (2012) Blood , vol.119 , Issue.2 , pp. 332-341
    • Buccisano, F.1    Maurillo, L.2    Del Principe, M.I.3    Del Poeta, G.4    Sconocchia, G.5    Lo-Coco, F.6
  • 15
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • 1:STN:280:DyaG28%2FltV2ktQ%3D%3D 13298683
    • Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309-14.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 16
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • 2140820 1:CAS:528:DyaB2sXitlyhuw%3D%3D 19872213
    • Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol. 1927;8(6):519-30.
    • (1927) J Gen Physiol , vol.8 , Issue.6 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 17
    • 77953560003 scopus 로고    scopus 로고
    • Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": A transcriptional informatics analysis with validation
    • 1:CAS:528:DC%2BC3cXht12kurrJ 20519932
    • Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, et al. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation. Cell Cycle. 2010;9(11):2201-19.
    • (2010) Cell Cycle , vol.9 , Issue.11 , pp. 2201-2219
    • Pavlides, S.1    Tsirigos, A.2    Vera, I.3    Flomenberg, N.4    Frank, P.G.5    Casimiro, M.C.6
  • 18
    • 74849087878 scopus 로고    scopus 로고
    • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    • 1:CAS:528:DC%2BC3cXotlWrtbc%3D 19923890
    • Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle. 2009;8(23):3984-4001.
    • (2009) Cell Cycle , vol.8 , Issue.23 , pp. 3984-4001
    • Pavlides, S.1    Whitaker-Menezes, D.2    Castello-Cros, R.3    Flomenberg, N.4    Witkiewicz, A.K.5    Frank, P.G.6
  • 19
    • 57449115616 scopus 로고    scopus 로고
    • Tumor metabolism: Cancer cells give and take lactate
    • 2582934 1:CAS:528:DC%2BD1cXhsVKgu73P 19033652
    • Semenza GL. Tumor metabolism: cancer cells give and take lactate. J Clin Invest. 2008;118(12):3835-7.
    • (2008) J Clin Invest , vol.118 , Issue.12 , pp. 3835-3837
    • Semenza, G.L.1
  • 20
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • 2582933 1:CAS:528:DC%2BD1cXhsVKgu7rI 19033663
    • Sonveaux P, Vegran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest. 2008;118(12):3930-42.
    • (2008) J Clin Invest , vol.118 , Issue.12 , pp. 3930-3942
    • Sonveaux, P.1    Vegran, F.2    Schroeder, T.3    Wergin, M.C.4    Verrax, J.5    Rabbani, Z.N.6
  • 21
    • 75149148563 scopus 로고    scopus 로고
    • Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
    • 2809806 1:CAS:528:DC%2BD1MXhtlers7fE 19881548
    • DeBerardinis RJ, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene. 2010;29(3):313-24.
    • (2010) Oncogene , vol.29 , Issue.3 , pp. 313-324
    • DeBerardinis, R.J.1    Cheng, T.2
  • 22
    • 0034856827 scopus 로고    scopus 로고
    • Glutamine and cancer
    • 1:CAS:528:DC%2BD3MXmslGlsLo%3D 11533309 discussion 50S-1S
    • Medina MA. Glutamine and cancer. J Nutr. 2001;131(9 Suppl):2539S-42S. discussion 50S-1S.
    • (2001) J Nutr , vol.131 , Issue.9 , pp. 2539S-42S
    • Medina, M.A.1
  • 23
    • 0015453103 scopus 로고
    • The Pasteur effect and the relations between respiration and fermentation
    • 1:CAS:528:DyaE3sXht1Shu7g%3D 4265190
    • Krebs HA. The Pasteur effect and the relations between respiration and fermentation. Essays Biochem. 1972;8:1-34.
    • (1972) Essays Biochem , vol.8 , pp. 1-34
    • Krebs, H.A.1
  • 24
    • 0016372384 scopus 로고
    • Pasteur effect and phosphofructokinase
    • 1:CAS:528:DyaE2MXjvFKmtQ%3D%3D 4370999
    • Ramaiah A. Pasteur effect and phosphofructokinase. Curr Top Cell Regul. 1974;8:297-345.
    • (1974) Curr Top Cell Regul , vol.8 , pp. 297-345
    • Ramaiah, A.1
  • 25
    • 0347419305 scopus 로고    scopus 로고
    • The molecular machinery of Keilin's respiratory chain
    • 1:CAS:528:DC%2BD3sXps1yqurk%3D 14641005
    • Rich PR. The molecular machinery of Keilin's respiratory chain. Biochem Soc Trans. 2003;31(Pt 6):1095-105.
    • (2003) Biochem Soc Trans , vol.31 , pp. 1095-1105
    • Rich, P.R.1
  • 26
    • 84867249149 scopus 로고    scopus 로고
    • Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
    • 3506713 1:CAS:528:DC%2BC38XhvVKgtLnO 23226794
    • Zheng J. Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (Review). Oncol Lett. 2012;4(6):1151-7.
    • (2012) Oncol Lett , vol.4 , Issue.6 , pp. 1151-1157
    • Zheng, J.1
  • 27
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • 1:CAS:528:DC%2BC3MXks1ags70%3D 21508971
    • Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011;11(5):325-37.
    • (2011) Nat Rev Cancer , vol.11 , Issue.5 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 28
    • 0347694776 scopus 로고    scopus 로고
    • Cancer metabolism: Facts, fantasy, and fiction
    • 1:CAS:528:DC%2BD3sXhtVSjurnM 14697210
    • Zu XL, Guppy M. Cancer metabolism: facts, fantasy, and fiction. Biochem Biophys Res Commun. 2004;313(3):459-65.
    • (2004) Biochem Biophys Res Commun , vol.313 , Issue.3 , pp. 459-465
    • Zu, X.L.1    Guppy, M.2
  • 29
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • 1:CAS:528:DC%2BD2MXit1Gnsro%3D 15585754
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23(5):1011-27.
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 30
    • 69349105825 scopus 로고    scopus 로고
    • GLUT1 gene is a potential hypoxic marker in colorectal cancer patients
    • 3087329 19619276
    • Chung FY, Huang MY, Yeh CS, Chang HJ, Cheng TL, Yen LC, et al. GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. BMC Cancer. 2009;9:241.
    • (2009) BMC Cancer , vol.9 , pp. 241
    • Chung, F.Y.1    Huang, M.Y.2    Yeh, C.S.3    Chang, H.J.4    Cheng, T.L.5    Yen, L.C.6
  • 31
    • 84876811654 scopus 로고    scopus 로고
    • Genotyping analysis and (1)(8)FDG uptake in breast cancer patients: A preliminary research
    • 3646684 1:CAS:528:DC%2BC3sXhtV2qurjO 23631762
    • Bravata V, Stefano A, Cammarata FP, Minafra L, Russo G, Nicolosi S, et al. Genotyping analysis and (1)(8)FDG uptake in breast cancer patients: a preliminary research. J Exp Clin Cancer Res. 2013;32:23.
    • (2013) J Exp Clin Cancer Res , vol.32 , pp. 23
    • Bravata, V.1    Stefano, A.2    Cammarata, F.P.3    Minafra, L.4    Russo, G.5    Nicolosi, S.6
  • 32
    • 84929940663 scopus 로고    scopus 로고
    • GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva
    • 4210616 25306097
    • Mayer A, Schmidt M, Seeger A, Serras AF, Vaupel P, Schmidberger H. GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva. BMC Cancer. 2014;14:760.
    • (2014) BMC Cancer , vol.14 , pp. 760
    • Mayer, A.1    Schmidt, M.2    Seeger, A.3    Serras, A.F.4    Vaupel, P.5    Schmidberger, H.6
  • 33
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • 1:CAS:528:DC%2BD28Xnsl2hs7Y%3D 16892078
    • Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene. 2006;25(34):4633-46.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 34
    • 84902201289 scopus 로고    scopus 로고
    • The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
    • 4038567 1:CAS:528:DC%2BC2cXpvFahsrk%3D 24762438
    • Yan M, Gingras MC, Dunlop EA, Nouet Y, Dupuy F, Jalali Z, et al. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J Clin Invest. 2014;124(6):2640-50.
    • (2014) J Clin Invest , vol.124 , Issue.6 , pp. 2640-2650
    • Yan, M.1    Gingras, M.C.2    Dunlop, E.A.3    Nouet, Y.4    Dupuy, F.5    Jalali, Z.6
  • 35
    • 84872159532 scopus 로고    scopus 로고
    • AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
    • 3545102 1:CAS:528:DC%2BC3sXnvVem 23274086
    • Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab. 2013;17(1):113-24.
    • (2013) Cell Metab , vol.17 , Issue.1 , pp. 113-124
    • Faubert, B.1    Boily, G.2    Izreig, S.3    Griss, T.4    Samborska, B.5    Dong, Z.6
  • 36
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • 3311998 1:CAS:528:DC%2BC38Xkt1ylsbc%3D 22439925
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell. 2012;21(3):297-308.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 37
    • 84866791348 scopus 로고    scopus 로고
    • Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy
    • 3488581 1:CAS:528:DC%2BC3sXitVWruw%3D%3D 23031740
    • Yoshida GJ, Fuchimoto Y, Osumi T, Shimada H, Hosaka S, Morioka H, et al. Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: increased expression of a CD44 variant isoform after chemotherapy. BMC Cancer. 2012;12:444.
    • (2012) BMC Cancer , vol.12 , pp. 444
    • Yoshida, G.J.1    Fuchimoto, Y.2    Osumi, T.3    Shimada, H.4    Hosaka, S.5    Morioka, H.6
  • 38
    • 84883274819 scopus 로고    scopus 로고
    • Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling
    • 1:CAS:528:DC%2BC3sXhtlCntb%2FL 23948691
    • Yoshida GJ, Saya H, Zouboulis CC. Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling. Biochem Biophys Res Commun. 2013;438(4):640-6.
    • (2013) Biochem Biophys Res Commun , vol.438 , Issue.4 , pp. 640-646
    • Yoshida, G.J.1    Saya, H.2    Zouboulis, C.C.3
  • 39
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • 1:CAS:528:DC%2BC3sXivVWjsr0%3D 23406030
    • Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(7):651-62.
    • (2013) N Engl J Med , vol.368 , Issue.7 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 40
    • 84878959237 scopus 로고    scopus 로고
    • Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells
    • 1:CAS:528:DC%2BC3sXptFKku7s%3D 23764003
    • Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, et al. Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell. 2013;23(6):811-25.
    • (2013) Cancer Cell , vol.23 , Issue.6 , pp. 811-825
    • Roesch, A.1    Vultur, A.2    Bogeski, I.3    Wang, H.4    Zimmermann, K.M.5    Speicher, D.6
  • 41
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • 1:CAS:528:DC%2BD28XjslGitLw%3D 16572188
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006;6(5):392-401.
    • (2006) Nat Rev Cancer , vol.6 , Issue.5 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 42
    • 82855167795 scopus 로고    scopus 로고
    • Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment
    • 3236330 21867571
    • Sotgia F, Martinez-Outschoorn UE, Pavlides S, Howell A, Pestell RG, Lisanti MP. Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment. Breast Cancer Res. 2011;13(4):213.
    • (2011) Breast Cancer Res , vol.13 , Issue.4 , pp. 213
    • Sotgia, F.1    Martinez-Outschoorn, U.E.2    Pavlides, S.3    Howell, A.4    Pestell, R.G.5    Lisanti, M.P.6
  • 43
    • 84901597401 scopus 로고    scopus 로고
    • A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer
    • 4039335 24886074
    • Pertega-Gomes N, Vizcaino JR, Attig J, Jurmeister S, Lopes C, Baltazar F. A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer. BMC Cancer. 2014;14:352.
    • (2014) BMC Cancer , vol.14 , pp. 352
    • Pertega-Gomes, N.1    Vizcaino, J.R.2    Attig, J.3    Jurmeister, S.4    Lopes, C.5    Baltazar, F.6
  • 44
    • 84936806214 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase to treat epilepsy
    • 26154793
    • Rho JM. Inhibition of lactate dehydrogenase to treat epilepsy. N Engl J Med. 2015;373(2):187-9.
    • (2015) N Engl J Med , vol.373 , Issue.2 , pp. 187-189
    • Rho, J.M.1
  • 45
    • 84878357576 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
    • 3542619 1:STN:280:DC%2BC3s3jtlOisA%3D%3D 23254289
    • Cahu J, Bustany S, Sola B. Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells. Cell Death Dis. 2012;3:e446.
    • (2012) Cell Death Dis , vol.3 , pp. e446
    • Cahu, J.1    Bustany, S.2    Sola, B.3
  • 46
    • 64549108961 scopus 로고    scopus 로고
    • Redox regulation and its emerging roles in stem cells and stem-like cancer cells
    • 1:CAS:528:DC%2BD1MXkt1Chs70%3D 18999985
    • Ogasawara MA, Zhang H. Redox regulation and its emerging roles in stem cells and stem-like cancer cells. Antioxid Redox Signal. 2009;11(5):1107-22.
    • (2009) Antioxid Redox Signal , vol.11 , Issue.5 , pp. 1107-1122
    • Ogasawara, M.A.1    Zhang, H.2
  • 47
    • 84892432945 scopus 로고    scopus 로고
    • Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation
    • 1:CAS:528:DC%2BC3sXhvFOgsLzP 24333422
    • Yoshida GJ, Saya H. Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation. Biochem Biophys Res Commun. 2014;443(2):622-7.
    • (2014) Biochem Biophys Res Commun , vol.443 , Issue.2 , pp. 622-627
    • Yoshida, G.J.1    Saya, H.2
  • 48
    • 84885378901 scopus 로고    scopus 로고
    • Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target
    • 3931310 1:CAS:528:DC%2BC3sXhsFOltbvM 24094812
    • Timmerman LA, Holton T, Yuneva M, Louie RJ, Padro M, Daemen A, et al. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell. 2013;24(4):450-65.
    • (2013) Cancer Cell , vol.24 , Issue.4 , pp. 450-465
    • Timmerman, L.A.1    Holton, T.2    Yuneva, M.3    Louie, R.J.4    Padro, M.5    Daemen, A.6
  • 50
    • 34249803325 scopus 로고    scopus 로고
    • The transport of glutamine into mammalian cells
    • 1:CAS:528:DC%2BD28Xht1WgsLnI 17127344
    • McGivan JD, Bungard CI. The transport of glutamine into mammalian cells. Front Biosci. 2007;12:874-82.
    • (2007) Front Biosci , vol.12 , pp. 874-882
    • McGivan, J.D.1    Bungard, C.I.2
  • 51
    • 84883178190 scopus 로고    scopus 로고
    • Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential
    • 1:CAS:528:DC%2BC3sXhtlyrtrjP 23747337 e5
    • Gao W, Chen L, Ma Z, Du Z, Zhao Z, Hu Z, et al. Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gastroenterology. 2013;145(3):636-46. e5.
    • (2013) Gastroenterology , vol.145 , Issue.3 , pp. 636-646
    • Gao, W.1    Chen, L.2    Ma, Z.3    Du, Z.4    Zhao, Z.5    Hu, Z.6
  • 52
    • 84936991599 scopus 로고    scopus 로고
    • TPO-induced metabolic reprogramming drives liver metastasis of colorectal cancer CD110+ tumor-initiating cells
    • 1:CAS:528:DC%2BC2MXhtV2itb7J 26140605
    • Wu Z, Wei D, Gao W, Xu Y, Hu Z, Ma Z, et al. TPO-induced metabolic reprogramming drives liver metastasis of colorectal cancer CD110+ tumor-initiating cells. Cell Stem Cell. 2015;17(1):47-59.
    • (2015) Cell Stem Cell , vol.17 , Issue.1 , pp. 47-59
    • Wu, Z.1    Wei, D.2    Gao, W.3    Xu, Y.4    Hu, Z.5    Ma, Z.6
  • 53
    • 84897938327 scopus 로고    scopus 로고
    • Regulation of Wnt/beta-catenin signaling by posttranslational modifications
    • 3977945 24594309
    • Gao C, Xiao G, Hu J. Regulation of Wnt/beta-catenin signaling by posttranslational modifications. Cell Biosci. 2014;4(1):13.
    • (2014) Cell Biosci , vol.4 , Issue.1 , pp. 13
    • Gao, C.1    Xiao, G.2    Hu, J.3
  • 54
    • 80052242132 scopus 로고    scopus 로고
    • Targeting cancer metabolism: A therapeutic window opens
    • 1:CAS:528:DC%2BC3MXhtFSltb3J 21878982
    • Vander Heiden MG. Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov. 2011;10(9):671-84.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.9 , pp. 671-684
    • Vander Heiden, M.G.1
  • 55
    • 84891846840 scopus 로고    scopus 로고
    • How does cancer cell metabolism affect tumor migration and invasion?
    • Han T, Kang D, Ji D, Wang X, Zhan W, Fu M, et al. How does cancer cell metabolism affect tumor migration and invasion? Cell Adhes Migr. 2013;7(5):395-403.
    • (2013) Cell Adhes Migr , vol.7 , Issue.5 , pp. 395-403
    • Han, T.1    Kang, D.2    Ji, D.3    Wang, X.4    Zhan, W.5    Fu, M.6
  • 56
    • 76249110471 scopus 로고    scopus 로고
    • Rethinking the Warburg effect with Myc micromanaging glutamine metabolism
    • 2818441 1:CAS:528:DC%2BC3cXht12ru7g%3D 20086171
    • Dang CV. Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res. 2010;70(3):859-62.
    • (2010) Cancer Res , vol.70 , Issue.3 , pp. 859-862
    • Dang, C.V.1
  • 57
    • 84877720366 scopus 로고    scopus 로고
    • The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4
    • 3684628 1:CAS:528:DC%2BC3sXnsFWis7w%3D 23663782
    • Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013;153(4):840-54.
    • (2013) Cell , vol.153 , Issue.4 , pp. 840-854
    • Csibi, A.1    Fendt, S.M.2    Li, C.3    Poulogiannis, G.4    Choo, A.Y.5    Chapski, D.J.6
  • 58
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • 1:CAS:528:DC%2BD28XhtFynu7bJ 17079682
    • Haigis MC, Guarente LP. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006;20(21):2913-21.
    • (2006) Genes Dev , vol.20 , Issue.21 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 59
    • 84919598908 scopus 로고    scopus 로고
    • Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer
    • 1:CAS:528:DC%2BC2cXitVyksLfL 25482439
    • Pan T, Gao L, Wu G, Shen G, Xie S, Wen H, et al. Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer. Biochem Biophys Res Commun. 2015;456(1):452-8.
    • (2015) Biochem Biophys Res Commun , vol.456 , Issue.1 , pp. 452-458
    • Pan, T.1    Gao, L.2    Wu, G.3    Shen, G.4    Xie, S.5    Wen, H.6
  • 60
    • 0015175596 scopus 로고
    • The pathway of glutamine and glutamate oxidation in isolated mitochondria from mammalian cells
    • 1178180 1:CAS:528:DyaE38Xkt1yksg%3D%3D 4401609
    • Kovacevic Z. The pathway of glutamine and glutamate oxidation in isolated mitochondria from mammalian cells. Biochem J. 1971;125(3):757-63.
    • (1971) Biochem J , vol.125 , Issue.3 , pp. 757-763
    • Kovacevic, Z.1
  • 61
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • 2783410 1:CAS:528:DC%2BD1MXhtlCjsrnM 19861459
    • Dang CV, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009;15(21):6479-83.
    • (2009) Clin Cancer Res , vol.15 , Issue.21 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 62
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • 1:CAS:528:DC%2BD1cXltlSmtrk%3D 18451130 discussion 80
    • Weinstein IB, Joe A. Oncogene addiction. Cancer Res. 2008;68(9):3077-80. discussion 80.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 63
    • 79955975040 scopus 로고    scopus 로고
    • Oncogene addiction in gliomas: Implications for molecular targeted therapy
    • 3113747 21575270
    • Yan W, Zhang W, Jiang T. Oncogene addiction in gliomas: implications for molecular targeted therapy. J Exp Clin Cancer Res. 2011;30:58.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 58
    • Yan, W.1    Zhang, W.2    Jiang, T.3
  • 64
    • 84902357848 scopus 로고    scopus 로고
    • Recent advances in drug repositioning for the discovery of new anticancer drugs
    • 4081601 1:CAS:528:DC%2BC2cXhslWntLvF 25013375
    • Shim JS, Liu JO. Recent advances in drug repositioning for the discovery of new anticancer drugs. Int J Biol Sci. 2014;10(7):654-63.
    • (2014) Int J Biol Sci , vol.10 , Issue.7 , pp. 654-663
    • Shim, J.S.1    Liu, J.O.2
  • 65
    • 60749128080 scopus 로고    scopus 로고
    • Pharmacology of proton pump inhibitors
    • 2855237 19006606
    • Shin JM, Sachs G. Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep. 2008;10(6):528-34.
    • (2008) Curr Gastroenterol Rep , vol.10 , Issue.6 , pp. 528-534
    • Shin, J.M.1    Sachs, G.2
  • 66
    • 84939621452 scopus 로고    scopus 로고
    • Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer
    • 4546346 26297142
    • Wang BY, Zhang J, Wang JL, Sun S, Wang ZH, Wang LP, et al. Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer. J Exp Clin Cancer Res. 2015;34(1):85.
    • (2015) J Exp Clin Cancer Res , vol.34 , Issue.1 , pp. 85
    • Wang, B.Y.1    Zhang, J.2    Wang, J.L.3    Sun, S.4    Wang, Z.H.5    Wang, L.P.6
  • 67
    • 9744260934 scopus 로고    scopus 로고
    • Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs
    • 1:CAS:528:DC%2BD2cXhtVSqsr%2FF 15547183
    • Luciani F, Spada M, De Milito A, Molinari A, Rivoltini L, Montinaro A, et al. Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. J Natl Cancer Inst. 2004;96(22):1702-13.
    • (2004) J Natl Cancer Inst , vol.96 , Issue.22 , pp. 1702-1713
    • Luciani, F.1    Spada, M.2    De Milito, A.3    Molinari, A.4    Rivoltini, L.5    Montinaro, A.6
  • 68
    • 84906966131 scopus 로고    scopus 로고
    • Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer
    • 4431491 25175076
    • Lindner K, Borchardt C, Schopp M, Burgers A, Stock C, Hussey DJ, et al. Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer. J Exp Clin Cancer Res. 2014;33:73.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 73
    • Lindner, K.1    Borchardt, C.2    Schopp, M.3    Burgers, A.4    Stock, C.5    Hussey, D.J.6
  • 69
    • 84875454018 scopus 로고    scopus 로고
    • XCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma
    • 1:CAS:528:DC%2BC3sXktVGisL0%3D 23319806
    • Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, et al. xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma. Cancer Res. 2013;73(6):1855-66.
    • (2013) Cancer Res , vol.73 , Issue.6 , pp. 1855-1866
    • Yoshikawa, M.1    Tsuchihashi, K.2    Ishimoto, T.3    Yae, T.4    Motohara, T.5    Sugihara, E.6
  • 70
    • 84872417679 scopus 로고    scopus 로고
    • Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
    • 3548977 1:CAS:528:DC%2BC3sXjvV2iuw%3D%3D 23291299
    • Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, et al. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. 2013;23(1):23-34.
    • (2013) Cancer Cell , vol.23 , Issue.1 , pp. 23-34
    • Kim, J.1    Aftab, B.T.2    Tang, J.Y.3    Kim, D.4    Lee, A.H.5    Rezaee, M.6
  • 71
    • 77950492233 scopus 로고    scopus 로고
    • Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
    • 4039177 1:CAS:528:DC%2BC3cXmsF2msb4%3D 20385363
    • Kim J, Tang JY, Gong R, Lee JJ, Clemons KV, Chong CR, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010;17(4):388-99.
    • (2010) Cancer Cell , vol.17 , Issue.4 , pp. 388-399
    • Kim, J.1    Tang, J.Y.2    Gong, R.3    Lee, J.J.4    Clemons, K.V.5    Chong, C.R.6
  • 72
    • 84875577954 scopus 로고    scopus 로고
    • The critical role of mast cell-derived hypoxia-inducible factor-1alpha in human and mice melanoma growth
    • 1:CAS:528:DC%2BC38XhslKmsb%2FN 23161568
    • Jeong HJ, Oh HA, Nam SY, Han NR, Kim YS, Kim JH, et al. The critical role of mast cell-derived hypoxia-inducible factor-1alpha in human and mice melanoma growth. Int J Cancer. 2013;132(11):2492-501.
    • (2013) Int J Cancer , vol.132 , Issue.11 , pp. 2492-2501
    • Jeong, H.J.1    Oh, H.A.2    Nam, S.Y.3    Han, N.R.4    Kim, Y.S.5    Kim, J.H.6
  • 73
    • 82955187599 scopus 로고    scopus 로고
    • Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms
    • 3204001 1:CAS:528:DC%2BC3MXhtl2rsr7N 21861192
    • Nicolau-Galmes F, Asumendi A, Alonso-Tejerina E, Perez-Yarza G, Jangi SM, Gardeazabal J, et al. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis. 2011;16(12):1253-67.
    • (2011) Apoptosis , vol.16 , Issue.12 , pp. 1253-1267
    • Nicolau-Galmes, F.1    Asumendi, A.2    Alonso-Tejerina, E.3    Perez-Yarza, G.4    Jangi, S.M.5    Gardeazabal, J.6
  • 74
    • 84884280144 scopus 로고    scopus 로고
    • Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathway
    • 1:CAS:528:DC%2BC3sXhtl2qtLzP 23973711
    • Park YH, Jung HH, Ahn JS, Im YH. Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathway. Biochem Biophys Res Commun. 2013;439(2):275-9.
    • (2013) Biochem Biophys Res Commun , vol.439 , Issue.2 , pp. 275-279
    • Park, Y.H.1    Jung, H.H.2    Ahn, J.S.3    Im, Y.H.4
  • 75
    • 4444252160 scopus 로고    scopus 로고
    • Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S)
    • 1:CAS:528:DC%2BD2cXntVOjt7c%3D 15337403
    • Strandberg TE, Pyorala K, Cook TJ, Wilhelmsen L, Faergeman O, Thorgeirsson G, et al. Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). Lancet. 2004;364(9436):771-7.
    • (2004) Lancet , vol.364 , Issue.9436 , pp. 771-777
    • Strandberg, T.E.1    Pyorala, K.2    Cook, T.J.3    Wilhelmsen, L.4    Faergeman, O.5    Thorgeirsson, G.6
  • 76
    • 84908080513 scopus 로고    scopus 로고
    • The target of metformin in type 2 diabetes
    • 25317875
    • Ferrannini E. The target of metformin in type 2 diabetes. N Engl J Med. 2014;371(16):1547-8.
    • (2014) N Engl J Med , vol.371 , Issue.16 , pp. 1547-1548
    • Ferrannini, E.1
  • 77
    • 84927666790 scopus 로고    scopus 로고
    • In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: Translational implications for human tumors
    • 4397725 25884842
    • Barbieri F, Thellung S, Ratto A, Carra E, Marini V, Fucile C, et al. In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors. BMC Cancer. 2015;15:228.
    • (2015) BMC Cancer , vol.15 , pp. 228
    • Barbieri, F.1    Thellung, S.2    Ratto, A.3    Carra, E.4    Marini, V.5    Fucile, C.6
  • 78
    • 84937511483 scopus 로고    scopus 로고
    • Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor
    • 1:CAS:528:DC%2BC2MXmt1Wlt7Y%3D 25862373
    • Kato H, Sekine Y, Furuya Y, Miyazawa Y, Koike H, Suzuki K. Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2015;461(1):115-21.
    • (2015) Biochem Biophys Res Commun , vol.461 , Issue.1 , pp. 115-121
    • Kato, H.1    Sekine, Y.2    Furuya, Y.3    Miyazawa, Y.4    Koike, H.5    Suzuki, K.6
  • 79
    • 84901696394 scopus 로고    scopus 로고
    • Direct effects of metformin in the endometrium: A hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
    • 4036091 24887156
    • Shao R, Li X, Feng Y, Lin JF, Billig H. Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma. J Exp Clin Cancer Res. 2014;33:41.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 41
    • Shao, R.1    Li, X.2    Feng, Y.3    Lin, J.F.4    Billig, H.5
  • 80
    • 84986915942 scopus 로고    scopus 로고
    • Membrane transporters for the special amino acid glutamine: Structure/function relationships and relevance to human health
    • 4127817 25157349
    • Pochini L, Scalise M, Galluccio M, Indiveri C. Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health. Front Chem. 2014;2:61.
    • (2014) Front Chem , vol.2 , pp. 61
    • Pochini, L.1    Scalise, M.2    Galluccio, M.3    Indiveri, C.4
  • 81
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • 1:CAS:528:DC%2BD28Xhslaqs74%3D 16469695
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124(3):471-84.
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 82
    • 84890860977 scopus 로고    scopus 로고
    • EpCAM expression in the prostate cancer makes the difference in the response to growth factors
    • 1:CAS:528:DC%2BC3sXhvFOhu7%2FO 24309103
    • Yoshida GJ, Saya H. EpCAM expression in the prostate cancer makes the difference in the response to growth factors. Biochem Biophys Res Commun. 2014;443(1):239-45.
    • (2014) Biochem Biophys Res Commun , vol.443 , Issue.1 , pp. 239-245
    • Yoshida, G.J.1    Saya, H.2
  • 83
    • 84886555397 scopus 로고    scopus 로고
    • Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma
    • 3832879 24168110
    • Betsunoh H, Fukuda T, Anzai N, Nishihara D, Mizuno T, Yuki H, et al. Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma. BMC Cancer. 2013;13:509.
    • (2013) BMC Cancer , vol.13 , pp. 509
    • Betsunoh, H.1    Fukuda, T.2    Anzai, N.3    Nishihara, D.4    Mizuno, T.5    Yuki, H.6
  • 84
    • 84867904232 scopus 로고    scopus 로고
    • High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas
    • 22813728
    • Yanagisawa N, Ichinoe M, Mikami T, Nakada N, Hana K, Koizumi W, et al. High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas. J Clin Pathol. 2012;65(11):1019-23.
    • (2012) J Clin Pathol , vol.65 , Issue.11 , pp. 1019-1023
    • Yanagisawa, N.1    Ichinoe, M.2    Mikami, T.3    Nakada, N.4    Hana, K.5    Koizumi, W.6
  • 85
    • 24044511771 scopus 로고    scopus 로고
    • Metabolic activation-related CD147-CD98 complex
    • 1351277 1:CAS:528:DC%2BD2MXpsFals7o%3D 15901826
    • Xu D, Hemler ME. Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics. 2005;4(8):1061-71.
    • (2005) Mol Cell Proteomics , vol.4 , Issue.8 , pp. 1061-1071
    • Xu, D.1    Hemler, M.E.2
  • 86
    • 84931265643 scopus 로고    scopus 로고
    • Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1
    • 4490376 1:CAS:528:DC%2BC2MXhtF2ktrnF 26065921
    • Takahashi RU, Miyazaki H, Takeshita F, Yamamoto Y, Minoura K, Ono M, et al. Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1. Nat Commun. 2015;6:7318.
    • (2015) Nat Commun , vol.6 , pp. 7318
    • Takahashi, R.U.1    Miyazaki, H.2    Takeshita, F.3    Yamamoto, Y.4    Minoura, K.5    Ono, M.6
  • 87
    • 0034795256 scopus 로고    scopus 로고
    • The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    • 1:CAS:528:DC%2BD3MXmvFOlsrk%3D 11533706
    • Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med. 2001;7(9):1028-34.
    • (2001) Nat Med , vol.7 , Issue.9 , pp. 1028-1034
    • Zhou, S.1    Schuetz, J.D.2    Bunting, K.D.3    Colapietro, A.M.4    Sampath, J.5    Morris, J.J.6
  • 88
    • 60949083043 scopus 로고    scopus 로고
    • Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity
    • 1:CAS:528:DC%2BD1MXivVehtrk%3D 19374858
    • Chin CN, Dallas-Yang Q, Liu F, Ho T, Ellsworth K, Fischer P, et al. Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity. Eur J Pharmacol. 2009;606(1-3):17-24.
    • (2009) Eur J Pharmacol , vol.606 , Issue.1-3 , pp. 17-24
    • Chin, C.N.1    Dallas-Yang, Q.2    Liu, F.3    Ho, T.4    Ellsworth, K.5    Fischer, P.6


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