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Volumn 9, Issue 8, 2018, Pages

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

Author keywords

[No Author keywords available]

Indexed keywords

LIPID PEROXIDE; MEPACRINE; TEMOZOLOMIDE; MAP1LC3B PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; SEQUESTOSOME 1; SQSTM1 PROTEIN, HUMAN;

EID: 85051276927     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/s41419-018-0864-7     Document Type: Article
Times cited : (201)

References (65)
  • 1
    • 84902489371 scopus 로고    scopus 로고
    • The epidemiology of glioma in adults: a “state of the science
    • PID: 24842956
    • Ostrom, Q. T. et al. The epidemiology of glioma in adults: a “state of the science”. Neuro. Oncol. 16, 896–913 (2014)
    • (2014) Neuro. Oncol. , vol.16 , pp. 896-913
    • Ostrom, Q.T.1
  • 3
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • PID: 15758009
    • Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New Engl. J. Med. 352, 987–996 (2005)
    • (2005) New Engl. J. Med. , vol.352 , pp. 987-996
    • Stupp, R.1
  • 4
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • PID: 15549107
    • Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396–401 (2004)
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 5
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • PID: 15466194
    • Galli, R. et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 64, 7011–7021 (2004)
    • (2004) Cancer Res. , vol.64 , pp. 7011-7021
    • Galli, R.1
  • 6
    • 84856741413 scopus 로고    scopus 로고
    • Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment
    • PID: 22290263
    • Nduom, E. K., Hadjipanayis, C. G. & Van Meir, E. G. Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment. Cancer J. 18, 100–106 (2012)
    • (2012) Cancer J. , vol.18 , pp. 100-106
    • Nduom, E.K.1    Hadjipanayis, C.G.2    Van Meir, E.G.3
  • 7
    • 85037104383 scopus 로고    scopus 로고
    • Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells
    • PID: 28726781
    • Pagotto, A. et al. Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells. Cell Death Dis. 8, e2943 (2017)
    • (2017) Cell Death Dis. , vol.8
    • Pagotto, A.1
  • 8
    • 0038743077 scopus 로고    scopus 로고
    • Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
    • PID: 12727826
    • Kanzawa, T., Kondo, Y., Ito, H., Kondo, S. & Germano, I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res. 63, 2103–2108 (2003)
    • (2003) Cancer Res. , vol.63 , pp. 2103-2108
    • Kanzawa, T.1    Kondo, Y.2    Ito, H.3    Kondo, S.4    Germano, I.5
  • 9
    • 1842865745 scopus 로고    scopus 로고
    • Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
    • PID: 14713959
    • Kanzawa, T. et al. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 11, 448–457 (2004)
    • (2004) Cell Death Differ. , vol.11 , pp. 448-457
    • Kanzawa, T.1
  • 10
    • 33847008972 scopus 로고    scopus 로고
    • DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells
    • PID: 16946731
    • Katayama, M., Kawaguchi, T., Berger, M. S. & Pieper, R. O. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ. 14, 548–558 (2007)
    • (2007) Cell Death Differ. , vol.14 , pp. 548-558
    • Katayama, M.1    Kawaguchi, T.2    Berger, M.S.3    Pieper, R.O.4
  • 11
    • 44449101761 scopus 로고    scopus 로고
    • Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma
    • PID: 18360710
    • Bilir, A. et al. Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma. Int. J. Oncol. 32, 829–839 (2008)
    • (2008) Int. J. Oncol. , vol.32 , pp. 829-839
    • Bilir, A.1
  • 12
    • 66349119373 scopus 로고    scopus 로고
    • Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity
    • PID: 19270491
    • Shingu, T. et al. Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity. Autophagy 5, 537–539 (2009)
    • (2009) Autophagy , vol.5 , pp. 537-539
    • Shingu, T.1
  • 13
    • 58749088233 scopus 로고    scopus 로고
    • Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
    • PID: 19048625
    • Shingu, T. et al. Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int. J. Cancer 124, 1060–1071 (2009)
    • (2009) Int. J. Cancer , vol.124 , pp. 1060-1071
    • Shingu, T.1
  • 14
    • 77954739712 scopus 로고    scopus 로고
    • A. Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
    • Geng, Y., Kohli, L., Klocke, B. J., & Roth, K. A. Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. 12, 473–481 (2010)
    • (2010) 12 , pp. 473-481
    • Geng, Y.1    Kohli, L.2    Klocke, B.J.3    Roth, K.4
  • 15
    • 4444313754 scopus 로고    scopus 로고
    • Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine
    • PID: 15727424
    • Briceño, E., Reyes, S. & Sotelo, J. Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine. Neurosurg. Focus 14, e3 (2003)
    • (2003) Neurosurg. Focus , vol.14
    • Briceño, E.1    Reyes, S.2    Sotelo, J.3
  • 16
    • 33645115547 scopus 로고    scopus 로고
    • Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial
    • PID: 16520474
    • Sotelo, J., Briceño, E. & López-González, M. A. Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 144, 337–343 (2006)
    • (2006) Ann. Intern. Med. , vol.144 , pp. 337-343
    • Sotelo, J.1    Briceño, E.2    López-González, M.A.3
  • 17
    • 66649116856 scopus 로고    scopus 로고
    • Chloroquine in glioblastoma-new horizons for an old drug
    • PID: 19326448
    • Munshi, A. Chloroquine in glioblastoma-new horizons for an old drug. Cancer 115, 2380–2383 (2009)
    • (2009) Cancer , vol.115 , pp. 2380-2383
    • Munshi, A.1
  • 18
    • 85014069382 scopus 로고    scopus 로고
    • Targeting autophagy in cancer stem cells as an anticancer therapy
    • PID: 28216370
    • Lei, Y. et al. Targeting autophagy in cancer stem cells as an anticancer therapy. Cancer Lett. 393, 33–39 (2017)
    • (2017) Cancer Lett. , vol.393 , pp. 33-39
    • Lei, Y.1
  • 19
    • 85013763791 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
    • PID: 26799652
    • Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1–222 (2016)
    • (2016) Autophagy , vol.12 , pp. 1-222
    • Klionsky, D.J.1
  • 20
    • 84873830422 scopus 로고    scopus 로고
    • Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage
    • Knizhnik, A. V. et al. Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage. PLoS One 8, e564–e565 (2013)
    • (2013) PLoS One , vol.8 , pp. e564-e565
    • Knizhnik, A.V.1
  • 21
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • PID: 17051156
    • Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756–760 (2006)
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1
  • 22
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • PID: 22854781
    • Chen, J. et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488, 522–526 (2012)
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1
  • 23
    • 85026901428 scopus 로고    scopus 로고
    • The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response
    • D’Alessandris, Q. G. et al. The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response. Neuro. Oncol. 8, 1097–1108 (2017)
    • (2017) Neuro. Oncol. , vol.8 , pp. 1097-1108
    • D’Alessandris, Q.G.1
  • 24
    • 84859609587 scopus 로고    scopus 로고
    • Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells
    • PID: 22406827
    • Guo, X. L. et al. Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett. 320, 171–179 (2012)
    • (2012) Cancer Lett. , vol.320 , pp. 171-179
    • Guo, X.L.1
  • 25
    • 37549056216 scopus 로고    scopus 로고
    • The roles of therapy-induced autophagy and necrosis in cancer treatment
    • PID: 18094407
    • Amaravadi, R. K. & Thompson, C. B. The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin. Cancer Res. 13, 7271–7279 (2007)
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7271-7279
    • Amaravadi, R.K.1    Thompson, C.B.2
  • 26
    • 84975882792 scopus 로고    scopus 로고
    • Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway
    • PID: 27328819
    • Chen, X. et al. Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. Sci. Rep. 6, 28423 (2016)
    • (2016) Sci. Rep. , vol.6
    • Chen, X.1
  • 27
    • 84929648600 scopus 로고    scopus 로고
    • Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors
    • Golden, E. B. et al. Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors. Neurosurg. Focus 3, E12 (2015)
    • (2015) Neurosurg. Focus , vol.3 , pp. E12
    • Golden, E.B.1
  • 28
    • 85036533976 scopus 로고    scopus 로고
    • Molecular mechanisms of cell death: recomandations of the Nomenclature Commitee on Cell Death 2018
    • Galluzzi, L. et al. Molecular mechanisms of cell death: recomandations of the Nomenclature Commitee on Cell Death 2018. Cell Death Differ. 10.1038/s41418-017-0012-4 (2018)
    • (2018) Cell Death Differ.
    • Galluzzi, L.1
  • 29
    • 85040691316 scopus 로고    scopus 로고
    • miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
    • Luo, M. et al. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ. 10.1038/s41418-017-0053-8 (2018)
    • (2018) Cell Death Differ.
    • Luo, M.1
  • 30
    • 84892685001 scopus 로고    scopus 로고
    • Regulation of ferroptotic cancer cell death by GPX4
    • PID: 24439385
    • Yang, W. S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317–331 (2014)
    • (2014) Cell , vol.156 , pp. 317-331
    • Yang, W.S.1
  • 31
    • 84898641223 scopus 로고    scopus 로고
    • Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine. Implications for cancer therapies
    • Pellegrini, P. et al. Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine. Implications for cancer therapies. Autophagy 4, 562–571 (2014)
    • (2014) Autophagy , vol.4 , pp. 562-571
    • Pellegrini, P.1
  • 32
    • 49949099841 scopus 로고    scopus 로고
    • Mesenchymal differentiation of glioblastoma stem cells
    • PID: 18497759
    • Ricci-Vitiani, L. et al. Mesenchymal differentiation of glioblastoma stem cells. Cell Death Differ. 15, 1491–1498 (2008)
    • (2008) Cell Death Differ. , vol.15 , pp. 1491-1498
    • Ricci-Vitiani, L.1
  • 33
    • 58149340463 scopus 로고    scopus 로고
    • Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    • PID: 19088037
    • Pallini, R. et al. Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin. Cancer Res. 14, 8205–8212 (2008)
    • (2008) Clin. Cancer Res. , vol.14 , pp. 8205-8212
    • Pallini, R.1
  • 34
    • 84883656941 scopus 로고    scopus 로고
    • Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma
    • PID: 23993863
    • Bhat, K. P. et al. Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma. Cancer Cell. 24, 331–346 (2013)
    • (2013) Cancer Cell. , vol.24 , pp. 331-346
    • Bhat, K.P.1
  • 35
    • 34548156768 scopus 로고    scopus 로고
    • Brain tumour stem cells: possibilities of new therapeutic strategies
    • PID: 17696813
    • Piccirillo, S. G. & Vescovi, A. L. Brain tumour stem cells: possibilities of new therapeutic strategies. Expert. Opin. Biol. Ther. 7, 1129–1135 (2007)
    • (2007) Expert. Opin. Biol. Ther. , vol.7 , pp. 1129-1135
    • Piccirillo, S.G.1    Vescovi, A.L.2
  • 36
    • 79955525434 scopus 로고    scopus 로고
    • Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway
    • Galan-Moya, E. M. et al. Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway. EMBO Rep. 5, 470–476 (2011)
    • (2011) EMBO Rep. , vol.5 , pp. 470-476
    • Galan-Moya, E.M.1
  • 37
    • 84964733829 scopus 로고    scopus 로고
    • Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas
    • Jennewein, L. et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget 15, 20016–20032 (2016)
    • (2016) Oncotarget , vol.15 , pp. 20016-20032
    • Jennewein, L.1
  • 38
    • 80052697287 scopus 로고    scopus 로고
    • The role of autophagy in cancer: therapeutic implications
    • PID: 21878654
    • Yang, Z. J., Chee, C. E., Huang & Sinicrope, F. A. The role of autophagy in cancer: therapeutic implications. Mol. Cancer Ther. 10, 1533–1541 (2011)
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1533-1541
    • Yang, Z.J.1    Chee, C.E.2    Huang3    Sinicrope, F.A.4
  • 39
    • 84956932895 scopus 로고    scopus 로고
    • Targeting autophagy to sensitive glioma to temozolomide treatment
    • Yuanliang, Y. et al. Targeting autophagy to sensitive glioma to temozolomide treatment. J. Exp. Clin. Cancer Res. 35, 23 (2016)
    • (2016) J. Exp. Clin. Cancer Res. , vol.35 , pp. 23
    • Yuanliang, Y.1
  • 40
    • 78751527443 scopus 로고    scopus 로고
    • A combined preclinical therapy of cannabinoids and temozolomide against glioma
    • PID: 21220494
    • Torres, S. et al. A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol. Cancer Ther. 10, 90–103 (2011)
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 90-103
    • Torres, S.1
  • 41
    • 63949085760 scopus 로고    scopus 로고
    • Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo
    • PID: 19277041
    • Ulasov, I. V. et al. Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo. Br. J. Cancer 100, 1154–1164 (2009)
    • (2009) Br. J. Cancer , vol.100 , pp. 1154-1164
    • Ulasov, I.V.1
  • 42
    • 65549166946 scopus 로고    scopus 로고
    • Bicarbonate increases tumor pH and inhibits spontaneous metastases
    • PID: 19276390
    • Robey, I. F. et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 69, 2260–2268 (2009)
    • (2009) Cancer Res. , vol.69 , pp. 2260-2268
    • Robey, I.F.1
  • 43
    • 85013469149 scopus 로고    scopus 로고
    • Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies
    • PID: 28195314
    • Pötzl, J. et al. Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies. Int. J. Cancer 140, 2125–2133 (2017)
    • (2017) Int. J. Cancer , vol.140 , pp. 2125-2133
    • Pötzl, J.1
  • 44
    • 84908666232 scopus 로고    scopus 로고
    • Therapeutic exploitation of necroptosis for cancer therapy
    • PID: 25065969
    • Fulda, S. Therapeutic exploitation of necroptosis for cancer therapy. Semin. Cell. Dev. Biol. 35, 51–56 (2014)
    • (2014) Semin. Cell. Dev. Biol. , vol.35 , pp. 51-56
    • Fulda, S.1
  • 45
    • 57649181391 scopus 로고    scopus 로고
    • Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
    • Hitomi., J. et al. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 7, 1311–1323 (2008)
    • (2008) Cell , vol.7 , pp. 1311-1323
    • Hitomi, J.1
  • 46
    • 34250748014 scopus 로고    scopus 로고
    • Shikonin circumvents cancer drug resistance by induction of a necroptotic death
    • PID: 17513612
    • Han, W. et al. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol. Cancer Ther. 6, 1641–1649 (2007)
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1641-1649
    • Han, W.1
  • 47
    • 84883648774 scopus 로고    scopus 로고
    • Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells
    • Racoma, I. O., Meisen, W. H., Wang, Q. E., Kaur, B. & Wani, A. A. Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells. PLoS One 8, 72882 (2013)
    • (2013) PLoS One , vol.8
    • Racoma, I.O.1    Meisen, W.H.2    Wang, Q.E.3    Kaur, B.4    Wani, A.A.5
  • 48
    • 84962637563 scopus 로고    scopus 로고
    • Mechanisms of ferroptosis
    • PID: 27048822
    • Cao, J. Y. & Dixon, S. J. Mechanisms of ferroptosis. Cell. Mol. Life Sci. 73, 2195–2209 (2016)
    • (2016) Cell. Mol. Life Sci. , vol.73 , pp. 2195-2209
    • Cao, J.Y.1    Dixon, S.J.2
  • 49
    • 85018960248 scopus 로고    scopus 로고
    • Ferroptosis: bug or feature?
    • Dixon, S. J. Ferroptosis: bug or feature? Immunol 277, 150–157 (2017)
    • (2017) Immunol , vol.277 , pp. 150-157
    • Dixon, S.J.1
  • 50
    • 84861541814 scopus 로고    scopus 로고
    • Ferroptosis: an iron-dependent form of non-apoptotic cell death
    • Dixon, S. J. et al. Ferroptosis: an iron-dependent form of non-apoptotic cell death. Cell 5, 1060–1072 (2012)
    • (2012) Cell , vol.5 , pp. 1060-1072
    • Dixon, S.J.1
  • 51
    • 84957429081 scopus 로고    scopus 로고
    • Ferroptosis: process and function
    • PID: 26794443
    • Xie, Y. et al. Ferroptosis: process and function. Cell Death Differ. 23, 369–379 (2016)
    • (2016) Cell Death Differ. , vol.23 , pp. 369-379
    • Xie, Y.1
  • 52
    • 84925286831 scopus 로고    scopus 로고
    • Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
    • PID: 25402683
    • Friedmann Angeli, J. P. et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell Biol. 16, 1180–1191 (2014)
    • (2014) Nat. Cell Biol. , vol.16 , pp. 1180-1191
    • Friedmann Angeli, J.P.1
  • 53
    • 85012284181 scopus 로고    scopus 로고
    • A mitochondrial-targeted nitroxide is a potent inhibitor of ferroptosis
    • Krainz, T. et al. A mitochondrial-targeted nitroxide is a potent inhibitor of ferroptosis. ACS Cent. Sci. 9, 653–659 (2016)
    • (2016) ACS Cent. Sci. , vol.9 , pp. 653-659
    • Krainz, T.1
  • 54
    • 84983666736 scopus 로고    scopus 로고
    • Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
    • PID: 27506793
    • Yang, W. S. et al. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc. Natl. Acad. Sci. Usa. 113, E4966–E4975 (2016)
    • (2016) Proc. Natl. Acad. Sci. Usa. , vol.113 , pp. E4966-E4975
    • Yang, W.S.1
  • 55
    • 84921647344 scopus 로고    scopus 로고
    • Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‐gamma‐lyase function
    • PID: 25585997
    • Chen, L. et al. Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‐gamma‐lyase function. Oncol. Rep. 33, 1465–1474 (2015)
    • (2015) Oncol. Rep. , vol.33 , pp. 1465-1474
    • Chen, L.1
  • 56
    • 85021891297 scopus 로고    scopus 로고
    • Salinomycin kills cancer stem cells by sequestering iron in lysosomes
    • PID: 28937680
    • Mai, T. T. et al. Salinomycin kills cancer stem cells by sequestering iron in lysosomes. Nat. Chem. 9, 1025–1033 (2017)
    • (2017) Nat. Chem. , vol.9 , pp. 1025-1033
    • Mai, T.T.1
  • 57
    • 85023177162 scopus 로고    scopus 로고
    • An iron hand over cancer stem cells
    • PID: 28613094
    • Hamaï, A. et al. An iron hand over cancer stem cells. Autophagy 13, 1465–1466 (2017)
    • (2017) Autophagy , vol.13 , pp. 1465-1466
    • Hamaï, A.1
  • 58
    • 84975132567 scopus 로고    scopus 로고
    • An essential role for functional lysosomes in ferroptosis of cancer cells
    • PID: 26759376
    • Torii, S. et al. An essential role for functional lysosomes in ferroptosis of cancer cells. Biochem. J. 473, 769–777 (2016)
    • (2016) Biochem. J. , vol.473 , pp. 769-777
    • Torii, S.1
  • 59
    • 84976292806 scopus 로고    scopus 로고
    • Autophagy promotes ferroptosis by degradation of ferritin
    • PID: 27245739
    • Hou, W. et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy 12, 1425–1428 (2016)
    • (2016) Autophagy , vol.12 , pp. 1425-1428
    • Hou, W.1
  • 60
    • 84982123825 scopus 로고    scopus 로고
    • Ferroptosis is an autophagic cell death process
    • PID: 27514700
    • Gao, M. et al. Ferroptosis is an autophagic cell death process. Cell Res. 26, 1021–1032 (2016)
    • (2016) Cell Res. , vol.26 , pp. 1021-1032
    • Gao, M.1
  • 61
    • 0038756365 scopus 로고    scopus 로고
    • Glioblastoma induces vascular endothelial cells to express telomerase in vitro
    • Casalbore, P., Maggiano, N., Levi, A., Larocca, L. M. & Pallini, R. Glioblastoma induces vascular endothelial cells to express telomerase in vitro. Cancer Res. 13, 3750–37544 (2003)
    • (2003) Cancer Res. , vol.13 , pp. 3750-37544
    • Casalbore, P.1    Maggiano, N.2    Levi, A.3    Larocca, L.M.4    Pallini, R.5
  • 62
    • 84901001820 scopus 로고    scopus 로고
    • Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo
    • PID: 24810059
    • Signore, M. et al. Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis. 5, e1223 (2014)
    • (2014) Cell Death Dis. , vol.5
    • Signore, M.1
  • 63
    • 0038447100 scopus 로고    scopus 로고
    • Evaluation of quinacrine treatment for prion diseases
    • PID: 12857915
    • Barret, A. et al. Evaluation of quinacrine treatment for prion diseases. J. Virol. 77, 8462–8469 (2003)
    • (2003) J. Virol. , vol.77 , pp. 8462-8469
    • Barret, A.1
  • 64
    • 0035908839 scopus 로고    scopus 로고
    • Old drugs to treat new variant Creutzfeldt-Jakob disease
    • PID: 11520533
    • Love, R. Old drugs to treat new variant Creutzfeldt-Jakob disease. Lancet 358, 563 (2001)
    • (2001) Lancet , vol.358 , pp. 563
    • Love, R.1
  • 65
    • 84866116474 scopus 로고    scopus 로고
    • A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells
    • Tate, C. M. et al. A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells. Cell Death Diff. 19, 1644–1654 (2012)
    • (2012) Cell Death Diff. , vol.19 , pp. 1644-1654
    • Tate, C.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.