AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity

Current Biology

Volumn 28, Issue 15, 2018, Pages 2388-2399.e5

  Song, Xinxin ^a,b   Zhu, Shan ^a   Chen, Pan ^b   Hou, Wen ^b   Wen, Qirong ^a   Liu, Jiao ^a   Xie, Yangchun ^b,c   Liu, Jinbao ^a   Klionsky, Daniel J ^d   Kroemer, Guido ^{e,f,g,h,i,j,k}   Lotze, Michael T ^b   Zeh, Herbert J ^b   Kang, Rui ^b   Tang, Daolin ^a,b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d UNIVERSITY OF MICHIGAN   (United States)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f CENTRE DE RECHERCHE DES CORDELIERS   (France)

^g INSERM   (France)

^h SORBONNE UNIVERSITÉ   (France)

ⁱ INSTITUT GUSTAVE ROUSSY   (France)

^j HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^k KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

more..

Author keywords

AMPK; autophagy; autosis; BECN1; cancer therapy; ferroptosis; lipid peroxidation; necroptosis; phosphorylation; SLC7A11

Indexed keywords

AMINO ACID TRANSPORTER; BECLIN 1; BECN1 PROTEIN, HUMAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PRKAA1 PROTEIN, HUMAN; PRKAA2 PROTEIN, HUMAN; SLC7A11 PROTEIN, HUMAN;

ANIMAL; APOPTOSIS; C57BL MOUSE; FEMALE; GENETICS; HCT 116 CELL LINE; HEK293 CELL LINE; HELA CELL LINE; HUMAN; MALE; METABOLISM; MOUSE; NUDE MOUSE; PHOSPHORYLATION;

AMINO ACID TRANSPORT SYSTEM Y+; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; BECLIN-1; FEMALE; HCT116 CELLS; HEK293 CELLS; HELA CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; PHOSPHORYLATION;

EID: 85052245827     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2018.05.094     Document Type: Article

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