Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis

Animal Cells and Systems

Volumn 22, Issue 5, 2018, Pages 334-340

  Park, Sujeong ^a   Oh, Jinjoo ^a   Kim, Minhee ^a   Jin, Eun Jung ^a  

^a Wonkwang University   (South Korea)

Author keywords

ACSL 4; bromelain; Colon cancer; ferroptosis; miRNA

Indexed keywords

EID: 85053050538     PISSN: 19768354     EISSN: 21512485     Source Type: Journal    
DOI: 10.1080/19768354.2018.1512521     Document Type: Article

References (22)

1. Amini A, Masoumi-Moghaddam S, Ehteda A, Morris DL., 2014. Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy. J Exp Clin Cancer Res. 33:92.
2. Bhatnagar P, Pant AB, Shukla Y, Chaudhari B, Kumar P, Gupta KC., 2015. Bromelain nanoparticles protect against 7,12-dimethylbenz(a)anthracene induced skin carcinogenesis in mouse model. Eur J Pharm Biopharm. 91:35–46. doi: 10.1016/j.ejpb.2015.01.015
3. Bhui K, Tyagi S, Prakash B, Shukla Y., 2010. Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells. Biofactors. 36:474–482. doi: 10.1002/biof.121
4. Bhui K, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y., 2012. Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis. Mol Carcinog. 51:231–243. doi: 10.1002/mc.20769
5. Birt DF, Phillips GJ., 2014. Diet, genes, and microbes: complexities of colon cancer prevention. Toxicol Pathol. 42:182–188. doi: 10.1177/0192623313506791
6. Brien S, Lewith G, Walker A, Hicks SM, Middleton D., 2004. Bromelain as a treatment for osteoarthritis: a review of Clinical Studies. Evid Based Complement Alternat Med. 1:251–257. doi: 10.1093/ecam/neh035
7. Castagnola P, Giaretti W., 2005. Mutant KRAS, chromosomal instability and prognosis in colorectal cancer. Biochim Biophys Acta. 1756:115–125.
8. Chobotova K, Vernallis AB, Majid FA., 2010. Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives. Cancer Lett. 290:148–156. doi: 10.1016/j.canlet.2009.08.001
9. Coppede F., 2014. The role of epigenetics in colorectal cancer. Expert Rev Gastroenterol Hepatol. 8:935–948. doi: 10.1586/17474124.2014.924397
10. Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A., 2012. Bromelain-induced apoptosis in GI-101A breast cancer cells. J Med Food. 15:344–349. doi: 10.1089/jmf.2011.0145
11. Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, et al. 2017. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 13:91–98. doi: 10.1038/nchembio.2239
12. Inoue Y, Saigusa S, Iwata T, Okugawa Y, Toiyama Y, Tanaka K, Uchida K, Mohri Y, Kusunoki M., 2012. The prognostic value of KRAS mutations in patients with colorectal cancer. Oncol Rep. 28:1579–1584. doi: 10.3892/or.2012.1974
13. Kane S, Goldberg MJ., 2000. Use of bromelain for mild ulcerative colitis. Ann Intern Med. 132:680. doi: 10.7326/0003-4819-132-8-200004180-00026
14. Kim DH., 2013. Colorectal cancer epidemic in Korea. Ann Coloproctol. 29:1–4. doi: 10.3393/ac.2013.29.1.1
15. Levi F, Pasche C, La Vecchia C, Lucchini F, Franceschi S., 1999. Food groups and colorectal cancer risk. Br J Cancer. 79:1283–1287. doi: 10.1038/sj.bjc.6690206
16. Liu X, Jakubowski M, Hunt JL., 2011. KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis. Am J Clin Pathol. 135:245–252. doi: 10.1309/AJCP7FO2VAXIVSTP
17. Pavan R, Jain S, Shraddha KA, Kumar A., 2012. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012:1–6. doi: 10.1155/2012/976203
18. Rajamanickam S, Agarwal R., 2008. Natural products and colon cancer: current status and future prospects. Drug Dev Res. 69:460–471. doi: 10.1002/ddr.20276
19. Romano B, Fasolino I, Pagano E, Capasso R, Pace S, De Rosa G, Milic N, Orlando P, Izzo AA, Borrelli F., 2014. The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects. Mol Nutr Food Res. 58:457–465. doi: 10.1002/mnfr.201300345
20. Secor ER, Jr, Carson W, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS., 2005. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol. 237:68–75. doi: 10.1016/j.cellimm.2005.10.002
21. Secor ER, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS., 2008. Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma. Evid Based Complement Alternat Med. 5:61–69. doi: 10.1093/ecam/nel110
22. Yang WS, Stockwell BR., 2016. Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol. 26:165–176. doi: 10.1016/j.tcb.2015.10.014