메뉴 건너뛰기




Volumn 17, Issue 3, 2018, Pages 299-313

Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links

Author keywords

Central obesity; Cytokines; Insulin resistance; Metabolic syndrome; Single nucleotide polymorphisms

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; BETA 3 ADRENERGIC RECEPTOR; FERRITIN; HEPCIDIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN SENSITIZING AGENT; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; URIC ACID;

EID: 85052990700     PISSN: 11093099     EISSN: 25208721     Source Type: Journal    
DOI: 10.1007/s42000-018-0051-3     Document Type: Review
Times cited : (161)

References (164)
  • 1
    • 84875686432 scopus 로고    scopus 로고
    • What is metabolic syndrome, and why are children getting it?
    • PID: 23356701
    • Weiss R, Bremer AA, Lustig RH (2013) What is metabolic syndrome, and why are children getting it? Ann N Y Acad Sci 1281:123–140
    • (2013) Ann N Y Acad Sci , vol.1281 , pp. 123-140
    • Weiss, R.1    Bremer, A.A.2    Lustig, R.H.3
  • 2
    • 25144459980 scopus 로고    scopus 로고
    • IDF epidemiology task force consensus group. The metabolic syndrome—a new worldwide definition
    • PID: 16182882
    • Alberti KG, Zimmet P, Shaw J (2005) IDF epidemiology task force consensus group. The metabolic syndrome—a new worldwide definition. Lancet 366:1059–1062
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 3
    • 42249093870 scopus 로고    scopus 로고
    • Metabolic syndrome pandemic
    • PID: 18174459
    • Grundy SM (2008) Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 28:629–663
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 629-663
    • Grundy, S.M.1
  • 4
    • 84958787579 scopus 로고    scopus 로고
    • Association between metabolic syndrome and cancer
    • PID: 26895247
    • Uzunlulu M, Telci Caklili O, Oguz A (2016) Association between metabolic syndrome and cancer. Ann Nutr Metab 68:173–179
    • (2016) Ann Nutr Metab , vol.68 , pp. 173-179
    • Uzunlulu, M.1    Telci Caklili, O.2    Oguz, A.3
  • 5
    • 0000939795 scopus 로고
    • Studien ueber das Hypertonie-Hyperglyca “mie-Hyperurika” miesyndrom
    • Kylin E (1923) Studien ueber das Hypertonie-Hyperglyca “mie-Hyperurika” miesyndrom. Zentralblatt fuer Innere Medizin 44:105–127
    • (1923) Zentralblatt fuer Innere Medizin , vol.44 , pp. 105-127
    • Kylin, E.1
  • 6
    • 0001217241 scopus 로고
    • Sexual differentiation. A factor affecting the forms of obesity
    • Vague J (1947) Sexual differentiation. A factor affecting the forms of obesity. Presse Med 30:S39–S40
    • (1947) Presse Med , vol.30 , pp. S39-S40
    • Vague, J.1
  • 7
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • PID: 3056758
    • Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37:1595–1607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 8
    • 84897522177 scopus 로고    scopus 로고
    • A comprehensive review on metabolic syndrome
    • PID: 24711954
    • Kaur J (2014) A comprehensive review on metabolic syndrome. Cardiol Res Pract 2014:943162
    • (2014) Cardiol Res Pract , vol.2014 , pp. 943162
    • Kaur, J.1
  • 9
    • 84929501636 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome in the United States, 2003–2012
    • PID: 25988468
    • Aguilar M, Bhuket T, Torres S, Liu B, Wong RJ (2015) Prevalence of the metabolic syndrome in the United States, 2003–2012. JAMA 313:1973–1974
    • (2015) JAMA , vol.313 , pp. 1973-1974
    • Aguilar, M.1    Bhuket, T.2    Torres, S.3    Liu, B.4    Wong, R.J.5
  • 10
    • 84923190501 scopus 로고    scopus 로고
    • Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies
    • PID: 25407540
    • O'Neill S, O'Driscol L (2015) Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev 16:1–12
    • (2015) Obes Rev , vol.16 , pp. 1-12
    • O'Neill, S.1    O'Driscol, L.2
  • 11
    • 85016045219 scopus 로고    scopus 로고
    • Sex and gender related prevalence, cardiovascular risk and therapeutic approach in metabolic syndrome: a review of the literature
    • PID: 28300617
    • Pucci G, Alcidi R, Tap L, Battista F, Mattace-Raso F, Schillaci Pucci G (2017) Sex and gender related prevalence, cardiovascular risk and therapeutic approach in metabolic syndrome: a review of the literature. Pharmacol Res 120:34–42
    • (2017) Pharmacol Res , vol.120 , pp. 34-42
    • Pucci, G.1    Alcidi, R.2    Tap, L.3    Battista, F.4    Mattace-Raso, F.5    Schillaci Pucci, G.6
  • 12
    • 79951698595 scopus 로고    scopus 로고
    • Age and sex differences in the clustering of metabolic syndrome factors: association with mortality risk
    • PID: 20699434
    • Kuk JL, Ardern CI (2010) Age and sex differences in the clustering of metabolic syndrome factors: association with mortality risk. Diabetes Care 33:2457–2461
    • (2010) Diabetes Care , vol.33 , pp. 2457-2461
    • Kuk, J.L.1    Ardern, C.I.2
  • 13
    • 84883311618 scopus 로고    scopus 로고
    • Prevalence and trends of metabolic syndrome in the adult US population, 1999–2010
    • PID: 23810877
    • Beltrán-Sánchez H, Harhay MO (2013) Prevalence and trends of metabolic syndrome in the adult US population, 1999–2010. J Am Coll Cardiol 62:697–703
    • (2013) J Am Coll Cardiol , vol.62 , pp. 697-703
    • Beltrán-Sánchez, H.1    Harhay, M.O.2
  • 14
    • 84888875523 scopus 로고    scopus 로고
    • Retrospective analysis of metabolic syndrome: prevalence and distribution in executive population in urban Pakistan
    • PID: 22988504
    • Ali NS, Khuwaja AK, Adnan-ur-Rehman, Nauji K (2012) Retrospective analysis of metabolic syndrome: prevalence and distribution in executive population in urban Pakistan. Int J Family Med 2012:649383
    • (2012) Int J Family Med , vol.2012 , pp. 649383
    • Ali, N.S.1    Khuwaja, A.K.2    Adnan-ur-Rehman3    Nauji, K.4
  • 15
    • 33645978121 scopus 로고    scopus 로고
    • Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation
    • PID: 16681555
    • Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 23:469–480
    • (2006) Diabet Med , vol.23 , pp. 469-480
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 16
    • 51349141684 scopus 로고    scopus 로고
    • Prevalence of metabolic syndrome in Pakistan
    • Basit A, Shera AS (2008) Prevalence of metabolic syndrome in Pakistan. Metab Syndr Relat Disord 6:15–17
    • (2008) Metab Syndr Relat Disord , vol.6 , pp. 15-17
    • Basit, A.1    Shera, A.S.2
  • 17
    • 66749086332 scopus 로고    scopus 로고
    • Prevalence of metabolic syndrome in urban Pakistan (Karachi): comparison of newly proposed International Diabetes Federation and modified Adult Treatment Panel III criteria
    • PID: 18928398
    • Hydrie MZ, Shera AS, Fawwad A, Basit A, Hussain A (2009) Prevalence of metabolic syndrome in urban Pakistan (Karachi): comparison of newly proposed International Diabetes Federation and modified Adult Treatment Panel III criteria. Metab Syndr Relat Disord 7:119–124
    • (2009) Metab Syndr Relat Disord , vol.7 , pp. 119-124
    • Hydrie, M.Z.1    Shera, A.S.2    Fawwad, A.3    Basit, A.4    Hussain, A.5
  • 18
    • 84930680618 scopus 로고    scopus 로고
    • Comparisons of different metabolic syndrome definitions and associations with coronary heart disease, stroke, and peripheral arterial disease in a rural Chinese population
    • PID: 25961739
    • Wen J, Yang J, Shi Y (2015) Comparisons of different metabolic syndrome definitions and associations with coronary heart disease, stroke, and peripheral arterial disease in a rural Chinese population. PLoS One 10:e0126832
    • (2015) PLoS One , vol.10
    • Wen, J.1    Yang, J.2    Shi, Y.3
  • 19
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • PID: 19805654
    • Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 20
    • 79955562491 scopus 로고    scopus 로고
    • Metabolic syndrome: definitions and controversies
    • PID: 21542944
    • Kassi E, Pervanidou P, Kaltsas G, Chrousos G (2011) Metabolic syndrome: definitions and controversies. BMC Med 9:48
    • (2011) BMC Med , vol.9 , pp. 48
    • Kassi, E.1    Pervanidou, P.2    Kaltsas, G.3    Chrousos, G.4
  • 21
    • 84861468217 scopus 로고    scopus 로고
    • Metabolic syndrome in type 2 diabetes: comparison of WHO, modified ATPIII & IDF criteria
    • PID: 22755342
    • Ahmed A, Khan T, Yasmeen T, Awan S, Islam N (2012) Metabolic syndrome in type 2 diabetes: comparison of WHO, modified ATPIII & IDF criteria. J Pak Med Assoc 62:569–574
    • (2012) J Pak Med Assoc , vol.62 , pp. 569-574
    • Ahmed, A.1    Khan, T.2    Yasmeen, T.3    Awan, S.4    Islam, N.5
  • 22
    • 30544433479 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    • PID: 16249550
    • Ford ES (2005) Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care 28:2745–2749
    • (2005) Diabetes Care , vol.28 , pp. 2745-2749
    • Ford, E.S.1
  • 23
    • 16244381893 scopus 로고    scopus 로고
    • The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity
    • PID: 15504932
    • Wisse BE (2004) The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 15:2792–2800
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2792-2800
    • Wisse, B.E.1
  • 24
    • 1842516705 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus
    • Laren PR, Kronenberg HM, Melmed S, Polonsky KS, (eds), Saunders, Philadelphia
    • Buse JB, Polonsky KS, Burant CF (2003) Type 2 diabetes mellitus. In: Laren PR, Kronenberg HM, Melmed S, Polonsky KS (eds) Williams text book of endocrinology. Saunders, Philadelphia, pp 1427–1442
    • (2003) Williams text book of endocrinology , pp. 1427-1442
    • Buse, J.B.1    Polonsky, K.S.2    Burant, C.F.3
  • 25
    • 84891648237 scopus 로고    scopus 로고
    • Insulin receptor signaling in normal and insulin-resistant states
    • Boucher J, Kleinridders A, Kahn CR (2014) Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol 6:a009191. 10.1101/cshperspect.a009191
    • (2014) Cold Spring Harb Perspect Biol , vol.6 , pp. a009191
    • Boucher, J.1    Kleinridders, A.2    Kahn, C.R.3
  • 26
    • 58549084978 scopus 로고    scopus 로고
    • Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans
    • PID: 19041393
    • Fröjdö S, Vidal H, Pirola L (2009) Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans. Biochim Biophys Acta 1792:83–92
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 83-92
    • Fröjdö, S.1    Vidal, H.2    Pirola, L.3
  • 27
    • 84866289860 scopus 로고    scopus 로고
    • Regulation of insulin signaling by the phosphatidylinositol 3, 4, 5-triphosphate phosphatase SKIP through the scaffolding function of Pak1
    • Ijuin T, Takenawa T (2012) Regulation of insulin signaling by the phosphatidylinositol 3, 4, 5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. J Mol Cell Biol 32:3570–3584
    • (2012) J Mol Cell Biol , vol.32 , pp. 3570-3584
    • Ijuin, T.1    Takenawa, T.2
  • 28
    • 84984825559 scopus 로고    scopus 로고
    • Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signaling in pluripotency and cell fate determination
    • Jason S, Cui W (2016) Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signaling in pluripotency and cell fate determination. Development 143:3050–3060
    • (2016) Development , vol.143 , pp. 3050-3060
    • Jason, S.1    Cui, W.2
  • 29
    • 77949307940 scopus 로고    scopus 로고
    • Mitogenic action of insulin: friend foe or “frenemy”?
    • PID: 19851749
    • Draznin B (2010) Mitogenic action of insulin: friend foe or “frenemy”? Diabetologia 53:229–233
    • (2010) Diabetologia , vol.53 , pp. 229-233
    • Draznin, B.1
  • 30
    • 59149097878 scopus 로고    scopus 로고
    • Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases
    • PID: 19146801
    • Schulman IH, Zhou MS (2009) Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases. Curr Hypertens Rep 11:48–55
    • (2009) Curr Hypertens Rep , vol.11 , pp. 48-55
    • Schulman, I.H.1    Zhou, M.S.2
  • 31
    • 84893178599 scopus 로고    scopus 로고
    • Link between insulin resistance and hypertension: what is the evidence from evolutionary biology?
    • PID: 24485020
    • Zhou M-S, Wang A, Yu H (2014) Link between insulin resistance and hypertension: what is the evidence from evolutionary biology? Diabetol Metab Syndr 6:12
    • (2014) Diabetol Metab Syndr , vol.6 , pp. 12
    • Zhou, M.-S.1    Wang, A.2    Yu, H.3
  • 32
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: a pathogenic paradox
    • PID: 18249166
    • Brown MS, Goldstein JL (2008) Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 7:95–96
    • (2008) Cell Metab , vol.7 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 33
    • 33846049659 scopus 로고    scopus 로고
    • Insulin and insulin resistance
    • PID: 16278749
    • Wilcox G (2005) Insulin and insulin resistance. Clin Biochem Rev 26:19
    • (2005) Clin Biochem Rev , vol.26 , pp. 19
    • Wilcox, G.1
  • 34
    • 54249147362 scopus 로고    scopus 로고
    • Adipose inflammation, insulin resistance, and cardiovascular disease
    • Shah A, Mehta N, Reilly MP (2008) Adipose inflammation, insulin resistance, and cardiovascular disease. J Parenter Enter Nutr 32:638–644
    • (2008) J Parenter Enter Nutr , vol.32 , pp. 638-644
    • Shah, A.1    Mehta, N.2    Reilly, M.P.3
  • 35
    • 85043221259 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and insulin resistance: an update
    • PID: 25385852
    • Montgomery MK, Turner N (2015) Mitochondrial dysfunction and insulin resistance: an update. Endocr Connect 4:R1–R15
    • (2015) Endocr Connect , vol.4 , pp. R1-R15
    • Montgomery, M.K.1    Turner, N.2
  • 36
  • 37
    • 19944366619 scopus 로고    scopus 로고
    • Regulation of plasma triglycerides in insulin resistance and diabetes
    • PID: 15925013
    • Ginsberg HN, Zhang YL, Hernandez-Ono A (2005) Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res 36:232–240
    • (2005) Arch Med Res , vol.36 , pp. 232-240
    • Ginsberg, H.N.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 38
    • 85019562792 scopus 로고    scopus 로고
    • Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio metabolism study
    • PID: 28052966
    • Gastaldelli A, Gaggini M, DeFronzo RA (2017) Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio metabolism study. Diabetes 66:815–822
    • (2017) Diabetes , vol.66 , pp. 815-822
    • Gastaldelli, A.1    Gaggini, M.2    DeFronzo, R.A.3
  • 39
    • 61849185113 scopus 로고    scopus 로고
    • Intramuscular lipid metabolism, insulin action, and obesity
    • PID: 18839419
    • Consitt LA, Bell JA, Houmard JA (2009) Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life 61:47–55
    • (2009) IUBMB Life , vol.61 , pp. 47-55
    • Consitt, L.A.1    Bell, J.A.2    Houmard, J.A.3
  • 40
    • 84857352823 scopus 로고    scopus 로고
    • Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
    • PID: 22360800
    • Martins AR, Nachbar RT, Gorjao R (2012) Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. Lipids Health Dis 11:30
    • (2012) Lipids Health Dis , vol.11 , pp. 30
    • Martins, A.R.1    Nachbar, R.T.2    Gorjao, R.3
  • 41
    • 75549085755 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
    • PID: 19875544
    • DeFronzo RA, Tripathy D (2009) Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32:S157–S163
    • (2009) Diabetes Care , vol.32 , pp. S157-S163
    • DeFronzo, R.A.1    Tripathy, D.2
  • 42
    • 34547911800 scopus 로고    scopus 로고
    • The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
    • PID: 17640906
    • Petersen KF, Dufour S, Savage DB et al (2007) The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A 104:12587–12594
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12587-12594
    • Petersen, K.F.1    Dufour, S.2    Savage, D.B.3
  • 43
    • 24044500307 scopus 로고    scopus 로고
    • Prevalence of insulin resistance in first degree relatives of type-2 diabetes mellitus patients: a prospective study in North Indian population
    • PID: 23105527
    • Kumar A, Tewari P, Sahoo SS, Srivastava AK (2005) Prevalence of insulin resistance in first degree relatives of type-2 diabetes mellitus patients: a prospective study in North Indian population. Indian J Clin Biochem 20:10–17
    • (2005) Indian J Clin Biochem , vol.20 , pp. 10-17
    • Kumar, A.1    Tewari, P.2    Sahoo, S.S.3    Srivastava, A.K.4
  • 44
    • 34249688687 scopus 로고    scopus 로고
    • Perspectives in diabetes. How can we prevent type 2 diabetes?
    • PID: 17389328
    • Buchanan TA (2007) Perspectives in diabetes. How can we prevent type 2 diabetes? Diabetes 56:1502–1507
    • (2007) Diabetes , vol.56 , pp. 1502-1507
    • Buchanan, T.A.1
  • 46
    • 36049004221 scopus 로고    scopus 로고
    • Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis
    • PID: 17823366
    • Gustafson B, Hammarstedt A, Andersson CX, Smith U (2007) Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 27:2276–2283
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2276-2283
    • Gustafson, B.1    Hammarstedt, A.2    Andersson, C.X.3    Smith, U.4
  • 47
    • 47149096915 scopus 로고    scopus 로고
    • Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    • PID: 18473870
    • Heilbronn LK, Campbell LV (2008) Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 14:1225–1230
    • (2008) Curr Pharm Des , vol.14 , pp. 1225-1230
    • Heilbronn, L.K.1    Campbell, L.V.2
  • 49
    • 85053012746 scopus 로고    scopus 로고
    • Insulin resistance study in diabetes mellitus type II and its correlation with obesity
    • Usman S, Jafri SA (2014) Insulin resistance study in diabetes mellitus type II and its correlation with obesity. Am J Life Sci 2:96–102
    • (2014) Am J Life Sci , vol.2 , pp. 96-102
    • Usman, S.1    Jafri, S.A.2
  • 50
    • 84899483130 scopus 로고    scopus 로고
    • Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs
    • PID: 24716628
    • Abu-Farha M, Behbehani MK, Elkum N (2014) Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. Cardiovasc Diabetol 13:76
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 76
    • Abu-Farha, M.1    Behbehani, M.K.2    Elkum, N.3
  • 52
    • 33847733103 scopus 로고    scopus 로고
    • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
    • PID: 17268472
    • Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M (2007) Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 13:332–339
    • (2007) Nat Med , vol.13 , pp. 332-339
    • Yamauchi, T.1    Nio, Y.2    Maki, T.3    Kobayashi, M.4    Takazawa, T.5    Iwabu, M.6
  • 53
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • PID: 16823476
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784–1792
    • (2006) J Clin Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 54
    • 33750578279 scopus 로고    scopus 로고
    • Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator activated receptor alpha
    • PID: 16936205
    • Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB (2006) Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator activated receptor alpha. Diabetes 55:2562–2570
    • (2006) Diabetes , vol.55 , pp. 2562-2570
    • Yoon, M.J.1    Lee, G.Y.2    Chung, J.J.3    Ahn, Y.H.4    Hong, S.H.5    Kim, J.B.6
  • 55
    • 0043025533 scopus 로고    scopus 로고
    • Adiponectin: more than just another fat cell hormone?
    • PID: 12882876
    • Chandran M, Phillips SA, Ciaraldi T, Henry RR (2003) Adiponectin: more than just another fat cell hormone? Diabetes Care 26:2442–2450
    • (2003) Diabetes Care , vol.26 , pp. 2442-2450
    • Chandran, M.1    Phillips, S.A.2    Ciaraldi, T.3    Henry, R.R.4
  • 56
    • 0034014647 scopus 로고    scopus 로고
    • An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls
    • PID: 10741683
    • Okamoto Y, Arita Y, Nishida M et al (2000) An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res 32:47–50
    • (2000) Horm Metab Res , vol.32 , pp. 47-50
    • Okamoto, Y.1    Arita, Y.2    Nishida, M.3
  • 57
    • 0344091550 scopus 로고    scopus 로고
    • Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol
    • PID: 12630939
    • Valsamakis G, Chetty R, McTernan PG, Al-Daghri NM, Barnett AH, Kumar S (2003) Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol. Diabetes Obes Metab 5:131–135
    • (2003) Diabetes Obes Metab , vol.5 , pp. 131-135
    • Valsamakis, G.1    Chetty, R.2    McTernan, P.G.3    Al-Daghri, N.M.4    Barnett, A.H.5    Kumar, S.6
  • 58
    • 84902747447 scopus 로고    scopus 로고
    • Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?
    • PID: 24957699
    • Fisman EZ, Tenenbaum A (2014) Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease? Cardiovasc Diabetol 13:103
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 103
    • Fisman, E.Z.1    Tenenbaum, A.2
  • 59
    • 44449111714 scopus 로고    scopus 로고
    • Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans
    • PID: 18510434
    • Swarbrick MM, Havel PJ (2008) Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab Syndr Relat Disord 6:87–102
    • (2008) Metab Syndr Relat Disord , vol.6 , pp. 87-102
    • Swarbrick, M.M.1    Havel, P.J.2
  • 61
    • 84878227620 scopus 로고    scopus 로고
    • Prospective study of serum adiponectin and incident metabolic syndrome
    • PID: 23275369
    • Kim JY, Ahn SV, Yoon JH et al (2013) Prospective study of serum adiponectin and incident metabolic syndrome. Diabetes Care 36:1547–1553
    • (2013) Diabetes Care , vol.36 , pp. 1547-1553
    • Kim, J.Y.1    Ahn, S.V.2    Yoon, J.H.3
  • 63
    • 84908015088 scopus 로고    scopus 로고
    • TNF and TNF-receptors: from mediators of cell death and inflammation to therapeutic giants—past, present and future
    • PID: 25169849
    • Sedger LM, McDermott MF (2014) TNF and TNF-receptors: from mediators of cell death and inflammation to therapeutic giants—past, present and future. Cytokine Growth Factor Rev 25:453–472
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 453-472
    • Sedger, L.M.1    McDermott, M.F.2
  • 64
    • 0036581014 scopus 로고    scopus 로고
    • Association of the TNF -308 G/A promoter polymorphism with insulin resistance in obesity
    • PID: 12006640
    • Dalziel B, Gosby AK, Richman RM, Bryson JM, Caterson ID (2002) Association of the TNF -308 G/A promoter polymorphism with insulin resistance in obesity. Obes Res 10:401–407
    • (2002) Obes Res , vol.10 , pp. 401-407
    • Dalziel, B.1    Gosby, A.K.2    Richman, R.M.3    Bryson, J.M.4    Caterson, I.D.5
  • 65
    • 40449113524 scopus 로고    scopus 로고
    • The role of inflammatory cytokines in diabetic nephropathy
    • PID: 18256353
    • Navarro-González JF, Mora-Fernández C (2008) The role of inflammatory cytokines in diabetic nephropathy. J Am Soc Nephrol 19:433–442
    • (2008) J Am Soc Nephrol , vol.19 , pp. 433-442
    • Navarro-González, J.F.1    Mora-Fernández, C.2
  • 66
    • 80052045203 scopus 로고    scopus 로고
    • Associations of -308G/A polymorphism of tumor necrosis factor (TNF)-α gene and serum TNF-α levels with measures of obesity, intra-abdominal and subcutaneous abdominal fat, subclinical inflammation and insulin resistance in Asian Indians in North India
    • PID: 21846948
    • Vikram NK, Bhatt SP, Bhushan B (2011) Associations of -308G/A polymorphism of tumor necrosis factor (TNF)-α gene and serum TNF-α levels with measures of obesity, intra-abdominal and subcutaneous abdominal fat, subclinical inflammation and insulin resistance in Asian Indians in North India. Dis Markers 31:39–46
    • (2011) Dis Markers , vol.31 , pp. 39-46
    • Vikram, N.K.1    Bhatt, S.P.2    Bhushan, B.3
  • 67
    • 33746234763 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha induces endothelial dysfunction in the prediabetic metabolic syndrome
    • PID: 16741160
    • Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM (2006) Tumor necrosis factor alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99:69–77
    • (2006) Circ Res , vol.99 , pp. 69-77
    • Picchi, A.1    Gao, X.2    Belmadani, S.3    Potter, B.J.4    Focardi, M.5    Chilian, W.M.6
  • 68
    • 61349156849 scopus 로고    scopus 로고
    • Interleukin-6 and insulin resistance
    • PID: 19251052
    • Kim JH, Bachmann RA, Chen J (2009) Interleukin-6 and insulin resistance. Vitam Horm 80:613–633
    • (2009) Vitam Horm , vol.80 , pp. 613-633
    • Kim, J.H.1    Bachmann, R.A.2    Chen, J.3
  • 69
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • PID: 16613757
    • Bastard J-P, Maachi M, Lagathu C et al (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4–12
    • (2006) Eur Cytokine Netw , vol.17 , pp. 4-12
    • Bastard, J.-P.1    Maachi, M.2    Lagathu, C.3
  • 70
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Mooney RA (2005) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51:3391–3399
    • (2005) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 71
    • 39149143637 scopus 로고    scopus 로고
    • Adipokines: the missing link between insulin resistance and obesity
    • PID: 18093861
    • Antuna-Puente B, Feve B, Fellahi S, Bastard J-P (2008) Adipokines: the missing link between insulin resistance and obesity. Diabete Metab 34:2–11
    • (2008) Diabete Metab , vol.34 , pp. 2-11
    • Antuna-Puente, B.1    Feve, B.2    Fellahi, S.3    Bastard, J.-P.4
  • 72
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • PID: 11287357
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745–E751
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , pp. E745-E751
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 73
    • 84892925036 scopus 로고    scopus 로고
    • Metabolic syndrome and risk of incident peripheral artery disease: the cardiovascular health study
    • PID: 24191289
    • Garg PK, Biggs ML, Carnethon M et al (2014) Metabolic syndrome and risk of incident peripheral artery disease: the cardiovascular health study. Hypertension 63:413–419
    • (2014) Hypertension , vol.63 , pp. 413-419
    • Garg, P.K.1    Biggs, M.L.2    Carnethon, M.3
  • 74
    • 77957198071 scopus 로고    scopus 로고
    • The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    • PID: 20863953
    • Mottillo S, Filion KB, Genest J et al (2010) The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 56:1113–1132
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1113-1132
    • Mottillo, S.1    Filion, K.B.2    Genest, J.3
  • 75
    • 24144484876 scopus 로고    scopus 로고
    • American Diabetes Association; European Association for the study of diabetes. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European association for the study of diabetes
    • PID: 16123508
    • Kahn RBJ, Ferrannini E, Stern M et al (2005) American Diabetes Association; European Association for the study of diabetes. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European association for the study of diabetes. Diabetes Care 28:2289–2304
    • (2005) Diabetes Care , vol.28 , pp. 2289-2304
    • Kahn, R.B.J.1    Ferrannini, E.2    Stern, M.3
  • 76
    • 80051988028 scopus 로고    scopus 로고
    • Plasma visfatin and adiponectin concentrations in physically active adolescent girls: relationships with insulin sensitivity and body composition variables
    • PID: 21932575
    • Jurimae J, Gruodyte R, Saar M et al (2011) Plasma visfatin and adiponectin concentrations in physically active adolescent girls: relationships with insulin sensitivity and body composition variables. J Pediatr Endocrinol Metab 24:419–425
    • (2011) J Pediatr Endocrinol Metab , vol.24 , pp. 419-425
    • Jurimae, J.1    Gruodyte, R.2    Saar, M.3
  • 77
    • 79958267115 scopus 로고    scopus 로고
    • Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents
    • PID: 21655067
    • Rhie YJ, Choi BM, Eun SH et al (2011) Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents. J Korean Med Sci 26:797–802
    • (2011) J Korean Med Sci , vol.26 , pp. 797-802
    • Rhie, Y.J.1    Choi, B.M.2    Eun, S.H.3
  • 78
    • 27544451465 scopus 로고    scopus 로고
    • Combined influence of body mass index and waist circumference on coronary artery disease risk factors among children and adolescents
    • PID: 15930225
    • Janssen I, Katzmarzyk PT, Srinivasan SR et al (2005) Combined influence of body mass index and waist circumference on coronary artery disease risk factors among children and adolescents. Pediatrics 115:1623–1630
    • (2005) Pediatrics , vol.115 , pp. 1623-1630
    • Janssen, I.1    Katzmarzyk, P.T.2    Srinivasan, S.R.3
  • 79
    • 84875967903 scopus 로고    scopus 로고
    • Triglyceride to HDL-c ratio and increased arterial stiffness in children, adolescents, and young adults
    • PID: 23460684
    • Urbina EM, Khoury PR, McCoy CE et al (2013) Triglyceride to HDL-c ratio and increased arterial stiffness in children, adolescents, and young adults. Pediatrics 131:e1082–e1090
    • (2013) Pediatrics , vol.131 , pp. e1082-e1090
    • Urbina, E.M.1    Khoury, P.R.2    McCoy, C.E.3
  • 80
    • 84869508884 scopus 로고    scopus 로고
    • Surrogate lipid markers for small dense low-density lipoprotein particles in overweight youth
    • PID: 22809659
    • Burns SF, Lee SJ, Arslanian SA (2012) Surrogate lipid markers for small dense low-density lipoprotein particles in overweight youth. J Pediatr 161:991–996
    • (2012) J Pediatr , vol.161 , pp. 991-996
    • Burns, S.F.1    Lee, S.J.2    Arslanian, S.A.3
  • 81
    • 84971280549 scopus 로고    scopus 로고
    • Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism
    • PID: 27234258
    • Sassoon DJ, Goodwill AG, Noblet JN et al (2016) Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism. Basic Res Cardiol 111:43
    • (2016) Basic Res Cardiol , vol.111 , pp. 43
    • Sassoon, D.J.1    Goodwill, A.G.2    Noblet, J.N.3
  • 82
    • 84859755460 scopus 로고    scopus 로고
    • Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?
    • PID: 22563249
    • Dincer UD (2012) Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy? Diabetes Metab Syndr Obes 5:89–99
    • (2012) Diabetes Metab Syndr Obes , vol.5 , pp. 89-99
    • Dincer, U.D.1
  • 83
    • 84989902351 scopus 로고    scopus 로고
    • Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction
    • PID: 27322594
    • Okatan EN, Durak AT, Turan B (2016) Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction. Can J Physiol Pharmacol 94:1064–1073
    • (2016) Can J Physiol Pharmacol , vol.94 , pp. 1064-1073
    • Okatan, E.N.1    Durak, A.T.2    Turan, B.3
  • 84
    • 84928994366 scopus 로고    scopus 로고
    • Calcium release channel RyR2 regulates insulin release and glucose homeostasis
    • PID: 25844899
    • Santulli G, Pagano G, Sardu C et al (2015) Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest 125:1968–1978
    • (2015) J Clin Invest , vol.125 , pp. 1968-1978
    • Santulli, G.1    Pagano, G.2    Sardu, C.3
  • 85
    • 84939947464 scopus 로고    scopus 로고
    • Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2
    • PID: 25694159
    • Lavorato M, Huang TQ, Iyer VR et al (2015) Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2. J Muscle Res Cell Motil 36:205–214
    • (2015) J Muscle Res Cell Motil , vol.36 , pp. 205-214
    • Lavorato, M.1    Huang, T.Q.2    Iyer, V.R.3
  • 86
    • 85020475960 scopus 로고    scopus 로고
    • What is lipotoxicity?
    • PID: 28585200
    • Engin AB (2017) What is lipotoxicity? Adv Exp Med Biol 960:197–220
    • (2017) Adv Exp Med Biol , vol.960 , pp. 197-220
    • Engin, A.B.1
  • 87
    • 0035156262 scopus 로고    scopus 로고
    • Obesity, body fat distribution, insulin sensitivity and islet beta-cell function as explanations for metabolic diversity
    • PID: 11160560
    • Kahn SE, Prigeon RL, Schwartz RS et al (2001) Obesity, body fat distribution, insulin sensitivity and islet beta-cell function as explanations for metabolic diversity. J Nutr 131:354S–360S
    • (2001) J Nutr , vol.131 , pp. 354S-360S
    • Kahn, S.E.1    Prigeon, R.L.2    Schwartz, R.S.3
  • 88
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue inflammation and cardiovascular disease
    • Berg AH, Scherer PE (2005) Adipose tissue inflammation and cardiovascular disease. Circ Res 90:939–949
    • (2005) Circ Res , vol.90 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 89
    • 12444334643 scopus 로고    scopus 로고
    • Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
    • Lelliot C, Vidal Puig AJ (2004) Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord 28:S22–S28
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. S22-S28
    • Lelliot, C.1    Vidal Puig, A.J.2
  • 90
    • 84980047785 scopus 로고    scopus 로고
    • Lipotoxicity: many roads to cell dysfunction and cell death: introduction to a thematic review series
    • PID: 27260998
    • Schaffer JE (2016) Lipotoxicity: many roads to cell dysfunction and cell death: introduction to a thematic review series. J Lipid Res 57:1327–1328
    • (2016) J Lipid Res , vol.57 , pp. 1327-1328
    • Schaffer, J.E.1
  • 92
    • 78650769395 scopus 로고    scopus 로고
    • Reactive oxygen and mechanisms of inflammatory liver injury: present concepts
    • PID: 21199529
    • Jaeschke H (2011) Reactive oxygen and mechanisms of inflammatory liver injury: present concepts. J Gastroenterol Hepatol 26:173–179
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 173-179
    • Jaeschke, H.1
  • 93
    • 79956335244 scopus 로고    scopus 로고
    • Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based colaus study
    • Lyngdoh T, Marques-Vidal P, Paccaud F (2011) Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based colaus study. PLoS One 2011:6
    • (2011) PLoS One , vol.2011
    • Lyngdoh, T.1    Marques-Vidal, P.2    Paccaud, F.3
  • 94
    • 84155188801 scopus 로고    scopus 로고
    • Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease
    • PID: 21953442
    • Kowdley KV, Belt P, Wilson LA, Yeh MM, Neuschwander-Tetri BA (2012) Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 55:77–85
    • (2012) Hepatology , vol.55 , pp. 77-85
    • Kowdley, K.V.1    Belt, P.2    Wilson, L.A.3    Yeh, M.M.4    Neuschwander-Tetri, B.A.5
  • 95
    • 34648813431 scopus 로고    scopus 로고
    • Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance
    • PID: 17729391
    • Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J (2007) Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. World J Gastroenterol 13:4699–4706
    • (2007) World J Gastroenterol , vol.13 , pp. 4699-4706
    • Kohgo, Y.1    Ikuta, K.2    Ohtake, T.3    Torimoto, Y.4    Kato, J.5
  • 96
    • 84944890985 scopus 로고    scopus 로고
    • Comparison of iron status and insulin resistance between non-diabetic offspring of type 2 diabetics and non-diabetic offspring of non-diabetics
    • Zafar U, Qureshi HJ, Imran M (2015) Comparison of iron status and insulin resistance between non-diabetic offspring of type 2 diabetics and non-diabetic offspring of non-diabetics. J Ayub Med Coll 27:307–311
    • (2015) J Ayub Med Coll , vol.27 , pp. 307-311
    • Zafar, U.1    Qureshi, H.J.2    Imran, M.3
  • 97
    • 84908206550 scopus 로고    scopus 로고
    • Insulin resistance and serum parameters of iron status in type 2 diabetics
    • Zafar U, Qureshi HJ, Karim S (2011) Insulin resistance and serum parameters of iron status in type 2 diabetics. Pak J Physiol 7:28–31
    • (2011) Pak J Physiol , vol.7 , pp. 28-31
    • Zafar, U.1    Qureshi, H.J.2    Karim, S.3
  • 98
    • 0036325879 scopus 로고    scopus 로고
    • Cross-talk between iron metabolism and diabetes
    • PID: 12145144
    • Fernandez-Real JM, Bermejo AL, Ricart W (2002) Cross-talk between iron metabolism and diabetes. Diabetes 51:2348–2354
    • (2002) Diabetes , vol.51 , pp. 2348-2354
    • Fernandez-Real, J.M.1    Bermejo, A.L.2    Ricart, W.3
  • 99
    • 84929575005 scopus 로고    scopus 로고
    • 2015 Hepcidin: regulation of the master iron regulator
    • PID: 26182354
    • Rishi G, Wallace DF, Subramaniam VN (2015) 2015 Hepcidin: regulation of the master iron regulator. Biosci Rep 35:e00192
    • (2015) Biosci Rep , vol.35
    • Rishi, G.1    Wallace, D.F.2    Subramaniam, V.N.3
  • 100
    • 79955958017 scopus 로고    scopus 로고
    • Hepcidin and iron regulation, 10 years later
    • PID: 21346250
    • Ganz T (2011) Hepcidin and iron regulation, 10 years later. Blood 117:4425–4433
    • (2011) Blood , vol.117 , pp. 4425-4433
    • Ganz, T.1
  • 101
    • 3142723189 scopus 로고    scopus 로고
    • Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
    • PID: 15240880
    • Ueki K, Kondo T, Tseng YH, Kahn CR (2004) Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A 101:10422–10427
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10422-10427
    • Ueki, K.1    Kondo, T.2    Tseng, Y.H.3    Kahn, C.R.4
  • 102
    • 84896797617 scopus 로고    scopus 로고
    • Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study
    • Martinelli N, Traglia M, Campostrini N, Biino G, Corbella M (2013) Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. PLoS One 8:10.1371
    • (2013) PLoS One , vol.8
    • Martinelli, N.1    Traglia, M.2    Campostrini, N.3    Biino, G.4    Corbella, M.5
  • 103
    • 84915758224 scopus 로고    scopus 로고
    • Review of hyperuricemia as new marker for metabolic syndrome
    • Billiet L, Doaty S, Katz JD, Velasquez MT (2014) Review of hyperuricemia as new marker for metabolic syndrome. JSRN Rheumatol 2014:852954
    • (2014) JSRN Rheumatol , vol.2014 , pp. 852954
    • Billiet, L.1    Doaty, S.2    Katz, J.D.3    Velasquez, M.T.4
  • 104
    • 84930163758 scopus 로고    scopus 로고
    • Association between serum uric acid level and metabolic syndrome and its sex difference in a Chinese community elderly population
    • PID: 25136366
    • Liu M, He Y, Jiang B (2014) Association between serum uric acid level and metabolic syndrome and its sex difference in a Chinese community elderly population. Int J Endocrinol 2014:754678
    • (2014) Int J Endocrinol , vol.2014 , pp. 754678
    • Liu, M.1    He, Y.2    Jiang, B.3
  • 105
    • 84957085149 scopus 로고    scopus 로고
    • Uric acid levels can predict metabolic syndrome and hypertension in adolescents: A 10-year longitudinal study
    • Sun HL, Pei D, Lue KH, Chen YL (2015) Uric acid levels can predict metabolic syndrome and hypertension in adolescents: a 10-year longitudinal study. PLoS One. 10.1371/journal.pone.0143786
    • (2015) Plos One
    • Sun, H.L.1    Pei, D.2    Lue, K.H.3    Chen, Y.L.4
  • 106
    • 33845895003 scopus 로고    scopus 로고
    • Association between serum uric acid level and components of the metabolic syndrome
    • Lin S-D, Tsai D-H, Hsu S-R (2006) Association between serum uric acid level and components of the metabolic syndrome. Chin Med J 69:512–516
    • (2006) Chin Med J , vol.69 , pp. 512-516
    • Lin, S.-D.1    Tsai, D.-H.2    Hsu, S.-R.3
  • 107
    • 84950282194 scopus 로고    scopus 로고
    • Uric acid in metabolic syndrome: from an innocent bystander to a central player
    • PID: 26703429
    • Kanbay M, Jensen T, Solak Y et al (2016) Uric acid in metabolic syndrome: from an innocent bystander to a central player. Eur J Intern Med 29:3–8
    • (2016) Eur J Intern Med , vol.29 , pp. 3-8
    • Kanbay, M.1    Jensen, T.2    Solak, Y.3
  • 108
    • 20244365646 scopus 로고    scopus 로고
    • Hyperuricemia induces endothelial dysfunction
    • PID: 15840020
    • Khosla UM, Zharikov S, Finch JL (2005) Hyperuricemia induces endothelial dysfunction. Kidney Int 67:1739–1742
    • (2005) Kidney Int , vol.67 , pp. 1739-1742
    • Khosla, U.M.1    Zharikov, S.2    Finch, J.L.3
  • 109
    • 84877832892 scopus 로고    scopus 로고
    • Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?
    • PID: 23588856
    • Soltani Z, Rasheed K, Kapusta DR, Reisin E (2013) Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? Curr Hypertens Rep 15:175–181
    • (2013) Curr Hypertens Rep , vol.15 , pp. 175-181
    • Soltani, Z.1    Rasheed, K.2    Kapusta, D.R.3    Reisin, E.4
  • 112
    • 84908287544 scopus 로고    scopus 로고
    • Vitamin D and cardiometabolic risk factors in adult non-diabetic offspring of type 2 diabetic parents
    • PID: 25831636
    • Roomi MA, Lone KP, Madassar A (2014) Vitamin D and cardiometabolic risk factors in adult non-diabetic offspring of type 2 diabetic parents. J Pak Med Assoc 64:1229
    • (2014) J Pak Med Assoc , vol.64 , pp. 1229
    • Roomi, M.A.1    Lone, K.P.2    Madassar, A.3
  • 113
    • 60549110414 scopus 로고    scopus 로고
    • Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent
    • PID: 19121992
    • Shahid A, Lone KP, Saeed S, Arslan M (2008) Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent. Hormones 7:313–319
    • (2008) Hormones , vol.7 , pp. 313-319
    • Shahid, A.1    Lone, K.P.2    Saeed, S.3    Arslan, M.4
  • 114
    • 84907274301 scopus 로고    scopus 로고
    • Recent advances in the molecular genetics of type 2 diabetes mellitus
    • PID: 24748926
    • Brunetti A (2014) Recent advances in the molecular genetics of type 2 diabetes mellitus. World J Diabetes 5:128–140
    • (2014) World J Diabetes , vol.5 , pp. 128-140
    • Brunetti, A.1
  • 115
    • 0034840005 scopus 로고    scopus 로고
    • Defining the genetic contribution of type 2 diabetes mellitus
    • PID: 11546824
    • van Tilburg J, Van Haeften TW, Pearson P, Wijmenga C (2001) Defining the genetic contribution of type 2 diabetes mellitus. J Med Genet 38:569–578
    • (2001) J Med Genet , vol.38 , pp. 569-578
    • van Tilburg, J.1    Van Haeften, T.W.2    Pearson, P.3    Wijmenga, C.4
  • 116
    • 84873502412 scopus 로고    scopus 로고
    • Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes
    • PID: 23396303
    • Kottyan LC, Woo JG, Keddache M et al (2012) Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes. SpringerPlus 1:66
    • (2012) SpringerPlus , vol.1 , pp. 66
    • Kottyan, L.C.1    Woo, J.G.2    Keddache, M.3
  • 117
    • 38449118682 scopus 로고    scopus 로고
    • Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study
    • PID: 17977958
    • Vaxillaire M, Veslot J, Dina C (2008) Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study. Diabetes 57:244–254
    • (2008) Diabetes , vol.57 , pp. 244-254
    • Vaxillaire, M.1    Veslot, J.2    Dina, C.3
  • 118
    • 84876062703 scopus 로고    scopus 로고
    • Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects
    • Y-y L, Yang Z-j, C-w Z, Wang X-m, Qian Y (2013) Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects. PLoS One 8:e61153
    • (2013) PLoS One , vol.8
    • Yang, Z.-J.1    Wang, X.-M.2    Qian, Y.3
  • 119
    • 84865680534 scopus 로고    scopus 로고
    • Association of TCF7L2 and ADIPOQ with body mass index, waist-hip ratio, and systolic blood pressure in an endogamous ethnic group of India
    • PID: 22583123
    • Gupta V, Khadgawat R, Tony Ng HK et al (2012) Association of TCF7L2 and ADIPOQ with body mass index, waist-hip ratio, and systolic blood pressure in an endogamous ethnic group of India. Genet Test Mol Biomarkers 16:948–951
    • (2012) Genet Test Mol Biomarkers , vol.16 , pp. 948-951
    • Gupta, V.1    Khadgawat, R.2    Tony Ng, H.K.3
  • 120
    • 84884934561 scopus 로고    scopus 로고
    • AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study
    • PID: 23653335
    • Chu H, Wang M, Zhong D, Shi D, Ma L, Tong N (2013) AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study. Diabetes Metab Res Rev 29:532–545
    • (2013) Diabetes Metab Res Rev , vol.29 , pp. 532-545
    • Chu, H.1    Wang, M.2    Zhong, D.3    Shi, D.4    Ma, L.5    Tong, N.6
  • 121
    • 84907983077 scopus 로고    scopus 로고
    • Association of ADIPOQ polymorphisms with obesity risk: a meta-analysis
    • PID: 25223469
    • Lu JF, Zhou Y, Huang GH, Jiang HX, Hu BL, Qin SY (2014) Association of ADIPOQ polymorphisms with obesity risk: a meta-analysis. Hum Immunol 75:1062–1068
    • (2014) Hum Immunol , vol.75 , pp. 1062-1068
    • Lu, J.F.1    Zhou, Y.2    Huang, G.H.3    Jiang, H.X.4    Hu, B.L.5    Qin, S.Y.6
  • 122
    • 0034938412 scopus 로고    scopus 로고
    • Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren’s syndrome and correlate with the clinical manifestations of the disease
    • PID: 11426023
    • Hulkkonen J, Pertovaara M, Antonen J, Pasternack A, Hurme M (2001) Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren’s syndrome and correlate with the clinical manifestations of the disease. Rheumatology 40:656–661
    • (2001) Rheumatology , vol.40 , pp. 656-661
    • Hulkkonen, J.1    Pertovaara, M.2    Antonen, J.3    Pasternack, A.4    Hurme, M.5
  • 123
    • 23044505300 scopus 로고    scopus 로고
    • C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance
    • PID: 16043746
    • Cardellini M, Perego L, D’Adamo M et al (2005) C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance. Diabetes Care 28:2007–2012
    • (2005) Diabetes Care , vol.28 , pp. 2007-2012
    • Cardellini, M.1    Perego, L.2    D’Adamo, M.3
  • 124
    • 84893875817 scopus 로고    scopus 로고
    • Association of Interleukin-6 gene promoter polymorphism with coronary artery disease in Pakistani families
    • Satti HS, Hussain S, Javed Q (2013) Association of Interleukin-6 gene promoter polymorphism with coronary artery disease in Pakistani families. Sci World J 2013:538365
    • (2013) Sci World J , vol.2013 , pp. 538365
    • Satti, H.S.1    Hussain, S.2    Javed, Q.3
  • 125
    • 85013655135 scopus 로고    scopus 로고
    • Association of IL-6 C-174G (rs 1800795) single nucleotide polymorphism with type 2 diabetes mellitus in Pakistani population
    • Nadeem A, Mumtaz S, Naveed AK et al (2017) Association of IL-6 C-174G (rs 1800795) single nucleotide polymorphism with type 2 diabetes mellitus in Pakistani population. J Pak Med Assoc 67(428):433
    • (2017) J Pak Med Assoc , vol.67 , Issue.428 , pp. 433
    • Nadeem, A.1    Mumtaz, S.2    Naveed, A.K.3
  • 126
    • 85053001448 scopus 로고    scopus 로고
    • IL-2 and TNF-alpha promoter polymorphisms in patients with acute kidney graft rejection
    • Pawlik A, Domanski L, Rozanski J et al (2005) IL-2 and TNF-alpha promoter polymorphisms in patients with acute kidney graft rejection. Transpl Immunol 37:49–52
    • (2005) Transpl Immunol , vol.37 , pp. 49-52
    • Pawlik, A.1    Domanski, L.2    Rozanski, J.3
  • 127
    • 77952883550 scopus 로고    scopus 로고
    • An association between asthma and TNF-308G/A polymorphism: meta-analysis
    • PID: 16865291
    • Aoki T, Hirota T, Tamari M, Ichikawa K, Takeda K, Arinami T (2006) An association between asthma and TNF-308G/A polymorphism: meta-analysis. J Hum Genet 51:677–685
    • (2006) J Hum Genet , vol.51 , pp. 677-685
    • Aoki, T.1    Hirota, T.2    Tamari, M.3    Ichikawa, K.4    Takeda, K.5    Arinami, T.6
  • 128
    • 84975828046 scopus 로고    scopus 로고
    • Association between the tumor necrosis factor-α-308G/A polymorphism and COPD susceptibility: a meta-analysis update
    • PID: 27382273
    • Zhang LG, Lu H, Lu Y et al (2016) Association between the tumor necrosis factor-α-308G/A polymorphism and COPD susceptibility: a meta-analysis update. Int J Chron Obstruct Pulmon Dis 11:1367–1379
    • (2016) Int J Chron Obstruct Pulmon Dis , vol.11 , pp. 1367-1379
    • Zhang, L.G.1    Lu, H.2    Lu, Y.3
  • 129
    • 84980361810 scopus 로고    scopus 로고
    • Adipokine gene single-nucleotide polymorphisms in Portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-α
    • PID: 27159547
    • Nascimento H, Vieira E, Coimbra S et al (2016) Adipokine gene single-nucleotide polymorphisms in Portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-α. Child Obes 12:300–313
    • (2016) Child Obes , vol.12 , pp. 300-313
    • Nascimento, H.1    Vieira, E.2    Coimbra, S.3
  • 130
    • 34548662472 scopus 로고    scopus 로고
    • Gene polymorphisms of TNF-alpha (-308), IL-10(-1082), IL-6(-174), and IL-1Ra(VNTR) related to susceptibility and severity of rheumatic heart disease
    • PID: 17607501
    • Settin A, Abdel-Hady H, El-Baz R et al (2007) Gene polymorphisms of TNF-alpha (-308), IL-10(-1082), IL-6(-174), and IL-1Ra(VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol 28:363–371
    • (2007) Pediatr Cardiol , vol.28 , pp. 363-371
    • Settin, A.1    Abdel-Hady, H.2    El-Baz, R.3
  • 131
    • 84861490094 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome
    • PID: 22372709
    • Babu BM, Reddy BP, Priya VH et al (2012) Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome. Genet Test Mol Biomarkers 16:359–365
    • (2012) Genet Test Mol Biomarkers , vol.16 , pp. 359-365
    • Babu, B.M.1    Reddy, B.P.2    Priya, V.H.3
  • 132
    • 84904123392 scopus 로고    scopus 로고
    • Hypoxia in diabetic kidneys
    • PID: 25054148
    • Takiyama Y, Haneda M (2014) Hypoxia in diabetic kidneys. Biomed Res Int 2014:837421
    • (2014) Biomed Res Int , vol.2014 , pp. 837421
    • Takiyama, Y.1    Haneda, M.2
  • 133
    • 85010916085 scopus 로고    scopus 로고
    • Targeting hypoxia-inducible factors for the treatment of anemia in chronic kidney disease patients
    • PID: 28118622
    • Locatelli F, Fishbane S, Block GA, Macdougall IC (2017) Targeting hypoxia-inducible factors for the treatment of anemia in chronic kidney disease patients. Am J Nephrol 45:187–199
    • (2017) Am J Nephrol , vol.45 , pp. 187-199
    • Locatelli, F.1    Fishbane, S.2    Block, G.A.3    Macdougall, I.C.4
  • 134
    • 84886412451 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and cardiovascular disease
    • PID: 23988176
    • Semenza GL (2014) Hypoxia-inducible factor 1 and cardiovascular disease. Annu Rev Physiol 76:39–56
    • (2014) Annu Rev Physiol , vol.76 , pp. 39-56
    • Semenza, G.L.1
  • 135
    • 26244439272 scopus 로고    scopus 로고
    • Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese
    • PID: 16046581
    • Yamada N, Horikawa Y, Oda N et al (2005) Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese. J Clin Endocrinol Metab 90:5841–5847
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5841-5847
    • Yamada, N.1    Horikawa, Y.2    Oda, N.3
  • 136
    • 69949165415 scopus 로고    scopus 로고
    • Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample
    • PID: 19691832
    • Nagy G, Kovacs-Nagy R, Kereszturi E, Somogyi A, Szekely A, Nemeth N (2009) Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample. BMC Med Genet 10:79
    • (2009) BMC Med Genet , vol.10 , pp. 79
    • Nagy, G.1    Kovacs-Nagy, R.2    Kereszturi, E.3    Somogyi, A.4    Szekely, A.5    Nemeth, N.6
  • 137
    • 84873855503 scopus 로고    scopus 로고
    • Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy
    • PID: 22991450
    • Gu HF, Zheng X, Abu Seman N et al (2013) Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy. Diabetes Care 36:415–421
    • (2013) Diabetes Care , vol.36 , pp. 415-421
    • Gu, H.F.1    Zheng, X.2    Abu Seman, N.3
  • 138
    • 84924388081 scopus 로고    scopus 로고
    • Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors?
    • PID: 25722444
    • Rankinen T, Sarzynski MA, Ghosh S, Bouchard C (2015) Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors? Circ Res 116:909–922
    • (2015) Circ Res , vol.116 , pp. 909-922
    • Rankinen, T.1    Sarzynski, M.A.2    Ghosh, S.3    Bouchard, C.4
  • 139
    • 10744226236 scopus 로고    scopus 로고
    • A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14
    • PID: 14988269
    • Silander K, Scott LJ, Valle TT, Mohlke KL, Stringham HM, Wiles KR (2004) A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes 53:821–829
    • (2004) Diabetes , vol.53 , pp. 821-829
    • Silander, K.1    Scott, L.J.2    Valle, T.T.3    Mohlke, K.L.4    Stringham, H.M.5    Wiles, K.R.6
  • 140
    • 84879409456 scopus 로고    scopus 로고
    • Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes
    • PID: 23769638
    • Jia Y, Hoang MH, Jun HJ, Lee JH, Lee SJ (2013) Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes. Bioorg Med Chem Lett 23:4185–4190
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 4185-4190
    • Jia, Y.1    Hoang, M.H.2    Jun, H.J.3    Lee, J.H.4    Lee, S.J.5
  • 141
    • 84884574859 scopus 로고    scopus 로고
    • Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator
    • PID: 23732298
    • Watanabe K, Sakurai K, Tsuchiya Y, Yamazoe Y, Yoshinari K (2013) Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. Biochem Pharmacol 86:428–436
    • (2013) Biochem Pharmacol , vol.86 , pp. 428-436
    • Watanabe, K.1    Sakurai, K.2    Tsuchiya, Y.3    Yamazoe, Y.4    Yoshinari, K.5
  • 142
    • 84875023712 scopus 로고    scopus 로고
    • Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells
    • PID: 23352501
    • Chen Y, Zhang S, Zhou T, Huang C, McLaughlin A, Chen G (2013) Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells. Toxicol Appl Pharmacol 268:106–112
    • (2013) Toxicol Appl Pharmacol , vol.268 , pp. 106-112
    • Chen, Y.1    Zhang, S.2    Zhou, T.3    Huang, C.4    McLaughlin, A.5    Chen, G.6
  • 143
    • 84888010785 scopus 로고    scopus 로고
    • Excess nitric oxide impairs LXR(α)- ABCA1-dependent cholesterol efflux in macrophage foam cells
    • PID: 23836449
    • Zhao JF, Shyue SK, Lin SJ, Wei J, Lee TS (2014) Excess nitric oxide impairs LXR(α)- ABCA1-dependent cholesterol efflux in macrophage foam cells. J Cell Physiol 229:117–125
    • (2014) J Cell Physiol , vol.229 , pp. 117-125
    • Zhao, J.F.1    Shyue, S.K.2    Lin, S.J.3    Wei, J.4    Lee, T.S.5
  • 144
    • 84921277920 scopus 로고    scopus 로고
    • Association of liver X receptor α (LXRα) gene polymorphism and ischemic stroke
    • PID: 25729942
    • Wang HX, Zhang K, Zhao L, Tang JW, Gao LY, Wei ZP (2015) Association of liver X receptor α (LXRα) gene polymorphism and ischemic stroke. Genet Mol Res 14:118–122
    • (2015) Genet Mol Res , vol.14 , pp. 118-122
    • Wang, H.X.1    Zhang, K.2    Zhao, L.3    Tang, J.W.4    Gao, L.Y.5    Wei, Z.P.6
  • 145
    • 34247233324 scopus 로고    scopus 로고
    • High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia
    • PID: 17272748
    • Nohara A, Kawashiri MA, Claudel T, Mizuno M, Tsuchida M, Takata M (2007) High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol 27:923–928
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 923-928
    • Nohara, A.1    Kawashiri, M.A.2    Claudel, T.3    Mizuno, M.4    Tsuchida, M.5    Takata, M.6
  • 146
    • 0037389235 scopus 로고    scopus 로고
    • Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in human and mice
    • PID: 12615678
    • Pennacchio LA, Rubin EA (2003) Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in human and mice. Arterioscler Thromb Vasc Biol 23:529–534
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 529-534
    • Pennacchio, L.A.1    Rubin, E.A.2
  • 148
    • 12944295219 scopus 로고    scopus 로고
    • The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins
    • PID: 15528295
    • O’Brien PJ, Alborn WE, Sloan JH et al (2005) The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. Clin Chem 51:351–359
    • (2005) Clin Chem , vol.51 , pp. 351-359
    • O’Brien, P.J.1    Alborn, W.E.2    Sloan, J.H.3
  • 149
    • 0141780842 scopus 로고    scopus 로고
    • Structure and interfacial properties of human apolipoprotein A-V
    • PID: 12810715
    • Weinberg RB, Cook VR, Beckstead JA et al (2003) Structure and interfacial properties of human apolipoprotein A-V. J Biol Chem 278:34438–34444
    • (2003) J Biol Chem , vol.278 , pp. 34438-34444
    • Weinberg, R.B.1    Cook, V.R.2    Beckstead, J.A.3
  • 150
    • 77955292466 scopus 로고    scopus 로고
    • Association of the apolipoprotein A5 gene–1131 T>C polymorphism with fasting plasma lipids: a meta-analysis in 37859 subjects
    • PID: 20696075
    • Zhao T, Zhao J (2010) Association of the apolipoprotein A5 gene–1131 T>C polymorphism with fasting plasma lipids: a meta-analysis in 37859 subjects. BMC Med Genet 11:120
    • (2010) BMC Med Genet , vol.11 , pp. 120
    • Zhao, T.1    Zhao, J.2
  • 151
    • 84874625399 scopus 로고    scopus 로고
    • Association of apolipoprotein A5 gene −1131T>C polymorphism with the risk of metabolic syndrome in Korean subjects
    • 7 pages
    • Song KW, Cha S, Yu S, Yu H, Oh SA, Kang NS (2013) Association of apolipoprotein A5 gene −1131T>C polymorphism with the risk of metabolic syndrome in Korean subjects. Bio Med Res Int 2013:585134 7 pages
    • (2013) Bio Med Res Int , vol.2013 , pp. 585134
    • Song, K.W.1    Cha, S.2    Yu, S.3    Yu, H.4    Oh, S.A.5    Kang, N.S.6
  • 152
    • 37249070800 scopus 로고    scopus 로고
    • APOA5 variants and metabolic syndrome in Caucasians
    • PID: 17768309
    • Grallert H, Sedlmeier EM, Huth C et al (2007) APOA5 variants and metabolic syndrome in Caucasians. J Lipid Res 48:2614–2621
    • (2007) J Lipid Res , vol.48 , pp. 2614-2621
    • Grallert, H.1    Sedlmeier, E.M.2    Huth, C.3
  • 153
    • 61349178824 scopus 로고    scopus 로고
    • The B3-adrenoceptor as a therapeutic target: current perspectives
    • PID: 19429463
    • Ursino MG, Vasina V, Raschi E, Crema F, De Ponti F (2009) The B3-adrenoceptor as a therapeutic target: current perspectives. Pharmacol Res 59:221–234
    • (2009) Pharmacol Res , vol.59 , pp. 221-234
    • Ursino, M.G.1    Vasina, V.2    Raschi, E.3    Crema, F.4    De Ponti, F.5
  • 154
    • 84897139514 scopus 로고    scopus 로고
    • Obesity-related gene ADRB2, ADRB3 and GHRL polymorphisms and the response to a weight loss diet intervention in adult women
    • PID: 24688286
    • Saliba LF, Reis RS, Brownson RC et al (2014) Obesity-related gene ADRB2, ADRB3 and GHRL polymorphisms and the response to a weight loss diet intervention in adult women. Genet Mol Biol 37:15–22
    • (2014) Genet Mol Biol , vol.37 , pp. 15-22
    • Saliba, L.F.1    Reis, R.S.2    Brownson, R.C.3
  • 156
    • 85022224402 scopus 로고    scopus 로고
    • The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: a meta-analysis
    • PID: 28404887
    • Yang H, Cai D, Zhu Q, Wu D, Wang Q, Wang Z (2017) The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: a meta-analysis. Oncotarget 8:46480–46490
    • (2017) Oncotarget , vol.8 , pp. 46480-46490
    • Yang, H.1    Cai, D.2    Zhu, Q.3    Wu, D.4    Wang, Q.5    Wang, Z.6
  • 157
    • 84863295854 scopus 로고    scopus 로고
    • Physical activity and risk of cardiovascular disease—a meta-analysis of prospective cohort studies
    • PID: 22470299
    • Li J, Siegrist J (2012) Physical activity and risk of cardiovascular disease—a meta-analysis of prospective cohort studies. Int J Environ Res Public Health 9:391–407
    • (2012) Int J Environ Res Public Health , vol.9 , pp. 391-407
    • Li, J.1    Siegrist, J.2
  • 158
    • 85011846490 scopus 로고    scopus 로고
    • Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management
    • Chaudhury A, Duvoor C, Reddy Dendi VS et al (2017) Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management. Front Endocrinol (Lausanne) 8:6. 10.3389/fendo.2017.00006
    • (2017) Front Endocrinol (Lausanne) , vol.8 , pp. 6
    • Chaudhury, A.1    Duvoor, C.2    Reddy Dendi, V.S.3
  • 159
    • 78649957959 scopus 로고    scopus 로고
    • Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes
    • PID: 21134520
    • Nyenwe EA, Jerkins TW, Umpierrez GE et al (2011) Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metab Clin Exp 60:1–23
    • (2011) Metab Clin Exp , vol.60 , pp. 1-23
    • Nyenwe, E.A.1    Jerkins, T.W.2    Umpierrez, G.E.3
  • 160
    • 33751023105 scopus 로고    scopus 로고
    • Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease?
    • PID: 21894646
    • Dawson J, Walters M (2006) Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? Br J Clin Pharmacol 62:633–644
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 633-644
    • Dawson, J.1    Walters, M.2
  • 161
    • 84875179301 scopus 로고    scopus 로고
    • An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice
    • PID: 23396211
    • Reilly SM, Chiang SH, Decker SJ (2013) An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nat Med 19:313–321
    • (2013) Nat Med , vol.19 , pp. 313-321
    • Reilly, S.M.1    Chiang, S.H.2    Decker, S.J.3
  • 162
    • 84971250018 scopus 로고    scopus 로고
    • Treatment of obesity: weight loss and bariatric surgery
    • Bruce M, Wolfe, Kvach E et al (2016) Treatment of obesity: weight loss and bariatric surgery. Circ Res 118:1844–1855
    • (2016) Circ Res , vol.118 , pp. 1844-1855
    • Bruce, M.1    Wolfe2    Kvach, E.3
  • 163
    • 85013078154 scopus 로고    scopus 로고
    • The physiology and molecular underpinnings of the effects of bariatric surgery on obesity and diabetes
    • PID: 27912678
    • Evers SS, Sandoval DA, Seeley RJ (2016) The physiology and molecular underpinnings of the effects of bariatric surgery on obesity and diabetes. Annu Rev Physiol 79:313–334
    • (2016) Annu Rev Physiol , vol.79 , pp. 313-334
    • Evers, S.S.1    Sandoval, D.A.2    Seeley, R.J.3
  • 164
    • 20644449050 scopus 로고    scopus 로고
    • Pathophysiology of dyslipidaemia in the metabolic syndrome
    • PID: 15937200
    • Kolovou G, Anagnostopoulou K, Cokkinos D (2005) Pathophysiology of dyslipidaemia in the metabolic syndrome. Postgrad Med J 81:358–366
    • (2005) Postgrad Med J , vol.81 , pp. 358-366
    • Kolovou, G.1    Anagnostopoulou, K.2    Cokkinos, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.