The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: A meta-analysis

Oncotarget

Volumn 8, Issue 28, 2017, Pages 46480-46490

  Yang, Hualing ^a,b   Cai, Dongmiao ^a,b   Zhu, Qingping ^a,b   Wu, Dongjin ^a,b   Wang, Qingxiang ^a,b   Wang, Zhanxiang ^a,b  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Blood pressure; Hypertension; Meta analysis; Polymorphism; 3 adrenoreceptor

Indexed keywords

ARGININE; TRYPTOPHAN; BETA 3 ADRENERGIC RECEPTOR; BIOLOGICAL MARKER;

ADRB3 GENE; AMINO ACID SUBSTITUTION; ARTICLE; BODY MASS; CHINESE; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MISSENSE MUTATION; RECEPTOR GENE; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; ALLELE; BLOOD PRESSURE; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MALE; META ANALYSIS; MUTATION; ODDS RATIO; PATHOPHYSIOLOGY; PHENOTYPE; RISK;

ALLELES; AMINO ACID SUBSTITUTION; BIOMARKERS; BLOOD PRESSURE; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; MALE; MUTATION; ODDS RATIO; PHENOTYPE; RECEPTORS, ADRENERGIC, BETA-3; RISK;

EID: 85022224402     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16666     Document Type: Article

References (43)

1. Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res. 2015; 116:991-1006
2. Cabia B, Andrade S, Carreira MC, Casanueva FF, Crujeiras AB. A role for novel adipose tissue-secreted factors in obesity-related carcinogenesis. Obes Rev. 2016; 17:361-376
3. Deiuliis JA, Liu LF, Belury MA, Rim JS, Shin S, Lee K. Beta(3)-adrenergic signaling acutely down regulates adipose triglyceride lipase in brown adipocytes. Lipids. 2010; 45:479-489
4. Erhardt E, Czako M, Csernus K, Molnar D, Kosztolanyi G. The frequency of Trp64Arg polymorphism of the beta3-adrenergic receptor gene in healthy and obese Hungarian children and its association with cardiovascular risk factors. Eur J Clin Nutr. 2005; 59:955-959
5. Philipson LH. beta-Agonists and metabolism. J Allergy Clin Immunol. 2002; 110:S313-317
6. Mund RA, Frishman WH. Brown adipose tissue thermogenesis: beta3-adrenoreceptors as a potential target for the treatment of obesity in humans. Cardiol Rev. 2013; 21:265-269
7. Dessy C, Balligand JL. Beta3-adrenergic receptors in cardiac and vascular tissues emerging concepts and therapeutic perspectives. Adv Pharmacol. 2010; 59:135-163
8. Gasparetti AL, Alvarez-Rojas F, de Araujo EP, Hirata AE, Saad MJ, Velloso LA. beta3-Adrenergic-dependent and-independent mechanisms participate in cold-induced modulation of insulin signal transduction in brown adipose tissue of rats. Pflugers Arch. 2005; 449:537-546.
9. Campagna F, Montali A, Baroni MG, Maria AT, Ricci G, Antonini R, Verna R, Arca M. Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperlipidemia. Metabolism. 2002; 51:1298-1305
10. Mirrakhimov AE, Kerimkulova AS, Lunegova OS, Moldokeeva CB, Zalesskaya YV, Abilova SS, Sovhozova NA, Aldashev AA, Mirrakhimov EM. An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances. Cardiovasc Diabetol. 2011; 10:89
11. Ikegami H, Yamato E, Fujisawa T, Hamada Y, Fujioka Y, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T. Analysis of candidate genes for insulin resistance in essential hypertension. Hypertens Res. 1996; 19:S31-34
12. Buettner R, Schaffler A, Arndt H, Rogler G, Nusser J, Zietz B, Enger I, Hugl S, Cuk A, Scholmerich J, Palitzsch KD. The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort. J Clin Endocrinol Metab. 1998; 83:2892-2897
13. Iwamoto Y, Ohishi M, Yuan M, Tatara Y, Kato N, Takeya Y, Onishi M, Maekawa Y, Kamide K, Rakugi H. beta-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients. Hypertens Res. 2011; 34:573-577
14. Grygiel-Gorniak B, Kaczmarek E, Mosor M, Przyslawski J, Nowak J. Association of PPAR-gamma2 and beta3-AR Polymorphisms With Postmenopausal Hypertension. J Clin Hypertens (Greenwich). 2015; 17:549-556
15. Yuan M, Ohishi M, Ito N, Sugimoto K, Takagi T, Terai M, Katsuya T, Rakugi H, Wu Z, Ogihara T. Genetic influences of beta-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients. Hypertens Res. 2006; 29:875-881
16. Wang L, Zhang B, Li M, Li C, Liu J, Liu Y, Wang Z, Zhou J, Wen S. Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals. Hypertens Res. 2014; 37:1068-1074
17. Tonolo G, Melis MG, Secchi G, Atzeni MM, Angius MF, Carboni A, Ciccarese M, Malavasi A, Maioli M. Association of Trp64Arg beta 3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population. J Hypertens. 1999; 17:33-38
18. Strazzullo P, Iacone R, Siani A, Cappuccio FP, Russo O, Barba G, Barbato A, D'Elia L, Trevisan M, Farinaro E. Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study. J Hypertens. 2001; 19:399-406
19. Ruixing Y, Jinzhen W, Shangling P, Weixiong L, Dezhai Y, Yuming C. Sex differences in environmental and genetic factors for hypertension. Am J Med. 2008; 121:811-819
20. Ringel J, Kreutz R, Distler A, Sharma AM. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus. Am J Hypertens. 2000; 13:1027-1031
21. Pamies-Andreu E, Garcia-Lozano R, Palmero-Palmero C, Garcia-Morillo S, Alonso-Arcas A, Stiefel P, Carneado de la Fuente J, Villar J. Genetic variation in the beta-3-adrenergic receptor in essential hypertension. Life Sci. 2000; 67:391-397
22. Oizumi T, Daimon M, Saitoh T, Kameda W, Yamaguchi H, Ohnuma H, Igarashi M, Eguchi H, Manaka H, Tominaga M, Kato T. Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample. Diabetes Care. 2001; 24:1579-1583
23. Nagano T, Matsuda Y, Tanioka T, Yoshioka T, Hiroi T, Yoshikawa K, Okabe K, Osaka K, Nagamine I, Takasaka Y. No association of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia. J Med Invest. 2005; 52:57-64
24. Mo W, Zhang GG, Yang TL, Dai XP, Li HH, Zeng H, Liu J, Tan YM, Zhou HH, Liu ZQ. The genetic polymorphisms of beta3-adrenergic receptor (AR) Trp64Arg and beta2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients. Clin Chem Lab Med. 2007; 45:493-498
25. Masuo K, Katsuya T, Fu Y, Rakugi H, Ogihara T, Tuck ML. Beta2-and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years. Circulation. 2005; 111:3429-3434
26. Kawaguchi H, Masuo K, Katsuya T, Sugimoto K, Rakugi H, Ogihara T, Tuck ML. beta2-and beta3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals. Hypertens Res. 2006; 29:951-959
27. Hui P, Nakayama T, Morita A, Sato N, Hishiki M, Saito K, Yoshikawa Y, Tamura M, Sato I, Takahashi T, Soma M, Izumi Y, Ozawa Y, et al. Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption. Hypertens Res. 2007; 30:585-592
28. Fujisawa T, Ikegami H, Yamato E, Hamada Y, Kamide K, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T. Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system. Am J Hypertens. 1997; 10:101-105
29. Filigheddu F, Reid JE, Troffa C, PinnaParpaglia P, Argiolas G, Testa A, Skolnick M, Glorioso N. Genetic polymorphisms of the beta-adrenergic system: association with essential hypertension and response to beta-blockade. Pharmacogenomics J. 2004; 4:154-160
30. Chou YC, Tsai CN, Lee YS, Pei JS. Association of adrenergic receptor gene polymorphisms with adolescent obesity in Taiwan. Pediatr Int. 2012; 54:111-116
31. Baba T, Nakajima S, Yajima Y. Beta3-adrenergic receptor gene polymorphism is not associated with hypertension in NIDDM patients without nephropathy. Horm Metab Res. 1998; 30:629-632
32. Sheng LJ, Ruan CC, Ma Y, Chen DR, Kong LR, Zhu DL, Gao PJ. Beta3 adrenergic receptor is involved in vascular injury in deoxycorticosterone acetate-salt hypertensive mice. FEBS Lett. 2016; 590:769-778
33. Niu W, Wu S, Zhang Y, Li W, Ji K, Gao P, Zhu D. Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population. J Hypertens. 2010; 28:1854-1861
34. Austin ED, Loyd JE. The genetics of pulmonary arterial hypertension. Circ Res. 2014; 115:189-202
35. Zafarmand MH, van der Schouw YT, Grobbee DE, de Leeuw PW, Bots ML. T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis. J Intern Med. 2008; 263:79-89
36. Kong H, Li X, Zhang S, Guo S, Niu W. The beta1-adrenoreceptor gene Arg389Gly and Ser49Gly polymorphisms and hypertension: a meta-analysis. Mol Biol Rep. 2013; 40:4047-4053
37. Kato N. Ethnic differences in genetic predisposition to hypertension. Hypertens Res. 2012; 35:574-581
38. Padmanabhan S, Caulfield M, Dominiczak AF. Genetic and molecular aspects of hypertension. Circ Res. 2015; 116:937-959
39. Kelly TN, He J. Genomic epidemiology of blood pressure salt sensitivity. J Hypertens. 2012; 30:861-873
40. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7:177-188
41. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327:557-560
42. Mavridis D, Salanti G. How to assess publication bias: funnel plot, trim-and-fill method and selection models. Evid Based Ment Health. 2014; 17:30
43. Palmer T, Sterne J. Meta-Analysis in Stata: An Updated Collection from the Stata Journal. 2nd edition. College Station, TX: Stata Press. 2016