Obesity-related gene ADRB2, ADRB3 and GHRL polymorphisms and the response to a weight loss diet intervention in adult women

Genetics and Molecular Biology

Volumn 37, Issue 1, 2014, Pages 15-22

  Saliba, Louise F ^a,b   Reis, Rodrigo S ^a,b   Brownson, Ross C ^c,d   Hino, Adriano A ^a,b   Tureck, Luciane V ^a   Valko, Cheryl ^c   de Souza, Ricardo L R ^a   Furtado Alle, Lupe ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^d USA   (United States)

Author keywords

Adrenergic receptor polymorphism; Ghrelin polymorphism; Nutrigenetics; Obesity; Weight loss

Indexed keywords

ADRB2 GENE; ADRB3 GENE; ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENOTYPE; GHRL GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR DYNAMICS; OBESITY; OUTCOME ASSESSMENT; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL STATUS; SYNDROME DELINEATION; TREATMENT RESPONSE; WEIGHT REDUCTION; YOUNG ADULT;

EID: 84897139514     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572014000100005     Document Type: Article

References (48)

1. Abete I, Navas-Carretero S, Marti A and Martinez JA (2012) Nutrigenetics and nutrigenomics of caloric restriction. Progr Mol Biol Translational Sci 108:323-346.
2. Ando T, Ichimaru Y, Konjiki F, Shoji M and Komaki G (2007) Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women. Am J Clin Nutr 86:25-32.
3. Avenell A, Sattar N and Lean M (2006) ABC of obesity. Management: Part I-Behaviour change, diet, and activity. BMJ 333:740-743.
4. Blundell JE (2006) Perspective on the central control of appetite. Obesity (Silver Spring) 14 Suppl 4:160S-163S.
5. Booth SL, Sallis JF, Ritenbaugh C, Hill JO, Birch LL, Frank LD, Glanz K, Himmelgreen DA, Mudd M, Popkin BM, et al. (2001) Environmental and societal factors affect food choice and physical activity: Rationale, influences, and leverage points. Nutr Rev 59:S21-S39; discussion S57-S65.
6. Brasil (2008) Guia alimentar para a População Brasileira: Promovendo a Alimentação Saudável. Ministério da Saúde, Brasília, 210 pp.
7. Bray MS (2008) Implications of gene-behavior interactions: Prevention and intervention for obesity. Obesity (Silver Spring) 16 Suppl 3:S72-S78.
8. Castaneda TR, Tong J, Datta R, Culler M and Tschop MH (2010) Ghrelin in the regulation of body weight and metabolism. Front Neuroendocrinol 31:44-60.
9. Daghestani MH, Warsy A, Al-Odaib AN, Eldali A, Al-Eisa NA, Omer SA and Hassan ZK (2012) Arginine 16 Glycine polymorphism in beta2-Adrenergic Receptor Gene is associated with obesity, hyperlipidemia, hyperleptinemia, and insulin resistance in Saudis. Int J Endocrinol 2012:945608.
10. de Luis DA, Aller R, Izaola O, Gonzalez Sagrado M and Conde R (2008) Relation of Trp64Arg polymorphism of beta 3-adrenergic receptor gene to adipocytokines and fat distribution in obese patients. Ann Nutr Metab 52:267-271.
11. Dinsa GD, Goryakin Y, Fumagalli E and Suhrcke M (2012) Obesity and socioeconomic status in developing countries: A systematic review. Obes Rev 13:1067-1079.
12. Drong AW, Lindgren CM and McCarthy MI (2012) The genetic and epigenetic basis of type 2 diabetes and obesity. Clin Pharmacol Ther 92:707-715.
13. Enocksson S, Shimizu M, Lonnqvist F, Nordenstrom J and Arner P (1995) Demonstration of an in vivo functional beta 3-adre-noceptor in man. J Clin Invest 95:2239-2245.
14. Finkelstein EA, Ruhm CJ and Kosa KM (2005) Economic causes and consequences of obesity. Annu Rev Public Health 26:239-257.
15. Garenc C, Perusse L, Chagnon YC, Rankinen T, Gagnon J, Borecki IB, Leon AS, Skinner JS, Wilmore JH, Rao DC, et al. (2003) Effects of beta2-adrenergic receptor gene variants on adiposity: The HERITAGE Family Study. Obes Res 11:612-618.
16. Hetherington MM and Cecil JE (2010) Gene-environment interactions in obesity. Forum Nutr 63:195-203.
17. Hill JO, Thompson H and Wyatt H (2005) Weight maintenance: What's missing? J Am Diet Assoc 105:S63-S66.
18. Hossain P, Kawar B and El-Nahas M (2007) Obesity and diabetes in the developing world-A growing challenge. N Engl J Med 356:213-215.
19. Insel PA (1996) Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors-Evolving concepts and clinical implications. N Engl J Med 334:580-585.
20. Isaak CK and Siow YL (2013) The evolution of nutrition research. Can J Physiol Pharmacol 91:257-267.
21. Jalba MS, Rhoads GG and Demissie K (2008) Association of codon 16 and codon 27 beta 2-adrenergic receptor gene polymorphisms with obesity: A meta-analysis. Obesity (Silver Spring) 16:2096-2106.
22. Kojima M and Kangawa K (2005) Ghrelin: Structure and function. Physiol Rev 85:495-522.
23. Korbonits M, Gueorguiev M, O'Grady E, Lecoeur C, Swan DC, Mein CA, Weill J, Grossman AB and Froguel P (2002) A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab 87:4005-4008.
24. Kurokawa N, Young EH, Oka Y, Satoh H, Wareham NJ, Sandhu MS and Loos RJ (2008) The ADRB3 Trp64Arg variant and BMI: A meta-analysis of 44 833 individuals. Int J Obes 32:1240-1249.
25. Lahiri DK and Nurnberger Jr JI (1991) A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19:5444.
26. Lange LA, Norris JM, Langefeld CD, Nicklas BJ, Wagenknecht LE, Saad MF and Bowden DW (2005) Association of adipose tissue deposition and beta-2 adrenergic receptor variants: The IRAS family study. Int J Obes 29:449-457.
27. Loos RJ (2012) Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab 26:211-226.
28. Mattevi VS, Zembrzuski VM and Hutz MH (2006) Impact of variation in ADRB2, ADRB3, and GNB3 genes on body mass index and waist circumference in a Brazilian population. Am J Hum Biol18:182-186.
29. Moreno-Aliaga MJ, Santos JL, Marti A and Martinez JA (2005) Does weight loss prognosis depend on genetic make-up? Obes Rev 6:155-168.
30. Oberkofler H, Esterbauer H, Hell E, Krempler F and Patsch W (2000) The Gln27Glu polymorphism in the beta2-adrenergic receptor gene is not associated with morbid obesity in Austrian women. Int J Obes Relat Metab Disord 24:388-390.
31. Pereira AC, Floriano MS, Mota GF, Cunha RS, Herkenhoff FL, Mill JG and Krieger JE (2003) Beta2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population. Hypertension 42:685-692.
32. Popkin BM (2004) The nutrition transition: An overview of world patterns of change. Nutr Rev 62:S140-143.
33. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Perusse L and Bouchard C (2006) The human obesity gene map: The 2005 update. Obesity (Silver Spring) 14:529-644.
34. Rawson ES, Nolan A, Silver K, Shuldiner AR and Poehlman ET (2002) No effect of the Trp64Arg beta(3)-adrenoceptor gene variant on weight loss, body composition, or energy expenditure in obese, caucasian postmenopausal women. Metabolism 51:801-805.
35. Rudkowska I and Perusse L (2012) Individualized weight management: What can be learned from nutrigenomics and nutrigenetics? Progr Mol Biol Translational Sci 108:347-382.
36. Ruiz JR, Larrarte E, Margareto J, Ares R and Labayen I (2011) Role of beta(2)-adrenergic receptor polymorphisms on body weight and body composition response to energy restriction in obese women: Preliminary results. Obesity (Silver Spring) 19:212-215.
37. Scofield MA, Deupree JD and Bylund DB (2002) Adrenergic receptor genes: cDNA and genomic library construction. Mol Biotechnol 21:171-197.
38. Seagle HM, Strain GW, Makris A and Reeves RS (2009) Position of the American Dietetic Association: Weight management. J Am Diet Assoc 109:330-346.
39. Swinburn BA, Caterson I, Seidell JC and James WP (2004) Diet, nutrition and the prevention of excess weight gain and obesity. Public Health Nutr 7:123-146.
40. Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML and Gortmaker SL (2011) The global obesity pandemic: Shaped by global drivers and local environments. Lancet 378:804-814.
41. Takenaka A, Nakamura S, Mitsunaga F, Inoue-Murayama M, Udono T and Suryobroto B (2012) Human-specific SNP in obesity genes, adrenergic receptor beta2 (ADRB2), Beta3 (ADRB3), and PPAR gamma2 (PPARG), during primate evolution. PLoS One 7:e43461.
42. Ukkola O (2011) Genetic variants of ghrelin in metabolic disorders. Peptides 32:2319-2322.
43. Ukkola O, Ravussin E, Jacobson P, Snyder EE, Chagnon M, Sjostrom L and Bouchard C (2001a) Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab 86:3996-3999.
44. Ukkola O, Tremblay A and Bouchard C (2001b) Beta-2 adrenergic receptor variants are associated with subcutaneous fat accumulation in response to long-term overfeeding. Int J Obes Relat Metab Disord 25:1604-1608.
45. Ukkola O, Ravussin E, Jacobson P, Perusse L, Rankinen T, Tschop M, Heiman ML, Leon AS, Rao DC, Skinner JS, et al. (2002) Role of ghrelin polymorphisms in obesity based on three different studies. Obes Res 10:782-791.
46. Wells JC, Marphatia AA, Cole TJ and McCoy D (2012) Associations of economic and gender inequality with global obesity prevalence: Understanding the female excess. Soc Sci Med 75:482-490.
47. WHO (2000) Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894, 253 pp.
48. Wing RR and Phelan S (2005) Long-term weight loss maintenance. Am J Clin Nutr 82:222S-225S.