Association of the TNF-α -308 G/A promoter polymorphism with insulin resistance in obesity

Obesity Research

Volumn 10, Issue 5, 2002, Pages 401-407

  Dalziel, Bronwen ^a   Gosby, Alison K ^a   Richman, Rosemary M ^b   Bryson, Janet M ^a   Caterson, Ian D ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

High density lipoprotein cholesterol; Homeostasis model assessment; Insulin resistance; Tumor necrosis factor

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ARTICLE; BLOOD; BLOOD PRESSURE; BODY COMPOSITION; BODY CONSTITUTION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOMEOSTASIS; HOMOZYGOTE; HUMAN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL DEVELOPMENT;

ADULT; ALLELES; BLOOD PRESSURE; BODY COMPOSITION; BODY CONSTITUTION; CHOLESTEROL, HDL; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMEOSTASIS; HOMOZYGOTE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX CHARACTERISTICS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036581014     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2002.55     Document Type: Article

References (32)

1. Halleux CM, Servais I, Reul BA, Detry R, Brichard SM. Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue: increased responsiveness to glucocorticoids in obesity. J Clin Endocrinol & Metab. 1998;83:902-10.
2. Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12.
3. Hotamisligil GS, Spiegelman BM. Tumor necrosis factor-alpha: a key component of the obesity-diabetes link. Diabetes. 1994;43:1271-8.
4. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest. 1994;94:1543-9.
5. Liu LS, Spelleken M, Rohrig K, Hauner H, Eckel J. Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor. Diabetes. 1998;47:515-22.
6. 307. J Biol Chem. 2000;275:9047-54.
7. Hamann A, Mantzoros C, Vidal-Puig A, Flier JS. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Commun. 1995;211:833-9.
8. Skoog T, van't Hooft FM, Kallin B, et al. A common functional polymorphism (C->A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha. Hum Mol Gen. 1999;8:1443-9.
9. Norman RA, Bogardus C, Ravussin E. Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest. 1995;96:158-62.
10. Kroeger KM, Carville KS, Abraham LJ. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol. 1997;34:391-9.
11. Louis E, Franchimont D, Piron A, et al. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol. 1998;113: 401-6.
12. Fernandez-Real JM, Gutierrez C, Ricart W, et al. The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels. Diabetes. 1997;46:1468-72.
13. Walston J, Seibert M, Yen CJ, Cheskin LJ, Andersen RE. Tumor necrosis factor-alpha -238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance. Diabetes. 1999;48:2096-8.
14. Hoffstedt J, Eriksson P, Hellstrom L, Rossner S, Ryden M, Arner P. Excessive fat accumulation is associated with the TNF alpha -308 G/A promoter polymorphism in women but not in men. Diabetologia. 2000;43:117-20.
15. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000;23:57-63.
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-9.
17. Milner CR, Craig JE, Hussey ND, Norman RJ. No association between the -308 polymorphism in the tumour necrosis factor alpha (TNF-alpha) promoter region and polycystic ovaries. Mol Hum Reprod. 1999;5:5-9.
18. Lee SC, Pu YB, Thomas GN, et al. Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome. Metabolism. 2000;49:1021-4.
19. Koch M, Rett K, Volk A, et al. The tumour necrosis factor-alpha -238 G-> A and -308 G-> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of type II diabetic patients. Diabetologia. 2000;43:181-4.
20. Rasmussen SK, Urhammer SA, Jensen JN, Hansen T, Borch-Johnsen K, Pedersen O. The -238 and -308 G->A polymorphisms of the tumor necrosis factor-alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians. J Clin Endocrinol Metab. 2000;85:1731-4.
21. Herrmann SM, Ricard S, Nicaud V, et al. Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity. Euro J Clin Invest. 1998;28:59-66.
22. Brand E, Schorr U, Kunz I, et al. Tumor necrosis factor-alpha-308 G/A polymorphism in obese Caucasians. Int J Obes Relat Metab Disord. 2001;25:581-5.
23. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995;95:2409-15.
24. Dandona P, Weinstock R, Thusu K, Abdel-Rahman E, Aljada A, Wadden T. Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab. 1998;83:2907-10.
25. Kras KM, Hausman DB, Martin RJ. Tumor necrosis factor-alpha stimulates cell proliferation in adipose tissue-derived stromal-vascular cell culture: promotion of adipose tissue expansion by paracrine growth factors. Obes Res. 2000;8:186-93.
26. Rahn Landstrom T, Mei J, Karlsson M, Manganiello V, Degerman E. Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP. Biochem J. 2000;346:337-43.
27. Pausova Z, Deslauriers B, Gaudet D, et al. Role of tumor necrosis factor-alpha gene locus in obesity and obesity-associated hypertension in French Canadians. Hypertension. 2000; 36:14-9.
28. Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest. 1997;100:2777-82.
29. da Silva B, Gapstur SM, Achenbach YH, et al. Lack of association between the -308 polymorphism of the tumor necrosis factor-alpha gene and the insulin resistance syndrome. J Investig Med. 2000;48:236-44.
30. Zhang B, Berger J, Hu E, et al. Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol. 1996;10:1457-66.
31. Perrey S, Ishibashi S, Yahagi N, et al. Thiazolidinedione-and tumor necrosis factor alpha-induced down-regulation of peroxisome proliferator-activated receptor-gamma mRNA in differentiated 3T3-L1 adipocytes. Metabolism. 2001;50:36-40.
32. Zeghari N, Vidai H, Younsi M, Ziegler O, Drouin P, Donner M. Adipocyte membrane phospholipids and PPAR-gamma expression in obese women: relationship to hyperinsulinemia. Am J Physiol Endocrinol Metab. 2000;279: E736-E43.