Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells

Cell Stem Cell

Volumn 20, Issue 2, 2017, Pages 177-190.e4

  Basak, Onur ^a,b   Beumer, Joep ^a,b   Wiebrands, Kay ^a,b   Seno, Hiroshi ^d   van Oudenaarden, Alexander ^a,b   Clevers, Hans ^a,b,c  

^a HUBRECHT INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c University Medical Center Utrecht Princess Máxima Center for Pediatric Oncology   (Netherlands)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

EGFR signaling; enteroendocrine cell; intestinal stem cells; Lgr5; organoids; quiescence

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LGR5 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; G PROTEIN COUPLED RECEPTOR; HORMONE; LGR5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FATE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; ENTEROENDOCRINE CELL; HORMONE SYNTHESIS; IN VITRO STUDY; INTESTINAL STEM CELL; INTESTINE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL LINEAGE; CYTOLOGY; GENE EXPRESSION PROFILING; INTESTINE; METABOLISM; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; STEM CELL;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; ENTEROENDOCRINE CELLS; GENE EXPRESSION PROFILING; HORMONES; INTESTINES; MAP KINASE SIGNALING SYSTEM; MICE; ORGANOIDS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NOTCH; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; STEM CELLS; WNT PROTEINS;

EID: 85008153076     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.11.001     Document Type: Article

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