-
1
-
-
33748039462
-
Symbiotic bacteria direct expression of an intestinal bactericidal lectin
-
Cash, H.L., Whitham, C.V., Behrendt, C.L., Hooper, L.V. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313, 1126-1130 (2006).
-
(2006)
Science
, vol.313
, pp. 1126-1130
-
-
Cash, H.L.1
Whitham, C.V.2
Behrendt, C.L.3
Hooper, L.V.4
-
2
-
-
84925293456
-
Epigenomic regulation of host-microbiota interactions
-
Alenghat, T., Artis, D. Epigenomic regulation of host-microbiota interactions. Trends Immunol. 35, 518-525 (2014).
-
(2014)
Trends Immunol.
, vol.35
, pp. 518-525
-
-
Alenghat, T.1
Artis, D.2
-
3
-
-
84920072945
-
Commensal microbiota regulates T cell fate decision in the gut
-
Furusawa, Y., Obata, Y., Hase, K. Commensal microbiota regulates T cell fate decision in the gut. Semin. Immunopathol. 37, 17-25 (2015).
-
(2015)
Semin. Immunopathol.
, vol.37
, pp. 17-25
-
-
Furusawa, Y.1
Obata, Y.2
Hase, K.3
-
4
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J.P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
5
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
-
6
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi, K.S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
-
7
-
-
84907597189
-
Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus
-
Ramanan, D., Tang, M.S., Bowcutt, R., Loke, P., Cadwell, K. Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity 41, 311-324 (2014).
-
(2014)
Immunity
, vol.41
, pp. 311-324
-
-
Ramanan, D.1
Tang, M.S.2
Bowcutt, R.3
Loke, P.4
Cadwell, K.5
-
8
-
-
70349468054
-
Nod2 is required for the regulation of commensal microbiota in the intestine
-
Petnicki-Ocwieja, T. et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc. Natl. Acad. Sci. USA 106, 15813-15818 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 15813-15818
-
-
Petnicki-Ocwieja, T.1
-
9
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett, J.C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
-
10
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke, A. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42, 1118-1125 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
-
11
-
-
79952195585
-
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
-
Anderson, C.A. et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat. Genet. 43, 246-252 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 246-252
-
-
Anderson, C.A.1
-
12
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
Zimprich, A. et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607 (2004).
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
-
13
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisán-Ruíz, C. et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600 (2004).
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisán-Ruíz, C.1
-
14
-
-
80054933395
-
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
-
Liu, Z. et al. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat. Immunol. 12, 1063-1070 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1063-1070
-
-
Liu, Z.1
-
15
-
-
78149473340
-
LRRK2 is involved in the IFN-? response and host response to pathogens
-
Gardet, A. et al. LRRK2 is involved in the IFN-? response and host response to pathogens. J. Immunol. 185, 5577-5585 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 5577-5585
-
-
Gardet, A.1
-
16
-
-
84873672050
-
Paneth cells: Maestros of the small intestinal crypts
-
Clevers, H.C., Bevins, C.L. Paneth cells: maestros of the small intestinal crypts. Annu. Rev. Physiol. 75, 289-311 (2013).
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 289-311
-
-
Clevers, H.C.1
Bevins, C.L.2
-
17
-
-
58549111588
-
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
-
Vaishnava, S., Behrendt, C.L., Ismail, A.S., Eckmann, L., Hooper, L.V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 105, 20858-20863 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 20858-20863
-
-
Vaishnava, S.1
Behrendt, C.L.2
Ismail, A.S.3
Eckmann, L.4
Hooper, L.V.5
-
18
-
-
84887621906
-
Paneth cells as a site of origin for intestinal inflammation
-
Adolph, T.E. et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-276 (2013).
-
(2013)
Nature
, vol.503
, pp. 272-276
-
-
Adolph, T.E.1
-
19
-
-
0033214433
-
Regulation of intestinal ?-defensin activation by the metalloproteinase matrilysin in innate host defense
-
Wilson, C.L. et al. Regulation of intestinal ?-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113-117 (1999).
-
(1999)
Science
, vol.286
, pp. 113-117
-
-
Wilson, C.L.1
-
20
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser, A. et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743-756 (2008).
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
-
21
-
-
0037417311
-
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
-
Salzman, N.H., Ghosh, D., Huttner, K.M., Paterson, Y., Bevins, C.L. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422, 522-526 (2003).
-
(2003)
Nature
, vol.422
, pp. 522-526
-
-
Salzman, N.H.1
Ghosh, D.2
Huttner, K.M.3
Paterson, Y.4
Bevins, C.L.5
-
22
-
-
34547762705
-
MyD88-mediated signals induce the bactericidal lectin RegIII? and protect mice against intestinal Listeria monocytogenes infection
-
Brandl, K., Plitas, G., Schnabl, B., DeMatteo, R.P., Pamer, E.G. MyD88-mediated signals induce the bactericidal lectin RegIII? and protect mice against intestinal Listeria monocytogenes infection. J. Exp. Med. 204, 1891-1900 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1891-1900
-
-
Brandl, K.1
Plitas, G.2
Schnabl, B.3
DeMatteo, R.P.4
Pamer, E.G.5
-
23
-
-
84864335926
-
Human ?-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets
-
Chu, H. et al. Human ?-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science 337, 477-481 (2012).
-
(2012)
Science
, vol.337
, pp. 477-481
-
-
Chu, H.1
-
24
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-263 (2008).
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
-
25
-
-
70349916647
-
UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans
-
Sumakovic, M. et al. UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans. J. Cell Biol. 186, 897-914 (2009).
-
(2009)
J. Cell Biol.
, vol.186
, pp. 897-914
-
-
Sumakovic, M.1
-
26
-
-
0034252293
-
Secretion of microbicidal ?-defensins by intestinal Paneth cells in response to bacteria
-
Ayabe, T. et al. Secretion of microbicidal ?-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1, 113-118 (2000).
-
(2000)
Nat. Immunol.
, vol.1
, pp. 113-118
-
-
Ayabe, T.1
-
27
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
-
29
-
-
33646749270
-
Dense-core secretory granule biogenesis
-
Kim, T., Gondre-Lewis, M.C., Arnaoutova, I., Loh, Y.P. Dense-core secretory granule biogenesis. Physiology (Bethesda) 21, 124-133 (2006).
-
(2006)
Physiology (Bethesda)
, vol.21
, pp. 124-133
-
-
Kim, T.1
Gondre-Lewis, M.C.2
Arnaoutova, I.3
Loh, Y.P.4
-
30
-
-
70349919803
-
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
-
Edwards, S.L. et al. Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2. J. Cell Biol. 186, 881-895 (2009).
-
(2009)
J. Cell Biol.
, vol.186
, pp. 881-895
-
-
Edwards, S.L.1
-
31
-
-
84869204463
-
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans
-
Sasidharan, N. et al. RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 109, 18944-18949 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 18944-18949
-
-
Sasidharan, N.1
-
32
-
-
0022457211
-
Quantitative light microscopic observations on Paneth cells of germ-free and ex-germ-free Wistar rats
-
Satoh, Y., Ishikawa, K., Ono, K., Vollrath, L. Quantitative light microscopic observations on Paneth cells of germ-free and ex-germ-free Wistar rats. Digestion 34, 115-121 (1986).
-
(1986)
Digestion
, vol.34
, pp. 115-121
-
-
Satoh, Y.1
Ishikawa, K.2
Ono, K.3
Vollrath, L.4
-
33
-
-
66449108669
-
Cd1d-dependent regulation of bacterial colonization in the intestine of mice
-
Nieuwenhuis, E.E. et al. Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J. Clin. Invest. 119, 1241-1250 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1241-1250
-
-
Nieuwenhuis, E.E.1
-
34
-
-
84899949037
-
Mouse Paneth cell antimicrobial function is independent of Nod2
-
Shanahan, M.T. et al. Mouse Paneth cell antimicrobial function is independent of Nod2. Gut 63, 903-910 (2014).
-
(2014)
Gut
, vol.63
, pp. 903-910
-
-
Shanahan, M.T.1
-
35
-
-
10744222688
-
Expression of NOD2 in Paneth cells: A possible link to Crohn's ileitis
-
Ogura, Y. et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 52, 1591-1597 (2003).
-
(2003)
Gut
, vol.52
, pp. 1591-1597
-
-
Ogura, Y.1
-
36
-
-
84880816067
-
Review series: Rab GTPases and membrane identity: Causal or inconsequential?
-
Barr, F.A. Review series: Rab GTPases and membrane identity: causal or inconsequential? J. Cell Biol. 202, 191-199 (2013).
-
(2013)
J. Cell Biol.
, vol.202
, pp. 191-199
-
-
Barr, F.A.1
-
37
-
-
84879768677
-
Rab GTPases-cargo direct interactions: Fine modulators of intracellular trafficking
-
Aloisi, A.L., Bucci, C. Rab GTPases-cargo direct interactions: fine modulators of intracellular trafficking. Histol. Histopathol. 28, 839-849 (2013).
-
(2013)
Histol. Histopathol.
, vol.28
, pp. 839-849
-
-
Aloisi, A.L.1
Bucci, C.2
-
38
-
-
84890735514
-
Genetic variants synthesize to produce Paneth cell phenotypes that define subtypes of Crohn's disease
-
VanDussen, K.L. et al. Genetic variants synthesize to produce Paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology 146, 200-209 (2014).
-
(2014)
Gastroenterology
, vol.146
, pp. 200-209
-
-
VanDussen, K.L.1
-
39
-
-
61649114427
-
A common role for Atg16L1 Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease
-
Cadwell, K., Patel, K.K., Komatsu, M., Virgin, H.W. 4th & Stappenbeck, T.S. A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy 5, 250-252 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 250-252
-
-
Cadwell, K.1
Patel, K.K.2
Komatsu, M.3
Virgin, I.V.H.W.4
Stappenbeck, T.S.5
-
40
-
-
77953904042
-
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
-
Cadwell, K. et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 141, 1135-1145 (2010).
-
(2010)
Cell
, vol.141
, pp. 1135-1145
-
-
Cadwell, K.1
-
41
-
-
70349991886
-
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
-
Alegre-Abarrategui, J. et al. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18, 4022-4034 (2009).
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4022-4034
-
-
Alegre-Abarrategui, J.1
-
42
-
-
73849121209
-
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
-
Travassos, L.H. et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat. Immunol. 11, 55-62 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 55-62
-
-
Travassos, L.H.1
-
43
-
-
84928926952
-
IRGM governs the core autophagy machinery to conduct antimicrobial defense
-
Chauhan, S., Mandell, M.A., Deretic, V. IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58, 507-521 (2015).
-
(2015)
Mol. Cell
, vol.58
, pp. 507-521
-
-
Chauhan, S.1
Mandell, M.A.2
Deretic, V.3
-
44
-
-
73849151394
-
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
-
Cooney, R. et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 16, 90-97 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 90-97
-
-
Cooney, R.1
-
45
-
-
84873281274
-
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
-
MacLeod, D.A. et al. RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 77, 425-439 (2013).
-
(2013)
Neuron
, vol.77
, pp. 425-439
-
-
MacLeod, D.A.1
-
46
-
-
84939610945
-
An early endosome regulator, Rab5b, is an LRRK2 kinase substrate
-
Yun, H.J. et al. An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. J. Biochem. 157, 485-495 (2015).
-
(2015)
J. Biochem.
, vol.157
, pp. 485-495
-
-
Yun, H.J.1
-
47
-
-
84910002760
-
LRRK2 transport is regulated by its novel interacting partner Rab32
-
Waschbüsch, D. et al. LRRK2 transport is regulated by its novel interacting partner Rab32. PLoS ONE 9, e111632 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e111632
-
-
Waschbüsch, D.1
-
48
-
-
84884898980
-
NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload
-
Zong, J. et al. NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload. Lab. Invest. 93, 1128-1136 (2013).
-
(2013)
Lab. Invest.
, vol.93
, pp. 1128-1136
-
-
Zong, J.1
-
49
-
-
0037085279
-
Activation of Paneth cell ?-defensins in mouse small intestine
-
Ayabe, T. et al. Activation of Paneth cell ?-defensins in mouse small intestine. J. Biol. Chem. 277, 5219-5228 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5219-5228
-
-
Ayabe, T.1
-
50
-
-
84888331271
-
In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture
-
Miyoshi, H., Stappenbeck, T.S. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nat. Protoc. 8, 2471-2482 (2013).
-
(2013)
Nat. Protoc.
, vol.8
, pp. 2471-2482
-
-
Miyoshi, H.1
Stappenbeck, T.S.2
|