Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Nature

Volumn 545, Issue 7653, 2017, Pages 234-237

  Janda, Claudia Y ^a   Dang, Luke T ^b   You, Changjiang ^c   Chang, Junlei ^a   Lau, Wim De ^d   Zhong, Zhendong A ^e   Yan, Kelley S ^a   Marecic, Owen ^a   Siepe, DIrk ^a   Li, Xingnan ^a   Moody, James D ^b   Williams, Bart O ^e   Clevers, Hans ^d   Piehler, Jacob ^c   Baker, David ^b   Kuo, Calvin J ^a   Garcia, K Christopher ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OSNABRÜCK   (Germany)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e VAN ANDEL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FRIZZLED PROTEIN; FRIZZLED PROTEIN 5; FRIZZLED PROTEIN 8; GLYCOPROTEIN; HETERODIMER; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MEMBRANE RECEPTOR; UNCLASSIFIED DRUG; VANTICTUMAB; WNT AGONIST; WNT PROTEIN; LIGAND;

CELLS AND CELL COMPONENTS; HYDROPHOBICITY; LIGAND; METABOLISM; MUSCLE; PROTEIN; RODENT; SECRETION;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HEPATOMEGALY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER CELL; LIVER METABOLISM; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; WNT SIGNALING PATHWAY; ZONATION; AGONISTS; ANIMAL; CELL DIFFERENTIATION; CELL LINEAGE; CHEMICAL PHENOMENA; CYTOLOGY; CYTOPLASM; HEK293 CELL LINE; INTESTINE; MESENCHYMAL STROMA CELL; METABOLISM; MOLECULAR MODEL; PATHOLOGY; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; SOLUBILITY; TISSUE CULTURE TECHNIQUE; WNT SIGNALING;

MAMMALIA;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; FRIZZLED RECEPTORS; HEK293 CELLS; HEPATOCYTES; HEPATOMEGALY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTESTINES; LIGANDS; LIVER; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MESENCHYMAL STROMAL CELLS; MICE; MODELS, MOLECULAR; ORGANOIDS; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; SOLUBILITY; TISSUE CULTURE TECHNIQUES; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 85018920897     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature22306     Document Type: Article

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