Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease

Gut

Volumn 48, Issue 2, 2001, Pages 176-185

  Cunliffe, R N ^a   Rose, F R A J ^a   Keyte, J ^b   Abberley, L ^a   Chan, W C ^b   Mahida, Y R ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Human defensin 5; Inflammatory bowel disease; Paneth cells

Indexed keywords

DEFENSIN; DEFENSIN 5; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL SECRETION; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PANETH CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; COLONY COUNT, MICROBIAL; DEFENSINS; ELECTROPHORESIS; EPITHELIAL CELLS; HUMANS; IMMUNE SERA; INFLAMMATORY BOWEL DISEASES; PANETH CELLS; PROTEIN PRECURSORS; RABBITS; SEQUENCE ANALYSIS, PROTEIN;

EID: 0035128862     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.2.176     Document Type: Article

References (32)

1. Normal alimentary tract flora
2. Experimental models of inflammatory bowel disease
3. Probing the gastrointestinal immune function using transgenic and knockout technology
4. Antimicrobial peptides in the gastrointestinal tract
5. Antibiotic peptides as mediators of innate immunity
6. Potential role of epithelial cell-derived histone H1 proteins in innate antimicrobial defense in the human gastrointestinal tract
7. Injured primary human colonic epithelial cells release specific antimicrobial activity while undergoing apoptosis
8. Expression of antimicrobial neutrophil defensin and lysozyme is induced in epithelial cells of active inflammatory bowel disease (IBD) mucosa
9. Paneth cells and innate immunity in the crypt microenvironment
10. The distribution of muramidase (lysozyme) in human tissues
11. Bactericidal properties of murine intestinal phospholipase A2
12. Expression of group II phospholipase A2 in the human gastrointestinal tract
13. Purification and primary structure of murine cryptdin-1, a Paneth cell defensin
14. Enteric defensins: Antibiotic peptide components of intestinal host defense
15. Mouse Paneth cell defensins: Primary structures and antibacterial activities of numerous cryptdin isoforms
16. Cryptdins: Antimicrobial defensins of the murine small intestine
17. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3
18. Paneth cells of the human small intestine express an antimicrobial peptide gene
19. Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel
20. Localization of human intestinal defensin 5 in Paneth cell granules
21. Broad-spectrum antimicrobial activity of human intestinal defensin 5
22. Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion
23. Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells
24. A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells
25. Paneth and goblet cell renewal in mouse duodenal crypts
26. On the presence of intermediate cells in the small intestine
27. Morphologic unity of Paneth cells
28. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract
29. Beta-defensins: Endogenous antibiotics of the innate host defense response
30. Isolation of human intestinal defensins from ileal neobladder urine
31. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
32. Defensins. Natural peptide antibiotics of human neutrophils