Dairy Products, Dairy Fatty Acids, and the Prevention of Cardiometabolic Disease: a Review of Recent Evidence

Current Atherosclerosis Reports

Volumn 20, Issue 5, 2018, Pages

  Yu, Edward ^a   Hu, Frank B ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b CHANNING LABORATORY   (United States)

Author keywords

Cardiovascular disease; Dairy; Odd chain fatty acids; Saturated fat; Yogurt

Indexed keywords

FATTY ACID; VEGETABLE OIL; YOGHURT;

CALORIE; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CHEESE; DAIRY PRODUCT; FAT INTAKE; FEEDING BEHAVIOR; FOOD ANALYSIS; FOOD COMPOSITION; FOOD INTAKE; HUMAN; INCIDENCE; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRITIONAL HEALTH; NUTRITIONAL VALUE; REVIEW; CALORIC INTAKE; COMPLICATION; DIET; PROSPECTIVE STUDY; RISK FACTOR;

CARDIOVASCULAR DISEASES; DAIRY PRODUCTS; DIABETES MELLITUS, TYPE 2; DIET; DIETARY FATS; ENERGY INTAKE; FATTY ACIDS; HUMANS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 85044385721     PISSN: 15233804     EISSN: 15346242     Source Type: Journal    
DOI: 10.1007/s11883-018-0724-z     Document Type: Review

References (81)

1. Gaucheron F. Milk and dairy products: a unique micronutrient combination. J Am Coll Nutr. 2011;30(5 Suppl 1):400s–9s.
2. Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation. 2017;136:e1–e23.
3. Agriculture USDo. Food Availability (Per Capita) Data System 2016 [cited 2017 July 26]. Available from: https://www.ers.usda.gov/data-products/food-availability-per-capita-data-system/.
4. Bainbridge ML, Cersosimo LM, Wright A-DG, Kraft J. Content and composition of branched-chain fatty acids in bovine milk are affected by lactation stage and breed of dairy cow. PLoS One. 2016;11(3):e0150386.
5. SR28 U. National Nutrient Database for Standard Reference, Release 28. US Department of Agriculture, Agricultural Research Service, Nutrient Data Laboratory http://www ars usda gov/ba/bhnrc/ndl Accessed. 2016;26.
6. Stefanov I, Baeten V, Abbas O, Colman E, Vlaeminck B, De Baets B, et al. Analysis of milk odd- and branched-chain fatty acids using Fourier transform (FT)-Raman spectroscopy. J Agric Food Chem. 2010;58(20):10804–11.
7. Lock AL, Bauman DE. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids. 2004;39(12):1197–206.
8. O'Donnell-Megaro AM, Barbano DM, Bauman DE. Survey of the fatty acid composition of retail milk in the United States including regional and seasonal variations. J Dairy Sci. 2011;94(1):59–65.
9. Sofie Biong A, Berstad P, Pedersen JI. Biomarkers for intake of dairy fat and dairy products. Eur J Lipid Sci Technol. 2006;108(10):827–34.
10. Horning MG, Martin DB, Karmen A, Vagelos PR. Fatty acid synthesis in adipose tissue. II. Enzymatic synthesis of branched chain and odd-numbered fatty acids. J Biol Chem. 1961;236:669–72.
11. Tserng KY, Kliegman RM, Miettinen EL, Kalhan SC. A rapid, simple, and sensitive procedure for the determination of free fatty acids in plasma using glass capillary column gas-liquid chromatography. J Lipid Res. 1981;22(5):852–8.
12. Eaton S, Bartlett KB, Pourfarzam M. Mammalian mitochondrial β-oxidation. Biochem J. 1996;320(2):345–57.
13. Jenkins B, West JA, Koulman A. A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (c15:0) and heptadecanoic acid (c17:0) in health and disease. Molecules. 2015;20(2):2425–44.
14. National Research Council Committee on Technological Options to Improve the Nutritional Attributes of Animal P. Factors affecting the composition of milk from dairy cows. Designing foods: animal product options in the marketplace. Washington (DC): National Academies Press (US) Copyright (c) 1988 by the National Academy of Sciences.; 1988
15. McGregor RA, Poppitt SD. Milk protein for improved metabolic health: a review of the evidence. Nutr Metab. 2013;10(1):46.
16. Jenness R. Biochemical and nutritional aspects of milk and colostrum. Lactation/edited by Bruce L Larson; written by Ralph R Anderson [et al]. 1985.
17. Scrimshaw NS, Murray EB. The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr. 1988;48(4):1142–59.
18. Willett WC, Reynolds RD, Cottrell-Hoehner S, Sampson L, Browne ML. Validation of a semi-quantitative food frequency questionnaire: comparison with a 1-year diet record. J Am Diet Assoc. 1987;87(1):43–7.
19. Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, et al. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires the Eating at America’s Table Study. Am J Epidemiol. 2001;154(12):1089–99.
20. Byers T, Marshall J, Anthony E, Fiedler R, Zielezny M. The reliability of dietary history from the distant past. Am J Epidemiol. 1987;125(6):999–1011.
21. van Liere MJ, Lucas F, Clavel F, Slimani N, Villeminot S. Relative validity and reproducibility of a French dietary history questionnaire. Int J Epidemiol. 1997;26(Suppl 1):S128–36.
22. Spain EGo. Relative validity and reproducibility of a diet history questionnaire in Spain. I. Foods. Int J Epidemiol. 1997;26(Suppl 1):S91–9.
23. Wolk A, Vessby B, Ljung H, Barrefors P. Evaluation of a biological marker of dairy fat intake. Am J Clin Nutr. 1998;68(2):291–5.
24. Wolk A, Furuheim M, Vessby B. Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. J Nutr. 2001;131(3):828–33.
25. Lankinen M, Schwab U. Biomarkers of dairy fat. Am J Clin Nutr. 2015;101(5):1101–2.
26. Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts GP, et al. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. J Biol Chem. 2005;280(11):9802–12.
27. Kondo N, Ohno Y, Yamagata M, Obara T, Seki N, Kitamura T, et al. Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. Nat Commun. 2014;5:5338.
28. Su X, Han X, Yang J, Mancuso DJ, Chen J, Bickel PE, et al. Sequential ordered fatty acid α oxidation and Δ9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes. Biochemistry. 2004;43(17):5033–44.
29. Roberts LD, Virtue S, Vidal-Puig A, Nicholls AW, Griffin JL. Metabolic phenotyping of a model of adipocyte differentiation. Physiol Genomics. 2009;39(2):109–19.
30. Weitkunat K, Schumann S, Nickel D, Hornemann S, Petzke KJ, Schulze MB, et al. Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate. Am J Clin Nutr. 2017:ajcn152702.
31. Health UDo, Services H. 2015–2020 dietary guidelines for Americans. Washington (DC): USDA. 2015.
32. Guo J, Astrup A, Lovegrove JA, Gijsbers L, Givens DI, Soedamah-Muthu SS. Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol. 2017;32(4):269–87.
33. de Goede J, Soedamah-Muthu SS, Pan A, Gijsbers L, Geleijnse JM. Dairy consumption and risk of stroke: a systematic review and updated dose–response meta-analysis of prospective cohort studies. J Am Heart Assoc: Cardiovasc Cerebrovasc Dis. 2016;5(5):e002787.
34. Soedamah-Muthu SS, Verberne LD, Ding EL, Engberink MF, Geleijnse JM. Dairy consumption and incidence of hypertension: a dose-response meta-analysis of prospective cohort studies. Hypertension. 2012;60(5):1131–7.
35. Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ 2017;356.
36. Kim Y, Je Y. Dairy consumption and risk of metabolic syndrome: a meta-analysis. Diabet Med. 2016;33(4):428–40.
37. Gijsbers L, Ding EL, Malik VS, de Goede J, Geleijnse JM, Soedamah-Muthu SS. Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies. Am J Clin Nutr. 2016;103:1111–24.
38. Mitri J, Barakatun N, Truong S, ElSayed N, Hamdy O. The effect of dairy consumption on lipid profile: a meta-analysis of randomized controlled trials. J Clin Lipidol. 2017;11(3):825–6.
39. Labonté M-È, Couture P, Richard C, Desroches S, Lamarche B. Impact of dairy products on biomarkers of inflammation: a systematic review of randomized controlled nutritional intervention studies in overweight and obese adults. Am J Clin Nutr. 2013;97(4):706–17.
40. Chen GC, Wang Y, Tong X, Szeto IM, Smit G, Li ZN, et al. Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies. Eur J Nutr 2016.
41. Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, et al. Dairy food intake and all-cause, cardiovascular disease, and cancer mortality: the Golestan cohort study. Am J Epidemiol. 2017;185(8):697–711.
42. Committee DGA. Scientific report of the 2015 dietary guidelines advisory committee. Washington (DC): USDA and US Department of Health and Human Services; 2015.
43. Hu FB, Rimm E, Smith-Warner SA, Feskanich D, Stampfer MJ, Ascherio A, et al. Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr. 1999;69(2):243–9.
44. Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB. Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med. 2001;161(15):1857–62.
45. Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC. Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr. 2000;72(4):912–21.
46. Kerver JM, Yang EJ, Bianchi L, Song WO. Dietary patterns associated with risk factors for cardiovascular disease in healthy US adults. Am J Clin Nutr. 2003;78(6):1103–10.
47. Saulnier DMA, Spinler JK, Gibson GR, Versalovic J. Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol. 2009;20(2):135–41.
48. Chen M, Pan A, Malik VS, Hu FB. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012;96(4):735–47.
49. Heller KJ. Probiotic bacteria in fermented foods: product characteristics and starter organisms1–3. Am J Clin Nutr. 2001;73(2):374s–9s.
50. Plessas S, Bosnea L, Alexopoulos A, Bezirtzoglou E. Potential effects of probiotics in cheese and yogurt production: a review. Engineering in Life Sciences. 2012;12(4):433–40.
51. Biong AS, Veierod MB, Ringstad J, Thelle DS, Pedersen JI. Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study. Eur J Clin Nutr. 2005;60(2):236–44.
52. Goldbohm RA, Chorus AM, Galindo Garre F, Schouten LJ, van den Brandt PA. Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr. 2011;93(3):615–27.
53. de Oliveira Otto MC, Mozaffarian D, Kromhout D, Bertoni AG, Sibley CT, Jacobs DR Jr, et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. Am J Clin Nutr. 2012;96(2):397–404.
54. Chen M, Li Y, Sun Q, Pan A, Manson JE, Rexrode KM, et al. Dairy fat and risk of cardiovascular disease in 3 cohorts of US adults. Am J Clin Nutr. 2016;104:1209–17.
55. Li Y, Hruby A, Bernstein AM, Ley SH, Wang DD, Chiuve SE, et al. Saturated fat as compared with unsaturated fats and sources of carbohydrates in relation to risk of coronary heart disease: a prospective cohort study. J Am Coll Cardiol. 2015;66(14):1538–48.
56. Liang J, Zhou Q, Kwame Amakye W, Su Y, Zhang Z. Biomarkers of dairy fat intake and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Crit Rev Food Sci Nutr. 2016:1–9.
57. Forouhi NG, Koulman A, Sharp SJ, Imamura F, Kröger J, Schulze MB, et al. Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study. Lancet Diabetes Endocrinol. 2014;2(10):810–8.
58. Krachler B, Norberg M, Eriksson JW, Hallmans G, Johansson I, Vessby B, et al. Fatty acid profile of the erythrocyte membrane preceding development of type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2008;18(7):503–10.
59. Hodge AM, English DR, O'Dea K, Sinclair AJ, Makrides M, Gibson RA, et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. Am J Clin Nutr. 2007;86(1):189–97.
60. Yakoob MY, Shi P, Willett WC, Rexrode KM, Campos H, Orav EJ, et al. Circulating biomarkers of dairy fat and risk of incident diabetes mellitus among men and women in the United States in two large prospective cohorts. Circulation. 2016;133(17):1645–54.
61. Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, et al. Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders. Am J Clin Nutr. 2014;100(6):1532–40.
62. Patel PS, Sharp SJ, Jansen E, Luben RN, Khaw K-T, Wareham NJ, et al. Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk cohort. Am J Clin Nutr. 2010;92(5):1214–22.
63. Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, et al. Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in US adults. Ann Intern Med. 2010;153(12):790–9.
64. Kröger J, Zietemann V, Enzenbach C, Weikert C, Jansen EH, Döring F, et al. Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study. Am J Clin Nutr. 2011;93(1):127–42.
65. Mozaffarian D, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, et al. Trans-palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the multi-ethnic study of atherosclerosis (MESA). Am J Clin Nutr. 2013;97(4):854–61.
66. Willett W. Nutritional epidemiology: Oxford University Press; 2012.
67. Risérus U, Marklund M. Milk fat biomarkers and cardiometabolic disease. Curr Opin Lipidol. 2017;28(1):46–51.
68. Rosell M, Johansson G, Berglund L, Vessby B, de Faire U, Hellenius ML. The relation between alcohol intake and physical activity and the fatty acids 14:0, 15:0 and 17:0 in serum phospholipids and adipose tissue used as markers for dairy fat intake. Br J Nutr. 2005;93(1):115–21.
69. Jenkins BJ, Seyssel K, Chiu S, Pan P-H, Lin S-Y, Stanley E, et al. Odd chain fatty acids; new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance. Sci Rep. 2017;7:44845.
70. Palmquist DL. Milk fat: origin of fatty acids and influence of nutritional factors thereon. In: Fox PF, McSweeney PLH, editors. Advanced dairy chemistry volume 2 lipids. Boston, MA: Springer US; 2006. p. 43–92.
71. Huth PJ, Park KM. Influence of dairy product and milk fat consumption on cardiovascular disease risk: a review of the evidence. Adv Nutr: Int Rev J. 2012;3(3):266–85.
72. Benatar JR, Sidhu K, Stewart RA. Effects of high and low fat dairy food on cardio-metabolic risk factors: a meta-analysis of randomized studies. PLoS One. 2013;8(10):e76480.
73. Jousilahti P, Laatikainen T, Peltonen M, Borodulin K, Männistö S, Jula A, et al. Primary prevention and risk factor reduction in coronary heart disease mortality among working aged men and women in eastern Finland over 40 years: population based observational study. BMJ. 2016;352
74. Gao D, Ning N, Wang C, Wang Y, Li Q, Meng Z, et al. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response Meta-analysis. PLoS One. 2013;8(9):e73965.
75. García Yu IA-L, Sánchez-Aguadero N, Recio-Rodríguez JI. Chapter 25 - Effect of the fat component of dairy products in cardiovascular health, vascular structure and function A2 - Watson, Ronald Ross. In: Collier RJ, Preedy VR, editors. Nutrients in dairy and their implications on health and disease: Academic Press; 2017. p. 325–32.
76. Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D, et al. Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol. 1999;149(6):531–40.
77. Popkin BM, Nielsen SJ. The sweetening of the world’s diet. Obes Res. 2003;11(11):1325–32.
78. Mattar R, de Campos Mazo DF, Carrilho FJ. Lactose intolerance: diagnosis, genetic, and clinical factors. Clin Exp Gastroenterol. 2012;5:113–21.
79. Dugan CE, Barona J, Fernandez ML. Increased dairy consumption differentially improves metabolic syndrome markers in male and female adults. Metab Syndr Relat Disord. 2014;12(1):62–9.
80. Wang H, Steffen LM, Vessby B, Basu S, Steinberger J, Moran A, et al. Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents. Obesity (Silver Spring). 2011;19(12):2404–10.
81. Dalmeijer GW, Struijk EA, van der Schouw YT, Soedamah-Muthu SS, Verschuren WMM, Boer JMA, et al. Dairy intake and coronary heart disease or stroke—a population-based cohort study. Int J Cardiol. 2013;167(3):925–9.