Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Nature Neuroscience

Volumn 21, Issue 3, 2018, Pages 329-340

  Spiller, Krista J ^a   Restrepo, Clark R ^a   Khan, Tahiyana ^a   Dominique, Myrna A ^a   Fang, Terry C ^b   Canter, Rebecca G ^b   Roberts, Christopher J ^b   Miller, Kelly R ^a   Ransohoff, Richard M ^c   Trojanowski, John Q ^a   Lee, Virginia M Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BIOGEN   (United States)

^c THIRD ROCK VENTURES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; COPPER ZINC SUPEROXIDE DISMUTASE; NEURON SPECIFIC NUCLEAR PROTEIN; PEXIDARTINIB; TAR DNA BINDING PROTEIN; 5-((5-CHLORO-1H-PYRROLO(2,3-B)PYRIDIN-3-YL)METHYL)-N-((6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)METHYL)PYRIDIN-2-AMINE; AMINOPYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; SOD1 PROTEIN, HUMAN;

ADULT; ALTERNATIVE RNA SPLICING; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CTSB GENE; CTSD GENE; CYTOPLASM; DISEASE EXACERBATION; DOWN REGULATION; FACIAL NERVE NUCLEUS; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE MUTATION; GENE ONTOLOGY; GLIOSIS; GRAY MATTER; HUMAN; HUMAN TISSUE; LPL GENE; MALE; MICROGLIA; MOTONEURON; MOUSE; MOUSE MODEL; MUTANT; NERVE CELL DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; SOD1 GENE; SPINAL CORD VENTRAL HORN; TDP 43 PROTEINOPATHY; TRANSCRIPTOMICS; TRANSGENE; TRIGEMINAL NUCLEUS; UPREGULATION; ANIMAL; BONE MARROW CELL; GENETICS; INFLAMMATION; MUTATION; PATHOLOGY; SKELETAL MUSCLE; SPINAL CORD; TRANSGENIC MOUSE;

AMINOPYRIDINES; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; GENE EXPRESSION PROFILING; GLIOSIS; HUMANS; INFLAMMATION; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCLE, SKELETAL; MUTATION; MYELOID CELLS; PYRROLES; RECOVERY OF FUNCTION; SPINAL CORD; SUPEROXIDE DISMUTASE-1; TDP-43 PROTEINOPATHIES;

EID: 85042226157     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/s41593-018-0083-7     Document Type: Article

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