The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Immunity

Volumn 47, Issue 3, 2017, Pages 566-581.e9

  Krasemann, Susanne ^a,b   Madore, Charlotte ^a   Cialic, Ron ^a   Baufeld, Caroline ^a   Calcagno, Narghes ^a   El Fatimy, Rachid ^a   Beckers, Lien ^a   O'Loughlin, Elaine ^a   Xu, Yang ^c   Fanek, Zain ^a   Greco, David J ^a   Smith, Scott T ^a   Tweet, George ^a   Humulock, Zachary ^a   Zrzavy, Tobias ^d   Conde Sanroman, Patricia ^e   Gacias, Mar ^e   Weng, Zhiping ^c   Chen, Hao ^c   Tjon, Emily ^a   Mazaheri, Fargol ^f   Hartmann, Kristin ^b   Madi, Asaf ^a   Ulrich, Jason D ^g   Glatzel, Markus ^b   Worthmann, Anna ^b   Heeren, Joerg ^b   Budnik, Bogdan ^h   Lemere, Cynthia ^a   Ikezu, Tsuneya ⁱ   Heppner, Frank L ^j   Litvak, Vladimir ^c   Holtzman, David M ^g   Lassmann, Hans ^d   Weiner, Howard L ^a,k   Ochando, Jordi ^e   Haass, Christian ^f,l,m   Butovsky, Oleg ^a,k   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d Medical University of Vienna   (Austria)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h HARVARD UNIVERSITY   (United States)

ⁱ BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^k BRIGHAM AND WOMEN S HOSPITAL   (United States)

^l UNIVERSITY OF MUNICH   (Germany)

^m Germany 3 Munich Cluster for Systems Neurology   (Germany)

more..

Author keywords

Alzheimer's disease; amyotrophic lateral sclerosis; APOE; microglia; multiple sclerosis; neurodegeneration; transcriptional regulation; TREM2

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; TRANSFORMING GROWTH FACTOR BETA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; AMYLOID PRECURSOR PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TRANSCRIPTOME; TREM2 PROTEIN, MOUSE;

ADULT; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AXON; BONE MARROW CELL; CD3+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE COURSE; FACIAL NERVE NUCLEUS; FEMALE; HIPPOCAMPUS; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL DEGENERATION; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TARGETING; SENILE PLAQUE; SYNAPSE; TGF BETA SIGNALING; AMYLOID PLAQUE; ANIMAL; BRAIN CORTEX; CLUSTER ANALYSIS; DEFICIENCY; DISEASE MODEL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MONOCYTE; NERVE CELL; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; CEREBRAL CORTEX; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; HUMANS; IMMUNE TOLERANCE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; MONOCYTES; NEURODEGENERATIVE DISEASES; NEURONS; PHAGOCYTOSIS; PHENOTYPE; PLAQUE, AMYLOID; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE-1; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA;

EID: 85031732784     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.08.008     Document Type: Article

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