Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

EMBO Journal

Volumn 32, Issue 13, 2013, Pages 1917-1926

  Tong, Jianbin ^a,b   Huang, Cao ^a   Bi, Fangfang ^a   Wu, Qinxue ^a   Huang, Bo ^a   Liu, Xionghao ^a   Li, Fang ^a   Zhou, Hongxia ^a   Xia, Xu Gang ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Amyotrophic lateral sclerosis; Astrocytes; Lcn2; Rats; TAR DNA binding protein 43

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; GLIAL FIBRILLARY ACIDIC PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TAR DNA BINDING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; ATROPHY; CELL ACTIVATION; CONTROLLED STUDY; DENERVATION; DISEASE COURSE; GENE EXPRESSION; MACROGLIA; MICROGLIA; MOTONEURON; MUTANT; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; SPINAL CORD; TRANSGENE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CELL DEATH; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; LIPOCALINS; MOTOR NEURONS; MUSCLE DENERVATION; MUSCULAR ATROPHY; MUTATION; PARALYSIS; RATS; RATS, TRANSGENIC; SPINAL CORD;

RATTUS;

EID: 84880217322     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.122     Document Type: Article

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