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Volumn 2, Issue 4, 2017, Pages

Cardiotoxicity of immune checkpoint inhibitors

Author keywords

cancer; cardiotoxicity; CTLA 4; immune checkpoints; melanoma; myocarditis; PD 1; PD L1

Indexed keywords


EID: 85041540936     PISSN: None     EISSN: 20597029     Source Type: Journal    
DOI: 10.1136/esmoopen-2017-000247     Document Type: Review
Times cited : (189)

References (141)
  • 1
    • 84955282878 scopus 로고    scopus 로고
    • Cancer therapy-related cardiac dysfunction and heart failure: Part 1: Defnitions, pathophysiology, risk factors, and imaging
    • Bloom MW, Hamo CE, Cardinale D, et al. Cancer therapy-related cardiac dysfunction and heart failure: part 1: defnitions, pathophysiology, risk factors, and imaging. Circ Heart Fail 2016;9:e002661.
    • (2016) Circ Heart Fail , vol.9 , pp. e002661
    • Bloom, M.W.1    Hamo, C.E.2    Cardinale, D.3
  • 2
    • 84959538467 scopus 로고    scopus 로고
    • Cancer therapy-related cardiac dysfunction and heart failure: Part 2: Prevention, treatment, guidelines, and future directions
    • Hamo CE, Bloom MW, Cardinale D, et al. Cancer therapy-related cardiac dysfunction and heart failure: part 2: prevention, treatment, guidelines, and future directions. Circ Heart Fail 2016;9:e002843.
    • (2016) Circ Heart Fail , vol.9 , pp. e002843
    • Hamo, C.E.1    Bloom, M.W.2    Cardinale, D.3
  • 3
    • 67649958842 scopus 로고    scopus 로고
    • Cardiovascular complications of cancer therapy: Incidence, pathogenesis, diagnosis, and management
    • Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol 2009;53:2231-47.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2231-2247
    • Yeh, E.T.1    Bickford, C.L.2
  • 4
    • 84877153703 scopus 로고    scopus 로고
    • The emerging issue of cardiac dysfunction induced by antineoplastic angiogenesis inhibitors
    • Tocchetti CG, Gallucci G, Coppola C, et al. The emerging issue of cardiac dysfunction induced by antineoplastic angiogenesis inhibitors. Eur J Heart Fail 2013;15:482-9.
    • (2013) Eur J Heart Fail , vol.15 , pp. 482-489
    • Tocchetti, C.G.1    Gallucci, G.2    Coppola, C.3
  • 5
    • 84876526107 scopus 로고    scopus 로고
    • Cancer drugs and the heart: Importance and management
    • Suter TM, Ewer MS. Cancer drugs and the heart: importance and management. Eur Heart J 2013;34:1102-11.
    • (2013) Eur Heart J , vol.34 , pp. 1102-1111
    • Suter, T.M.1    Ewer, M.S.2
  • 6
    • 84991219713 scopus 로고    scopus 로고
    • Cardiovascular toxic effects of targeted cancer therapies
    • Moslehi JJ. Cardiovascular toxic effects of targeted cancer therapies. N Engl J Med 2016;375:1457-67.
    • (2016) N Engl J Med , vol.375 , pp. 1457-1467
    • Moslehi, J.J.1
  • 7
    • 84975059616 scopus 로고    scopus 로고
    • Resistance mechanisms to immune-checkpoint blockade in cancer: Tumor-intrinsic and-extrinsic factors
    • Pitt JM, Vétizou M, Daillère R, et al. Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and-extrinsic factors. Immunity 2016;44:1255-69.
    • (2016) Immunity , vol.44 , pp. 1255-1269
    • Pitt, J.M.1    Vétizou, M.2    Daillère, R.3
  • 8
    • 85007452454 scopus 로고    scopus 로고
    • Cancer immunotherapy innovator James Allison receives the 2015 Lasker-DeBakey clinical medical research award
    • Hurst JH. Cancer immunotherapy innovator James Allison receives the 2015 Lasker-DeBakey clinical medical research award. J Clin Invest 2015;125:3732-6.
    • (2015) J Clin Invest , vol.125 , pp. 3732-3736
    • Hurst, J.H.1
  • 9
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 10
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T, Eder J P, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3
  • 11
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563-7.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3
  • 12
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014;515:568-71.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3
  • 13
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 2015;373:123-35.
    • (2015) N Engl J Med , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 14
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015;373:1627-39.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 15
    • 84976511909 scopus 로고    scopus 로고
    • PD-1 Blockade with pembrolizumab in advanced merkel-cell Carcinoma
    • Nghiem PT, Bhatia S, Lipson EJ, et al. PD-1 Blockade with pembrolizumab in advanced merkel-cell Carcinoma. N Engl J Med 2016;374:2542-52.
    • (2016) N Engl J Med , vol.374 , pp. 2542-2552
    • Nghiem, P.T.1    Bhatia, S.2    Lipson, E.J.3
  • 16
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
    • Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 2016;387:1540-50.
    • (2016) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3
  • 17
    • 84962038946 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial
    • Fehrenbacher L, Spira A, Ballinger M, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet 2016;387:1837-46.
    • (2016) Lancet , vol.387 , pp. 1837-1846
    • Fehrenbacher, L.1    Spira, A.2    Ballinger, M.3
  • 18
    • 85015755043 scopus 로고    scopus 로고
    • Pembrolizumab as second-line therapy for advanced urothelial Carcinoma
    • Bellmunt J, de Wit R, Vaughn DJ, et al. Pembrolizumab as second-line therapy for advanced urothelial Carcinoma. N Engl J Med 2017;376:1015-26.
    • (2017) N Engl J Med , vol.376 , pp. 1015-1026
    • Bellmunt, J.1    De Wit, R.2    Vaughn, D.J.3
  • 19
    • 84979240618 scopus 로고    scopus 로고
    • Nivolumab in patients with relapsed or refractory hematologic malignancy: Preliminary results of a phase Ib study
    • Lesokhin AM, Ansell SM, Armand P, et al. Nivolumab in patients with relapsed or refractory hematologic malignancy: preliminary results of a phase Ib study. J Clin Oncol 2016;34:2698-704.
    • (2016) J Clin Oncol , vol.34 , pp. 2698-2704
    • Lesokhin, A.M.1    Ansell, S.M.2    Armand, P.3
  • 20
    • 85021725768 scopus 로고    scopus 로고
    • Pembrolizumab in patients with CLL and richter transformation or with relapsed CLL
    • Ding W, LaPlant BR, Call TG, et al. Pembrolizumab in patients with CLL and richter transformation or with relapsed CLL. Blood 2017;129:3419-27.
    • (2017) Blood , vol.129 , pp. 3419-3427
    • Ding, W.1    LaPlant, B.R.2    Call, T.G.3
  • 21
    • 85029217850 scopus 로고    scopus 로고
    • Pembrolizumab, pomalidomide, and low-dose dexamethasone for relapsed/refractory multiple myeloma
    • Badros A, Hyjek E, Ma N, et al. Pembrolizumab, pomalidomide, and low-dose dexamethasone for relapsed/refractory multiple myeloma. Blood 2017;130:1189-97.
    • (2017) Blood , vol.130 , pp. 1189-1197
    • Badros, A.1    Hyjek, E.2    Ma, N.3
  • 22
    • 85020736227 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma
    • Nayak L, Iwamoto FM, LaCasce A, et al. PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma. Blood 2017;129:3071-3.
    • (2017) Blood , vol.129 , pp. 3071-3073
    • Nayak, L.1    Iwamoto, F.M.2    LaCasce, A.3
  • 23
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial
    • Westin JR, Chu F, Zhang M, et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol 2014;15:69-77.
    • (2014) Lancet Oncol , vol.15 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3
  • 24
    • 84925545111 scopus 로고    scopus 로고
    • Clinical blockade of PD1 and LAG3-potential mechanisms of action
    • Nguyen LT, Ohashi PS. Clinical blockade of PD1 and LAG3-potential mechanisms of action. Nat Rev Immunol 2015;15:45-56.
    • (2015) Nat Rev Immunol , vol.15 , pp. 45-56
    • Nguyen, L.T.1    Ohashi, P.S.2
  • 25
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison J P. The future of immune checkpoint therapy. Science 2015;348:56-61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 26
    • 84941280057 scopus 로고    scopus 로고
    • Beyond CTLA-4 and PD-1, the generation Z of negative checkpoint regulators
    • Le Mercier I, Lines JL, Noelle RJ. Beyond CTLA-4 and PD-1, the generation Z of negative checkpoint regulators. Front Immunol 2015;6:418.
    • (2015) Front Immunol , vol.6 , pp. 418
    • Le Mercier, I.1    Lines, J.L.2    Noelle, R.J.3
  • 27
    • 84941711371 scopus 로고    scopus 로고
    • Anti-PD-1/PD-L1 therapy of human cancer: Past, present, and future
    • Chen L, Han X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. J Clin Invest 2015;125:3384-91.
    • (2015) J Clin Invest , vol.125 , pp. 3384-3391
    • Chen, L.1    Han, X.2
  • 28
    • 84994120928 scopus 로고    scopus 로고
    • PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas
    • Goodman A, Patel S P, Kurzrock R. PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat Rev Clin Oncol 2017;14:203-20.
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 203-220
    • Goodman, A.1    Patel, S.P.2    Kurzrock, R.3
  • 29
    • 84903269067 scopus 로고    scopus 로고
    • Ipilimumab in patients with cancer and the management of dermatologic adverse events
    • Lacouture ME, Wolchok JD, Yosipovitch G, et al. Ipilimumab in patients with cancer and the management of dermatologic adverse events. J Am Acad Dermatol 2014;71:161-9.
    • (2014) J Am Acad Dermatol , vol.71 , pp. 161-169
    • Lacouture, M.E.1    Wolchok, J.D.2    Yosipovitch, G.3
  • 30
    • 84997633422 scopus 로고    scopus 로고
    • Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy
    • Heinzerling L, Ott PA, Hodi FS, et al. Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy. J Immunother Cancer 2016;4:50.
    • (2016) J Immunother Cancer , vol.4 , pp. 50
    • Heinzerling, L.1    Ott, P.A.2    Hodi, F.S.3
  • 31
    • 85019549399 scopus 로고    scopus 로고
    • Neurotoxicity from immune-checkpoint inhibition in the treatment of melanoma: A single centre experience and review of the literature
    • Spain L, Walls G, Julve M, et al. Neurotoxicity from immune-checkpoint inhibition in the treatment of melanoma: a single centre experience and review of the literature. Ann Oncol 2017;28:377-85.
    • (2017) Ann Oncol , vol.28 , pp. 377-385
    • Spain, L.1    Walls, G.2    Julve, M.3
  • 32
    • 84964345287 scopus 로고    scopus 로고
    • Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
    • Hofmann L, Forschner A, Loquai C, et al. Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy. Eur J Cancer 2016;60:190-209.
    • (2016) Eur J Cancer , vol.60 , pp. 190-209
    • Hofmann, L.1    Forschner, A.2    Loquai, C.3
  • 33
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptor-defcient mice
    • Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-defcient mice. Science 2001;291:319-22.
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1    Okazaki, T.2    Tanaka, Y.3
  • 34
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H, Zhu G, Tamada K, et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999;5:1365-9.
    • (1999) Nat Med , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3
  • 35
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000;192:1027-34.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 36
    • 84994144982 scopus 로고    scopus 로고
    • Fulminant myocarditis with combination immune checkpoint blockade
    • Johnson DB, Balko JM, Compton ML, et al. Fulminant myocarditis with combination immune checkpoint blockade. N Engl J Med 2016;375:1749-55.
    • (2016) N Engl J Med , vol.375 , pp. 1749-1755
    • Johnson, D.B.1    Balko, J.M.2    Compton, M.L.3
  • 37
    • 10744220884 scopus 로고    scopus 로고
    • Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-defcient mice
    • Okazaki T, Tanaka Y, Nishio R, et al. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-defcient mice. Nat Med 2003;9:1477-83.
    • (2003) Nat Med , vol.9 , pp. 1477-1483
    • Okazaki, T.1    Tanaka, Y.2    Nishio, R.3
  • 38
    • 35648959740 scopus 로고    scopus 로고
    • Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart
    • Grabie N, Gotsman I, DaCosta R, et al. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation 2007;116:2062-71.
    • (2007) Circulation , vol.116 , pp. 2062-2071
    • Grabie, N.1    Gotsman, I.2    DaCosta, R.3
  • 39
    • 53149113444 scopus 로고    scopus 로고
    • Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice
    • Lucas JA, Menke J, Rabacal WA, et al. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol 2008;181:2513-21.
    • (2008) J Immunol , vol.181 , pp. 2513-2521
    • Lucas, J.A.1    Menke, J.2    Rabacal, W.A.3
  • 40
    • 77954019731 scopus 로고    scopus 로고
    • PD-1 defciency results in the development of fatal myocarditis in MRL mice
    • Wang J, Okazaki IM, Yoshida T, et al. PD-1 defciency results in the development of fatal myocarditis in MRL mice. Int Immunol 2010;22:443-52.
    • (2010) Int Immunol , vol.22 , pp. 443-452
    • Wang, J.1    Okazaki, I.M.2    Yoshida, T.3
  • 41
    • 84861109547 scopus 로고    scopus 로고
    • PD-1 protects against infammation and myocyte damage in T cell-mediated myocarditis
    • Tarrio ML, Grabie N, Bu DX, et al. PD-1 protects against infammation and myocyte damage in T cell-mediated myocarditis. J Immunol 2012;188:4876-84.
    • (2012) J Immunol , vol.188 , pp. 4876-4884
    • Tarrio, M.L.1    Grabie, N.2    Bu, D.X.3
  • 42
    • 84978821866 scopus 로고    scopus 로고
    • Drug-induced myocarditis after nivolumab treatment in a patient with PDL1-negative squamous cell carcinoma of the lung
    • Semper H, Muehlberg F, Schulz-Menger J, et al. Drug-induced myocarditis after nivolumab treatment in a patient with PDL1-negative squamous cell carcinoma of the lung. Lung Cancer 2016;99:117-9.
    • (2016) Lung Cancer , vol.99 , pp. 117-119
    • Semper, H.1    Muehlberg, F.2    Schulz-Menger, J.3
  • 43
    • 84992025975 scopus 로고    scopus 로고
    • Acute Lymphocytic Myocarditis with Anti-PD-1 Antibody Nivolumab
    • Tadokoro T, Keshino E, Makiyama A, et al. Acute Lymphocytic Myocarditis With Anti-PD-1 Antibody Nivolumab. Circ Heart Fail 2016;9:e003514.
    • (2016) Circ Heart Fail , vol.9 , pp. e003514
    • Tadokoro, T.1    Keshino, E.2    Makiyama, A.3
  • 44
    • 84977156516 scopus 로고    scopus 로고
    • Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: A case of takotsubo-like syndrome
    • Geisler B P, Raad RA, Esaian D, et al. Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: a case of takotsubo-like syndrome. J Immunother Cancer 2015;3:4.
    • (2015) J Immunother Cancer , vol.3 , pp. 4
    • Geisler, B.P.1    Raad, R.A.2    Esaian, D.3
  • 45
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity 2013;39:1-10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 46
    • 45749134564 scopus 로고    scopus 로고
    • The anticancer immune response: Indispensable for therapeutic success?
    • Zitvogel L, Apetoh L, Ghiringhelli F, et al. The anticancer immune response: indispensable for therapeutic success? J Clin Invest 2008;118:1991-2001.
    • (2008) J Clin Invest , vol.118 , pp. 1991-2001
    • Zitvogel, L.1    Apetoh, L.2    Ghiringhelli, F.3
  • 47
    • 84988661380 scopus 로고    scopus 로고
    • Circulating and disseminated tumour cells-mechanisms of immune surveillance and escape
    • Mohme M, Riethdorf S, Pantel K. Circulating and disseminated tumour cells-mechanisms of immune surveillance and escape. Nat Rev Clin Oncol 2017;14:155-67.
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 155-167
    • Mohme, M.1    Riethdorf, S.2    Pantel, K.3
  • 48
    • 84937759727 scopus 로고    scopus 로고
    • The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma
    • Mahoney KM, Freeman GJ, McDermott DF. The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma. Clin Ther 2015;37:764-82.
    • (2015) Clin Ther , vol.37 , pp. 764-782
    • Mahoney, K.M.1    Freeman, G.J.2    McDermott, D.F.3
  • 49
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupuslike autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H, et al. Development of lupuslike autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999;11:141-51.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 50
    • 0028867835 scopus 로고
    • Manipulation of costimulatory signals to enhance antitumor T-cell responses
    • Allison J P, Hurwitz AA, Leach DR. Manipulation of costimulatory signals to enhance antitumor T-cell responses. Curr Opin Immunol 1995;7:682-6.
    • (1995) Curr Opin Immunol , vol.7 , pp. 682-686
    • Allison, J.P.1    Hurwitz, A.A.2    Leach, D.R.3
  • 51
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
    • Sharma P, Allison J P. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 2015;161:205-14.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 52
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 53
    • 0033524482 scopus 로고    scopus 로고
    • A two-step, two-signal model for the primary activation of precursor helper T cells
    • Bretscher PA. A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci USA 1999;96:185-90.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 185-190
    • Bretscher, P.A.1
  • 54
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-7.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3
  • 55
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice defcient in Ctla-4
    • Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice defcient in Ctla-4. Science 1995;270:985-8.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 56
    • 0023270567 scopus 로고
    • A new member of the immunoglobulin superfamily-CTLA-4
    • Brunet J F, Denizot F, Luciani M F, et al. A new member of the immunoglobulin superfamily-CTLA-4. Nature 1987;328:267-70.
    • (1987) Nature , vol.328 , pp. 267-270
    • Brunet, J.F.1    Denizot, F.2    Luciani, M.F.3
  • 57
    • 0025830902 scopus 로고
    • CTLA-4 is a second receptor for the B cell activation antigen B7
    • Linsley PS, Brady W, Urnes M, et al. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991;174:561-9.
    • (1991) J Exp Med , vol.174 , pp. 561-569
    • Linsley, P.S.1    Brady, W.2    Urnes, M.3
  • 58
    • 0022632220 scopus 로고
    • A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes
    • Martin PJ, Ledbetter JA, Morishita Y, et al. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol 1986;136:3282-7.
    • (1986) J Immunol , vol.136 , pp. 3282-3287
    • Martin, P.J.1    Ledbetter, J.A.2    Morishita, Y.3
  • 59
    • 0027761138 scopus 로고
    • Identifcation of an alternative CTLA-4 ligand costimulatory for T cell activation
    • Hathcock KS, Laszlo G, Dickler HB, et al. Identifcation of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 1993;262:905-7.
    • (1993) Science , vol.262 , pp. 905-907
    • Hathcock, K.S.1    Laszlo, G.2    Dickler, H.B.3
  • 60
    • 0027767762 scopus 로고
    • Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
    • Freeman GJ, Gribben JG, Boussiotis VA, et al. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 1993;262:909-11.
    • (1993) Science , vol.262 , pp. 909-911
    • Freeman, G.J.1    Gribben, J.G.2    Boussiotis, V.A.3
  • 61
    • 0027362823 scopus 로고
    • B70 antigen is a second ligand for CTLA-4 and CD28
    • Azuma M, Ito D, Yagita H, et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 1993;366:76-9.
    • (1993) Nature , vol.366 , pp. 76-79
    • Azuma, M.1    Ito, D.2    Yagita, H.3
  • 62
    • 0025322552 scopus 로고
    • T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    • Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci USA 1990;87:5031-5.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5031-5035
    • Linsley, P.S.1    Clark, E.A.2    Ledbetter, J.A.3
  • 63
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008;322:271-5.
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 64
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, et al. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 2009;206:1717-25.
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3
  • 65
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison J P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 66
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott D F, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 67
    • 85014307275 scopus 로고    scopus 로고
    • New checkpoints in cancer immunotherapy
    • Ni L, Dong C. New checkpoints in cancer immunotherapy. Immunol Rev 2017;276:52-65.
    • (2017) Immunol Rev , vol.276 , pp. 52-65
    • Ni, L.1    Dong, C.2
  • 68
    • 84994104553 scopus 로고    scopus 로고
    • Molecular and biochemical aspects of the PD-1 checkpoint pathway
    • Boussiotis VA. Molecular and biochemical aspects of the PD-1 checkpoint pathway. N Engl J Med 2016;375:1767-78.
    • (2016) N Engl J Med , vol.375 , pp. 1767-1778
    • Boussiotis, V.A.1
  • 69
    • 34547794178 scopus 로고    scopus 로고
    • PD-1 and PD-1 ligands: From discovery to clinical application
    • Okazaki T, Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol 2007;19:813-24.
    • (2007) Int Immunol , vol.19 , pp. 813-824
    • Okazaki, T.1    Honjo, T.2
  • 70
    • 84930615422 scopus 로고    scopus 로고
    • Upregulation of programmed death-1 and Its ligand in cardiac injury models: Interaction with GADD153
    • Baban B, Liu J Y, Qin X, et al. Upregulation of programmed death-1 and Its ligand in cardiac injury models: interaction with GADD153. PLoS One 2015;10:e0124059.
    • (2015) PLoS One , vol.10 , pp. e0124059
    • Baban, B.1    Liu, J.Y.2    Qin, X.3
  • 71
    • 85019744578 scopus 로고    scopus 로고
    • PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
    • Gordon SR, Maute RL, Dulken BW, et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature 2017;545:495-9.
    • (2017) Nature , vol.545 , pp. 495-499
    • Gordon, S.R.1    Maute, R.L.2    Dulken, B.W.3
  • 72
    • 84864324543 scopus 로고    scopus 로고
    • Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
    • Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, et al. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med 2012;209:1201-17.
    • (2012) J Exp Med , vol.209 , pp. 1201-1217
    • Yokosuka, T.1    Takamatsu, M.2    Kobayashi-Imanishi, W.3
  • 73
    • 4444317516 scopus 로고    scopus 로고
    • PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    • Sheppard KA, Fitz LJ, Lee JM, et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett 2004;574:37-41.
    • (2004) FEBS Lett , vol.574 , pp. 37-41
    • Sheppard, K.A.1    Fitz, L.J.2    Lee, J.M.3
  • 74
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010;236:219-42.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 75
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:1039-800.
    • (2002) Nat Med , vol.8 , pp. 1039-1800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 76
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y, Wood CR, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001;2:261-8.
    • (2001) Nat Immunol , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 77
    • 43549115533 scopus 로고    scopus 로고
    • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
    • Azuma T, Yao S, Zhu G, et al. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008;111:3635-43.
    • (2008) Blood , vol.111 , pp. 3635-3643
    • Azuma, T.1    Yao, S.2    Zhu, G.3
  • 78
    • 84959865627 scopus 로고    scopus 로고
    • Regulation of PD-L1: A novel role of pro-survival signalling in cancer
    • Chen J, Jiang CC, Jin L, et al. Regulation of PD-L1: a novel role of pro-survival signalling in cancer. Ann Oncol 2016;27:409-16.
    • (2016) Ann Oncol , vol.27 , pp. 409-416
    • Chen, J.1    Jiang, C.C.2    Jin, L.3
  • 79
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015;348:124-8.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 80
    • 84961989625 scopus 로고    scopus 로고
    • PD-1 blockade expands intratumoral memory T cells
    • Ribas A, Shin DS, Zaretsky J, et al. PD-1 blockade expands intratumoral memory T cells. Cancer Immunol Res 2016;4:194-203.
    • (2016) Cancer Immunol Res , vol.4 , pp. 194-203
    • Ribas, A.1    Shin, D.S.2    Zaretsky, J.3
  • 81
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010;28:3167-75.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 82
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott D F, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014;32:1020-30.
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3
  • 83
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015;372:320-30.
    • (2015) N Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 84
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 85
    • 85008239423 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): A phase 3, open-label, multicentre randomised controlled trial
    • Rittmeyer A, Barlesi F, Waterkamp D, et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet 2017;389:255-65.
    • (2017) Lancet , vol.389 , pp. 255-265
    • Rittmeyer, A.1    Barlesi, F.2    Waterkamp, D.3
  • 86
    • 84951126341 scopus 로고    scopus 로고
    • Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer
    • Hamanishi J, Mandai M, Ikeda T, et al. Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer. J Clin Oncol 2015;33:4015-22.
    • (2015) J Clin Oncol , vol.33 , pp. 4015-4022
    • Hamanishi, J.1    Mandai, M.2    Ikeda, T.3
  • 87
    • 84965032301 scopus 로고    scopus 로고
    • Safety profles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination
    • Boutros C, Tarhini A, Routier E, et al. Safety profles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Nat Rev Clin Oncol 2016;13:473-86.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 473-486
    • Boutros, C.1    Tarhini, A.2    Routier, E.3
  • 88
    • 85020949564 scopus 로고    scopus 로고
    • Cancer immunotherapy trials not immune from imprecise selection of patients
    • Garon EB. Cancer immunotherapy trials not immune from imprecise selection of patients. N Engl J Med 2017;376:2483-5.
    • (2017) N Engl J Med , vol.376 , pp. 2483-2485
    • Garon, E.B.1
  • 89
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 2015;373:23-34.
    • (2015) N Engl J Med , vol.373 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 90
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 2015;372:2006-17.
    • (2015) N Engl J Med , vol.372 , pp. 2006-2017
    • Ma, P.1    Chesney, J.2    Pavlick, A.C.3
  • 91
    • 84992315668 scopus 로고    scopus 로고
    • Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
    • Moynihan KD, Opel C F, Szeto GL, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat Med 2016;22:1402-10.
    • (2016) Nat Med , vol.22 , pp. 1402-1410
    • Moynihan, K.D.1    Opel, C.F.2    Szeto, G.L.3
  • 92
    • 84885716979 scopus 로고    scopus 로고
    • TIM3(+)FOXP3(+) regulatory T cells are tissue-specifc promoters of T-cell dysfunction in cancer
    • Sakuishi K, Ngiow S F, Sullivan JM, et al. TIM3(+)FOXP3(+) regulatory T cells are tissue-specifc promoters of T-cell dysfunction in cancer. Oncoimmunology 2013;2:e23849.
    • (2013) Oncoimmunology , vol.2 , pp. e23849
    • Sakuishi, K.1    Ngiow, S.F.2    Sullivan, J.M.3
  • 93
    • 84874635440 scopus 로고    scopus 로고
    • Tim-3 expression defnes regulatory T cells in human tumors
    • Yan J, Zhang Y, Zhang J P, et al. Tim-3 expression defnes regulatory T cells in human tumors. PLoS One 2013;8:e58006.
    • (2013) PLoS One , vol.8 , pp. e58006
    • Yan, J.1    Zhang, Y.2    Zhang, J.P.3
  • 94
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory T cells
    • Huang CT, Workman CJ, Flies D, et al. Role of LAG-3 in regulatory T cells. Immunity 2004;21:503-13.
    • (2004) Immunity , vol.21 , pp. 503-513
    • Huang, C.T.1    Workman, C.J.2    Flies, D.3
  • 95
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifes human and mouse T regulatory type 1 cells
    • Gagliani N, Magnani C F, Huber S, et al. Coexpression of CD49b and LAG-3 identifes human and mouse T regulatory type 1 cells. Nat Med 2013;19:739-46.
    • (2013) Nat Med , vol.19 , pp. 739-746
    • Gagliani, N.1    Magnani, C.F.2    Huber, S.3
  • 96
    • 69549124480 scopus 로고    scopus 로고
    • CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2
    • Okamura T, Fujio K, Shibuya M, et al. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci USA 2009;106:13974-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13974-13979
    • Okamura, T.1    Fujio, K.2    Shibuya, M.3
  • 97
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo SR, Turnis ME, Goldberg MV, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012;72:917-27.
    • (2012) Cancer Res , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 98
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infltrating NY-ESO-1-specifc CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • Matsuzaki J, Gnjatic S, Mhawech-Fauceglia P, et al. Tumor-infltrating NY-ESO-1-specifc CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci USA 2010;107:7875-80.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7875-7880
    • Matsuzaki, J.1    Gnjatic, S.2    Mhawech-Fauceglia, P.3
  • 99
    • 57849101994 scopus 로고    scopus 로고
    • The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
    • Yu X, Harden K, Gonzalez LC, et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 2009;10:48-57.
    • (2009) Nat Immunol , vol.10 , pp. 48-57
    • Yu, X.1    Harden, K.2    Gonzalez, L.C.3
  • 100
    • 70449597272 scopus 로고    scopus 로고
    • The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
    • Stanietsky N, Simic H, Arapovic J, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009;106:17858-63.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17858-17863
    • Stanietsky, N.1    Simic, H.2    Arapovic, J.3
  • 101
    • 84919494669 scopus 로고    scopus 로고
    • The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function
    • Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell 2014;26:923-37.
    • (2014) Cancer Cell , vol.26 , pp. 923-937
    • Johnston, R.J.1    Comps-Agrar, L.2    Hackney, J.3
  • 102
    • 0037810670 scopus 로고    scopus 로고
    • BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    • Watanabe N, Gavrieli M, Sedy JR, et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 2003;4:670-9.
    • (2003) Nat Immunol , vol.4 , pp. 670-679
    • Watanabe, N.1    Gavrieli, M.2    Sedy, J.R.3
  • 103
    • 2442477456 scopus 로고    scopus 로고
    • An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection
    • Han P, Goularte OD, Rufner K, et al. An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection. J Immunol 2004;172:5931-9.
    • (2004) J Immunol , vol.172 , pp. 5931-5939
    • Han, P.1    Goularte, O.D.2    Rufner, K.3
  • 104
    • 80052414652 scopus 로고    scopus 로고
    • Active immunotherapy combined with blockade of a coinhibitory pathway achieves regression of large tumor masses in cancer-prone mice
    • Lasaro MO, Sazanovich M, Giles-Davis W, et al. Active immunotherapy combined with blockade of a coinhibitory pathway achieves regression of large tumor masses in cancer-prone mice. Mol Ther 2011;19:1727-36.
    • (2011) Mol Ther , vol.19 , pp. 1727-1736
    • Lasaro, M.O.1    Sazanovich, M.2    Giles-Davis, W.3
  • 105
    • 84897445677 scopus 로고    scopus 로고
    • VISTA is an immune checkpoint molecule for human T cells
    • Lines JL, Pantazi E, Mak J, et al. VISTA is an immune checkpoint molecule for human T cells. Cancer Res 2014;74:1924-32.
    • (2014) Cancer Res , vol.74 , pp. 1924-1932
    • Lines, J.L.1    Pantazi, E.2    Mak, J.3
  • 106
    • 84897429090 scopus 로고    scopus 로고
    • VISTA Regulates the development of protective antitumor immunity
    • Le Mercier I, Chen W, Lines JL, et al. VISTA Regulates the development of protective antitumor immunity. Cancer Res 2014;74:1933-44.
    • (2014) Cancer Res , vol.74 , pp. 1933-1944
    • Le Mercier, I.1    Chen, W.2    Lines, J.L.3
  • 107
    • 84895904745 scopus 로고    scopus 로고
    • Mitigating the toxic effects of anticancer immunotherapy
    • Gangadhar TC, Vonderheide RH. Mitigating the toxic effects of anticancer immunotherapy. Nat Rev Clin Oncol 2014;11:91-9.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 91-99
    • Gangadhar, T.C.1    Vonderheide, R.H.2
  • 108
    • 84953309212 scopus 로고    scopus 로고
    • Immune-related adverse events with immune checkpoint blockade: A comprehensive review
    • Michot JM, Bigenwald C, Champiat S, et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer 2016;54:139-48.
    • (2016) Eur J Cancer , vol.54 , pp. 139-148
    • Michot, J.M.1    Bigenwald, C.2    Champiat, S.3
  • 109
    • 84957839638 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 Pathways: Similarities, differences, and implications of their inhibition
    • Buchbinder EI, Desai A. CTLA-4 and PD-1 Pathways: similarities, differences, and implications of their inhibition. Am J Clin Oncol 2016;39:98-106.
    • (2016) Am J Clin Oncol , vol.39 , pp. 98-106
    • Buchbinder, E.I.1    Desai, A.2
  • 110
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 111
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • Weber JS, Kähler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol 2012;30:2691-7.
    • (2012) J Clin Oncol , vol.30 , pp. 2691-2697
    • Weber, J.S.1    Kähler, K.C.2    Hauschild, A.3
  • 112
    • 84876248304 scopus 로고    scopus 로고
    • Endocrine side effects induced by immune checkpoint inhibitors
    • Corsello SM, Barnabei A, Marchetti P, et al. Endocrine side effects induced by immune checkpoint inhibitors. J Clin Endocrinol Metab 2013;98:1361-75.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1361-1375
    • Corsello, S.M.1    Barnabei, A.2    Marchetti, P.3
  • 113
    • 33645846313 scopus 로고    scopus 로고
    • Tissue expression of PD-L1 mediates peripheral T cell tolerance
    • Keir ME, Liang SC, Guleria I, et al. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 2006;203:883-95.
    • (2006) J Exp Med , vol.203 , pp. 883-895
    • Keir, M.E.1    Liang, S.C.2    Guleria, I.3
  • 114
    • 84959231890 scopus 로고    scopus 로고
    • Diagnosis, monitoring and management of immune-related adverse drug reactions of anti-PD-1 antibody therapy
    • Eigentler TK, Hassel JC, Berking C, et al. Diagnosis, monitoring and management of immune-related adverse drug reactions of anti-PD-1 antibody therapy. Cancer Treat Rev 2016;45:7-18.
    • (2016) Cancer Treat Rev , vol.45 , pp. 7-18
    • Eigentler, T.K.1    Hassel, J.C.2    Berking, C.3
  • 115
    • 85059025761 scopus 로고    scopus 로고
    • Toxicity profle of approved anti-PD-1 monoclonal antibodies in solid tumors: A systematic review and meta-analysis of randomized clinical trials
    • Costa R, Carneiro BA, Agulnik M, et al. Toxicity profle of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials. Oncotarget 2017;8:8910-20.
    • (2017) Oncotarget , vol.8 , pp. 8910-8920
    • Costa, R.1    Carneiro, B.A.2    Agulnik, M.3
  • 116
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013;369:122-33.
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 117
    • 84949988089 scopus 로고    scopus 로고
    • Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
    • Naidoo J, Page DB, Li BT, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol 2015;26:2375-91.
    • (2015) Ann Oncol , vol.26 , pp. 2375-2391
    • Naidoo, J.1    Page, D.B.2    Li, B.T.3
  • 118
    • 85013483689 scopus 로고    scopus 로고
    • Cardiovascular toxicities associated with cancer immunotherapies
    • Wang DY, Okoye GD, Neilan TG, et al. Cardiovascular toxicities associated with cancer immunotherapies. Curr Cardiol Rep 2017;19:21.
    • (2017) Curr Cardiol Rep , vol.19 , pp. 21
    • Wang, D.Y.1    Okoye, G.D.2    Neilan, T.G.3
  • 119
    • 85013892577 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors in challenging populations
    • Johnson DB, Sullivan RJ, Menzies AM. Immune checkpoint inhibitors in challenging populations. Cancer 2017;123:1904-11.
    • (2017) Cancer , vol.123 , pp. 1904-1911
    • Johnson, D.B.1    Sullivan, R.J.2    Menzies, A.M.3
  • 120
    • 85016931320 scopus 로고    scopus 로고
    • Cardiac complications of cancer therapy: Pathophysiology, identifcation, prevention, treatment, and future directions
    • Jain D, Russell RR, Schwartz RG, et al. Cardiac complications of cancer therapy: pathophysiology, identifcation, prevention, treatment, and future directions. Curr Cardiol Rep 2017;19:36.
    • (2017) Curr Cardiol Rep , vol.19 , pp. 36
    • Jain, D.1    Russell, R.R.2    Schwartz, R.G.3
  • 121
    • 85065407616 scopus 로고    scopus 로고
    • From molecular mechanisms to clinical management of antineoplastic drug-induced cardiovascular Toxicity: A translational overview
    • (Epub ahead of print: 15 May 2017)
    • Tocchetti CG, Cadeddu C, Di Lisi D, et al. From molecular mechanisms to clinical management of antineoplastic drug-induced cardiovascular Toxicity: a translational overview. Antioxid Redox Signal 2017 (Epub ahead of print: 15 May 2017).
    • (2017) Antioxid Redox Signal
    • Tocchetti, C.G.1    Cadeddu, C.2    Di Lisi, D.3
  • 122
    • 84872339660 scopus 로고    scopus 로고
    • The price of tumor control: An analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network
    • Voskens CJ, Goldinger SM, Loquai C, et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. PLoS One 2013;8:e53745.
    • (2013) PLoS One , vol.8 , pp. e53745
    • Voskens, C.J.1    Goldinger, S.M.2    Loquai, C.3
  • 123
    • 84958817747 scopus 로고    scopus 로고
    • Left ventricular dysfunction after treatment with ipilimumab for metastatic melanoma
    • Roth ME, Muluneh B, Jensen BC, et al. Left ventricular dysfunction after treatment with ipilimumab for metastatic melanoma. Am J Ther 2016;23:e1925-8.
    • (2016) Am J Ther , vol.23 , pp. e1925-e1928
    • Roth, M.E.1    Muluneh, B.2    Jensen, B.C.3
  • 124
    • 84980509873 scopus 로고    scopus 로고
    • Late onset ipilimumab-induced pericarditis and pericardial effusion: A rare but life threatening complication
    • Yun S, Vincelette ND, Mansour I, et al. Late onset ipilimumab-induced pericarditis and pericardial effusion: a rare but life threatening complication. Case Rep Oncol Med 2015;2015:1-5.
    • (2015) Case Rep Oncol Med , vol.2015 , pp. 1-5
    • Yun, S.1    Vincelette, N.D.2    Mansour, I.3
  • 125
    • 84997637224 scopus 로고    scopus 로고
    • Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma
    • Läubli H, Balmelli C, Bossard M, et al. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. J Immunother Cancer 2015;3:11.
    • (2015) J Immunother Cancer , vol.3 , pp. 11
    • Läubli, H.1    Balmelli, C.2    Bossard, M.3
  • 126
    • 84992025975 scopus 로고    scopus 로고
    • Acute lymphocytic myocarditis with anti-PD-1 antibody nivolumab
    • Tadokoro T, Keshino E, Makiyama A, et al. Acute lymphocytic myocarditis with anti-PD-1 antibody nivolumab. Circ Heart Fail 2016;9:e003514.
    • (2016) Circ Heart Fail , vol.9 , pp. e003514
    • Tadokoro, T.1    Keshino, E.2    Makiyama, A.3
  • 127
    • 84979527884 scopus 로고    scopus 로고
    • Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer
    • (Epub ahead of print: 20 Jul 2016)
    • Gibson R, Delaune J, Szady A, et al. Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. BMJ Case Rep 2016;2016 (Epub ahead of print: 20 Jul 2016).
    • (2016) BMJ Case Rep , vol.2016
    • Gibson, R.1    Delaune, J.2    Szady, A.3
  • 128
    • 84997418743 scopus 로고    scopus 로고
    • Systemic infammation in a melanoma patient treated with immune checkpoint inhibitors-an autopsy study
    • Koelzer VH, Rothschild SI, Zihler D, et al. Systemic infammation in a melanoma patient treated with immune checkpoint inhibitors-an autopsy study. J Immunother Cancer 2016;4:13.
    • (2016) J Immunother Cancer , vol.4 , pp. 13
    • Koelzer, V.H.1    Rothschild, S.I.2    Zihler, D.3
  • 129
    • 2942522528 scopus 로고    scopus 로고
    • Prognostic value of troponin I in cardiac risk stratifcation of cancer patients undergoing high-dose chemotherapy
    • Cardinale D, Sandri MT, Colombo A, et al. Prognostic value of troponin I in cardiac risk stratifcation of cancer patients undergoing high-dose chemotherapy. Circulation 2004;109:2749-54.
    • (2004) Circulation , vol.109 , pp. 2749-2754
    • Cardinale, D.1    Sandri, M.T.2    Colombo, A.3
  • 130
    • 84988969683 scopus 로고    scopus 로고
    • Chemotherapy-induced cardiotoxicity: Importance of early detection
    • Cardinale D, Cipolla CM. Chemotherapy-induced cardiotoxicity: importance of early detection. Expert Rev Cardiovasc Ther 2016;14:1297-9.
    • (2016) Expert Rev Cardiovasc Ther , vol.14 , pp. 1297-1299
    • Cardinale, D.1    Cipolla, C.M.2
  • 131
    • 64349106997 scopus 로고    scopus 로고
    • Myocarditis
    • Cooper LT. Myocarditis. N Engl J Med 2009;360:1526-38.
    • (2009) N Engl J Med , vol.360 , pp. 1526-1538
    • Cooper, L.T.1
  • 132
    • 85019333926 scopus 로고    scopus 로고
    • Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab
    • Menzies AM, Johnson DB, Ramanujam S, et al. Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab. Ann Oncol 2017;28:368-76.
    • (2017) Ann Oncol , vol.28 , pp. 368-376
    • Menzies, A.M.1    Johnson, D.B.2    Ramanujam, S.3
  • 133
    • 85013046049 scopus 로고    scopus 로고
    • Prevalence of autoimmune disease among patients with lung cancer: Implications for immunotherapy treatment options
    • Khan SA, Pruitt SL, Xuan L, et al. Prevalence of autoimmune disease among patients with lung cancer: implications for immunotherapy treatment options. JAMA Oncol 2016;2:1507-8.
    • (2016) JAMA Oncol , vol.2 , pp. 1507-1508
    • Khan, S.A.1    Pruitt, S.L.2    Xuan, L.3
  • 134
    • 84961596355 scopus 로고    scopus 로고
    • Effcacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma who have progressed on anti-PD-1 therapy
    • Prashanth P, Grant AM, Atkinson V, et al. Effcacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma who have progressed on anti-PD-1 therapy. J Clin Oncol 2015;33(Suppl):abstr 9059.
    • (2015) J Clin Oncol , vol.33 , pp. 059
    • Prashanth, P.1    Grant, A.M.2    Atkinson, V.3
  • 135
    • 84947703441 scopus 로고    scopus 로고
    • Ipilimumab in metastatic melanoma patients with pre-existing autoimmune disorders
    • Douglas BJ, Nikhil IK, Puzanov I, et al. Ipilimumab in metastatic melanoma patients with pre-existing autoimmune disorders. J Clin Oncol 2015;33(Suppl):abstr 9019.
    • (2015) J Clin Oncol , vol.33 , pp. 9019
    • Douglas, B.J.1    Nikhil, I.K.2    Puzanov, I.3
  • 136
    • 84977138755 scopus 로고    scopus 로고
    • Immunotherapy combined or sequenced with targeted therapy in the treatment of solid tumors: Current perspectives
    • Atkins MB, Larkin J. Immunotherapy combined or sequenced with targeted therapy in the treatment of solid tumors: current perspectives. J Natl Cancer Inst 2016;108:414.
    • (2016) J Natl Cancer Inst , vol.108 , pp. 414
    • Atkins, M.B.1    Larkin, J.2
  • 137
    • 84959133719 scopus 로고    scopus 로고
    • Combination cancer immunotherapies tailored to the tumour microenvironment
    • Smyth MJ, Ngiow SF, Ribas A, et al. Combination cancer immunotherapies tailored to the tumour microenvironment. Nat Rev Clin Oncol 2016;13:143-58.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 143-158
    • Smyth, M.J.1    Ngiow, S.F.2    Ribas, A.3
  • 138
    • 85028448586 scopus 로고    scopus 로고
    • Clinical trial of the anti-PD-L1 antibody BMS-936559 in HIV-1 infected participants on suppressive antiretroviral therapy
    • Gay CL, Bosch RJ, Ritz J, et al. Clinical trial of the anti-PD-L1 antibody BMS-936559 in HIV-1 infected participants on suppressive antiretroviral therapy. J Infect Dis 2017;215:1725-33.
    • (2017) J Infect Dis , vol.215 , pp. 1725-1733
    • Gay, C.L.1    Bosch, R.J.2    Ritz, J.3
  • 139
    • 85018516222 scopus 로고    scopus 로고
    • Immune checkpoints and their inhibition in cancer and infectious diseases
    • Dyck L, Mills KHG. Immune checkpoints and their inhibition in cancer and infectious diseases. Eur J Immunol 2017;47:765-79.
    • (2017) Eur J Immunol , vol.47 , pp. 765-779
    • Dyck, L.1    Mills, K.H.G.2
  • 140
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
    • Vétizou M, Pitt JM, Daillère R, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 2015;350:1079-84.
    • (2015) Science , vol.350 , pp. 1079-1084
    • Vétizou, M.1    Pitt, J.M.2    Daillère, R.3
  • 141
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifdobacterium promotes antitumor immunity and facilitates anti-PD-L1 effcacy
    • Sivan A, Corrales L, Hubert N, et al. Commensal Bifdobacterium promotes antitumor immunity and facilitates anti-PD-L1 effcacy. Science 2015;350:1084-9.
    • (2015) Science , vol.350 , pp. 1084-1089
    • Sivan, A.1    Corrales, L.2    Hubert, N.3


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