Tissue expression of PD-L1 mediates peripheral T cell tolerance

Journal of Experimental Medicine

Volumn 203, Issue 4, 2006, Pages 883-895

  Keir, Mary E ^a   Liang, Spencer C ^a   Guleria, Indira ^a   Latchman, Yvette E ^a,d   Qipo, Andi ^c   Albacker, Lee A ^a   Koulmanda, Maria ^c   Freeman, Gordon J ^b   Sayegh, Mohamed H ^a   Sharpe, Arlene H ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d PUGET SOUND BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; PROGRAMMED DEATH 1; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BONE MARROW; CD4+ T LYMPHOCYTE; CELL PROTECTION; CELLULAR IMMUNITY; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMATOPOIETIC CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; IMMUNOREGULATION; JUVENILE DIABETES MELLITUS; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS ISLET CELL; PARENCHYMA; PERIPHERAL LYMPHOCYTE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; TISSUE DISTRIBUTION; TRANSPLANTATION;

ANIMALS; ANTIGENS, CD80; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, TYPE 1; HEMATOPOIETIC STEM CELLS; IMMUNE TOLERANCE; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; ORGAN SPECIFICITY; PEPTIDES; T-LYMPHOCYTES;

EID: 33645846313     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20051776     Document Type: Article

References (37)

1. Anderson, M.S., and J.A. Bluestone. 2005. The NOD mouse: a model of immune dysregulation. Annu. Rev. Immunol. 23:447-485.
2. Keir, M.E., and A.H. Sharpe. 2005. The B7/CD28 costimulatory family in autoimmunity. Immunol. Rev. 204:128-143.
3. Chen, L. 2004. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4:336-347.
4. Greenwald, R.J., Y.E. Latchman, and A.H. Sharpe. 2002. Negative co-receptors on lymphocytes. Curr. Opin. Immunol. 14:391-396.
5. Chambers, C.A., M.S. Kuhns, J.G. Egen, and J.P. Allison. 2001. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19:565-594.
6. Dong, C., R.I. Nurieva, and D.V. Prasad. 2003. Immune regulation by novel costimulatory molecules. Immunol. Res. 28:39-48.
7. Greenwald, R.J., G.J. Freeman, and A.H. Sharpe. 2005. The B7 family revisited. Annu. Rev. Immunol. 23:515-548.
8. Khoury, S.J., and M.H. Sayegh. 2004. The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity. 20:529-538.
9. Yamazaki, T., H. Akiba, H. Iwai, H. Matsuda, M. Aoki, Y. Tanno, T. Shin, H. Tsuchiya, D.M. Pardoll, K. Okumura, et al. 2002. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169:5538-5545.
10. Eppihimer, M.J., J. Gunn, G.J. Freeman, E.A. Greenfield, T. Chernova, J. Erickson, and J.P. Leonard. 2002. Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells. Microcirculation. 9:133-145.
11. Schoop, R., P. Wahl, M. Le Hir, U. Heemann, M. Wang, and R.P. Wuthrich. 2004. Suppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells. Nephrol. Dial. Transplant. 19:2713-2720.
12. Nakazawa, A., I. Dotan, J. Brimnes, M. Allez, L. Shao, F. Tsushima, M. Azuma, and L. Mayer. 2004. The expression and function of co-stimulatory molecules B7H and B7-H1 on colonic epithelial cells. Gastroenterology. 126:1347-1357.
13. Latchman, Y., C.R. Wood, T. Chernova, D. Chaudhary, M. Borde, I. Chernova, Y. Iwai, A.J. Long, J.A. Brown, R. Nunes, et al. 2001. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2:261-268.
14. Tseng, S.Y., M. Otsuji, K. Gorski, X. Huang, J.E. Slansky, S.I. Pai, A. Shalabi, T. Shin, D.M. Pardoll, and H. Tsuchiya. 2001. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193:839-846.
15. Latchman, Y.E., S.C. Liang, Y. Wu, T. Chernova, R.A. Sobel, M. Klemm, V.K. Kuchroo, G.J. Freeman, and A.H. Sharpe. 2004. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl. Acad. Sci. USA. 101:10691-10696.
16. Dong, H., G. Zhu, K. Tamada, and L. Chen. 1999. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5:1365-1369.
17. Liang, S.C., R.J. Greenwald, Y.E. Latchman, L. Rosas, A. Satoskar, G.J. Freeman, and A.H. Sharpe. 2006. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Eur. J. Immunol. 36:58-64.
18. Dong, H., G. Zhu, K. Tamada, D.B. Flies, J.M. van Deursen, and L. Chen. 2004. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity. 20:327-336.
19. Shin, T., K. Yoshimura, E.B. Crafton, H. Tsuchiya, F. Housseau, H. Koseki, R.D. Schulick, L. Chen, and D.M. Pardoll. 2005. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J. Exp. Med. 201:1531-1541.
20. Kearney, E.R., K.A. Pape, D.Y. Loh, and M.K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:327-339.
21. Ansari, M.J., A.D. Salama, T. Chitnis, R.N. Smith, H. Yagita, H. Akiba, T. Yamazaki, M. Azuma, H. Iwai, S.J. Khoury, et al. 2003. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 198:63-69.
22. Liang, S.C., Y.E. Latchman, J.E. Buhlmann, M.F. Tomczak, B.H. Horwitz, G.J. Freeman, and A.H. Sharpe. 2003. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur. J. Immunol. 33:2706-2716.
23. Wang, J., T. Yoshida, F. Nakaki, H. Hiai, T. Okazaki, and T. Honjo. 2005. Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc. Natl. Acad. Sci. USA. 102:11823-11828.
24. Andre, I., A. Gonzalez, B. Wang, J. Katz, C. Benoist, and D. Mathis. 1996. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc. Natl. Acad. Sci. USA. 93:2260-2263.
25. Turley, S., L. Poirot, M. Hattori, C. Benoist, and D. Mathis. 2003. Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J. Exp. Med. 198:1527-1537.
26. Serreze, D.V., S.A. Fleming, H.D. Chapman, S.D. Richard, E.H. Leiter, and R.M. Tisch. 1998. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J. Immunol. 161:3912-3918.
27. Serreze, D.V., H.D. Chapman, D.S. Varnum, M.S. Hanson, P.C. Reifsnyder, S.D. Richard, S.A. Fleming, E.H. Leiter, and L.D. Shultz. 1996. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig μ null mice. J. Exp. Med. 184:2049-2053.
28. Luhder, F., C. Chambers, J.P. Allison, C. Benoist, and D. Mathis. 2000. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc. Natl. Acad. Sci. USA. 97:12204-12209.
29. Subudhi, S.K., P. Zhou, L.M. Yerian, R.K. Chin, J.C. Lo, R.A. Anders, Y. Sun, L. Chen, Y. Wang, M.L. Alegre, and Y.X. Fu. 2004. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest. 113:694-700.
30. Wu, A.J., H. Hua, S.H. Munson, and H.O. McDevitt. 2002. Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA. 99:12287-12292.
31. Vijayakrishnan, L., J.M. Slavik, Z. Illes, R.J. Greenwald, D. Rainbow, B. Greve, L.B. Peterson, D.A. Hafler, G.J. Freeman, and A.H. Sharpe, et al. 2004. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 20:563-575.
32. Liu, X., J.X. Gao, J. Wen, L. Yin, O. Li, T. Zuo, T.F. Gajewski, Y.X. Fu, P. Zheng, and Y. Liu. 2003. B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med. 197:1721-1730.
33. Nishimura, H., T. Okazaki, Y. Tanaka, K. Nakatani, M. Hara, A. Matsumori, S. Sasayama, A. Mizoguchi, H. Hiai, N. Minato, and T. Honjo. 2001. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 291:319-322.
34. Guleria, I., A. Khosroshahi, M.J. Ansari, A. Habicht, M. Azuma, H. Yagita, R.J. Noelle, A. Coyle, A.L. Mellor, S.J. Khoury, and M.H. Sayegh. 2005. A critical role for the programmed death ligand 1 in feto-maternal tolerance. J. Exp. Med. 202:231-237.
35. Ansel, K.M., R.J. Greenwald, S. Agarwal, C.H. Bassing, S. Monticelli, J. Interlandi, I.M. Djuretic, D.U. Lee, A.H. Sharpe, F.W. Alt, and A. Rao. 2004. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat. Immunol. 5:1251-1259.
36. Gotoh, M., T. Maki, T. Kiyoizumi, S. Satomi, and A.P. Monaco. 1985. An improved method for isolation of mouse pancreatic islets. Transplantation. 40:437-438.
37. Shultz, L.D., P.A. Lang, S.W. Christianson, B. Gott, B. Lyons, S. Umeda, E. Leiter, R. Hesselton, E.J. Wagar, J.H. Leif, et al. 2000. NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells. J. Immunol. 164:2496-2507.