메뉴 건너뛰기




Volumn 27, Issue 3, 2016, Pages 409-416

Regulation of PD-L1: A novel role of pro-survival signalling in cancer

Author keywords

Akt; HIF 1ANHMRC projectAPP1083496; immune checkpoint; MAPK; NF B; STAT3

Indexed keywords

BIOLOGICAL MARKER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; MICRORNA 197; MICRORNA 200; MICRORNA 34A; MICRORNA 513; MICRORNA 570; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT3 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CD274 PROTEIN, HUMAN; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BINDING; STAT3 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84959865627     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdv615     Document Type: Review
Times cited : (630)

References (98)
  • 1
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: harnessing the T cell response
    • Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012; 12: 269-281.
    • (2012) Nat Rev Immunol , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 2
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, DranoffG. Cancer immunotherapy comes of age. Nature 2011; 480: 480-489.
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 3
    • 18344375283 scopus 로고    scopus 로고
    • Immunotherapy and chemotherapy-a practical partnership
    • Lake RA, Robinson BW. Immunotherapy and chemotherapy-a practical partnership. Nat Rev Cancer 2005; 5: 397-405.
    • (2005) Nat Rev Cancer , vol.5 , pp. 397-405
    • Lake, R.A.1    Robinson, B.W.2
  • 4
    • 41149097574 scopus 로고    scopus 로고
    • Adoptive cell transfer: a clinical path to effective cancer immunotherapy
    • Rosenberg SA, Restifo NP, Yang JC et al. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 2008; 8: 299-308.
    • (2008) Nat Rev Cancer , vol.8 , pp. 299-308
    • Rosenberg, S.A.1    Restifo, N.P.2    Yang, J.C.3
  • 5
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • KantoffPW, Higano CS, Shore ND et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363: 411-422.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 6
    • 80053567512 scopus 로고    scopus 로고
    • Cell transfer immunotherapy for metastatic solid cancer-what clinicians need to know
    • Rosenberg SA. Cell transfer immunotherapy for metastatic solid cancer-what clinicians need to know. Nat Rev Clin Oncol 2011; 8: 577-585.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 577-585
    • Rosenberg, S.A.1
  • 7
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer 2012; 12: 265-277.
    • (2012) Nat Rev Cancer , vol.12 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 8
    • 84877575144 scopus 로고    scopus 로고
    • Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors
    • Kochenderfer JN, Rosenberg SA. Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. Nat Rev Clin Oncol 2013; 10: 267-276.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 267-276
    • Kochenderfer, J.N.1    Rosenberg, S.A.2
  • 9
    • 84890214448 scopus 로고    scopus 로고
    • CAR T cells: driving the road from the laboratory to the clinic
    • Cheadle EJ, Gornall H, Baldan V et al. CAR T cells: driving the road from the laboratory to the clinic. Immunol Rev 2014; 257: 91-106.
    • (2014) Immunol Rev , vol.257 , pp. 91-106
    • Cheadle, E.J.1    Gornall, H.2    Baldan, V.3
  • 10
    • 84945122687 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors: new insights and current place in cancer therapy
    • La-Beck NM, Jean GW, Huynh C et al. Immune checkpoint inhibitors: new insights and current place in cancer therapy. Pharmacotherapy 2015; 35: 963-976.
    • (2015) Pharmacotherapy , vol.35 , pp. 963-976
    • La-Beck, N.M.1    Jean, G.W.2    Huynh, C.3
  • 11
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366: 2455-2465.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 12
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366: 2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 13
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12: 252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 14
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013; 369: 122-133.
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 15
    • 84873336707 scopus 로고    scopus 로고
    • The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition
    • Jiang X, Zhou J, Giobbie-Hurder A et al. The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition. Clin Cancer Res 2013; 19: 598-609.
    • (2013) Clin Cancer Res , vol.19 , pp. 598-609
    • Jiang, X.1    Zhou, J.2    Giobbie-Hurder, A.3
  • 17
    • 84878962707 scopus 로고    scopus 로고
    • PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer
    • Song M, Chen D, Lu B et al. PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer. PLoS One 2013; 8: e65821.
    • (2013) PLoS One , vol.8
    • Song, M.1    Chen, D.2    Lu, B.3
  • 18
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004; 4: 336-347.
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 19
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992; 11: 3887.
    • (1992) EMBO J , vol.11 , pp. 3887
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 20
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M, Johnson LA, Heemskerk B et al. Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009; 114: 1537-1544.
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3
  • 21
    • 78449243489 scopus 로고    scopus 로고
    • Immune checkpoint proteins: a new therapeutic paradigm for cancer-preclinical background: CTLA-4 and PD-1 blockade
    • Weber J. Immune checkpoint proteins: a new therapeutic paradigm for cancer-preclinical background: CTLA-4 and PD-1 blockade. Semin Oncol 2010; 430-439.
    • (2010) Semin Oncol , pp. 430-439
    • Weber, J.1
  • 22
    • 75449110618 scopus 로고    scopus 로고
    • Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion
    • Blackburn SD, Crawford A, Shin H et al. Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion. J Virol 2010; 84: 2078-2089.
    • (2010) J Virol , vol.84 , pp. 2078-2089
    • Blackburn, S.D.1    Crawford, A.2    Shin, H.3
  • 23
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley PS, Greene JL, Brady W et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994; 1: 793-801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3
  • 24
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999; 11: 141-151.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 25
    • 12144290320 scopus 로고    scopus 로고
    • Structural and functional analysis of the costimulatory receptor programmed death-1
    • Zhang X, Schwartz J-CD, Guo X et al. Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity 2004; 20: 337-347.
    • (2004) Immunity , vol.20 , pp. 337-347
    • Zhang, X.1    Schwartz, J.-C.D.2    Guo, X.3
  • 27
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192: 1027-1034.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 28
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y, Wood CR, Chernova T et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001; 2: 261-268.
    • (2001) Nat Immunol , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 29
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 2007; 8: 239-245.
    • (2007) Nat Immunol , vol.8 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 30
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, costimulates T-cell proliferation and interleukin-10 secretion
    • Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, costimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999; 5: 1365-1369.
    • (1999) Nat Med , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 31
    • 84884698526 scopus 로고    scopus 로고
    • The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies
    • Shi L, Chen S, Yang L, Li Y. The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies. J Hematol Oncol 2013; 6: 74.
    • (2013) J Hematol Oncol , vol.6 , pp. 74
    • Shi, L.1    Chen, S.2    Yang, L.3    Li, Y.4
  • 32
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1 (PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1 (PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 2012; 24: 207-212.
    • (2012) Curr Opin Immunol , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 33
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco LM, Salinas VH, Brown KE et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009; 206: 3015-3029.
    • (2009) J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3
  • 34
    • 80053305855 scopus 로고    scopus 로고
    • Development of a sandwich ELISA for evaluating soluble PD-L1 (CD274) in human sera of different ages as well as supernatants of PD-L1+ cell lines
    • Chen Y, Wang Q, Shi B et al. Development of a sandwich ELISA for evaluating soluble PD-L1 (CD274) in human sera of different ages as well as supernatants of PD-L1+ cell lines. Cytokine 2011; 56: 231-238.
    • (2011) Cytokine , vol.56 , pp. 231-238
    • Chen, Y.1    Wang, Q.2    Shi, B.3
  • 35
    • 84907497893 scopus 로고    scopus 로고
    • High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial
    • Rossille D, Gressier M, Damotte D et al. High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial. Leukemia 2014; 28: 2367-2375.
    • (2014) Leukemia , vol.28 , pp. 2367-2375
    • Rossille, D.1    Gressier, M.2    Damotte, D.3
  • 36
    • 84977889511 scopus 로고    scopus 로고
    • Detection of soluble B7-H4 molecules in serum of patients with breast cancer and its clinical significance
    • Junjun C, Hongbing S, Xiao Z et al. Detection of soluble B7-H4 molecules in serum of patients with breast cancer and its clinical significance. J Int Transl Med 2013; 1: 215-218.
    • (2013) J Int Transl Med , vol.1 , pp. 215-218
    • Junjun, C.1    Hongbing, S.2    Xiao, Z.3
  • 37
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria J-C, Kowanetz M et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014; 515: 563-567.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.-C.2    Kowanetz, M.3
  • 38
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • Gao Q, Wang X-Y, Qiu S-J et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res 2009; 15: 971-979.
    • (2009) Clin Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1    Wang, X.-Y.2    Qiu, S.-J.3
  • 39
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi J, Mandai M, Iwasaki M et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA 2007; 104: 3360-3365.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3
  • 40
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
    • Spranger S, Spaapen RM, Zha Y et al. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. Sci Transl Med 2013; 5: 200ra116-200ra116.
    • (2013) Sci Transl Med , vol.5
    • Spranger, S.1    Spaapen, R.M.2    Zha, Y.3
  • 41
    • 84941637917 scopus 로고    scopus 로고
    • The status of PD-L1 and tumor-infiltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAFV600
    • Massi D, Brusa D, Merelli B et al. The status of PD-L1 and tumor-infiltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAFV600. Ann Oncol 2015; 26: 1980-1987.
    • (2015) Ann Oncol , vol.26 , pp. 1980-1987
    • Massi, D.1    Brusa, D.2    Merelli, B.3
  • 42
    • 84927613720 scopus 로고    scopus 로고
    • PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics
    • Massi D, Brusa D, Merelli B et al. PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics. Ann Oncol 2014; 25: 2433-2442.
    • (2014) Ann Oncol , vol.25 , pp. 2433-2442
    • Massi, D.1    Brusa, D.2    Merelli, B.3
  • 43
    • 84875171283 scopus 로고    scopus 로고
    • PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction
    • Abiko K, Mandai M, Hamanishi J et al. PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. Clin Cancer Res 2013; 19: 1363-1374.
    • (2013) Clin Cancer Res , vol.19 , pp. 1363-1374
    • Abiko, K.1    Mandai, M.2    Hamanishi, J.3
  • 44
    • 84866550084 scopus 로고    scopus 로고
    • Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells
    • Wang L, Liu H, Chen X et al. Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells. Plos One 2012; 7(e45491): 1-11.
    • (2012) Plos One , vol.7 , pp. 1-11
    • Wang, L.1    Liu, H.2    Chen, X.3
  • 45
    • 84923251407 scopus 로고    scopus 로고
    • Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
    • Chen L, Gibbons DL, Goswami S et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun 2014; 5(article 5241): 1-12.
    • (2014) Nat Commun , vol.5 , pp. 1-12
    • Chen, L.1    Gibbons, D.L.2    Goswami, S.3
  • 46
    • 84938579430 scopus 로고    scopus 로고
    • Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells
    • Alsuliman A, Colak D, Al-Harazi O et al. Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells. Mol Cancer 2015; 14: 1.
    • (2015) Mol Cancer , vol.14 , pp. 1
    • Alsuliman, A.1    Colak, D.2    Al-Harazi, O.3
  • 47
    • 17844368327 scopus 로고    scopus 로고
    • The MAPK signalling pathways and colorectal cancer
    • Fang JY, Richardson BC. The MAPK signalling pathways and colorectal cancer. Lancet Oncol 2005; 6: 322-327.
    • (2005) Lancet Oncol , vol.6 , pp. 322-327
    • Fang, J.Y.1    Richardson, B.C.2
  • 48
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 49
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon A, Hagan S, Rath O, Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007; 26: 3279-3290.
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 50
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 51
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
    • Sumimoto H, Imabayashi F, Iwata T, Kawakami Y. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J Exp Med 2006; 203: 1651-1656.
    • (2006) J Exp Med , vol.203 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3    Kawakami, Y.4
  • 52
    • 84905107708 scopus 로고    scopus 로고
    • Combined BRAFV600E-and SRCinhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
    • Borre PV, Gunda V, McFadden DG et al. Combined BRAFV600E-and SRCinhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer. Oncotarget 2014; 5: 3996.
    • (2014) Oncotarget , vol.5 , pp. 3996
    • Borre, P.V.1    Gunda, V.2    McFadden, D.G.3
  • 53
    • 84938289871 scopus 로고    scopus 로고
    • Up-regulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation
    • Chen N, Fang W, Zhan J et al. Up-regulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation. J Thorac Oncol 2015; 10: 910-923.
    • (2015) J Thorac Oncol , vol.10 , pp. 910-923
    • Chen, N.1    Fang, W.2    Zhan, J.3
  • 54
    • 77956319878 scopus 로고    scopus 로고
    • Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T-cell-mediated immune surveillance
    • Landsberg J, Gaffal E, Cron M et al. Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T-cell-mediated immune surveillance. Pigment Cell Melanoma Res 2010; 23: 649-660.
    • (2010) Pigment Cell Melanoma Res , vol.23 , pp. 649-660
    • Landsberg, J.1    Gaffal, E.2    Cron, M.3
  • 55
    • 84925778807 scopus 로고    scopus 로고
    • Novel Roles of c-Met in the Survival of Renal Cancer Cells through the Regulation of HO-1 and PD-L1 Expression
    • Balan M, Teran EMY, Waaga-Gasser AM et al. Novel Roles of c-Met in the Survival of Renal Cancer Cells through the Regulation of HO-1 and PD-L1 Expression. J Biol Chem 2015; 290: 8110-8120.
    • (2015) J Biol Chem , vol.290 , pp. 8110-8120
    • Balan, M.1    Teran, E.M.Y.2    Waaga-Gasser, A.M.3
  • 56
    • 84866529268 scopus 로고    scopus 로고
    • Paclitaxel Induced B7-H1 Expression in Cancer Cells via the MAPK Pathway
    • Gong W, Song Q, Lu X et al. Paclitaxel Induced B7-H1 Expression in Cancer Cells via the MAPK Pathway. J Chemother 2011; 23: 295-299.
    • (2011) J Chemother , vol.23 , pp. 295-299
    • Gong, W.1    Song, Q.2    Lu, X.3
  • 57
    • 79952202494 scopus 로고    scopus 로고
    • Cisplatin induces programmed death-1-ligand 1 (PD-L1) over-expression in hepatoma H22 cells via Erk/MAPK signaling pathway
    • Qin X, Liu C, Zhou Y, Wang G. Cisplatin induces programmed death-1-ligand 1 (PD-L1) over-expression in hepatoma H22 cells via Erk/MAPK signaling pathway. Cell Mol Biol (Noisy-le-grand) 2009; 56: OL1366-OL1372.
    • (2009) Cell Mol Biol (Noisy-le-grand) , vol.56 , pp. OL1366-OL1372
    • Qin, X.1    Liu, C.2    Zhou, Y.3    Wang, G.4
  • 58
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: downstream AKTion blocks apoptosis
    • Franke TF, Kaplan DR, Cantley LC. PI3K: downstream AKTion blocks apoptosis. Cell 1997; 88: 435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 59
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 60
    • 84924024228 scopus 로고    scopus 로고
    • Signaling pathways in HPV-associated cancers and therapeutic implications
    • Chen J. Signaling pathways in HPV-associated cancers and therapeutic implications. Rev Med Virol 2015; 25: 24-53.
    • (2015) Rev Med Virol , vol.25 , pp. 24-53
    • Chen, J.1
  • 61
    • 84941117248 scopus 로고    scopus 로고
    • Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice
    • Chen J, Zhang XD, Proud C. Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice. Sci Signal 2015; 8(pe1): 1-3.
    • (2015) Sci Signal , vol.8 , pp. 1-3
    • Chen, J.1    Zhang, X.D.2    Proud, C.3
  • 62
    • 84874634909 scopus 로고    scopus 로고
    • PI (4, 5) P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma
    • Ye Y, Jin L, Wilmott JS et al. PI (4, 5) P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nat commun 2013; 4: 1508.
    • (2013) Nat commun , vol.4 , pp. 1508
    • Ye, Y.1    Jin, L.2    Wilmott, J.S.3
  • 63
    • 84893407807 scopus 로고    scopus 로고
    • SHIP2 signaling in normal and pathological situations: its impact on cell proliferation
    • Schurmans S, Roger PP, Erneux C. SHIP2 signaling in normal and pathological situations: its impact on cell proliferation. Adv Biol Regul 2014; 54: 142-151.
    • (2014) Adv Biol Regul , vol.54 , pp. 142-151
    • Schurmans, S.1    Roger, P.P.2    Erneux, C.3
  • 64
    • 84892743258 scopus 로고    scopus 로고
    • A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition
    • Cheng H, Liu P, Zhang F et al. A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Cancer Res 2014; 74: 15-23.
    • (2014) Cancer Res , vol.74 , pp. 15-23
    • Cheng, H.1    Liu, P.2    Zhang, F.3
  • 65
    • 84927539299 scopus 로고    scopus 로고
    • Inducible but not constitutive expression of PD-L1 in human melanoma cells is dependent on activation of NF-κB
    • Gowrishankar K, Gunatilake D, Gallagher SJ et al. Inducible but not constitutive expression of PD-L1 in human melanoma cells is dependent on activation of NF-κB. Plos One 2015; 10(e0123410): 1-19.
    • (2015) Plos One , vol.10 , pp. 1-19
    • Gowrishankar, K.1    Gunatilake, D.2    Gallagher, S.J.3
  • 66
    • 84903277871 scopus 로고    scopus 로고
    • Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
    • Pollizzi KN, Powell JD. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat Rev Immunol 2014; 14: 435-446.
    • (2014) Nat Rev Immunol , vol.14 , pp. 435-446
    • Pollizzi, K.N.1    Powell, J.D.2
  • 68
    • 84918591282 scopus 로고    scopus 로고
    • Mechanisms of hypoxia-mediated immune escape in cancer
    • Barsoum IB, Koti M, Siemens DR, Graham CH. Mechanisms of hypoxia-mediated immune escape in cancer. Cancer Res 2014; 74: 7185-7190.
    • (2014) Cancer Res , vol.74 , pp. 7185-7190
    • Barsoum, I.B.1    Koti, M.2    Siemens, D.R.3    Graham, C.H.4
  • 69
    • 84907853348 scopus 로고    scopus 로고
    • Hypoxia in the intestine or solid tumors: A beneficial or deleterious alarm signal?
    • Shehade H, Oldenhove G, Moser M. Hypoxia in the intestine or solid tumors: A beneficial or deleterious alarm signal? Eur J Immunol 2014; 44: 2550-2557.
    • (2014) Eur J Immunol , vol.44 , pp. 2550-2557
    • Shehade, H.1    Oldenhove, G.2    Moser, M.3
  • 70
    • 84893872087 scopus 로고    scopus 로고
    • A mechanism of hypoxiamediated escape from adaptive immunity in cancer cells
    • Barsoum IB, Smallwood CA, Siemens DR, Graham CH. A mechanism of hypoxiamediated escape from adaptive immunity in cancer cells. Cancer Res 2014; 74: 665-674.
    • (2014) Cancer Res , vol.74 , pp. 665-674
    • Barsoum, I.B.1    Smallwood, C.A.2    Siemens, D.R.3    Graham, C.H.4
  • 71
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1a, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman MZ, Desantis G, Janji B et al. PD-L1 is a novel direct target of HIF-1a, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med 2014; 211: 781-790.
    • (2014) J Exp Med , vol.211 , pp. 781-790
    • Noman, M.Z.1    Desantis, G.2    Janji, B.3
  • 72
    • 84906939724 scopus 로고    scopus 로고
    • Cell cycle progression in response to oxygen levels
    • Ortmann B, Druker J, Rocha S. Cell cycle progression in response to oxygen levels. Cell Mol Life Sci 2014; 71: 3569-3582.
    • (2014) Cell Mol Life Sci , vol.71 , pp. 3569-3582
    • Ortmann, B.1    Druker, J.2    Rocha, S.3
  • 73
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004; 4: 437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 74
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 2011; 11: 393-410.
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 75
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007; 26: 225-239.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 76
    • 84938803844 scopus 로고    scopus 로고
    • Targeting hypoxia at the forefront of anticancer immune responses
    • Noman MZ, Chouaib S. Targeting hypoxia at the forefront of anticancer immune responses. OncoImmunology 2014; 3(e954463): 1-3.
    • (2014) OncoImmunology , vol.3 , pp. 1-3
    • Noman, M.Z.1    Chouaib, S.2
  • 77
    • 58549102319 scopus 로고    scopus 로고
    • Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
    • Marzec M, Zhang Q, Goradia A et al. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proc Natl Acad Sci USA 2008; 105: 20852-20857.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20852-20857
    • Marzec, M.1    Zhang, Q.2    Goradia, A.3
  • 78
    • 84920031403 scopus 로고    scopus 로고
    • EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy
    • Fang W, Zhang J, Hong S et al. EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy. Oncotarget 2014; 5: 12189-12202.
    • (2014) Oncotarget , vol.5 , pp. 12189-12202
    • Fang, W.1    Zhang, J.2    Hong, S.3
  • 79
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 80
    • 84890130945 scopus 로고    scopus 로고
    • Alterations of immune response of non-small cell lung cancer with azacytidine
    • Wrangle J, Wang W, Koch A et al. Alterations of immune response of non-small cell lung cancer with azacytidine. Oncotarget 2013; 4: 2067.
    • (2013) Oncotarget , vol.4 , pp. 2067
    • Wrangle, J.1    Wang, W.2    Koch, A.3
  • 81
    • 65649111753 scopus 로고    scopus 로고
    • MicroRNA signatures in liver diseases
    • Chen X-M. MicroRNA signatures in liver diseases. World J Gastroenterol 2009; 15: 1665.
    • (2009) World J Gastroenterol , vol.15 , pp. 1665
    • Chen, X.-M.1
  • 82
    • 84921028577 scopus 로고    scopus 로고
    • Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia
    • Wang X, Li J, Dong K et al. Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia. Cell Signal 2015; 27: 443-452.
    • (2015) Cell Signal , vol.27 , pp. 443-452
    • Wang, X.1    Li, J.2    Dong, K.3
  • 83
    • 71949093867 scopus 로고    scopus 로고
    • Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513
    • Gong A-Y, Zhou R, Hu G et al. Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513. J Infect Dis 2010; 201: 160-169.
    • (2010) J Infect Dis , vol.201 , pp. 160-169
    • Gong, A.-Y.1    Zhou, R.2    Hu, G.3
  • 84
    • 74949132184 scopus 로고    scopus 로고
    • Disruption of microRNA expression in human airway cells by diesel exhaust particles is linked to tumorigenesis-associated pathways
    • Jardim MJ, Fry RC, Jaspers I et al. Disruption of microRNA expression in human airway cells by diesel exhaust particles is linked to tumorigenesis-associated pathways. Environ Health Perspect 2009; 117: 1745-1751.
    • (2009) Environ Health Perspect , vol.117 , pp. 1745-1751
    • Jardim, M.J.1    Fry, R.C.2    Jaspers, I.3
  • 85
    • 84878234062 scopus 로고    scopus 로고
    • A miR-570 binding site polymorphism in the B7-H1 gene is associated with the risk of gastric adenocarcinoma
    • Wang W, Li F, Mao Y et al. A miR-570 binding site polymorphism in the B7-H1 gene is associated with the risk of gastric adenocarcinoma. Hum Genet 2013; 132: 641-648.
    • (2013) Hum Genet , vol.132 , pp. 641-648
    • Wang, W.1    Li, F.2    Mao, Y.3
  • 86
    • 84927005034 scopus 로고    scopus 로고
    • The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer
    • Fujita Y, Yagishita S, Hagiwara K et al. The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer. Mol Ther 2015; 23: 717-727.
    • (2015) Mol Ther , vol.23 , pp. 717-727
    • Fujita, Y.1    Yagishita, S.2    Hagiwara, K.3
  • 87
    • 84860394613 scopus 로고    scopus 로고
    • Multiple signal pathways in obesity-associated cancer
    • Chen J. Multiple signal pathways in obesity-associated cancer. Obes Rev 2011; 12: 1063-1070.
    • (2011) Obes Rev , vol.12 , pp. 1063-1070
    • Chen, J.1
  • 88
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9: 798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 89
    • 77950283280 scopus 로고    scopus 로고
    • Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
    • Hino R, Kabashima K, Kato Y et al. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer 2010; 116: 1757-1766.
    • (2010) Cancer , vol.116 , pp. 1757-1766
    • Hino, R.1    Kabashima, K.2    Kato, Y.3
  • 90
    • 80052476869 scopus 로고    scopus 로고
    • High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
    • Mu C-Y, Huang J-A, Chen Y et al. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol 2011; 28: 682-688.
    • (2011) Med Oncol , vol.28 , pp. 682-688
    • Mu, C.-Y.1    Huang, J.-A.2    Chen, Y.3
  • 91
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson RH, Kuntz SM, Leibovich BC et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 2006; 66: 3381-3385.
    • (2006) Cancer Res , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3
  • 92
    • 77957551174 scopus 로고    scopus 로고
    • Increase of programmed death-1-expressing intratumoral CD8T cells predicts a poor prognosis for nasopharyngeal carcinoma
    • Hsu M-C, Hsiao J-R, Chang K-C et al. Increase of programmed death-1-expressing intratumoral CD8T cells predicts a poor prognosis for nasopharyngeal carcinoma. Mod Pathol 2010; 23: 1393-1403.
    • (2010) Mod Pathol , vol.23 , pp. 1393-1403
    • Hsu, M.-C.1    Hsiao, J.-R.2    Chang, K.-C.3
  • 93
    • 84938491216 scopus 로고    scopus 로고
    • PD-L1 expression predicts tyrosine kinase inhibitor response and better prognosis in a cohort of patients with EGFR mutation-positive lung adenocarcinoma
    • Lin C, Li M, Liu J et al. PD-L1 expression predicts tyrosine kinase inhibitor response and better prognosis in a cohort of patients with EGFR mutation-positive lung adenocarcinoma. Clin Lung Cancer 2015; 16: e25-e35.
    • (2015) Clin Lung Cancer , vol.16 , pp. e25-e35
    • Lin, C.1    Li, M.2    Liu, J.3
  • 94
    • 84891534246 scopus 로고    scopus 로고
    • Programmed death ligand-1 expression in non-small cell lung cancer
    • Velcheti V, Schalper KA, Carvajal DE et al. Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest 2014; 94: 107-116.
    • (2014) Lab Invest , vol.94 , pp. 107-116
    • Velcheti, V.1    Schalper, K.A.2    Carvajal, D.E.3
  • 95
    • 79951961755 scopus 로고    scopus 로고
    • Resistance to BRAF inhibition in melanomas
    • Solit DB, Rosen N. Resistance to BRAF inhibition in melanomas. N Engl J Med 2011; 364: 772.
    • (2011) N Engl J Med , vol.364 , pp. 772
    • Solit, D.B.1    Rosen, N.2
  • 96
    • 84937630840 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition for the treatment of BRAF-mutated metastatic melanoma
    • Queirolo P, Picasso V, Spagnolo F. Combined BRAF and MEK inhibition for the treatment of BRAF-mutated metastatic melanoma. Cancer Treat Rev 2015; 41: 519-526.
    • (2015) Cancer Treat Rev , vol.41 , pp. 519-526
    • Queirolo, P.1    Picasso, V.2    Spagnolo, F.3
  • 97
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman M, DranoffG. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer 2012; 12: 237-251.
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 98
    • 84927666190 scopus 로고    scopus 로고
    • The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD1, PD-L1 and CTLA-4
    • Liu L, Mayes PA, Eastman S et al. The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD1, PD-L1 and CTLA-4. Clin Cancer Res 2015: 21: 1639-1651.
    • (2015) Clin Cancer Res , vol.21 , pp. 1639-1651
    • Liu, L.1    Mayes, P.A.2    Eastman, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.