Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation

Journal of Biological Chemistry

Volumn 293, Issue 4, 2018, Pages 1218-1228

  Bernard, Karen ^a   Logsdon, Naomi J ^a   Benavides, Gloria A ^b,c   Sanders, Yan ^a   Zhang, Jianhua ^b,c   Darley Usmar, Victor M ^b,c   Thannickal, Victor J ^a,d  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; FIBROBLASTS; METABOLISM; METABOLITES;

CRITICAL COMPONENT; EXTRACELLULAR MATRIX PROTEIN; GLUTAMINE LEVELS; HYPOXIA INDUCIBLE FACTOR-1 ALPHA; P38 MITOGEN-ACTIVATED PROTEIN KINASE; SMOOTH MUSCLE ACTINS; STEADY STATE CONCENTRATION; TRANSFORMING GROWTH FACTORS;

PROTEINS;

2 OXOGLUTARIC ACID; CITRIC ACID; FIBRONECTIN; FUMARIC ACID; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MALIC ACID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD3 PROTEIN; SUCCINIC ACID; TRANSFORMING GROWTH FACTOR BETA1; GLS1 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN;

AMINO ACID METABOLISM; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CITRIC ACID CYCLE; CONTROLLED STUDY; FETUS; GLUTAMINOLYSIS; HUMAN; HUMAN CELL; LUNG FIBROBLAST; METABOLITE; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; UPREGULATION; CELL LINE; CYTOLOGY; GENETICS; METABOLISM;

CELL DIFFERENTIATION; CELL LINE; GLUTAMINASE; GLUTAMINE; HUMANS; KETOGLUTARIC ACIDS; MYOFIBROBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85041232292     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.RA117.000444s     Document Type: Article

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