Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Redox Biology

Volumn 8, Issue , 2016, Pages 136-148

  Smith, M Ryan ^a,b   Vayalil, Praveen K ^a,b   Zhou, Fen ^a,b   Benavides, Gloria A ^a,b   Beggs, Reena R ^a   Golzarian, Hafez ^b   Nijampatnam, Bhavitavya ^b   Oliver, Patsy G ^c   Smith, Robin A J ^d   Murphy, Michael P ^e   Velu, Sadanandan E ^b   Landar, Aimee ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c The University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Bioenergetics; IBTP; Krebs cycle; Redox signaling; Seahorse extracellular flux analysis; Tricarboxylic acid cycle

Indexed keywords

ACONITATE HYDRATASE; ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; CITRIC ACID; ELECTROPHILE; GLUTAMINASE; GLUTAMINASE C; GLUTAMINE; IODOBUTYL TRIPHENYLPHOSPHONIUM; ISOCITRIC ACID; MITOCHONDRIAL PROTEIN; PHOSPHINE DERIVATIVE; SUCCINIC ACID; UNCLASSIFIED DRUG; THIOL DERIVATIVE;

ACIDIFICATION; ADENOCARCINOMA CELL LINE; ARTICLE; BIOENERGY; BREAST ADENOCARCINOMA; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CELLULAR PARAMETERS; CHEMICAL REACTION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GLUTAMINOLYSIS; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; MCF 10A CELL LINE; MDA MB 231 CELL LINE; METABOLIC INHIBITION; METABOLOMICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL THIOL MODIFICATION; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; OXYGEN CONSUMPTION RATE; PRIORITY JOURNAL; BREAST TUMOR; ENERGY METABOLISM; FEMALE; GENETICS; METABOLISM; METABOLOME; MITOCHONDRION; PHYSIOLOGICAL STRESS; PROCEDURES; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; BREAST NEOPLASMS; CELL LINE, TUMOR; ENERGY METABOLISM; FEMALE; GLUTAMINASE; HUMANS; METABOLOME; METABOLOMICS; MITOCHONDRIA; STRESS, PHYSIOLOGICAL; SULFHYDRYL COMPOUNDS;

EID: 84954212197     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2016.01.002     Document Type: Article

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