HIF-1α promotes glutamine-mediated redox homeostasis and glycogen-dependent bioenergetics to support postimplantation bone cell survival

Cell Metabolism

Volumn 23, Issue 2, 2016, Pages 265-279

  Stegen, Steve ^a   Van Gastel, Nick ^a   Eelen, Guy ^a   Ghesquière, Bart ^a   D'Anna, Flora ^a   Thienpont, Bernard ^a   Goveia, Jermaine ^a   Torrekens, Sophie ^a   Van Looveren, Riet ^a   Luyten, Frank P ^a,b   Maxwell, Patrick H ^c   Wielockx, Ben ^d   Lambrechts, Diether ^a   Fendt, Sarah Maria ^a   Carmeliet, Peter ^a   Carmeliet, Geert ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; GLYCOGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; GLS1 PROTEIN, MOUSE; GLUTAMINASE; REACTIVE OXYGEN METABOLITE;

ADAPTATION; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOENERGY; BONE CELL; BONE REGENERATION; CELL METABOLISM; CELL RESPIRATION; CELL SURVIVAL; CELL THERAPY; CELL VIABILITY; CONTROLLED STUDY; DETOXIFICATION; ENERGY BALANCE; GLUTATHIONE METABOLISM; GLYCOGEN METABOLISM; HOMEOSTASIS; MOUSE; NONHUMAN; NUTRIENT; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; REGENERATIVE MEDICINE; ANIMAL; ENERGY METABOLISM; GENE DELETION; GENE SILENCING; METABOLISM; OSTEOCYTE; OXIDATION REDUCTION REACTION; PATHOLOGY; PERIOSTEUM; TRANSPLANTATION;

ANIMALS; BONE REGENERATION; CELL RESPIRATION; CELL SURVIVAL; ENERGY METABOLISM; GENE DELETION; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GLUTAMINASE; GLUTAMINE; GLYCOGEN; HOMEOSTASIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOCYTES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PERIOSTEUM; REACTIVE OXYGEN SPECIES;

EID: 84957941184     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.01.002     Document Type: Article

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