Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Cell Metabolism

Volumn 24, Issue 6, 2016, Pages 807-819

  Arts, Rob J W ^a   Novakovic, Boris ^b   ter Horst, Rob ^a   Carvalho, Agostinho ^c,d   Bekkering, Siroon ^a   Lachmandas, Ekta ^a   Rodrigues, Fernando ^c,d   Silvestre, Ricardo ^c,d   Cheng, Shih Chin ^a,e   Wang, Shuang Yin ^b   Habibi, Ehsan ^b   Gonçalves, Luís G ^f   Mesquita, Inês ^c,d   Cunha, Cristina ^c,d   van Laarhoven, Arjan ^a   van de Veerdonk, Frank L ^a   Williams, David L ^g   van der Meer, Jos W M ^a   Logie, Colin ^b   O'Neill, Luke A ^h   Dinarello, Charles A ^a,i   Riksen, Niels P ^a   van Crevel, Reinout ^a   Clish, Clary ^j   Notebaart, Richard A ^a   Joosten, Leo A B ^a   Stunnenberg, Hendrik G ^b   Xavier, Ramnik J ^j,k   Netea, Mihai G ^a   more..

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c UNIVERSITY OF MINHO   (Portugal)

^d UNIVERSITY OF MINHO   (Portugal)

^e NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^f INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^g East Tennessee State University   (United States)

^h TRINITY COLLEGE DUBLIN   (Ireland)

ⁱ UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^j BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^k MASSACHUSETTS GENERAL HOSPITAL   (United States)

more..

Author keywords

cholesterol metabolism; epigenetics; glutamine metabolism; glycolysis; trained immunity

Indexed keywords

BETA GLUCAN; CHOLESTEROL; FUMARIC ACID; GLUTAMIC ACID; GLUTAMINE; HISTONE DEMETHYLASE; INTERLEUKIN 1; MESSENGER RNA; METFORMIN; RETINOBLASTOMA BINDING PROTEIN 2; TUMOR NECROSIS FACTOR; FUMARIC ACID DERIVATIVE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

AMINOLYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG ACCUMULATION; ENZYME INHIBITION; EPIGENETICS; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOLOGICAL MEMORY; IN VIVO STUDY; INNATE IMMUNITY; METABOLISM; MONOCYTE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; BIOLOGICAL MODEL; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGICAL TOLERANCE; MACROPHAGE; PENTOSE PHOSPHATE CYCLE; PROTEIN DEGRADATION;

CHOLESTEROL; EPIGENESIS, GENETIC; FUMARATES; GLUCOSE; GLUTAMINE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNE TOLERANCE; IMMUNITY, INNATE; MACROPHAGES; MODELS, BIOLOGICAL; PENTOSE PHOSPHATE PATHWAY; PROTEOLYSIS;

EID: 85003874481     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.10.008     Document Type: Article

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