Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Shi, Jindong ^a   Feng, Jingjing ^a   Xie, Juan ^a   Mei, Zhoufang ^a   Shi, Tianyun ^a   Wang, Shengmei ^a   Du, Yong ^a   Yang, Gong ^a   Wu, Yougen ^a   Cheng, Xiaojiao ^b   Li, Shanqun ^a   Zhu, Liming ^c   Yang, Chung S ^c   Tu, Shuiping ^b   Jie, Zhijun ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 6; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION; GENETICS; HUMAN; LUNG TUMOR; MALE; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE; MYOFIBROBLAST; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOMARKERS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; INTERLEUKIN-6; JANUS KINASE 2; LUNG NEOPLASMS; MALE; MICE; MOLECULAR TARGETED THERAPY; MYOFIBROBLASTS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85027840673     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-09020-8     Document Type: Article

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