Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor

Journal of Biological Chemistry

Volumn 279, Issue 2, 2004, Pages 1359-1367

  Horowitz, Jeffrey C ^a   Lee, Daniel Y ^a   Waghray, Meghna ^a   Keshamouni, Venkateshwar G ^a   Thomas, Peedikayil E ^a   Zhang, Hengmin ^a   Cui, Zongbin ^a   Thannickal, Victor J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME KINETICS; ENZYMES; GROWTH KINETICS;

APOPTOSIS; PHARMACOLOGICAL INHIBITION;

BIOCHEMISTRY;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AUTOCRINE MOTILITY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL SURVIVAL; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FETUS LUNG; GENE INDUCTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MESENCHYME CELL; MYOFIBROBLAST; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TARGET CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DENSITOMETRY; DNA, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GROWTH SUBSTANCES; HUMANS; IMIDAZOLES; LUNG; MESODERM; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PHOSPHORYLATION; PLASMIDS; PYRIDINES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 0345832090     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306248200     Document Type: Article

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