Chromosomal instability drives metastasis through a cytosolic DNA response

Nature

Volumn 553, Issue 7689, 2018, Pages 467-472

  Bakhoum, Samuel F ^a,b   Ngo, Bryan ^b   Laughney, Ashley M ^a   Cavallo, Julie Ann ^a,b   Murphy, Charles J ^b   Ly, Peter ^c   Shah, Pragya ^d   Sriram, Roshan K ^b   Watkins, Thomas B K ^e   Taunk, Neil K ^a   Duran, Mercedes ^a,b   Pauli, Chantal ^f   Shaw, Christine ^a   Chadalavada, Kalyani ^a   Rajasekhar, Vinagolu K ^a   Genovese, Giulio ^g   Venkatesan, Subramanian ^h   Birkbak, Nicolai J ^e,h   McGranahan, Nicholas ^e,h   Lundquist, Mark ^b   LaPlant, Quincey ^a   Healey, John H ^a   Elemento, Olivier ^b   Chung, Christine H ⁱ   Lee, Nancy Y ^a   Imielenski, Marcin ^b   Nanjangud, Gouri ^a   Pe'er, Dana ^a   Cleveland, Don W ^c   Powell, Simon N ^a   Lammerding, Jan ^d   Swanton, Charles ^e,h   Cantley, Lewis C ^b   more..

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d School of Operations Research and Industrial Engineering   (United States)

^e THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^h UNIVERSITY COLLEGE LONDON   (United Kingdom)

ⁱ H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; EXTRACHROMOSOMAL DNA; GENOMIC DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; DNA; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE;

CANCER; CELL COMPONENT; CHROMOSOME; DNA; GENETIC ANALYSIS; GENOMICS; TUMOR;

ANEUPLOIDY; ARTICLE; CELL INVASION; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; CYTOSOL; DISEASE ASSOCIATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE REPRESSION; HUMAN; INNATE IMMUNITY; METASTASIS; MICRONUCLEUS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR MODEL; ANIMAL; BRAIN TUMOR; BREAST TUMOR; CELL LINE; DRUG SCREENING; ENZYMOLOGY; FEMALE; GENETICS; HEAD AND NECK TUMOR; INFLAMMATION; MESODERM; METABOLISM; MOUSE; PATHOLOGY; SECONDARY; SQUAMOUS CELL CARCINOMA;

ANIMALS; BRAIN NEOPLASMS; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CELL LINE; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; CYTOSOL; DNA, NEOPLASM; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; INFLAMMATION; MEMBRANE PROTEINS; MESODERM; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; NEOPLASM METASTASIS; NF-KAPPA B; NUCLEOTIDYLTRANSFERASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85041110925     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature25432     Document Type: Article

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